This document discusses guidelines for responding to opioid overdoses, including: - 2015 CPR guidelines recommended compression-only CPR for laypeople responding to overdoses, as ventilations can be a barrier to initiating lifesaving efforts. - Naloxone programs train individuals to administer the opioid-reversing drug to overdose victims, as simple CPR often does not work for opioid overdoses. - European guidelines from 2015 still recommend explaining protocols for overdose response in plain language.