This document discusses liposomal drug delivery systems. It begins by defining liposomes as small artificial vesicles made of cholesterol and phospholipids that range from 20nm to 5000nm in size. It then describes the key components of phospholipids that make up liposomes and commonly used phospholipids. The document classifies liposomes based on their ability to interact with cells and their size/bilayer number. It outlines the mechanism of liposomal drug delivery and advantages such as improved drug efficacy, stability, and ability to deliver both hydrophobic and hydrophilic drugs. Example applications including chemotherapy and products from Cipla are also mentioned.

1. TOPIC:- LIPOSOMAL DRUG DELIVERY SYSTEM
Presented by:-
Pradeep kumar pal
M.Pharm (1st yr Student)
(Pharmaceutics)

2. INTRODUCTION
 Liposome derives from two Greek words Lipo means
(fat) and Soma means (body);
 Liposome's are small artificial vesicles of spherical
shape that can be created from cholesterol and
natural non-toxic phospholipids.
 The size of a liposome ranges from 20 nm up to
5000nm.

5. 1. Phospholipids are a class of lipids that are a components of all
cell membranes. Each phospholipids molecules has 2 major
parts:
i. Head is made from three molecular components:
choline, phosphate and glycerol which is hydrophillic in
nature.
ii. Tail with a long chain which are hydrophobic in natrue.
2. Cholesterols is generally used steroid in the formulation of
liposomes.
Cholesterol appear to reduce the interactions with blood
proteins.

6. Commonly used other Phospholipids
Natural phospholipid
1.PC- Phosphatidyl choline
2.PE- Phosphatidyl ethanolamine
3.PS- Phosphatidyl serine
Synthetic phosholipid
1. DOPC = Dioleoyl Phosphatidylcholine
2. DOPE = Dioleoyl phosphatidyl ethanolamine
3. DSPC = Distearoyl phosphatidyl choline

7. CLASSIFICATION OF LIPOSOMES
Based on the ability of liposomes to interact with cells:-
• Non-interactive sterically stabilized (long-circulating) liposome's (LCL)
• Highly interactive cationic liposomes.
Based on size and number of bilayers:-
• Multilamellar vesicles (MLV) (>0.5um)
• Large unilamellar vesicles (LUV) (>100nm)
• Small unilamellar vesicles (SUV) (20-100nm)
Based on composition:-
• Conventional liposomes (CL)
• pH-sensitive liposomes
• Cationic liposomes
• Immuno liposomes
• Long-circulating liposomes (LCL)

8. Mechanism of liposomal drug
delivery system

10. Advantages of LDDS
Suitable for delivery of hydrophobic,hydrophilic drugs
Liposomes increases efficacy and therapeutic index of
drug (actinomycin-D).
Liposome increased stability via encapsulation.
Liposomes can complex both with negatively and
positively charged molecules.
Suitable to give localized action in particular tissues.
Suitable to administer via various routes.

11. Disadvantage of LDDS
 Low solubility.
 Batch to batch variation.
 Once administered, can’t removed.
 Difficult in large scale manufacture and sterilization.
 Very high production cost.

12. Application of Liposomes
 Chelation therapy for treatment of heavy metal
poisoning.
 Liposomes as Protein Carriers in Immunology.
 Diagnostic imaging of tumors
 Act on specific targeting site
 Oral Drug Delivery
 Cosmetics

13. These can be used for Chemotherapy of certain
types of Cancers.
Cipla has developed two Liposomal
formulation for targeted DDS
1. Liposomal Amphotericin-B
Phosome
2. Liposomal Peglated Doxorubicin
Oncodox-PEG