Lifestyle modification in epilepsy
Lifestyle Modifications
Lifestyle modifications can include:
Adequate sleep: Fatigue is one of the most common seizure triggers, and disrupted sleep can make the brain more vulnerable to misfiring.
Avoiding drugs and alcohol: These can be triggers for seizures in patients with epilepsy. Even one or two drinks can provoke seizures.
Minimizing emotional stress: Although there is not definitive proof that stress causes seizures, those who maintain healthy stress levels have reported that they believe it reduces their risk.
Frequency of exercise: In addition to a range of health benefits, regular exercise can help reduce risk of seizure. However, you should consult your physician before starting a new exercise routine, as some exercise can, rarely, cause seizures.
This slide contains in-dept knowledge about prescribing in geriatric patients. Steps how to overcome polypharmacy and how to increase medication adherence in geriatrics. It also tells about geriatrics care. Examples of case studies are also included.
This slide contains in-dept knowledge about prescribing in geriatric patients. Steps how to overcome polypharmacy and how to increase medication adherence in geriatrics. It also tells about geriatrics care. Examples of case studies are also included.
Definition
Epidemiology
Etiology
Pathophysiology
Classification
Diagnosis
Treatment
Anti Seizure Drugs Prices in Jordan
Two Medical cases
New drug approvals
Definition
Epidemiology
Etiology
Pathophysiology
Classification
Diagnosis
Treatment
Anti Seizure Drugs Prices in Jordan
Two Medical cases
New drug approvals
Epilepsy is a common neurological condition, and still largely shrouded by stigmatisation. This presentation explored practical steps to the management of epilepsy, discusses the new classification of epilepsy, and touched on some relevant lifestyle changes.
Prognosis of epilepsy disease definition, mortality, relapse risks explainedsahil136
pilepsy is a neurological disorder marked by recurrent sudden episodes of convulsions, sensory disturbances, loss of consciousness correlated with abnormal electrical activity in the brain.
Parkinsonism is a clinical syndrome and, typically, when the condition
appears to be idiopathic and responsive to levodopa therapy, is referred
to as Parkinson’s disease1
• The four cardinal features of the parkinsonian syndrome are:2
– Bradykinesia
– Muscular rigidity
– Resting tremor
– Postural instability (and gait impairment)
• These features are not always observed in every patient, at any given
time
To make a diagnosis of PD, the physician must distinguish between
different forms of parkinsonism:1
– Parkinson’s disease
– Secondary parkinsonism
– Parkinsonism as part of another neurodegenerative disorder (e.g., multiple
system atrophy, progressive supranuclear palsy, corticobasal degeneration, or
Lewy body dementia)
SCALES COMMONLY USED IN
PARKINSON’S DISEASE
RESEARCH
SCALES COMMONLY USED IN
PARKINSON’S DISEASE
RESEARCH
Progressive multifocal leukoencephalopathy (PML) is a disease of the white matter of the brain, caused by a virus infection that targets cells that make myelin--the material that insulates nerve cells (neurons). Polyomavirus JC (often called JC virus) is carried by a majority of people and is harmless except among those with lowered immune defenses. The disease is rare and occurs in patients undergoing chronic corticosteroid or immunosuppressive therapy for organ transplant, or individuals with cancer (such as Hodgkin’s disease or lymphoma). Individuals with autoimmune conditions such as multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus -- some of whom are treated with biological therapies that allow JC virus reactivation -- are at risk for PML as well. PML is most common among individuals with HIV-1 infection / acquired immune deficiency syndrome (AIDS). Currently, the best available therapy is reversal of the immune-deficient state, since there are no effective drugs that block virus infection without toxicity. Reversal may be achieved by using plasma exchange to accelerate the removal of the therapeutic agents that put patients at risk for PML. In the case of HIV-associated PML, immediately beginning anti-retroviral therapy will benefit most individuals. Several new drugs that laboratory tests found effective against infection are being used in PML patients with special permission of the U.S. Food and Drug Administration. Hexadecyloxypropyl-Cidofovir (CMX001) is currently being studied as a treatment option for JVC because of its ability to suppress JVC by inhibiting viral DNA replication.
In general, PML has a mortality rate of 30-50 percent in the first few months following diagnosis but depends on the severity of the underlying disease and treatment received. Those who survive PML can be left with severe neurological disabilities.
Sequencing in management of Multiple sclerosisAmr Hassan
Sequencing of DMTs for individual multiple sclerosis patients should be designed in such a way to maximize disease control and minimize risk based on the mechanism of action, pharmacokinetic and pharmacodynamic properties of each therapy. This includes the DMT patients are being switched from to those they are being switched to. The reversibility of immune system effects should be a key consideration for DMT sequence selection. This feature varies across DMTs and should factor more prominently in decision making as newer treatments become available for the prevention of disability accumulation in patients with progressive MS. In this short review, we discuss the landscape of existing therapies with an eye to the future when planning for optimal DMT sequencing. While no cure exists for MS, efforts are being directed toward research in neuroregeneration with the hope for positive outcomes.
A neuromuscular disorder that leads to weakness of skeletal muscles.
Symptoms
Causes
Prevention
Complications
Common tests & procedures
Neurological examination:
Repetitive nerve stimulation test:
Antibody test:
Pulmonary function tests (PFTs): To check any breathing difficulty.
CT scan: To rule out a presence of tumor in thymus.
Magnetic resonance imaging (MRI): MRI of the chest is performed to rule out a presence of tumor in thymus.
Edrophonium (Tensilon) test:
Medication
Procedures
Nutrition
Prediction of outcome of Multiple sclerosisAmr Hassan
Prediction of outcome of Multiple sclerosis
An understanding of the natural history of multiple sclerosis(MS) in a patient is important to begin proper treatment at the correct time, especially when there is a high risk for poor prognosis. Factors that predict unfavorable prognosis are a primary or secondary progressive course, older age at disease onset, short interval between first and second attacks, initial cerebellar or pyramidal symptoms, a large number of functional systems involved at onset, moderate to severe disability within the first 2 years, and the presence of typical plaques or greater lesion volume shown by magnetic resonance imaging results during the first 5 years. However, there are no established laboratory tests able to predict long-term prognosis.
Childhood demyelinating syndromes
In the past decade, the number of studies related to demyelinating diseases in children has exponentially increased. Demyelinating disease in children may be monophasic or chronic. Typical monophasic disorders in children are acute disseminated encephalomyelitis and clinically isolated syndromes, including optic neuritis and transverse myelitis. However, some cases of acute disseminated encephalomyelitis or clinically isolated syndrome progress to become chronic disorders, including multiple sclerosis and neuromyelitis optica. This review summarizes the current knowledge on monophasic and chronic demyelinating disorders in children, focusing on an approach to diagnosis and management.
Diabetic polyneuropathy
Diabetic polyneuropathy (DPN) is defined as peripheral nerve dysfunction. There are three main alterations involved in the pathologic changes of DPN: inflammation, oxidative stress, and mitochondrial dysfunction.
Excessive daytime sleepiness
The most common causes of excessive daytime sleepiness are sleep deprivation, obstructive sleep apnea, and sedating medications. Other potential causes of excessive daytime sleepiness include certain medical and psychiatric conditions and sleep disorders, such as narcolepsy.
Vagal Nerve stimulation
Vagus nerve stimulation (VNS) is a medical treatment that involves delivering electrical impulses to the vagus nerve. It is used as an add-on treatment for certain types of intractable epilepsy and treatment-resistant depression. Frequent side effects include coughing and shortness of breath. Serious side effects may include trouble talking and cardiac arrest.
Dystonia
Dystonia is a movement disorder in which your muscles contract involuntarily, causing repetitive or twisting movements.
The condition can affect one part of your body (focal dystonia), two or more adjacent parts (segmental dystonia) or all parts of your body (general dystonia). The muscle spasms can range from mild to severe. They may be painful, and they can interfere with your performance of day-to-day tasks.
Dystonia: Causes, Types, Symptoms, and Treatments
Trigeminal neuralgia is sudden, severe facial pain. It's often described as a sharp shooting pain or like having an electric shock in the jaw, teeth or gums.
Trigeminal neuralgia
Contents
Overview
Symptoms
Causes
Diagnosis
Treatment
Nootropics and smart drugs are natural or synthetic substances that can be taken to improve mental performance in healthy people.
They have gained popularity in today’s highly competitive society and are most often used to boost memory, focus, creativity, intelligence and motivation.
Here’s a look at the ]best nootropics and how they enhance performance.
Nystagmus is a condition of involuntary (or voluntary, in some cases)eye movement, acquired in infancy or later in life, that in extremely rare cases may result in reduced or limited vision. Due to the involuntary movement of the eye, it has been called "dancing eyes"Contents
1 Causes
1.1 Early-onset nystagmus
1.2 Acquired nystagmus
1.3 Other causes
2 Diagnosis
2.1 Pathologic nystagmus
2.2 Physiological nystagmus
3 Treatment
4 Epidemiology
Basics of Neuroradiology
Neuroradiology is an essential tool in management of patients with neurological and neurosurgical disorders. The aim of this presentation will be to acquaint the reader to understand how images are formed on a computed tomography (CT) and magnetic resonance imaging (MRI) along with a review of the relevant neuroanatomy. This understanding will be helpful to the reader in interpretation of images and diagnosis of various neurological disorders.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
2. • Specific time of day or night
• Sleep deprivation – overtired, not sleeping well, not getting enough
sleep
• At times of fevers or other illnesses
• Flashing bright lights or patterns
• Alcohol or drug use
• Stress
• Associated with menstrual cycle (women) or other hormonal
changes
• Not eating well, low blood sugar
• Specific foods, excess caffeine or other products that may aggravate
seizures
• Use of certain medication
Seizures triggers
4. • Preclinical studies suggest that caffeine increases
seizure susceptibility.
• In some cases, chronic use of caffeine may protect
against seizures.
• Caffeine lowers the efficacy of several drugs, especially
topiramate.
• It is unclear how these findings in models can be
translated to the clinical condition.
• Until clinical studies suggest otherwise, caffeine intake
should be considered as a factor in achieving and
maintaining seizure control in epilepsy.
Caffeine
5. Driving
• Huge variation from State to State
• Ranges from 3 months to 18 months
seizure-free periods
• Many States have ‘no set seizure-free
period
6. Epilepsy and Driving in Europe
E C Directive Group 1
• 1st Seizure
• Epilepsy
• Provoked seizure
• Sleep seizures
• Other seizures wihout
influence on driving ability
• Other loss of consciousness
• Seizure because of change of
medication
• 6 months
• 12 months
• Varies
• 12 months + no other seizures
• 12 months + no other seizures
• Varies
• 3 mo
Driving
7. Country Law
Seizure-
free
period
Andorra 2 years
Argentina
There are no specific laws prohibiting people with epilepsy from driving. Patients
generally rely on advice from their physicians.[6]
Australia
Patients must be seizure-free for 3–6 months for recently diagnosed seizures, and
for two years for chronic epilepsy.[7][8] Exact laws vary by state or territory.[6]
3 months
to 2 years
Austria
The most common seizure-free period required is 2 years, but in some cases, this
can be extended to 3. Insurance companies are not required to make liability
payments in accidents caused by seizures.[6]
2–3 years
Belgium Seizure-free period required depends on the type of seizure.[6] 1–2 years
Bermuda 1 year
Brazil 1 year
Bulgaria Those who have ever had a seizure are prohibited from driving.[9]
Canada Exact laws may vary by province/territory. See Canada below. 1 year
Central African
Republic
Those who have ever had a seizure are prohibited from driving.[9]
China Those who have ever had a seizure are prohibited from driving.[9]
Croatia 2 years
Cyprus 1 year
Czech Republic[10] Physician may set additional more restrictions (like no night driving), for
professional drivers seizure-free period is 10 years
1 year
Denmark
The national health board is involved in epilepsy cases in determining exact length
of disqualification, which is usually 2 years. Physician input is recommended.[6] 2 years
Egypt 2 years
Estonia
Required seizure-free period of one year for cars and motorcycles and of five years
for trucks and buses[11] 1–5 years
8. • Pace your exercise to avoid getting too tired or
hyperventilation.
• Avoid exercising in the middle of the day during hot weather.
• Try relaxation or slow breathing exercises when anxious or if
you begin to hyperventilate.
Exercise
11. • The British Sub-Aqua Club (BSAC) currently
says that people must be seizure-free for five
years (or three years if seizures only happen in
their sleep) and off AEDs for five years, before
they consider scuba diving.
Scuba diving
19. • Affects up to 5% of people with epilepsy.
• For someone with photosensitive epilepsy triggers can
include:
✓playing video games
✓watching moving computer games
✓watching a faulty television or other light source that
flickers slowly
✓strobe lights.
• The common rate for a flashing light to trigger seizures
is between 3 and 30 hertz (flashes per second).
Photosensitive epilepsy
21. • There are many mechanisms by which video
games may induce seizures. These are:
• Photosensitivity
• Pattern sensitivity
• Emotional and cognitive excitation (excitement or
frustration)
• Proprioceptive stimulation (movement/praxis).
• Fatigue, sleep deprivation and prolonged playing
are facilitating factors.
Video Games induced seizures
23. • The Harding FPA (flash and pattern analyser)
is proprietary software.
• Used to analyse video content for flashing
and stationary patterns which may cause
harm to those who suffer from photosensitive
epilepsy.
The Harding FPA
25. • Installing an anti-glare cover for your computer
monitor
• Changing computer and display screen settings
• Closing window blinds and covering up other
contrasting light or visual patterns
• Opting for natural or warm lighting to avoid
fluorescents
Lifestyle modification in PSE
26. • Fixing any broken, flickering, or malfunctioning
light (fluorescent or otherwise)
• Taking frequent breaks to rest your eyes
• Wearing polarized sunglasses for outdoor
activities to reduce sharp glare.
• Avoid playing when having fatigue and insomnia.
• Photosensitive children should not play electronic
games when they are alone.
Lifestyle modification in PSE
27. • It refers to seizures induced
by television viewing in
photosensitive patients.
• children aged 10–12 years.
• There is a two-fold
preponderance of girls.
• Flickering television set or
at a close distance to the
screen.
Television Epilepsy
28. • Watch TV from a distance
of at least 2 m in a well-
illuminated room
• Use a remote control
• View on a 100 Hz TV.
• Try not to watch for a long
time especially while they
are tired and sleepy.
Lifestyle modification in TV-induced
seizures
31. • Hot water epilepsy (HWE) is
induced by bathing with hot
water usually over 37 degrees
and pouring over the head.
• 2nd most common type of RE
after photosensitive epilepsy.
HWE
32. • Photosensitivity is reported to occur in
approximately 40% of patients with juvenile
myoclonic epilepsy.
• Sleep deprivation
• Alcohol intake
• HV
JME
CAE
35. • Once a day – take the forgotten dose as soon as you remember it;
or
• Twice a day – take the forgotten dose if you remember within six
hours after it was due, otherwise don’t take the forgotten dose
and just take the next dose at the due time.
• It is important that if you miss a dose you do not take twice as
much at the next dose time. Taking a larger dose than normal
could cause side effects.
Medication Schedule