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Lecture 41 objective 4
Monophasic potential and its method of recording and its importance in clinical cardiology
Definition:
Monophasic action potentials (MAPs) are extracellularly recorded wave forms that under
optimal conditions can reproduce the repolarization time course of transmembrane action
potentials (TAPs) [1, 2].
MAPs can be recorded from the endocardium and epicardium of the in situ beating heart,
including that of human subjects.
https://link.springer.com/book/10.1007/978-3-642-60851-3
Monophasic recording of action Potential: one microelectrode is placed inside the nerve fiber
and other electrode on the outer surface.
These electrodes are then connected to the cathode ray oscilloscope.
Reference: Khurna text book
The monophasic action potential is of lesser magnitude than the transmembrane action potential
(10-40 mV), but accurately reflects the onset of depolarization and the entire repolarization phase
of the transmembrane potential.
To record the MAP, one electrode of a bipolar or unipolar electrode configuration must be in
intimate contact with “injured myocardium” .Reversible, local injury can be produced by either
mild pressure or suction.
Reference:
Method and theory of monophasic action potential recording
Author links open overlay panelMichael R.Franz
Reference:
Arq. Bras. Cardiol. vol.72 n.2 São Paulo Feb. 1999
https://doi.org/10.1590/S0066-782X1999000200010

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Lecture 41 objective 4 monophasci potential

  • 1. Lecture 41 objective 4 Monophasic potential and its method of recording and its importance in clinical cardiology Definition: Monophasic action potentials (MAPs) are extracellularly recorded wave forms that under optimal conditions can reproduce the repolarization time course of transmembrane action potentials (TAPs) [1, 2]. MAPs can be recorded from the endocardium and epicardium of the in situ beating heart, including that of human subjects. https://link.springer.com/book/10.1007/978-3-642-60851-3 Monophasic recording of action Potential: one microelectrode is placed inside the nerve fiber and other electrode on the outer surface. These electrodes are then connected to the cathode ray oscilloscope. Reference: Khurna text book The monophasic action potential is of lesser magnitude than the transmembrane action potential (10-40 mV), but accurately reflects the onset of depolarization and the entire repolarization phase of the transmembrane potential. To record the MAP, one electrode of a bipolar or unipolar electrode configuration must be in intimate contact with “injured myocardium” .Reversible, local injury can be produced by either mild pressure or suction. Reference: Method and theory of monophasic action potential recording Author links open overlay panelMichael R.Franz
  • 2. Reference: Arq. Bras. Cardiol. vol.72 n.2 São Paulo Feb. 1999 https://doi.org/10.1590/S0066-782X1999000200010