1. Lecture 41 objective 4
Monophasic potential and its method of recording and its importance in clinical cardiology
Definition:
Monophasic action potentials (MAPs) are extracellularly recorded wave forms that under
optimal conditions can reproduce the repolarization time course of transmembrane action
potentials (TAPs) [1, 2].
MAPs can be recorded from the endocardium and epicardium of the in situ beating heart,
including that of human subjects.
https://link.springer.com/book/10.1007/978-3-642-60851-3
Monophasic recording of action Potential: one microelectrode is placed inside the nerve fiber
and other electrode on the outer surface.
These electrodes are then connected to the cathode ray oscilloscope.
Reference: Khurna text book
The monophasic action potential is of lesser magnitude than the transmembrane action potential
(10-40 mV), but accurately reflects the onset of depolarization and the entire repolarization phase
of the transmembrane potential.
To record the MAP, one electrode of a bipolar or unipolar electrode configuration must be in
intimate contact with “injured myocardium” .Reversible, local injury can be produced by either
mild pressure or suction.
Reference:
Method and theory of monophasic action potential recording
Author links open overlay panelMichael R.Franz
![Lecture 41 objective 4
Monophasic potential and its method of recording and its importance in clinical cardiology
Definition:
Monophasic action potentials (MAPs) are extracellularly recorded wave forms that under
optimal conditions can reproduce the repolarization time course of transmembrane action
potentials (TAPs) [1, 2].
MAPs can be recorded from the endocardium and epicardium of the in situ beating heart,
including that of human subjects.
https://link.springer.com/book/10.1007/978-3-642-60851-3
Monophasic recording of action Potential: one microelectrode is placed inside the nerve fiber
and other electrode on the outer surface.
These electrodes are then connected to the cathode ray oscilloscope.
Reference: Khurna text book
The monophasic action potential is of lesser magnitude than the transmembrane action potential
(10-40 mV), but accurately reflects the onset of depolarization and the entire repolarization phase
of the transmembrane potential.
To record the MAP, one electrode of a bipolar or unipolar electrode configuration must be in
intimate contact with “injured myocardium” .Reversible, local injury can be produced by either
mild pressure or suction.
Reference:
Method and theory of monophasic action potential recording
Author links open overlay panelMichael R.Franz](https://image.slidesharecdn.com/lecture41objective4monophascipotential-201022204613/85/Lecture-41-objective-4-monophasci-potential-1-320.jpg)
