Nafld

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NAFLD is a disease caused by obesity and epigenetic factors such as having an obese mother or not being breastfed. The disease begins with excess fat building up in the liver due to obesity which can then progress to inflammation and damage of the liver cells if not addressed. The pathogenesis involves genetic and environmental factors that influence how the body processes and stores fat in the liver.

Healthcare

Pathogenesis
• Obesity
• Epigenetics
– Obese mothers
– Brest feeding

Autosomal recessive inheritance refers to the pattern of inheritance of a condition directly or indirectly due to a recessive faulty gene copy located on an autosome Conditions that follow a pattern of autosomal recessive inheritance usually affect men and women equally and include cystic fibrosis, thalassaemia, Tay-Sachs disease and haemochromatosis. These autosomal recessive conditions are more common in individuals of certain ethnic or cultural backgrounds Where both parents are unaffected carriers of the autosomal recessive faulty gene for a particular genetic condition, there is 1 chance in 4 (25% chance) in every pregnancy that their child will inherit the faulty gene copy from both parents and be affected by or predisposed to develop the condition When only one parent is an unaffected carrier of the autosomal recessive faulty gene, there is no chance that their child will be affected by or predisposed to develop the condition Where both parents affected by the condition, they will both have two copies of the autosomal recessive faulty genes. All of their children will also be affected by or predisposed to develop the condition Where one parent is an unaffected carriers of the autosomal recessive faulty gene for a particular genetic condition, and the other parent is affected by the condition, 1 chance in 2 (50% chance) in every pregnancy that they will have a child who inherits both copies of the faulty gene. In this case, the child will be affected or predisposed to develop the condition

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45X LOSS OF WHOLE OR PART OF X XP DELETION OR XQ DELETION OR ISO CHROMOSOME XP OR XQ OR RING CHROMOSOME X CLINICAL FEATURES- FEMALE INFANTILISM • Webbed neck * Coarctation and other cardiac AS A R • Short height * Horseshoe kidney • Broad chest * Hypothyroidism • Wide carrying angle arm * High LH FSH • Infantile ovaries

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When we talk about genetic disease, the first thing that come in our mind is "Down Syndrome". Down syndrome: is a genetic disease that comes from a meiotic nondisjunction in the DNA of the divided cell, so cause a three chromosomes in the Number (21). Down syndrome is continuous with the life of person, and the patient needs a special care from his society, family, and even his country. In this report, I will discuss everything about "Down Syndrome", causes, symptoms, diagnosis and even treatment. I will also mention some samples of people with Down syndrome who did interesting things in our world. The maternal age is one of the most common cause of Down Syndrome, sometimes the radiation causes this syndrome or increase its risk. No treatment is known for Down Syndrome, but they can be rehabilitated for life. Finally, I hope you enjoy and take benefit from this report, and know everything about this common disease which is very difficult to get along with normal people

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