VMware Workstation is desktop virtualization software that uses a type 1 hypervisor to provide virtual machines and cloud computing capabilities, while VMware vSphere is the brand name for VMware's suite of virtualization products including VMware ESXi, vCenter Server, and vSphere client for remotely managing virtual machines on ESXi hosts from Windows. VCenter server provides centralized management of multiple ESXi hosts and virtual machines with advanced features like vMotion, high availability, and distributed resource scheduling.