2016 Data Commons and Data Science Workshop June 7th and June 8th 2016. Genomic Data Commons, FAIR, NCI and making data more findable, publicly accessible, interoperable (machine readable), reusable and support recognition and attribution
May 2016 NCI Cancer Center Directors meeting. Data Sharing and the Cancer Genomic Data Commons (GDC). Focus is on cancer genomic and clinical phenotype data.
DOE-NCI Pilots presentation at the Frederick National Laboratory Advisory Com...Warren Kibbe
May 2016 FNLAC presentation of the DOE-NCI partnership around three pilots focused on existing projects in NCI and existing NSCI directives and activities in DOE.
Pace of technology innovation, changes in publication, separating data generation from publishing insights. Given at the 2018 VIVO conference at Duke University.
NCI Cancer Genomics, Open Science and PMI: FAIR Warren Kibbe
Talk given to the NLM Fellows on July 8, 2016. Touches on Cancer Genomics, Open Science and PMI: FAIR in NCI genomics thinking and projects. Includes discussion of the Genomic Data Commons (GDC), Cancer Data Ecosystem, Data sharing, and the NCI cancer clinical trials open API.
2016 Data Commons and Data Science Workshop June 7th and June 8th 2016. Genomic Data Commons, FAIR, NCI and making data more findable, publicly accessible, interoperable (machine readable), reusable and support recognition and attribution
May 2016 NCI Cancer Center Directors meeting. Data Sharing and the Cancer Genomic Data Commons (GDC). Focus is on cancer genomic and clinical phenotype data.
DOE-NCI Pilots presentation at the Frederick National Laboratory Advisory Com...Warren Kibbe
May 2016 FNLAC presentation of the DOE-NCI partnership around three pilots focused on existing projects in NCI and existing NSCI directives and activities in DOE.
Pace of technology innovation, changes in publication, separating data generation from publishing insights. Given at the 2018 VIVO conference at Duke University.
NCI Cancer Genomics, Open Science and PMI: FAIR Warren Kibbe
Talk given to the NLM Fellows on July 8, 2016. Touches on Cancer Genomics, Open Science and PMI: FAIR in NCI genomics thinking and projects. Includes discussion of the Genomic Data Commons (GDC), Cancer Data Ecosystem, Data sharing, and the NCI cancer clinical trials open API.
Ethical, Legal, and Social Implications of ELSI Learning Health Systems 2017 Conference, University of Michigan. Learning from the experience and outcomes of every cancer patient
Cancer Moonshot, Data sharing and the Genomic Data CommonsWarren Kibbe
Gave the inaugural Informatics Grand Rounds at City of Hope on September 8th. NIH Commons, Genomic Data Commons, NCI Cloud Pilots, Cancer Moonshot and rationale for changing incentives around data sharing all discussed.
National Cancer Data Ecosystem and Data SharingWarren Kibbe
Grand Rounds at the Siteman Cancer Center at Washington University. Highlighting the Genomic Data Commons and the National Cancer Data Ecosystem defined by the Cancer Moonshot Blue Ribbon Panel
Day 2 Big Data panel at the NIH BD2K All Hands 2016 meetingWarren Kibbe
Big data in oncology and implications for open data, open science, rapid innovation, data reuse, reproducibility and data sharing. Cancer Moonshot, Precisions Medicine Initiative (PMI), the Genomic Data Commons, NCI Cloud Pilots, NCI-DOE Pilots, and the Cancer Research Data Ecosystem.
Nci clinical genomics data sharing ncra sept 2016Warren Kibbe
Gave an update on the Cancer Research Data Ecosystem, the Genomic Data Commons, Cloud Pilots, incentives for data sharing in cancer research to the NCI Council of Research Advocates (NCRA) on Monday, September 26th, 2016
Converged IT Summit - NCI Data SharingWarren Kibbe
Cancer Moonshot, Data Sharing, Genomic Data Commons, NCI Cloud Pilots, Cancer Research Data Ecosystem, technology advances, chemotherapy advances, MATCH, NCI Cancer Moonshot Blue Ribbon Panel Recommendations
NCI Cancer Imaging Program - Cancer Research Data EcosystemWarren Kibbe
Given to the NCI Cancer Imaging Program monthly telecon on January 9th, 2017. NCI Genomic Data Commons, Beau Biden Cancer Moonshot Blue Ribbon Panel, Cancer Research Data Ecosystem and the role of imaging in precision medicine
Ethical, Legal, and Social Implications of ELSI Learning Health Systems 2017 Conference, University of Michigan. Learning from the experience and outcomes of every cancer patient
Cancer Moonshot, Data sharing and the Genomic Data CommonsWarren Kibbe
Gave the inaugural Informatics Grand Rounds at City of Hope on September 8th. NIH Commons, Genomic Data Commons, NCI Cloud Pilots, Cancer Moonshot and rationale for changing incentives around data sharing all discussed.
National Cancer Data Ecosystem and Data SharingWarren Kibbe
Grand Rounds at the Siteman Cancer Center at Washington University. Highlighting the Genomic Data Commons and the National Cancer Data Ecosystem defined by the Cancer Moonshot Blue Ribbon Panel
Day 2 Big Data panel at the NIH BD2K All Hands 2016 meetingWarren Kibbe
Big data in oncology and implications for open data, open science, rapid innovation, data reuse, reproducibility and data sharing. Cancer Moonshot, Precisions Medicine Initiative (PMI), the Genomic Data Commons, NCI Cloud Pilots, NCI-DOE Pilots, and the Cancer Research Data Ecosystem.
Nci clinical genomics data sharing ncra sept 2016Warren Kibbe
Gave an update on the Cancer Research Data Ecosystem, the Genomic Data Commons, Cloud Pilots, incentives for data sharing in cancer research to the NCI Council of Research Advocates (NCRA) on Monday, September 26th, 2016
Converged IT Summit - NCI Data SharingWarren Kibbe
Cancer Moonshot, Data Sharing, Genomic Data Commons, NCI Cloud Pilots, Cancer Research Data Ecosystem, technology advances, chemotherapy advances, MATCH, NCI Cancer Moonshot Blue Ribbon Panel Recommendations
NCI Cancer Imaging Program - Cancer Research Data EcosystemWarren Kibbe
Given to the NCI Cancer Imaging Program monthly telecon on January 9th, 2017. NCI Genomic Data Commons, Beau Biden Cancer Moonshot Blue Ribbon Panel, Cancer Research Data Ecosystem and the role of imaging in precision medicine
Oncology Big Data: A Mirage or Oasis of Clinical Value? Michael Peters
The title of the presentation, Oncology Big Data: A Mirage or Oasis of Clinical Value, reflects what I believe the field of Oncology is challenged with on a growing basis, from a clinical and business side perspective.
Presentation "The Impact of All Data on Healthcare"
Keith Perry
Associate VP & Deputy CIO
UT MD Anderson Cancer Center
With continuing advancement in both technology and medicine, the drive is on to make all data meaningful to drive medical discovery and create actionable outcomes. With tools and capabilities to capture more data than ever before, the challenge becomes linking existing structured and unstructured clinical data with genomic data to increase the industry’s analytical footprint.
Learning Objectives:
∙ Discuss the need to make all data meaningful in order to speed discovery of new knowledge
∙ Provide examples of an analytical direction that supports evolution in medicine
∙ Expose the challenges facing the industry with respect to ~omits
Improving health care outcomes with responsible data scienceWessel Kraaij
Keynote presentation by Wessel Kraaij at the Dutch pattern recognition and impage processing society (NVPBV) 29/5/2018, Eindhoven.
This talk discusses
1. trends in health care and respondible data science and their intersection
2. Secure federated analytics on distributed data repositories
3. Generating clinically relevant hypotheses from patient forum discussions.
SAMSI Precision Medicine Keynote, August 2018: Data: where Precision Oncology...Warren Kibbe
The promise of precision medicine in oncology is predicated on the availability of accurate, high quality data from the clinic and the laboratory. Likewise, a Learning Health System is one in which we use data to monitor that we are following guidelines and care pathways to deliver the best care and not revert to prior practices (regression testing for care!) and also provide real world evidence to determine effectiveness and identify populations that would benefit from novel therapies. Into this mix of clinical drivers are the rapidly changing capabilities in instrumentation, computing, computation, and the pervasive use of sensors and smart devices. I will highlight a few of the obvious and perhaps not as obvious opportunities in leveraging the increasingly digital landscape in healthcare and biomedical research as we move toward a national learning health system for cancer.
Precision Medicine & Biomarkers Leaders Summit - Boston USA - 7th & 8th MayTony Couch
Global Engage is pleased to announce the 2018 Precision Medicine & Biomarkers Leaders Summit USA taking place on May 7-8th in Boston, MA. The event is part of our highly successful Drug Discovery Series which includes conferences on Biologics, Medicinal Chemistry, NASH, Pharmaceutical R&D IT and the Human Microbiome amongst others. It is also the sister meeting of the European Precision Medicine Summit which has run successfully since 2013.
Data sharing drivers in precision oncology, biomedical research, and healthcare. Accelerating discovery, innovation, providing credit for all stakeholders - patients, researchers, care providers, payers.
Next Generation Dx Summit 2015 - Moving Assays to the ClinicJames Prudhomme
The Next Generation Dx Summit, entering its seventh year, brings together more than 800 diagnostics professionals from across the world, providing comprehensive programming and valuable networking opportunities. Spanning from clinical diagnostics to business strategy, this year’s expanded program encompasses predictive cancer biomarkers, companion diagnostics, infectious disease, point-of-care, pharmacy-based diagnostics, cell-free DNA, commercialization, cancer immunotherapy, and reimbursement. With widespread coverage of all the most relevant diagnostics topics, the Next Generation Dx Summit promises to be a must-attend event to hear the latest announcements and developments in this rapidly evolving field.
Seventh Annual Next Generation Dx SummitJaime Hodges
The Next Generation Dx Summit (www.nextgenerationdx.com), entering its seventh year, brings together more than 800 diagnostics professionals from across the world, providing comprehensive programming and valuable networking opportunities. Spanning from clinical diagnostics to business strategy, this year’s expanded program encompasses predictive cancer biomarkers, companion diagnostics, infectious disease, point-of-care, pharmacy-based diagnostics, cell-free DNA, commercialization, cancer immunotherapy, and reimbursement. With widespread coverage of all the most relevant diagnostics topics, the Next Generation Dx Summit promises to be a must-attend event to hear the latest announcements and developments in this rapidly evolving field.
From personal health data to a personalized adviceWessel Kraaij
Invited talk at the health track of ICT.OPEN 2018, 20-3-2018
1. Related Data science challenges to Digital Health trends
2. Designing an infrastructure to support secure learning from distributed health data repositories, for personalized health advice
3. Supporting patients with rare diseases with patient driven research and the generation of new hypotheses based on patient experiences.
Similar to Lombardi comprehensive cancer center Georgetown (20)
Updated Policy Brief: Cooperatives Bring Fiber Internet Access to Rural AmericaEd Dodds
Originally published in 2017, our report, Cooperatives Fiberize Rural America: A Trusted Model for the Internet Era, focuses on cooperatives as a proven model for deploying fiber optic Internet access across the country. An update in the spring of 2019 included additional information about the rate co-ops are expanding Internet service, and now we’ve updated it again, with a new map and personal stories from areas where co-ops have drastically impacted local life.
Digital Inclusion and Meaningful Broadband Adoption Initiatives Colin Rhinesm...Ed Dodds
This report presents findings from a national study of digital inclusion organizations that help low-income individuals and families adopt high-speed Internet service. The study looked at eight digital inclusion organizations across the United States that are working at the important intersection between making high-speed Internet available and strengthening digital skills—two essential and interrelated components of digital inclusion, which is focused on increasing digital access, skills, and relevant content.
Innovation Accelerators:
Defining Characteristics Among Startup Assistance Organizations by C. Scott Dempwolf, Jennifer Auer, and
Michelle D’Ippolito
Optimal Solutions Group, LLC
College Park, MD 20740
contract number SBAHQ -13-M-0197
Release Date: October 2014
This report was developed under a contract with the Small Business Administration, Office of Advocacy, and contains information and analysis that were reviewed by officials of the Office of Advocacy. However, the final conclusions of the report do not necessarily reflect the views of the Office of Advocacy.
Executive Summary. Thriving in a Turbulent, Technological and Transformed Global Economy | Council on Competitiveness 900 17th Street, NW, Suite 700 Washington, D.C. 20006 T 202 682 4292 Compete.org
America has long been a nation of innovators. The United States is the birthplace of the Internet, which today connects three billion people around the world. American scientists and engineers sequenced the human genome, invented the semiconductor, and sent humankind to the moon. And America is not done yet. For an advanced economy such as the United States, innovation is a wellspring of economic growth. While many countries can grow by adopting existing technologies and business practices, America must continually innovate because our workers and firms are often operating at the technological frontier. Innovation is also a powerful tool for addressing our most pressing challenges as a nation, such as enabling more Americans to lead longer, healthier lives, and accelerating the transition to a low-carbon economy.
Report to the President and Congress Ensuring Leadership in Federally Funded ...Ed Dodds
In the report, PCAST focuses on eight R&D areas: cybersecurity, IT and health, Big Data and data-intensive computing, IT and the physical world, privacy protection, cyber-human systems, high capability computing, and foundational computing research. All of these areas help to achieve the Nation’s priorities. For example, Big Data, IT and the physical world, and high-capability computing are essential contributors to addressing issues within energy and the environment.
Data Act Federal Register Notice Public Summary of ResponsesEd Dodds
Summary of Responses to the Treasury Bureau of the Fiscal Service Notice in the Federal Register on 9/26/2014 for “Public Input on the Establishment of Financial Data Standards (Data Exchange)
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS
Lombardi comprehensive cancer center Georgetown
1. Lombardi Comprehensive
Cancer Center
Cancer Informatics Summit
2/21/2013
Subha Madhavan, Ph.D.
Director, Innovation Center for Biomedical Informatics
Georgetown University Medical Center
Director, Clinical Research Informatics
Lombardi Comprehensive Cancer Center
2. Vincent T. Lombardi
• Famous professional
football coach
• Fell ill at Washington
Redskins’ practice on
Georgetown
University field
• Treated for cancer at
Georgetown
“Winning isn’t everything, it’s
the only thing.”
• Cancer Center
named in his honor
3. Lombardi – At a glance
• Established in 1970
• In 1974, Georgetown Lombardi became the 16th
NCI-designated Comprehensive Cancer Center
• Over $100M in research funding ever year
– $35M CCSG + peer-reviewed funding base
• 94 full members; 186 cancer-connected faculty
members
• 4 Research programs & 9 Shared resources
• 220 ongoing trials
4. Key Accomplishments
• Development of human papillomavirus (HPV)
vaccine to prevent cervical cancer
– R. Schlegel
• Discovery of GADD-4 DNA repair gene
– A. Fornace
• Nuclear hormone receptor networks in breast
cancer
– R. Clarke
• Monoclonal antibody therapy
– L. Weiner
5. General Organizational Structure
Director
(Weiner)
Deputy Director
(Atkins)
Clinical Care
(Marshall)
Clinical
Research
(Giaccone)
Population
Sciences
(Mandelblatt)
Basic Research
(Wellstein)
Minority Health
(Campbell)
Shared
Resources
(Byers)
Administration
(VanderHoek)
6. Another view of the cancer center
IAC
EAC
Director
Deputy Dir
Community
Advisory Council
AD
Basic/Transl
Network
Representative
Administration
Research Education
MO
CPC
BC
ET
Trial Oversight
AD Clinical
Shared Resources
AD
Administration
AD Minority
Health
AD
Population
AD Shared
Resources
8. Innovation Center for Biomedical Informatics (ICBI)
http://icbi.georgetown.edu/
•
•
•
•
•
•
Faculty – 5
Senior staff members – 5
Research associates – 5
Support staff – 2
Consultants – 5
Students/Trainees - 2
Expertise in bioinformatics, clinical informatics, biomathematics,
biostatistics, clinical genomics, molecular biology, high-throughput
molecular assays, enterprise class software development, data
management, data security, & project management
9. Informatics Org Chart
Cancer
Center
Director
CCSG SR
Director
CTSA PI
Dean of
Research
ICBI Director
Director, Operations
Office Manager
Highthroughput
omics
Financial Analyst
Communications/
Scientific writing
Technology
Development
Health IT
ChemiInformatics
Data Coordination
& Biocuration
FTEs supporting Cancer Center – 8
Total FTEs - 22
Clinical
Research
Informatics
12. Integrated Data Environment:
G-DOC Links to Many of Data Silos
Pathway Studio
Cytoscape
• Systems biology
• Literature
•Visualization
networks
JMol/Marvin
Ingenuity Analysis
• Molecule
Visualization
•Pathways, GO,
Variants
G-DOC
RedCap
Clinical
Research
JBrowse
•Genome
Visualization
Disease
Classification
Tools
EHR’s
15. Next Generation Sequencing
Big Data Analytics on the Cloud
Genomic Data
De-identified Clinical data
PC
User
Genome Data
Amazon S3
Bucket
Amazon EC2
Compute
Instances
G-DOC Web
Portal
Clinical Data
Amazon
Glacier Vault
MongoDB EC2
Instances
Oracle RDS
Instance
16. Informatics for
Discovery, Clinical Research, Clinical Care
• ‘omics’ data analysis
Clinical Research
Clinical Education
• EHR/PHR integration
• Informatics
education
• Biomarker discovery
• Partnerships
• Disease
classification
• Joint grants
• Genotype-Phenotype
correlation
• Contracted services
• Biospecimen
management and
analysis
• Medical internships
• Joint appointments
• Shared resources
• Shared IP
• Technology/method
development
• Joint publications
Basic/Traslational
Biospecimen
Website : https://icbi.georgetown.edu
Email : icbi@georgetown.edu
17. Challenges & Opportunities
Major Challenges:
Diverse set of policies and regulations across
participating institutions
Lack of resources (human and IT)
Multiple clinical & research information silo’es
Significant Opportunities/Strengths:
Technology development
Community engagement
Test bed for innovation
‘omics’ methods & integration
Collaborations with CTSA
