The WONCA Culturally Sensitive Depression Guideline recognizes the challenges family physicians face in recognizing and managing depression in patients from diverse cultural backgrounds. It proposes a "look, listen and test" framework for mental health assessment, involving observing the patient, listening to their language and metaphors, and testing psychological functioning and physical health. The guideline acknowledges differences in how symptoms are described across cultures and the importance of interpreters. It aims to improve recognition of depressive disorders in primary care settings.
International Journal of Humanities and Social Science Invention (IJHSSI) is an international journal intended for professionals and researchers in all fields of Humanities and Social Science. IJHSSI publishes research articles and reviews within the whole field Humanities and Social Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
International Journal of Humanities and Social Science Invention (IJHSSI) is an international journal intended for professionals and researchers in all fields of Humanities and Social Science. IJHSSI publishes research articles and reviews within the whole field Humanities and Social Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
The research report addresses the stigma related to the mental health in our society. This study was intended to increase understanding of peoples’ views of mental illness by developing and administering measures of knowledge and attitudes of people toward mental illnesses.
The research conducted through questionnaires regarding the mental health stigma is reviewed and analyzed that indicates that the majority of the general public holds negative stereotypes towards people with psychological problems.
Hence, a model has been proposed to illustrate what are the peoples’ attitudes towards and knowledge about the mental health, why is it a taboo to talk about this topic, how can this stigma prevent the people from getting help for the psychological difficulties and solutions for reducing and dealing with the mental health stigma are discussed.
FAST-NU
COMPUTER SCIENCE DEPARTMENT
PSYCHOLOGY
COURSE INSTRUCTOR: Miss sumarah rashid
Section: GR-4
Group members:
Taban Shaukat 16K3937
Huzaifah Punjani 16K3924
Anas Bin Faisal 16K4064
Abeer Zehra 16K4068
Maria Ahmed 16K4058
Management of Psychiatric Emergencies at Primary Care: Suicide and AggressionTuti Mohd Daud
These slides are not meant to be comprehensive in covering the two major topics in psychiatric emergencies. Readers are encouraged to refer to the references provided for further reading.
International Association for Hospice and Palliative Care (IAHPC) – Международная ассоциация хосписной и паллиативной Помощи – некоммерческая организация, которая занимается развитием паллиативной помощи по всему миру.
Одно из приоритетных направлений работы ассоциации - образование. Во многих странах учебники по паллиативной помощи дороги или труднодоступны, поэтому IAHPC бесплатно распространяет руководство по паллиативной помощи.
Пока мы выкладываем это руководство на английском языке, но надеемся вскоре перевести его на русский - с вашей помощью, с помощью жертвователей и наших друзей.
Вы тоже можете помочь фонду - достаточно отправить СМС на номер 3443 со словом Вера и суммой пожертвования. Например, Вера 100.
Также пожертвование можно сделать через Пейпал, Яндекс-деньги, или просто кредитной карточкой - все варианты есть у нас на сайте hospicefund.ru/help
this presentation tells us about the Terminal illness. the stages in grieving both of the patient and their family is explained in it. This presentation also gives us tips to cope up with grief. this presentation is from the perspective of a counselor and tells us how counselling helps the terminally ill person to recover.
1. To understand the circumstances and consequences of terminal illness and death.
2. To understand grief in the context of impending death- both in the aware patient, the caregiver and loved ones
3. To explore the understanding of death across cultures
4. To develop relevant skills in dealing with death in clinical situations, with specific reference to dementia
No special investigations are always available or required to make a psychiatry diagnosis. All emphasis is put on proper detailed history taking and mental status examination. This slides provides the best approach one can use to come up with a psychiatric diagnosis.
How to take history and mental status examination for a psychiatry patient.
Making a formulation and assessment of premorbid personality.
A step guide for better clerkship and diagnosis making in psychiatry.
AUTUMN OF LIFE-A LAST GASP-LOSS, GRIEF AND
END- OF- LIFE
MASLOW'S HIERARCHY, ANTICIPATORY GRIEF, DIMENSION OF GRIEVING, GRIEF AWARENESS, Five Wishes, NEEDS OF DYING PERSONS AND SURVIVORS
The research report addresses the stigma related to the mental health in our society. This study was intended to increase understanding of peoples’ views of mental illness by developing and administering measures of knowledge and attitudes of people toward mental illnesses.
The research conducted through questionnaires regarding the mental health stigma is reviewed and analyzed that indicates that the majority of the general public holds negative stereotypes towards people with psychological problems.
Hence, a model has been proposed to illustrate what are the peoples’ attitudes towards and knowledge about the mental health, why is it a taboo to talk about this topic, how can this stigma prevent the people from getting help for the psychological difficulties and solutions for reducing and dealing with the mental health stigma are discussed.
FAST-NU
COMPUTER SCIENCE DEPARTMENT
PSYCHOLOGY
COURSE INSTRUCTOR: Miss sumarah rashid
Section: GR-4
Group members:
Taban Shaukat 16K3937
Huzaifah Punjani 16K3924
Anas Bin Faisal 16K4064
Abeer Zehra 16K4068
Maria Ahmed 16K4058
Management of Psychiatric Emergencies at Primary Care: Suicide and AggressionTuti Mohd Daud
These slides are not meant to be comprehensive in covering the two major topics in psychiatric emergencies. Readers are encouraged to refer to the references provided for further reading.
International Association for Hospice and Palliative Care (IAHPC) – Международная ассоциация хосписной и паллиативной Помощи – некоммерческая организация, которая занимается развитием паллиативной помощи по всему миру.
Одно из приоритетных направлений работы ассоциации - образование. Во многих странах учебники по паллиативной помощи дороги или труднодоступны, поэтому IAHPC бесплатно распространяет руководство по паллиативной помощи.
Пока мы выкладываем это руководство на английском языке, но надеемся вскоре перевести его на русский - с вашей помощью, с помощью жертвователей и наших друзей.
Вы тоже можете помочь фонду - достаточно отправить СМС на номер 3443 со словом Вера и суммой пожертвования. Например, Вера 100.
Также пожертвование можно сделать через Пейпал, Яндекс-деньги, или просто кредитной карточкой - все варианты есть у нас на сайте hospicefund.ru/help
this presentation tells us about the Terminal illness. the stages in grieving both of the patient and their family is explained in it. This presentation also gives us tips to cope up with grief. this presentation is from the perspective of a counselor and tells us how counselling helps the terminally ill person to recover.
1. To understand the circumstances and consequences of terminal illness and death.
2. To understand grief in the context of impending death- both in the aware patient, the caregiver and loved ones
3. To explore the understanding of death across cultures
4. To develop relevant skills in dealing with death in clinical situations, with specific reference to dementia
No special investigations are always available or required to make a psychiatry diagnosis. All emphasis is put on proper detailed history taking and mental status examination. This slides provides the best approach one can use to come up with a psychiatric diagnosis.
How to take history and mental status examination for a psychiatry patient.
Making a formulation and assessment of premorbid personality.
A step guide for better clerkship and diagnosis making in psychiatry.
AUTUMN OF LIFE-A LAST GASP-LOSS, GRIEF AND
END- OF- LIFE
MASLOW'S HIERARCHY, ANTICIPATORY GRIEF, DIMENSION OF GRIEVING, GRIEF AWARENESS, Five Wishes, NEEDS OF DYING PERSONS AND SURVIVORS
Meeting People Where They Are: Taking Spiritual Assessment - Tessie Mandevill...wwuextendeded
Meeting People Where They Are: Taking Spiritual Assessment – Tessie Mandeville, Reverend & Bobbi Virta, Reverend
Presented at the 2015 Palliative Care Summer Institute conference at Bellingham Technical College
Reply to this student post with less than 20 similarity APA style .docxchris293
Reply to this student post with less than 20 % similarity APA style
1- What originates to attention when you consider about culture? For a lot of us, we instantly think of what’s correct in visible of us: distinctive idioms, diverse clothing and different food. But a humanity’s culture also influences an individual’s principles, customs and beliefs. It influences in what way you view confident concepts or behaviors, and in the event of mental health, it can influence whether or not you pursue help, what type of help you pursue and what sustenance you have nearby you. It is significant that we understand the role culture plays in mental health care so we can sustenance our loved ones and inspire treatment once it is required most. (Kapil, Rubina, 2019). There are four ways culture be able to influence mental health:
-
Cultural stigma
. Each culture has a diverse method of seeing at mental health. For various, there is increasing stigma round mental health, and mental health trials are measured a weakness and something to hide. This should make it firmer for those struggling to conversation flexibly and request for help.
-
Understanding symptoms
. Culture should impact how individuals designate and impression about their symptoms. It can affect whether somebody selects to identify and dialogue around only physical signs, only emotional signs or both.
-
Community Support
. Cultural influences can regulate how much sustenance somebody acquires from their family and communal when it comes to mental health. Since of prevailing stigma, sectors are occasionally left to find mental health management and provision alone.
-
Resources
. When watching for mental health treatment, you want to discourse to a person who appreciates your precise skills and apprehensions. It can occasionally be problematic or time-consuming to discovery possessions and treatment choices that take into explanation specific cultures influences and needs.
These are simply a few conducts culture can influence the observation of and treatment for mental health. Each culture and individual is dissimilar and appearance a single journey to recovery. You can support discourse the mental health of subgroups by considerate the role culture plays in mental health and by suitable skilled to help those round you. Mental Health First Aid gives individuals the expertise to recognize signs of mental health and element use contests and action stages to take to help them get treatment
2- Culture is an attractive piece of our lives, but it can similarly negatively impact our approaches in the direction of mental health. Mental disease is still stigmatized in many values. Persons may be disinclined to even dialog about mental health, let alone seek action. For example, African American community were “not very open to acknowledging psychological problems,” and they remained also averse to seek specialized help. In addition, Asian cultures incline to brand mental illness by respectin.
Running head: SCHIZOPHRENIA 1
Working with Families
1. Effects of a psych educational intervention program on the attitudes and health perceptions of relatives of patients with schizophrenia
The article highlights the importance of both family and relatives to support the victim who has schizophrenia. Moreover, the article goes further and highlights the purpose of the study. The article assesses the effectiveness of a family psych educational program in the different outlook and health insights of the relatives of the patient with suffering from schizophrenia. Various programs aid in supporting both the family and relatives to gain more information about the schizophrenia and how they can best offer support to them.
The psych educational program was efficient in adjusting to the caregivers’ outlooks. Nonetheless, the program did not influence the perceptions of healthcare. Moreover, the family and relative psych educational management program transforms the deleterious approaches of both family and relatives to schizophrenia. On the other hand, not all the agenda of this type may advance health difficulties; otherwise, their consequences might only appear in a long-term condition or situation.
The psycho-educational plan gave an enhancement in the outlooks of families to schizophrenia. Besides, this signifies that they have known how to think, feel, and act, in a positive method in regards to the disorder.
Seeing the unfortunate result of the majority of people who have schizophrenia, the process has made it possible for individuals to discover the influence of psych educational programs, which may aid indirectly or directly to advancing the quality and the course of life of these people and their families. Besides, it is vital to evaluate the efficiency of the agendas in diverse cultures and nations.
2. The Mediating Effect of Family Cohesion in Reducing Patient Symptoms and Family Distress in a Culturally Informed Family Therapy for Schizophrenia: A Parallel-Process Latent-Growth Model
The paper examines whether a CIT-S (Culturally Informed Family Therapy for Schizophrenia outdid the usual family psych education (PSY-ED) by not only in reducing patient schizophrenia signs but also in diminishing a person’s DASS. Since CIT-S nurtured family consistency in therapy; moreover, it is anticipated that an increase in family solidity would facilitate the cure effects.
The procedure permitted individual’s to be fixed in latent-change or latent-growth models to check the treatment impacts and guarantee the model fit was sufficient prior to joining them to parallel-procedure models and investigating the secondary outcomes. The latent-change model is assessing the medication influence on family solidity from standard to average, as shown in a Time Treatment Interaction (TTI). The CIT-S team displayed a natural growth of approximately on.
Palliative care in the practice of a family doctor a Presentation by Amit kumar
palliative care,end of life care,palliative,what is palliative care,palliative care doctor,palliative care end of life,does palliative care help with quality of life?,what is hospice palliative care,center to advance palliative care,palliative care documentary,cme palliative care,day in the life,family doctor,palliative care vs hospice,palliative care video,what is palliative care vs hospice,get palliative care,how to get palliative care, family doctor practice, family medicine, hospice care
Senior Healthcare Consultant (Geriatric) class at Piedmont Hospitalsnomadicnurse
The first of a 2-day class on Geriatric issues for nursing staff at all 4 Piedmont hospitals funded by a HRSA Comprehensive Geriatric Education Grant 2009-2012.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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1. Primary Care Mental Health 2005;3:145–7 # 2005 Radcliffe Publishing
Development and policy
Look, listen and test: mental health
assessment – the WONCA Culturally
Sensitive Depression Guideline
Gabriel O Ivbijaro MBBS FRCGP FWACPsych MMedSci DFFP MA
Visiting Fellow, London South Bank University; Family Practitioner, The Forest Road Medical Centre PMS
Mental Health Practice, London, UK
Lucja A Kolkiewicz MBBS MRCPsych
Consultant Psychiatrist, The John Howard Centre, London, UK
Eleni Palazidou MD PhD MRCP MRCPsych
Consultant Psychiatrist and Honorary Senior Lecturer, St Clements Hospital, London, UK
Henk Parmentier MD DFFP
Visiting Research Fellow Institute of Psychiatry; Lead GP, STaRNet London; 53 Smitham Bottom Lane,
Purley, Surrey, UK
ABSTRACT
The World Organization of Family Doctors approach to history taking in general practice,
(WONCA) published the Culturally Sensitive Depres- recommends the use of interpreters to aid commu-
sion Guideline in 2004. This guideline recognises the nication and proposes ‘look, listen and test’ as a
difficulties faced by family physicians in the recog- schema for mental health assessment in primary
nition and management of depression in patients care.
from diverse cultural backgrounds. It explores the
metaphor used by patients from different ethnic
backgrounds when describing psychological dis- Keywords: culture, depression, mental health
tress. It recognises the importance of a longitudinal assessment, primary care
Introduction
The World Health Organization (WHO) predicted With globalisation and urbanisation, there is an
that, by the year 2020, depressive illness would be increasing need for the family physician to acknow-
the second most common cause of disability world- ledge the cultural dimension in the presentation
wide, after ischaemic heart disease.1 As patients and management of a depressive illness. In recog-
suffering from a depressive disorder often make their nition of this, the World Organization of Family
first presentation to their family physician, there Doctors (WONCA) Culturally Sensitive Depression
are a number of guidelines available emphasising a Guideline produced in 2004, focuses primarily on
variety of aspects of the care and management of the difference cultural diversity makes to the pres-
this condition. In the UK, the 2004 National Insti- entation of the core symptoms of depression.3 This
tute for Clinical Excellence (NICE) guideline for the guideline brings together research evidence and
management of depression in primary and second- clinical practice, in the management of cultural
ary care focuses on a stepped care approach to the diversity and depression.
recognition and treatment of depressive disorder.2
2. 146 GO Ivbijaro, LA Kolkiewicz, E Palazidou et al
WONCA Culturally Sensitive Mental health assessment:
Depression Guideline: what are ‘look, listen and test’
the challenges?
It is estimated that approximately 60% of cases of
depression in the community present to primary
The WONCA Culturally Sensitive Depression Guideline
care, and approximately 60% of these cases remain
recognises that family physicians have a long-term
unrecognised by the family physician.4,5 Some of
relationship with their patients through short, mul-
the reasons suggested to account for this lack of
tiple encounters focused on a variety of medical and
recognition include the milder nature of illness
social reasons.3 Due to time constraints and training
patients present to primary care, and the fact that
issues, the family physician may have difficulty car-
many presentations of depressive disorder are somatic
rying out a full mental state assessment. The guide-
in nature. The WONCA guideline recognises this
line recommends a number of key principles that
difficulty and supports the use of the framework
support a holistic approach to the recognition and
provided by ‘look, listen and test’ to enable the
management of depression in primary care (Box 1).
family physician to more effectively assess the
presenting patient’s mental health.
Box 1 Key principles supporting the
recognition and management of depression
Look
1 A longitudinal approach to history taking
2 Information gathering in the context of an Assessment begins from the moment that we first
individual’s cultural and religious beliefs and meet the patient, and does not require any specific
taboos probe. It is simply a description of what we, as the
3 The use of appropriate healthcare workers physicians, or the long-term carers have observed.
and interpreters to understand the indi- The family physician can describe the mood, and
vidual’s culture the affective response that the patient shows. Look at
4 The use of ‘look, listen and test’ schema for the patient in a holistic way. We may observe de-
mental health assessment in the primary care pressed mood on the face, restricted affect, which
setting refers to an observed behaviour rather than the
patient’s subjective experience. The patient’s face
may be expressionless or unchanging. The process of
looking continues throughout the consultation, and
an emotionless expression when emotional material
History taking is being discussed may be observed. Alternatively we
may notice tearfulness, crying or even normal mood.
The WONCA guideline recommends a longitudinal We notice the person’s style of dressing, noting if
approach to history taking when managing depres- they have taken care of their appearance. The patient’s
sive illness. The individual’s history can be obtained body language may show evidence of agitation, re-
either during one session or through multiple con- duction in movement, restlessness, slumped shoulders
sultations. This history should cover neonatal and or lack of eye contact.
early childhood experience, including family, edu- The WONCA Culturally Sensitive Depression Guide-
cational, employment, relationship, substance mis- line recommends that any inference made from the
use, medical and psychiatric history. information obtained from looking, be interpreted
The guideline recognises that there are difficulties in the context of the patient’s cultural, social and
obtaining histories from patients whose culture may religious beliefs. It is important to distinguish a
differ from that of the attending physician. Patients reduction in emotional range from normal reticence
may describe their feelings and symptoms through in the presence of strangers, which may be culturally
the use of metaphors that may be alien to the as- determined.
sessing family physician. In such circumstances it
recommends the use of experienced interpreters and
healthcare workers who may have some knowledge
Listen
of the individual’s culture to aid communication. As
family physicians provide continuity of health care Language is the mirror to our inner lives. Listen in
over time, they may have access to useful information a non-judgemental, empathic way to your patient
contained in the patient’s previous case notes. from the first moment that you meet them, noting
3. The WONCA Culturally Sensitive Depression Guideline 147
the metaphors that they use. Note the volume, speed, but differs in two key areas. It recognises the differ-
inflection of speech and sighs, which may all be ent use of language and metaphor across diverse
clues to low mood. When you listen you will be able populations in the description of psychological
to note response latency and poverty of speech. The states, providing a tool that family physicians can
content of speech should be noted and this may be refer to when trying to understand the metaphor
persecutory or suspicious. We may hear the patient used by their patients. It also proposes the system of
describe hopelessness, lack of feeling or feelings of ‘look, listen and test’ as a framework to aid the
guilt and self-blame. In severe cases, we may be faced increased recognition of depressive disorder. This
by a mute individual. simple but comprehensive framework can be used in
Listening can be a passive process during which all primary care settings. The WONCA Culturally
we do not probe, or an active process, during which Sensitive Depression Guideline is available at www.
we clarify what the patient has said through direct globalfamilydoctor.com.
and indirect questioning. If we are not fluent in the
same language as the patient, it is important to use a
trained interpreter in order to minimise the loss of ACKNOWLEDGEMENTS
meaning. Such interpreters require regular super- The authors are grateful to the members of the
vision in order to maintain and improve their com- International Reference Group who contributed to
petence when interpreting predominantly feeling the development of the WONCA Culturally Sensitive
and emotion-based communications. The quality of Depression Guideline.
our information gathering depends on our inter-
preter’s competence and skills.
REFERENCES
1 Murray CJL and Lopez AD. Alternative projections
Test of mortality and disability by cause 1990–2020:
global burden of disease study. The Lancet 1997;
The testing phase covers psychological functioning 349:1498–504.
and physical assessment. The WONCA Culturally 2 National Institute for Clinical Excellence. Depres-
Sensitive Depression Guideline suggests that the family sion – management of depression in primary and sec-
physician should be able to routinely test attention, ondary care. Clinical Guideline 23; 2004. www.nice.
concentration and memory through the consultation, org.uk (accessed 16 August 2005).
3 WONCA. Culturally Sensitive Depression Guideline;
including where possible the use of accredited
2004. www.globalfamilydoctor.com (accessed 16
screening tools where they are available. It strongly
August 2005).
recommends that all patients suspected of suffering 4 Meltzer H, Bebbington P, Brugha T et al. The reluc-
from depressive disorder, even with a predominantly tance to seek treatment for neurotic disorders.
somatic presentation, should be actively tested for Journal of Mental Health 2000;9:319–27.
the presence of suicidal ideas, suicidal intent and 5 Thompson C, Ostler K, Peveler RC et al. Dimen-
hopelessness. Common physical causes of low mood, sional perspective on the recognition of depressive
such as hypothyroidism, anaemia, long-term (chronic) symptoms in primary care: The Hampshire De-
illnesses and substance misuse, should also be ac- pression Project 3. British Journal of Psychiatry 2001;
tively tested for. The family physician should bear in 179:317–27.
mind that such physical conditions may also occur
co-morbidly with depressive disorder.
CONFLICTS OF INTEREST
None.
Conclusion ADDRESS FOR CORRESPONDENCE
Gabriel O Ivbijaro, The Forest Road Medical Centre
The WONCA Culturally Sensitive Depression Guideline PMS Mental Health Practice, 354–358 Forest Road,
recognises that many depression guidelines have London E17 5JG, UK. Tel: +44 (0)20 8925 7854; fax:
been produced worldwide and, many are similar in +44 (0)20 8521 6505; email: gabluc@aol.com
nature, as they recommend a variety of evidence-
based treatment interventions. The WONCA guide- Accepted July 2005
line bears a number of similarities to these guidelines,