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Liver Disease
Hossam GHONEIM, MD
Outline
• The Liver Histology and pathology, overview
• Evaluation of liver disease and scoring
• Nutrition in Liver disease
• Two vessels supplying blood to the liver
The Hepatic Artery
The Portal Vein
• One vessel draining blood from the liver
The Hepatic Vein
The Portal Tract:
Portal Vein
Bile
Duct
Hepatic Artery
Liver cell plates
The “interface”
Fibrous connective tissue
Portal Tracts
Central Vein or
Terminal
Hepatic Venule
Liver Lobule (bounded by
brown dotted line)
Liver Acinus (acinar
zones as shown)
Blood flow
Bile flow
• Zone 1: Region immediately surrounding portal
tract. First area exposed to portal blood.
• Zone 2: The middle region.
• Zone 3: Closest to central vein.
Receives the least oxygenated blood. Most
susceptible to hypoxic damage.
Cirrhosis
• “A diffuse process characterised by fibrosis
and a conversion of normal architecture into
structurally abnormal nodules.”
• Many different causes
• Thought to be progressive and irreversible
Fibrous bands + nodules = cirrhosis
Complications
• Portal Hypertension and Varices
– May have other causes
• Ascites
• Porto-systemic Encephalopathy
• Renal Failure
• Hepatocellular Carcinoma
Complications of portal hypertension
• Varices – Oesophageal
Rectal
Caput medusa
• Ascites
• Hepatic encephalopathy
Sites of Collateral Circulation
• Gastro Oesphageal Junction
• Rectum
• Diaphragm
• Retroperitoneum
• Umbilical
Examination
• General: Ill/well.
• Hands: Clubbing, palmar erythema,
dupuytren’s contracture, leuconychia,
liver flap.
• Face: Jaundice, mucous membranes,
telangiectasia.
• Chest: Gynaecomastia, lack of secondary sexual
hair, spider naevi.
Ascites
Evaluating liver disease
Evaluation of severity
Summary
Nutrition in Liver disease
Summary
• No Fasting
• Limit Salt
• DO NOT LIMIT protein unless in HE and for a
very short period of time
• In compensated cirrhosis decrease fat and
carbs carefully
• In decompensated cirrhosis increase protein
esp vegetable protein
Thank You

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Liver disease

  • 2. Outline • The Liver Histology and pathology, overview • Evaluation of liver disease and scoring • Nutrition in Liver disease
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  • 6. • Two vessels supplying blood to the liver The Hepatic Artery The Portal Vein • One vessel draining blood from the liver The Hepatic Vein
  • 7. The Portal Tract: Portal Vein Bile Duct Hepatic Artery Liver cell plates The “interface” Fibrous connective tissue
  • 8. Portal Tracts Central Vein or Terminal Hepatic Venule Liver Lobule (bounded by brown dotted line) Liver Acinus (acinar zones as shown)
  • 11. • Zone 1: Region immediately surrounding portal tract. First area exposed to portal blood. • Zone 2: The middle region. • Zone 3: Closest to central vein. Receives the least oxygenated blood. Most susceptible to hypoxic damage.
  • 12. Cirrhosis • “A diffuse process characterised by fibrosis and a conversion of normal architecture into structurally abnormal nodules.” • Many different causes • Thought to be progressive and irreversible
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  • 14. Fibrous bands + nodules = cirrhosis
  • 15. Complications • Portal Hypertension and Varices – May have other causes • Ascites • Porto-systemic Encephalopathy • Renal Failure • Hepatocellular Carcinoma
  • 16. Complications of portal hypertension • Varices – Oesophageal Rectal Caput medusa • Ascites • Hepatic encephalopathy
  • 17. Sites of Collateral Circulation • Gastro Oesphageal Junction • Rectum • Diaphragm • Retroperitoneum • Umbilical
  • 18. Examination • General: Ill/well. • Hands: Clubbing, palmar erythema, dupuytren’s contracture, leuconychia, liver flap. • Face: Jaundice, mucous membranes, telangiectasia. • Chest: Gynaecomastia, lack of secondary sexual hair, spider naevi.
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  • 74. Summary • No Fasting • Limit Salt • DO NOT LIMIT protein unless in HE and for a very short period of time • In compensated cirrhosis decrease fat and carbs carefully • In decompensated cirrhosis increase protein esp vegetable protein