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Telmisartan Tablets USP Taj Pharma SmPCTajPharmaQC
Telmisartan Tablets USP 20mg/40mg/80mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Telmisartan Dosage & Rx Info | Telmisartan Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Telmisartan -Drug Information –Taj Pharma, Telmisartan dose Taj pharmaceuticals Telmisartan interactions, Taj Pharmaceutical Telmisartan contraindications, Telmisartan price, Telmisartan Taj Pharma Telmisartan SmPC-Taj Pharma Stay connected to all updated on Telmisartan Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
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Olmesartan 20mg/40mg Tablets USP Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Olmesartan Dosage & Rx Info | Olmesartan Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Olmesartan-Drug Information –Taj Pharma, Olmesartan dose Taj pharmaceuticals Olmesartan interactions, Taj Pharmaceutical Olmesartan contraindications, Olmesartan price, Olmesartan Taj Pharma Olmesartan SmPC-Taj Pharma Stay connected to all updated on Olmesartan Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Irbesartan 150 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
IRBESARTAN Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, IRBESARTAN Dosage & Rx Info | IRBESARTAN Uses, Side Effects -: Indications, Side Effects, Warnings, IRBESARTAN - Drug Information - Taj Pharma, IRBESARTAN dose Taj pharmaceuticals IRBESARTAN interactions, Taj Pharmaceutical IRBESARTAN contraindications, IRBESARTAN price, IRBESARTAN Taj Pharma Irbesartan 150 mg film-coated tablets SMPC- Taj Pharma . Stay connected to all updated on IRBESARTAN Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Telmisartan tablets ip 20mg, 40mg, 80mg taj pharma SmPCTajPharmaQC
Telmisartan Tablets IP 20mg; 40mg; 80mg (Telmisar) Taj PharmaTaj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Telmisartan Tablets IP 20mg; 40mg; 80mg (Telmisar) Taj PharmaDosage & Rx Info | Telmisartan Tablets IP 20mg; 40mg; 80mg (Telmisar) Taj PharmaUses, Side Effects, Telmisartan Tablets IP 20mg; 40mg; 80mg (Telmisar) Taj PharmaIndications, Side Effects, Warnings, Telmisartan Tablets IP 20mg; 40mg; 80mg (Telmisar) Taj Pharma- Drug Information – Taj Pharma, Telmisartan Tablets IP 20mg; 40mg; 80mg (Telmisar) Taj Pharmadose Taj pharmaceuticals Telmisartan Tablets IP 20mg; 40mg; 80mg (Telmisar) Taj Pharmainteractions, Taj Pharmaceutical Telmisartan Tablets IP 20mg; 40mg; 80mg (Telmisar) Taj Pharmacontraindications, Telmisartan Tablets IP 20mg; 40mg; 80mg (Telmisar) Taj Pharmaprice, Telmisartan Tablets IP 20mg; 40mg; 80mg (Telmisar) Taj PharmaTaj Pharma Telmisartan Tablets IP 20mg; 40mg; 80mg (Telmisar) Taj PharmaSMPC- Taj Pharma Stay connected to all updated on Telmisartan Tablets IP 20mg; 40mg; 80mg (Telmisar) Taj PharmaTaj Pharmaceuticals Taj pharmaceuticals Hyderabad. Summary of Product Characteristics, SmPC.
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Lisinopril Tablets USP 2.5mg, 5mg, 10mg, 20mg, 30mg, 40mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Lisinopril Dosage & Rx Info | Lisinopril Uses, Side Effects Lisinopril: Indications, Side Effects, Warnings, Lisinopril-Drug Information –Taj Pharma, Lisinopril dose Taj pharmaceuticals Lisinopril interactions, Taj Pharmaceutical Lisinopril contraindications, Lisinopril price, Lisinopril Taj Pharma Lisinopril SmPC- Taj Pharma Stay connected to all updated on Lisinopril Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
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Olmesartan 20mg/40mg Tablets USP Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Olmesartan Dosage & Rx Info | Olmesartan Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Olmesartan-Drug Information –Taj Pharma, Olmesartan dose Taj pharmaceuticals Olmesartan interactions, Taj Pharmaceutical Olmesartan contraindications, Olmesartan price, Olmesartan Taj Pharma Olmesartan SmPC-Taj Pharma Stay connected to all updated on Olmesartan Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Irbesartan 150 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
IRBESARTAN Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, IRBESARTAN Dosage & Rx Info | IRBESARTAN Uses, Side Effects -: Indications, Side Effects, Warnings, IRBESARTAN - Drug Information - Taj Pharma, IRBESARTAN dose Taj pharmaceuticals IRBESARTAN interactions, Taj Pharmaceutical IRBESARTAN contraindications, IRBESARTAN price, IRBESARTAN Taj Pharma Irbesartan 150 mg film-coated tablets SMPC- Taj Pharma . Stay connected to all updated on IRBESARTAN Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
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Lisinopril Tablets USP 2.5mg, 5mg, 10mg, 20mg, 30mg, 40mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Lisinopril Dosage & Rx Info | Lisinopril Uses, Side Effects Lisinopril: Indications, Side Effects, Warnings, Lisinopril-Drug Information –Taj Pharma, Lisinopril dose Taj pharmaceuticals Lisinopril interactions, Taj Pharmaceutical Lisinopril contraindications, Lisinopril price, Lisinopril Taj Pharma Lisinopril SmPC- Taj Pharma Stay connected to all updated on Lisinopril Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
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Flutamide Tablets USP 250mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Flutamide Dosage & Rx Info | Flutamide Uses, Side Effects Flutamide: Indications, Side Effects, Warnings, Flutamide -Drug Information –Taj Pharma, Flutamide dose Taj pharmaceuticals Flutamide interactions, Taj Pharmaceutical Flutamide contraindications, Flutamide price, Flutamide Taj Pharma Flutamide SmPC-Taj Pharma Stay connected to all updated on Flutamide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
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Sartel (Telmisartan Tablets) is a prescription medicine used to treat high blood pressure (hypertension) and for reduction in Cardiovascular (CV) risk in patients unable to take ACE inhibitors.
Ramipril Tablets BP 5mg, 10mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Ramipril Dosage & Rx Info | Ramipril Uses, Side Effects Ramipril: Indications, Side Effects, Warnings, Ramipril-Drug Information –Taj Pharma, Ramipril dose Taj pharmaceuticals Ramipril interactions, Taj Pharmaceutical Ramipril contraindications, Ramipril price, Ramipril Taj Pharma Ramipril SmPC-Taj Pharma Stay connected to all updated on Ramipril Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
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Olmesartan medoxomil and Amlodipine Tablets 20mg/5mg, 40mg/5mg, 40mg/10mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Olmesartan medoxomil and Amlodipine Dosage & Rx Info | Olmesartan medoxomil and Amlodipine Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Olmesartan medoxomil and Amlodipine-Drug Information –Taj Pharma, Olmesartan medoxomil and Amlodipine dose Taj pharmaceuticals Olmesartan medoxomil and Amlodipine interactions, Taj Pharmaceutical Olmesartan medoxomil and Amlodipine contraindications, Olmesartan medoxomil and Amlodipine price, Olmesartan medoxomil and Amlodipine Taj Pharma Olmesartan medoxomil and Amlodipine SmPC-Taj Pharma Stay connected to all updated on Olmesartan medoxomil and Amlodipine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Simvastatin Tablets USP Taj Pharma SmPCTajPharmaQC
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Captopril Tablets SmPC Taj PharmaceuticalsTajPharmaQC
Captopril Tablets USP 25mg, 50mg, 100mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Captopril Dosage & Rx Info | Captopril Uses, Side Effects Captopril: Indications, Side Effects, Warnings, Captopril -Drug Information –Taj Pharma, Captopril dose Taj pharmaceuticals Captopril interactions, Taj Pharmaceutical Captopril contraindications, Captopril price, Captopril Taj Pharma Captopril SmPC- Taj Pharma Stay connected to all updated on Captopril Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Decitabine for Injection Taj Pharma SmPCTajPharmaQC
Decitabine for Injection 50mg/Vial Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Decitabine Dosage & Rx Info | Decitabine Uses, Side Effects Decitabine: Indications, Side Effects, Warnings, Decitabine -Drug Information –Taj Pharma, Decitabine dose Taj pharmaceuticals Decitabine interactions, Taj Pharmaceutical Decitabine contraindications, Decitabine price, Decitabine Taj Pharma Decitabine SmPC-Taj Pharma Stay connected to all updated on Decitabine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Telmisartan Tablets USP 20mg/40mg/80mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Telmisartan Dosage & Rx Info | Telmisartan Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Telmisartan -Drug Information –Taj Pharma, Telmisartan dose Taj pharmaceuticals Telmisartan interactions, Taj Pharmaceutical Telmisartan contraindications, Telmisartan price, Telmisartan Taj Pharma Telmisartan SmPC-Taj Pharma Stay connected to all updated on Telmisartan Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Ramipril 10mg tablets smpc taj pharmaceuticalsTaj Pharma
Ramipril Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Ramipril Dosage & Rx Info | Ramipril Uses, Side Effects -: Indications, Side Effects, Warnings, Ramipril - Drug Information - Taj Pharma, Ramipril dose Taj pharmaceuticals Ramipril interactions, Taj Pharmaceutical Ramipril contraindications, Ramipril price, Ramipril Taj Pharma Ramipril 10mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Ramipril Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Telmisartan Tablets USP Taj Pharma SmPCTajPharmaQC
Telmisartan Tablets USP 20mg/40mg/80mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Telmisartan Dosage & Rx Info | Telmisartan Uses, Side Effects Telmisartan: Indications, Side Effects, Warnings, Telmisartan-Drug Information –Taj Pharma, Telmisartan dose Taj pharmaceuticals Telmisartan interactions, Taj Pharmaceutical Telmisartan contraindications, Telmisartan price, Telmisartan Taj Pharma Telmisartan SmPC-Taj Pharma Stay connected to all updated on Telmisartan Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Valsartan and HCTZ Tablets USP Taj Pharma SmPCTajPharmaQC
Valsartan and HCTZ Tablets USP 80mg/12.5mg, 160mg/12.5mg, 320mg/12.5mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Valsartan and HCTZ Dosage & Rx Info | Valsartan and HCTZ Uses, Side Effects Valsartan and HCTZ: Indications, Side Effects, Warnings, Valsartan and HCTZ-Drug Information –Taj Pharma, Valsartan and HCTZ dose Taj pharmaceuticals Valsartan and HCTZ interactions, Taj Pharmaceutical Valsartan and HCTZ contraindications, Valsartan and HCTZ price, Valsartan and HCTZ Taj Pharma Valsartan and HCTZ SmPC-Taj Pharma Stay connected to all updated on Valsartan and HCTZ Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
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Duloxetine Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Duloxetine Dosage & Rx Info | Duloxetine Uses, Side Effects -: Indications, Side Effects, Warnings, Duloxetine - Drug Information - Taj Pharma, Duloxetine dose Taj pharmaceuticals Duloxetine interactions, Taj Pharmaceutical Duloxetine contraindications, Duloxetine price, Duloxetine Taj Pharma Duloxetine 20 mg gastro-resistant capsules SMPC- Taj Pharma . Stay connected to all updated on Duloxetine Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
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Lisinopril 10mg Tablets Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Lisinopril Dosage & Rx Info | Lisinopril Uses, Side Effects - Lisinopril: Indications, Side Effects, Warnings, Lisinopril - Drug Information - Taj Pharma, Lisinopril dose Taj pharmaceuticals Lisinopril interactions, Taj Pharmaceutical Lisinopril contraindications, Lisinopril price, Lisinopril Taj Pharma Lisinopril 10mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Lisinopril Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
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Flutamide Tablets USP 250mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Flutamide Dosage & Rx Info | Flutamide Uses, Side Effects Flutamide: Indications, Side Effects, Warnings, Flutamide -Drug Information –Taj Pharma, Flutamide dose Taj pharmaceuticals Flutamide interactions, Taj Pharmaceutical Flutamide contraindications, Flutamide price, Flutamide Taj Pharma Flutamide SmPC-Taj Pharma Stay connected to all updated on Flutamide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Atorvastatin 40 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Atorvastatin 40mg Tablets Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Atorvastatin Dosage & Rx Info | Atorvastatin Uses, Side Effects - Atorvastatin : Indications, Side Effects, Warnings, Atorvastatin - Drug Information - Taj Pharma, Atorvastatin dose Taj pharmaceuticals Atorvastatin interactions, Taj Pharmaceutical Atorvastatin contraindications, Atorvastatin price, Atorvastatin Taj Pharma anti-arrhythmics Atorvastatin 40 mg film-coated tablets SMPC- Taj Pharma . Stay connected to all updated on Atorvastatin Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Sartel (Telmisartan Tablets) is a prescription medicine used to treat high blood pressure (hypertension) and for reduction in Cardiovascular (CV) risk in patients unable to take ACE inhibitors.
Ramipril Tablets BP 5mg, 10mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Ramipril Dosage & Rx Info | Ramipril Uses, Side Effects Ramipril: Indications, Side Effects, Warnings, Ramipril-Drug Information –Taj Pharma, Ramipril dose Taj pharmaceuticals Ramipril interactions, Taj Pharmaceutical Ramipril contraindications, Ramipril price, Ramipril Taj Pharma Ramipril SmPC-Taj Pharma Stay connected to all updated on Ramipril Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Olmesartan medoxomil and Amlodipine Tablets Taj Pharma SmPCTajPharmaQC
Olmesartan medoxomil and Amlodipine Tablets 20mg/5mg, 40mg/5mg, 40mg/10mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Olmesartan medoxomil and Amlodipine Dosage & Rx Info | Olmesartan medoxomil and Amlodipine Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Olmesartan medoxomil and Amlodipine-Drug Information –Taj Pharma, Olmesartan medoxomil and Amlodipine dose Taj pharmaceuticals Olmesartan medoxomil and Amlodipine interactions, Taj Pharmaceutical Olmesartan medoxomil and Amlodipine contraindications, Olmesartan medoxomil and Amlodipine price, Olmesartan medoxomil and Amlodipine Taj Pharma Olmesartan medoxomil and Amlodipine SmPC-Taj Pharma Stay connected to all updated on Olmesartan medoxomil and Amlodipine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Simvastatin Tablets USP Taj Pharma SmPCTajPharmaQC
Simvastatin Tablets USP 20mg, 40mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Simvastatin Dosage & Rx Info | Simvastatin Uses, Side Effects Simvastatin: Indications, Side Effects, Warnings, Simvastatin-Drug Information –Taj Pharma, Simvastatin dose Taj pharmaceuticals Simvastatin interactions, Taj Pharmaceutical Simvastatin contraindications, Simvastatin price, Simvastatin Taj Pharma Simvastatin SmPC-Taj Pharma Stay connected to all updated on Simvastatin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Captopril Tablets SmPC Taj PharmaceuticalsTajPharmaQC
Captopril Tablets USP 25mg, 50mg, 100mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Captopril Dosage & Rx Info | Captopril Uses, Side Effects Captopril: Indications, Side Effects, Warnings, Captopril -Drug Information –Taj Pharma, Captopril dose Taj pharmaceuticals Captopril interactions, Taj Pharmaceutical Captopril contraindications, Captopril price, Captopril Taj Pharma Captopril SmPC- Taj Pharma Stay connected to all updated on Captopril Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Decitabine for Injection Taj Pharma SmPCTajPharmaQC
Decitabine for Injection 50mg/Vial Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Decitabine Dosage & Rx Info | Decitabine Uses, Side Effects Decitabine: Indications, Side Effects, Warnings, Decitabine -Drug Information –Taj Pharma, Decitabine dose Taj pharmaceuticals Decitabine interactions, Taj Pharmaceutical Decitabine contraindications, Decitabine price, Decitabine Taj Pharma Decitabine SmPC-Taj Pharma Stay connected to all updated on Decitabine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Telmisartan Tablets USP 20mg/40mg/80mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Telmisartan Dosage & Rx Info | Telmisartan Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Telmisartan -Drug Information –Taj Pharma, Telmisartan dose Taj pharmaceuticals Telmisartan interactions, Taj Pharmaceutical Telmisartan contraindications, Telmisartan price, Telmisartan Taj Pharma Telmisartan SmPC-Taj Pharma Stay connected to all updated on Telmisartan Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Ramipril 10mg tablets smpc taj pharmaceuticalsTaj Pharma
Ramipril Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Ramipril Dosage & Rx Info | Ramipril Uses, Side Effects -: Indications, Side Effects, Warnings, Ramipril - Drug Information - Taj Pharma, Ramipril dose Taj pharmaceuticals Ramipril interactions, Taj Pharmaceutical Ramipril contraindications, Ramipril price, Ramipril Taj Pharma Ramipril 10mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Ramipril Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Telmisartan Tablets USP Taj Pharma SmPCTajPharmaQC
Telmisartan Tablets USP 20mg/40mg/80mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Telmisartan Dosage & Rx Info | Telmisartan Uses, Side Effects Telmisartan: Indications, Side Effects, Warnings, Telmisartan-Drug Information –Taj Pharma, Telmisartan dose Taj pharmaceuticals Telmisartan interactions, Taj Pharmaceutical Telmisartan contraindications, Telmisartan price, Telmisartan Taj Pharma Telmisartan SmPC-Taj Pharma Stay connected to all updated on Telmisartan Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Valsartan and HCTZ Tablets USP Taj Pharma SmPCTajPharmaQC
Valsartan and HCTZ Tablets USP 80mg/12.5mg, 160mg/12.5mg, 320mg/12.5mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Valsartan and HCTZ Dosage & Rx Info | Valsartan and HCTZ Uses, Side Effects Valsartan and HCTZ: Indications, Side Effects, Warnings, Valsartan and HCTZ-Drug Information –Taj Pharma, Valsartan and HCTZ dose Taj pharmaceuticals Valsartan and HCTZ interactions, Taj Pharmaceutical Valsartan and HCTZ contraindications, Valsartan and HCTZ price, Valsartan and HCTZ Taj Pharma Valsartan and HCTZ SmPC-Taj Pharma Stay connected to all updated on Valsartan and HCTZ Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
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Telmisartan/HCTZ Tablets 40mg/12.5 and 80mg/12.5mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Telmisartan/HCTZ Dosage & Rx Info | Telmisartan/HCTZ Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Telmisartan/HCTZ -Drug Information –Taj Pharma, Telmisartan/HCTZ dose Taj pharmaceuticals Telmisartan/HCTZ interactions, Taj Pharmaceutical Telmisartan/HCTZ contraindications, Telmisartan/HCTZ price, Telmisartan/HCTZ Taj Pharma Telmisartan/HCTZ SmPC-Taj Pharma Stay connected to all updated on Telmisartan/HCTZ Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
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Telmisartan Tablets IP 20mg; 40mg; 80mg (Telmisar) Taj Pharma SmPCTajPharmaQC
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Sartel H Tablets (Generic Telmisartan and Hydrochlorothiazide Tablets)Clearsky Pharmacy
Sartel H Tablets (Generic Telmisartan and Hydrochlorothiazide Tablets) is combination of an angiotensin II receptor blocker (ARB) and a thiazide diuretic indicated for the treatment of hypertension, alone or with other antihypertensive agents, to lower blood pressure.
Lowering blood pressure decreases the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. This medicine is not prescribed for initial therapy of hypertension.
Cresar-H (Generic Telmisartan and Hydrochlorothiazide Tablets) The Swiss Pharmacy
Cresar-H (Generic Telmisartan and Hydrochlorothiazide Tablets) is used for the treatment of hypertension, to lower blood pressure as second line therapy. This fixed dose combination is not indicated for initial therapy for the treatment of hypertension. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions.
Cresar H / Cresar 80 H should be taken in patients whose blood pressure is not adequately controlled by Telmisartan alone.
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Candesartan and Hydrochlorothiazide Tablets SmPC Taj PharmaceuticalsTajPharmaQC
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Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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RX
TELMISARTAN
TABLETS
40MG
1.NAME OF THE MEDICINAL PRODUCT
Telmisartan 40 mg tablets
2. QUALITATIVE AND QUANTITATIVE
COMPOSITION
ach tablet contains 40 mg telmisartan.
Excipient(s) with known effect
Each tablet contains 153.381 mg lactose (as
lactose anhydrous and lactose monohydrate) and
1.94 mg (0.084 mmol) sodium (as sodium
hydroxide).
For the full list of excipients, see section 6.1.
3. PHARMACEUTICAL FORM
Tablet.
White, oblong, plane tablet, scored on one side.
The tablets are 11.5-11.8 mm long and 6.4-6.8
mm wide.
The tablet with a score line can be divided into
equal doses.
4. CLINICAL PARTICULARS
4.1 Therapeutic indications
Hypertension:
Treatment of essential hypertension in adults.
Cardiovascular prevention:
Reduction of cardiovascular morbidity in adults
with:
• manifest atherothrombotic cardiovascular
disease (history of coronary heart disease,
stroke, or peripheral arterial disease) or
• type 2 diabetes mellitus with documented
target organ damage
4.2 Posology and method of administration
Posology
Treatment of essential hypertension:
The usually effective dose is 40 mg once daily.
Some patients may already benefit at a daily
dose of 20 mg. In cases where the target blood
pressure is not achieved, the dose of telmisartan
can be increased to a maximum of 80 mg once
daily. Alternatively, telmisartan may be used in
combination with thiazide-type diuretics such as
hydrochlorothiazide, which has been shown to
have an additive blood pressure lowering effect
with telmisartan. When considering raising the
dose, it must be borne in mind that the
maximum antihypertensive effect is generally
attained four to eight weeks after the start of
treatment (see section 5.1).
Cardiovascular prevention:
The recommended dose is 80 mg once daily. It
is not known whether doses lower than 80 mg of
telmisartan are effective in reducing
cardiovascular morbidity.
When initiating telmisartan therapy for the
reduction of cardiovascular morbidity, close
monitoring of blood pressure is recommended,
and if appropriate adjustment of medicinal
products that lower blood pressure may be
necessary.
Special populations
Renal impairment
Limited experience is available in patients with
severe renal impairment or haemodialysis. A
lower starting dose of 20 mg is recommended in
these patients (see section 4.4).
No posology adjustment is required for patients
with mild to moderate renal impairment.
Hepatic impairment
Telmisartan is contraindicated in patients with
severe hepatic impairment (see section 4.3).In
patients with mild to moderate hepatic
impairment, the posology should not exceed 40
mg once daily (see section 4.4).
Elderly
No dose adjustment is necessary for elderly
patients.
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Paediatric population
The safety and efficacy of Telmisartan in
children and adolescents aged below 18 years
have not been established.
Currently available data are described in section
5.1 and 5.2 but no recommendation on a
posology can be made.
Method of administration
Telmisartan tablets are for once-daily oral
administration and should be taken with liquid,
with or without food.
4.3 Contraindications
• Hypersensitivity to the active substance or to
any of the excipients listed in section 6.1.
• Second and third trimester of pregnancy (see
sections 4.4 and 4.6).
• Biliary obstructive disorders.
• Severe hepatic impairment.
• The concomitant use of telmisartan with
aliskiren-containing products is contraindicated
in patients with diabetes mellitus or renal
impairment (GFR < 60 ml/min/1.73 m2) (see
sections 4.5 and 5.1).
4.4 Special Warnings and precautions for use
Pregnancy
Angiotensin II receptor antagonists should not
be initiated during pregnancy. Unless continued
angiotensin II receptor antagonist therapy is
considered essential, patients planning
pregnancy should be changed to alternative
antihypertensive treatments which have an
established safety profile for use in pregnancy.
When pregnancy is diagnosed, treatment with
angiotensin II receptor antagonists should be
stopped immediately, and, if appropriate,
alternative therapy should be started (see
sections 4.3 and 4.6).
Hepatic impairment:
Telmisartan is not to be given to patients with
cholestasis, biliary obstructive disorders or
severe hepatic impairment (see section 4.3) since
telmisartan is mostly eliminated with the bile.
These patients can be expected to have reduced
hepatic clearance for telmisartan. Telmisartan
should be used only with caution in patients with
mild to moderate hepatic impairment.
Renovascular hypertension
There is an increased risk of severe hypotension
and renal insufficiency when patients with
bilateral renal artery stenosis or stenosis of the
artery to a single functioning kidney are treated
with medicinal products that affect the renin-
angiotensin-aldosterone system.
Renal impairment and kidney transplantation
When Telmisartan is used in patients with
impaired renal function, periodic monitoring of
potassium and creatinine serum levels is
recommended. There is no experience regarding
the administration of Telmisartan in patients
with recent kidney transplantation
Intravascular hypovolaemia
Symptomatic hypotension, especially after the
first dose of Telmisartan, may occur in patients
who are volume and/or sodium depleted by
vigorous diuretic therapy, dietary salt restriction,
diarrhoea or vomiting. Such conditions should
be corrected before the administration of
Telmisartan. Volume and/or sodium depletion
should be corrected prior to administration of
Telmisartan.
Dual blockade of the renin-angiotensin-
aldosterone system (RAAS)
There is evidence that the concomitant use of
ACE-inhibitors, angiotensin II receptor blockers
or aliskiren increases the risk of hypotension,
hyperkalaemia and decreased renal function
(including acute renal failure). Dual blockade of
RAAS through the combined use of ACE-
inhibitors, angiotensin II receptor blockers or
aliskiren is therefore not recommended (see
sections 4.5 and 5.1).
If dual blockade therapy is considered absolutely
necessary, this should only occur under
specialist supervision and subject to frequent
close monitoring of renal function, electrolytes
and blood pressure.
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ACE-inhibitors and angiotensin II receptor
blockers should not be used concomitantly in
patients with diabetic nephropathy.
Other conditions with stimulation of the renin-
angiotensin-aldosterone system
In patients whose vascular tone and renal
function depend predominantly on the activity of
the renin-angiotensin-aldosterone system (e.g.
patients with severe congestive heart failure or
underlying renal disease, including renal artery
stenosis), treatment with medicinal products that
affect this system such as telmisartan has been
associated with acute hypotension,
hyperazotaemia, oliguria, or rarely acute renal
failure (see section 4.8).
Primary aldosteronism
Patients with primary aldosteronism generally
will not respond to antihypertensive medicinal
products acting through inhibition of the renin-
angiotensin system. Therefore, the use of
telmisartan is not recommended.
Aortic and mitral valve stenosis, obstructive
hypertrophic cardiomyopathy
As with other vasodilators, special caution is
indicated in patients suffering from aortic or
mitral stenosis, or obstructive hypertrophic
cardiomyopathy.
Diabetic patients treated with insulin or
antidiabetics
In these patients hypoglycaemia may occur
under telmisartan treatment. Therefore, in these
patients an appropriate blood glucose monitoring
should be considered; a dose adjustment of
insulin or antidiabetics may be required, when
indicated.
Hyperkalaemia
The use of medicinal products that affect the
renin-angiotensin-aldosterone system may cause
hyperkalaemia.
In the elderly, in patients with renal
insufficiency, in diabetic patients, in patients
concomitantly treated with other medicinal
products that may increase potassium levels,
and/or in patients with intercurrent events,
hyperkalaemia may be fatal.
Before considering the concomitant use of
medicinal products that affect the renin-
angiotensin-aldosterone system, the benefit risk
ratio should be evaluated.
The main risk factors for hyperkalaemia to be
considered are:
• Diabetes mellitus, renal impairment, age (> 70
years)
• Combination with one or more other medicinal
products that affect the renin-angiotensin-
aldosterone system and/or potassium
supplements. Medicinal products or therapeutic
classes of medicinal products that may provoke
hyperkalaemia are salt substitutes containing
potassium, potassium-sparing diuretics, ACE
inhibitors, angiotensin II receptor antagonists,
non steroidal anti-inflammatory medicinal
products (NSAIDs, including selective COX-2
inhibitors), heparin, immunosuppressives
(cyclosporin or tacrolimus), and trimethoprim.
• Intercurrent events, in particular dehydratation,
acute cardiac decompensation, metabolic
acidosis, worsening of renal function, sudden
worsening of the renal condition (e.g. infectious
diseases), cellular lysis (e.g. acute limb
ischaemia, rhabdomyolysis, extend trauma).
Close-monitoring of serum potassium in at risk
patients is recommended (see section 4.5).
Lactose
This medicinal product contains lactose. Patients
with rare hereditary problems of galactose
intolerance, total lactase deficiency or glucose-
galactose malabsorption should not take this
medicinal product.
Sodium
This medicinal product contains less than 1
mmol sodium (23 mg) per tablet, that is to say
essentially 'sodium-free'.
Ethnic differences
As observed for angiotensin converting enzyme
inhibitors, telmisartan and the other angiotensin
II receptor antagonists are apparently less
effective in lowering blood pressure in black
people than in non-blacks, possibly because of
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higher prevalence of low-renin states in the
black hypertensive population.
Other
As with any antihypertensive agent, excessive
reduction of blood pressure in patients with
ischaemic cardiopathy or ischaemic
cardiovascular disease could result in a
myocardial infarction or stroke.
4.5 Interaction with other medicinal products
and other forms of interaction
Digoxin
When telmisartan was co-administered with
digoxin, median increases in digoxin peak
plasma concentration (49%) and in trough
concentration (20%) were observed. When
initiating, adjusting, and discontinuing
telmisartan, monitor digoxin levels in order to
maintain levels within the therapeutic range.
As with other medicinal products acting on the
renin-angiotensin-aldosterone system,
telmisartan may provoke hyperkalaemia (see
section 4.4). The risk may increase in case of
treatment combination with other medicinal
products that may also provoke hyperkalaemia
(salt substitutes containing potassium,
potassium-sparing diuretics, ACE inhibitors,
angiotensin II receptor antagonists, non steroidal
anti-inflammatory medicinal products (NSAIDs,
including selective COX-2 inhibitors), heparin,
immunosuppressives (cyclosporin or
tacrolimus), and trimethoprim).
The occurrence of hyperkalaemia depends on
associated risk factors. The risk is increased in
case of the above-mentioned treatment
combinations. The risk is particularly high in
combination with potassium sparing-diuretics,
and when combined with salt substitutes
containing potassium. A combination with ACE
inhibitors or NSAIDs, for example, presents a
lesser risk provided that precautions for use are
strictly followed.
Concomitant use not recommended
Potassium sparing diuretics or potassium
supplements
Angiotensin II receptor antagonists such as
telmisartan, attenuate diuretic induced potassium
loss. Potassium sparing diuretics e.g.
spirinolactone, eplerenone, triamterene, or
amiloride, potassium supplements, or potassium-
containing salt substitutes may lead to a
significant increase in serum potassium. If
concomitant use is indicated because of
documented hypokalaemia, they should be used
with caution and with frequent monitoring of
serum potassium.
Lithium
Reversible increases in serum lithium
concentrations and toxicity have been reported
during concomitant administration of lithium
with angiotensin converting enzyme inhibitors,
and with angiotensin II receptor antagonists,
including telmisartan. If use of the combination
proves necessary, careful monitoring of serum
lithium levels is recommended.
Concomitant use requiring caution
Non-steroidal anti-inflammatory medicinal
products
NSAIDs (i.e. acetylsalicylic acid at anti-
inflammatory dosage regimens, COX-2
inhibitors and non-selective NSAIDs) may
reduce the antihypertensive effect of angiotensin
II receptor antagonists. In some patients with
compromised renal function (e.g. dehydrated
patients or elderly patients with compromised
renal function), the co-administration of
angiotensin II receptor antagonists and agents
that inhibit cyclo-oxygenase may result in
further deterioration of renal function, including
possible acute renal failure, which is usually
reversible. Therefore, the combination should be
administered with caution, especially in the
elderly. Patients should be adequately hydrated
and consideration should be given to monitoring
of renal function after initiation of concomitant
therapy and periodically thereafter.
In one study the co-administration of telmisartan
and ramipril led to an increase of up to 2.5 fold
in the AUC0-24 and Cmax of ramipril and
ramiprilat. The clinical relevance of this
observation is not known.
Diuretics (thiazide or loop diuretics)
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Prior treatment with high dose diuretics such as
furosemide (loop diuretic) and
hydrochlorothiazide (thiazide diuretic) may
result in volume depletion, and in a risk of
hypotension when initiating therapy with
telmisartan.
To be taken into account with concomitant use
Other antihypertensive agents
The blood pressure lowering effect of
telmisartan can be increased by concomitant use
of other antihypertensive medicinal products.
Clinical trial data has shown that dual blockade
of the renin-angiotensin-aldosterone-system
(RAAS) through the combined use of ACE-
inhibitors, angiotensin II receptor blockers or
aliskiren is associated with a higher frequency of
adverse events such as hypotension,
hyperkalaemia and decreased renal function
(including acute renal failure) compared to the
use of a single RAAS-acting agent (see sections
4.3, 4.4 and 5.1).
Based on their pharmacological properties it can
be expected that the following medicinal
products may potentiate the hypotensive effects
of all antihypertensives including telmisartan:
Baclofen, amifostine. Furthermore, orthostatic
hypotension may be aggravated by alcohol,
barbiturates, narcotics, or antidepressants.
Corticosteroids (systemic use)
Reduction of the antihypertensive effect.
4.6 Fertility, Pregnancy and lactation
Pregnancy
The use of angiotensin II receptor antagonists is not
recommended during the first trimester of
pregnancy (see section 4.4). The use of angiotensin
II receptor antagonists is contraindicated during the
second and third trimesters of pregnancy (see
sections 4.3 and 4.4).
There are no adequate data from the use of
Telmisartan in pregnant women. Studies in
animals have shown reproductive toxicity (see
section 5.3).
Epidemiological evidence regarding the risk of
teratogenicity following exposure to ACE
inhibitors during the first trimester of pregnancy
has not been conclusive; however a small
increase in risk cannot be excluded. Whilst there
is no controlled epidemiological data on the risk
with angiotensin II receptor antagonists, similar
risks may exist for this class of medicinal
products. Unless continued angiotensin II
receptor antagonist therapy is considered
essential, patients planning pregnancy should be
changed to alternative anti-hypertensive
treatments which have an established safety
profile for use in pregnancy. When pregnancy is
diagnosed, treatment with angiotensin II
receptor antagonists should be stopped
immediately, and, if appropriate, alternative
therapy should be started.
Exposure to angiotensin II receptor antagonists
therapy during the second and third trimesters is
known to induce human foetotoxicity (decreased
renal function, oligohydramnios, skull
ossification retardation) and neonatal toxicity
(renal failure, hypotension, hyperkalaemia) (see
section 5.3).
Should exposure to angiotensin II receptor
antagonists have occurred from the second
trimester of pregnancy, ultrasound check of
renal function and skull is recommended.
Infants whose mothers have taken angiotensin II
receptor antagonists should be closely observed
for hypotension (see also sections 4.3 and 4.4).
Breast-feeding
Because no information is available regarding
the use of Telmisartan during breast-feeding,
Telmisartan is not recommended and alternative
treatments with better established safety profiles
during breast-feeding are preferable, especially
while nursing a newborn or preterm infant.
Fertility
In preclinical studies, no effects of telmisartan
on male and female fertility were observed.
4.7 Effects on ability to drive and use
machines
When driving vehicles or operating machinery it
should be taken into account that dizziness or
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drowsiness may occasionally occur when taking
antihypertensive therapy such as Telmisartan.
4.8 Undesirable Effects
Summary of the safety profile
Serious adverse reactions include anaphylactic
reaction and angioedema which may occur
rarely (≥1/10,000 to <1/1,000), and acute renal
failure.
The overall incidence of adverse reactions
reported with telmisartan was usually
comparable to placebo (41.4% vs 43.9%) in
controlled trials in patients treated for
hypertension. The incidence of adverse reactions
was not dose related and showed no correlation
with gender, age or race of the patients. The
safety profile of telmisartan in patients treated
for the reduction of cardiovascular morbidity
was consistent with that obtained in
hypertensive patients.
The adverse reactions listed below have been
accumulated from controlled clinical trials in
patients treated for hypertension and from post-
marketing reports. The listing also takes into
account serious adverse reactions and adverse
reactions leading to discontinuation reported in
three clinical long-term studies including 21,642
patients treated with telmisartan for the
reduction of cardiovascular morbidity for up to
six years.
Tabulated summary of adverse reactions
Adverse reactions have been ranked under
headings of frequency using the following
convention:
very common (≥1/10); common (≥1/100 to
<1/10); uncommon (≥1/1,000 to <1/100); rare
(≥1/10,000 to <1/1,000); very rare (< 1/10,000)
Within each frequency grouping, adverse
reactions are presented in order of decreasing
seriousness.
Infections and infestations
Uncommon: Upper respiratory tract infection
including pharyngitis and sinusitis, urinary tract
infection including cystitis
Rare: Sepsis including fatal outcome1
Blood and the lymphatic system disorders
Uncommon: Anaemia
Rare: Eosinophilia, thrombocytopenia
Immune system disorders
Rare: Anaphylactic reaction, hypersensitivity
Metabolism and nutrition disorders
Uncommon: Hyperkalaemia
Rare: Hypoglycaemia (in diabetic patients)
Psychiatric disorders
Uncommon: Depression, insomnia
Rare: Anxiety
Nervous system disorders
Uncommon: Syncope
Rare: Somnolence
Eye disorders
Rare: Visual disturbance
Ear and labyrinth disorders
Uncommon: Vertigo
Cardiac disorders
Uncommon: Bradycardia
Rare: Tachycardia
Vascular disorders
Uncommon: Hypotension2
, orthostatic
hypotension
Respiratory, thoracic and mediastinal
disorders
Uncommon: Dyspnoea, cough
Very rare: Interstitial lung disease3
Gastrointestinal disorders
Uncommon: Abdominal pain, diarrhoea,
dyspepsia , flatulence, vomiting
Rare: Stomach discomfort, dry mouth, dysgeusia
Hepato-biliary disorders
Rare: Hepatic function abnormal/liver disorder4
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Skin and subcutaneous tissue disorders
Uncommon: Hyperhidrosis, pruritus, rash
Rare: Angioedema (also with fatal outcome),
eczema, erythema, urticaria, drug eruption, toxic
skin eruption
Muscoloskeletal and connective tissue
disorders
Uncommon: Myalgia, back pain (e.g. sciatica),
muscle spasms
Rare: Arthralgia, pain in extremity, tendon pain
(tendonitis like symptoms)
Renal and urinary disorders
Uncommon: Renal impairment including acute
renal failure
General disorders and administration site
conditions
Uncommon: Chest pain, asthenia (weakness)
Rare: Influenza-like illness
Investigations
Uncommon: Blood creatinine increased
Rare: Blood uric acid increased, hepatic enzyme
increased, blood creatine phosphokinase
increased, haemoglobin decreased
1,2,3,4: for further descriptions, please see sub-
section “Description of selected adverse
reactions”
Description of selected adverse reactions
1
Sepsis
In the PRoFESS trial, an increased incidence of
sepsis was observed with telmisartan compared
with placebo. The event may be a chance finding
or related to a mechanism currently not known
(see section 5.1).
2
Hypotension
This adverse reaction was reported as common
in patients with controlled blood pressure who
were treated with telmisartan for the reduction of
cardiovascular morbidity on top of standard
care.
3
Interstitial lung disease
Cases of interstitial lung disease have been
reported from post-marketing experience in
temporal association with the intake of
telmisartan. However, a causal relationship has
not been established.
4
Hepatic function abnormal / liver disorder
Most cases of hepatic function abnormal / liver
disorder from post-marketing experience
occurred in Japanese patients. Japanese patients
are more likely to experience these adverse
reactions.
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after
authorisation of the medicinal product is
important. It allows continued monitoring of the
benefit/risk balance of the medicinal product.
4.9 Overdose
There is limited information available with
regard to overdose in humans.
Symptoms: The most prominent manifestations
of telmisartan overdose were hypotension and
tachycardia; bradycardia, dizziness, increase in
serum creatinine, and acute renal failure have
also been reported.
Treatment: Telmisartan is not removed by
haemodialysis. The patient should be closely
monitored, and the treatment should be
symptomatic and supportive. Management
depends on the time since ingestion and the
severity of the symptoms. Suggested measures
include induction of emesis and / or gastric
lavage. Activated charcoal may be useful in the
treatment of overdose. Serum electrolytes and
creatinine should be monitored frequently. If
hypotension occurs, the patient should be placed
in a supine position, with salt and volume
replacement given quickly.
5. PHARMACOLOGICAL PROPERTIES
5.1 Pharmacodynamic properties
P Pharmacotherapeutic group: Angiotensin II
Antagonists, plain
Mechanism of action
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Telmisartan is an orally active and specific
angiotensin II receptor (type AT1) antagonist.
Telmisartan displaces angiotensin II with very
high affinity from its binding site at the
AT1 receptor subtype, which is responsible for
the known actions of angiotensin II. Telmisartan
does not exhibit any partial agonist activity at
the AT1 receptor. Telmisartan selectively binds
the AT1 receptor. The binding is long-lasting.
Telmisartan does not show affinity for other
receptors, including AT2 and other less
characterised AT receptors. The functional role
of these receptors is not known, nor is the effect
of their possible overstimulation by angiotensin
II, whose levels are increased by telmisartan.
Plasma aldosterone levels are decreased by
telmisartan. Telmisartan does not inhibit human
plasma renin or block ion channels. Telmisartan
does not inhibit angiotensin converting enzyme
(kininase II), the enzyme which also degrades
bradykinin. Therefore it is not expected to
potentiate bradykinin-mediated adverse events.
In human, an 80 mg dose of telmisartan almost
completely inhibits the angiotensin II evoked
blood pressure increase. The inhibitory effect is
maintained over 24 hours and still measurable
up to 48 hours.
Clinical efficacy and safety
Treatment of essential hypertension
After the first dose of telmisartan, the
antihypertensive activity gradually becomes
evident within 3 hours. The maximum reduction
in blood pressure is generally attained 4 to 8
weeks after the start of treatment and is
sustained during long-term therapy.
The antihypertensive effect persists constantly
over 24 hours after dosing and includes the last 4
hours before the next dose as shown by
ambulatory blood pressure measurements. This
is confirmed by trough to peak ratios
consistently above 80 % seen after doses of 40
and 80 mg of telmisartan in placebo controlled
clinical studies. There is an apparent trend to a
dose relationship to a time to recovery of
baseline systolic blood pressure (SBP). In this
respect data concerning diastolic blood pressure
(DBP) are inconsistent.
In patients with hypertension telmisartan reduces
both systolic and diastolic blood pressure
without affecting pulse rate. The contribution of
the medicinal product's diuretic and natriuretic
effect to its hypotensive activity has still to be
defined. The antihypertensive efficacy of
telmisartan is comparable to that of agents
representative of other classes of
antihypertensive medicinal products
(demonstrated in clinical trials comparing
telmisartan to amlodipine, atenolol, enalapril,
hydrochlorothiazide, and lisinopril).
Upon abrupt cessation of treatment with
telmisartan, blood pressure gradually returns to
pre-treatment values over a period of several
days without evidence of rebound hypertension.
The incidence of dry cough was significantly
lower in patients treated with telmisartan than in
those given angiotensin converting enzyme
inhibitors in clinical trials directly comparing the
two antihypertensive treatments.
Cardiovascular prevention
ONTARGET (ONgoing Telmisartan Alone and
in Combination
with Ramipril Global Endpoint Trial) compared
the effects of telmisartan, ramipril and the
combination of telmisartan and ramipril on
cardiovascular outcomes in 25620 patients aged
55 years or older with a history of coronary
artery disease, stroke, TIA, peripheral arterial
disease, or type 2 diabetes mellitus accompanied
by evidence of end-organ damage (e.g.
retinopathy, left ventricular hypertrophy, macro-
or microalbuminuria), which is a population at
risk for cardiovascular events.
Patients were randomized to one of the three
following treatment groups: telmisartan 80 mg
(n = 8542), ramipril 10 mg (n = 8576), or the
combination of telmisartan 80 mg plus ramipril
10 mg (n = 8502), and followed for a mean
observation time of 4.5 years.
Telmisartan showed a similar effect to ramipril
in reducing the primary composite endpoint of
cardiovascular death, non-fatal myocardial
infarction, non-fatal stroke, or hospitalization for
congestive heart failure. The incidence of the
primary endpoint was similar in the telmisartan
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(16.7 %) and ramipril (16.5 %) groups. The
hazard ratio for telmisartan vs. ramipril was 1.01
(97.5 % CI 0.93 - 1.10, p (non-inferiority) =
0.0019 at a margin of 1.13). The all-cause
mortality rate was 11.6 % and 11.8 % among
telmisartan and ramipril treated patients,
respectively.
Telmisartan was found to be similarly effective
to ramipril in the pre-specified secondary
endpoint of cardiovascular death, non-fatal
myocardial infarction, and non-fatal stroke [0.99
(97.5 % CI 0.90 - 1.08), p (non-inferiority) =
0.0004], the primary endpoint in the reference
study HOPE (The Heart Outcomes Prevention
Evaluation Study), which had investigated the
effect of ramipril vs. placebo.
TRANSCEND randomized ACE-I intolerant
patients with otherwise similar inclusion criteria
as ONTARGET to telmisartan 80 mg (n=2954)
or placebo (n=2972), both given on top of
standard care.
The mean duration of follow up was 4 years and
8 months. No statistically significant difference
in the incidence of the primary composite
endpoint (cardiovascular death, non-fatal
myocardial infarction, non-fatal stroke, or
hospitalization for congestive heart failure) was
found [15.7 % in the telmisartan and 17.0 % in
the placebo groups with a hazard ratio of 0.92
(95 % CI 0.81 - 1.05, p = 0.22)]. There was
evidence for a benefit of telmisartan compared
to placebo in the pre-specified secondary
composite endpoint of cardiovascular death,
non-fatal myocardial infarction, and non-fatal
stroke [0.87 (95 % CI 0.76 - 1.00, p = 0.048)].
There was no evidence for benefit on
cardiovascular mortality (hazard ratio 1.03, 95
% CI 0.85 - 1.24).
Cough and angioedema were less frequently
reported in patients treated with telmisartan than
in patients treated with ramipril, whereas
hypotension was more frequently reported with
telmisartan.
Combining telmisartan with ramipril did not add
further benefit over ramipril or telmisartan
alone. CV mortality and all cause mortality were
numerically higher with the combination. In
addition, there was a significantly higher
incidence of hyperkalaemia, renal failure,
hypotension and syncope in the combination
arm. Therefore the use of a combination of
telmisartan and ramipril is not recommended in
this population.
In the "Prevention Regimen For Effectively
avoiding Second Strokes" (PRoFESS) trial in
patients 50 years and older, who recently
experienced stroke, an increased incidence of
sepsis was noted for telmisartan compared with
placebo, 0.70 % vs. 0.49 % [RR 1.43 (95 %
confidence interval 1.00 - 2.06)]; the incidence
of fatal sepsis cases was increased for patients
taking telmisartan (0.33 %) vs. patients taking
placebo (0.16 %) [RR 2.07 (95 % confidence
interval 1.14 - 3.76)]. The observed increased
occurrence rate of sepsis associated with the use
of telmisartan may be either a chance finding or
related to a mechanism not currently known.
Two large randomised, controlled trials
(ONTARGET (ONgoing Telmisartan Alone and
in combination with Ramipril Global Endpoint
Trial) and VA NEPHRON-D (The Veterans
Affairs Nephropathy in Diabetes)) have
examined the use of the combination of an ACE-
inhibitor with an angiotensin II receptor blocker.
ONTARGET was a study conducted in patients
with a history of cardiovascular or
cerebrovascular disease, or type 2 diabetes
mellitus accompanied by evidence of end-organ
damage. For more detailed information see
above under the heading “Cardiovascular
prevention”.VA NEPHRON-D was a study in
patients with type 2 diabetes mellitus and
diabetic nephropathy.
These studies have shown no significant
beneficial effect on renal and/or cardiovascular
outcomes and mortality, while an increased risk
of hyperkalaemia, acute kidney injury and/or
hypotension as compared to monotherapy was
observed. Given their similar pharmacodynamic
properties, these results are also relevant for
other ACE-inhibitors and angiotensin II receptor
blockers.
ACE-inhibitors and angiotensin II receptor
blockers should therefore not be used
concomitantly in patients with diabetic
nephropathy.
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ALTITUDE (Aliskiren Trial in Type 2 Diabetes
Using Cardiovascular and Renal Disease
Endpoints) was a study designed to test the
benefit of adding aliskiren to a standard therapy
of an ACE-inhibitor or an angiotensin II receptor
blocker in patients with type 2 diabetes mellitus
and chronic kidney disease, cardiovascular
disease, or both. The study was terminated early
because of an increased risk of adverse
outcomes. Cardiovascular death and stroke were
both numerically more frequent in the aliskiren
group than in the placebo group and adverse
events and serious adverse events of interest
(hyperkalaemia, hypotension and renal
dysfunction) were more frequently reported in
the aliskiren group than in the placebo group.
Paediatric population
The safety and efficacy of telmisartan in
children and adolescents aged below 18 years
have not been established.
The blood pressure lowering effects of two
doses of telmisartan were assessed in 76
hypertensive, largely overweight patients aged 6
to < 18 years (body weight ≥ 20 kg and ≤ 120
kg, mean 74.6 kg), after taking telmisartan 1
mg/kg (n =29 treated) or 2 mg/kg (n = 31
treated) over a four-week treatment period. By
inclusion the presence of secondary
hypertension was not investigated. In some of
the investigated patients the doses used were
higher than those recommended in the treatment
of hypertension in the adult population, reaching
a daily dose comparable to 160 mg, which was
tested in adults. After adjustment for age group
effects mean SBP changes from baseline
(primary objective) were -14.5 (1.7) mm Hg in
the telmisartan 2 mg/kg group, -9.7 (1.7) mm Hg
in the telmisartan 1 mg/kg group, and -6.0 (2.4)
in the placebo group. The adjusted DBP changes
from baseline were -8.4 (1.5) mm Hg, -4.5 (1.6)
mm Hg and -3.5 (2.1) mm Hg respectively. The
change was dose dependent. The safety data
from this study in patients aged 6 to < 18 years
appeared generally similar to that observed in
adults. The safety of long term treatment of
telmisartan in children and adolescents was not
evaluated.
An increase in eosinophils reported in this
patient population has not been recorded in
adults. Its clinical significance and relevance is
unknown.
These clinical data do not allow to make
conclusions on the efficacy and safety of
telmisartan in hypertensive paediatric
population.
5.2 Pharmacokinetic properties
Absorption
Absorption of telmisartan is rapid although the
amount absorbed varies. The mean absolute
bioavailability for telmisartan is about 50 %.
When telmisartan is taken with food, the
reduction in the area under the plasma
concentration-time curve (AUC0-∞) of
telmisartan varies from approximately 6 % (40
mg dose) to approximately 19 % (160 mg dose).
By 3 hours after administration, plasma
concentrations are similar whether telmisartan is
taken fasting or with food.
Linearity/non-linearity
The small reduction in AUC is not expected to
cause a reduction in the therapeutic efficacy.
There is no linear relationship between doses
and plasma levels. Cmax and to a lesser extent
AUC increase disproportionately at doses above
40 mg.
Distribution
Telmisartan is largely bound to plasma protein
(>99.5 %), mainly albumin and alpha-1 acid
glycoprotein. The mean steady state apparent
volume of distribution (Vdss) is approximately
500 l.
Biotransformation
Telmisartan is metabolised by conjugation to the
glucuronide of the parent compound. No
pharmacological activity has been shown for the
conjugate.
Elimination
Telmisartan is characterised by biexponential
decay pharmacokinetics with a terminal
elimination half-life of >20 hours. The
maximum plasma concentration (Cmax) and, to a
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smaller extent, the area under the plasma
concentration-time curve (AUC), increase
disproportionately with dose. There is no
evidence of clinically relevant accumulation of
telmisartan taken at the recommended dose.
Plasma concentrations were higher in females
than in males, without relevant influence on
efficacy.
After oral (and intravenous) administration,
telmisartan is nearly exclusively excreted with
the faeces, mainly as unchanged compound.
Cumulative urinary excretion is <1 % of dose.
Total plasma clearance (Cltot) is high
(approximately 1,000 ml/min) compared with
hepatic blood flow (about 1,500 ml/min).
Special Populations
Paediatric population
The pharmacokinetics of two doses of
telmisartan were assessed as a secondary
objective in hypertensive patients (n = 57) aged
6 to < 18 years after taking telmisartan 1 mg/kg
or 2 mg/kg over a four-week treatment period.
Pharmacokinetic objectives included the
determination of the steady-state of telmisartan
in children and adolescents, and investigation of
age related differences. Although the study was
too small for a meaningful assessment of the
pharmacokinetics of children under 12 years of
age, the results are generally consistent with the
findings in adults and confirm the non-linearity
of telmisartan, particularly for Cmax.
Gender
Differences in plasma concentrations were
observed, with Cmax and AUC being
approximately 3- and 2-fold higher, respectively,
in females compared to males.
Elderly
The pharmacokinetics of telmisartan do not
differ between the elderly and those younger
than 65 years.
Renal impairment
In patients with mild to moderate and severe
renal impairment, doubling of plasma
concentrations was observed. However, lower
plasma concentrations were observed in patients
with renal insufficiency undergoing dialysis.
Telmisartan is highly bound to plasma protein in
renal-insufficient patients and cannot be
removed by dialysis. The elimination half-life is
not changed in patients with renal impairment.
Hepatic impairment
Pharmacokinetic studies in patients with hepatic
impairment showed an increase in absolute
bioavailability up to nearly 100 %. The
elimination half-life is not changed in patients
with hepatic impairment.
5.3 Preclinical safety data
In preclinical safety studies, doses producing
exposure comparable to that in the clinical
therapeutic range caused reduced red cell
parameters (erythrocytes, haemoglobin,
haematocrit), changes in renal haemodynamics
(increased blood urea nitrogen and creatinine),
as well as increased serum potassium in
normotensive animals. In dogs, renal tubular
dilation and atrophy were observed. Gastric
mucosal injury (erosion, ulcers or inflammation)
also was noted in rats and dogs. These
pharmacologically-mediated undesirable effects,
known from preclinical studies with both
angiotensin converting enzyme inhibitors and
angiotensin II receptor antagonists, were
prevented by oral sodium chloride solution
supplementation.
In both species, increased plasma renin activity
and hypertrophy/hyperplasia of the renal
juxtaglomerular cells were observed. These
changes, also a class effect of angiotensin
converting enzyme inhibitors and other
angiotensin II receptor antagonists, do not
appear to have clinical significance.
No clear evidence of a teratogenic effect was
observed, however at toxic dose levels of
telmisartan an effect on the postnatal
development of the offsprings such as lower
body weight and delayed eye opening was
observed.
There was no evidence of mutagenicity and
relevant clastogenic activity in in vitro studies
and no evidence of carcinogenicity in rats and
mice.
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6. PHARMACEUTICAL PARTICULARS
6.1 List of excipients
Sodium hydroxide
Meglumine
Povidone K25
Lactose monohydrate
Povidone
Crospovidone
Lactose anhydrous
Magnesium stearate
6.2 Incompatibilities
Not applicable.
6.3 Shelf life
2 years.
6.4 Special precautions for storage
Store in the original package in order to protect
from moisture.
6.5 Nature and contents of container
Alu//Alu blisters containing 7, 10, 14, 20, 21,
28, 30, 50, 56, 60, 84, 90, 98, 100 tablets.
Alu//Alu unit dose blisters containing 28 tablets.
Not all pack sizes may be marketed.
6.6 Special precautions for disposal and other
handling
No special requirements.
Any unused medicinal product or waste material
should be disposed of in accordance with local
requirements.
7. MANUFACTURER:
Manufactured in India by:
TAJ PHARMACEUTICALS LTD.
Mumbai, India
At:388/34, Changodar Industrial Estate
Changodar- 382 210
Dist- Ahmedabad. Gujarat (India)
MFG. LIC NO: G/25A/4795-A