General Pathology

1. Prof.Dr.
Khalil Hassan Zenad
Aljeboori
Copyrights©2017lAliraqiaUniversitylDentistrylPathologylProf.Dr.KhalilHassanZenadAljeboori.
Lecture 30
HEMATOPATHOLOGY

2. Copyrights©2017lAliraqiaUniversitylDentistrylPathologylProf.Dr.KhalilHassanZenadAljeboori.
Neutrophilic leukocytosis:
1. Acute bacterial infection, pyogenic bacteria.
2. Sterile inflammation in tissue necrosis and infarction, burns.
Eosinophilic leukocytosis (eosinophilia)
1. Allergic disorders
2. Parasitic infestation
3. Drugs reaction
4. Malignancy such as Hodgkins and non-Hodgkins diseases.
5. Collagen vascular disorders
6. Some vasculitides
7. Atheroemboli diseases.
Basophils leukocytosis:
Chronic myeloid leukemia
Diseases of leukopoietic system:
Disorders of white cells include deficiency (leukopenia) and proliferative disorders may be reactive or neoplastic,
reactive proliferation in response to infectious diseases include:

3. Copyrights©2017lAliraqiaUniversitylDentistrylPathologylProf.Dr.KhalilHassanZenadAljeboori.
Monocytosis
1. Tuberculosis
2. Rickettsiosis
3. Malaria.
4. Bacterial endocarditis.
5. Collagen vascular disease (SLE).
6. Inflammatory bowel disease (ulcerative colitis).
Lymphocytosis:
1. Accompanies monocytosis in many disorders associated with chronic immunological stimulation
( T.B., Brucellosis).
2. Viral infection e.g (hepatitis, cytomegalovirus , Epstein-barr virus (infectious mononucleosis) the RE
system affected so splenomegaly, lymphadenopathy, increase mononuclear cells in blood may be
reach to 40000/ul and 50-90% large lymphocytes.
3. Bordetella pertussis infection.

4. Copyrights©2017lAliraqiaUniversitylDentistrylPathologylProf.Dr.KhalilHassanZenadAljeboori.
Agranulocytosis:
This is marked decrease or absence of neutrophils in the differential count.
Most cases occur with sensitivity to certain drugs such as amidopyrine, organic arsenicals, sulfonamide,
gold salts, thiouracil so low count of neutrophils but not anemia, fever, weakness and ulcer.
Leukemia:
Various form of leukemia, fatal characterized by un controlled proliferation of leukopoietic tissue.
They may be classified into three broad categories based on origin of neoplastic cells.
A. Lymphoid neoplasms:
which include non-Hodkins lymphoma, Hodkins lymphoma, lymphocytic leukemia and plasma cell
dyscrasias and related disorders.
B. Myeloid neoplasms:
arise from stem cells that produce element of blood granulocytes, red cells and platelets.

5. Copyrights©2017lAliraqiaUniversitylDentistrylPathologylProf.Dr.KhalilHassanZenadAljeboori.
1. Acute myelogenous leukemia, immature progenitor cells in bone marrow.
2. Chronic myeloproliferative disorders in which increase production of formed blood
element that lead to elevated blood cell counts.
3. Myelodysplastic syndromes in which ineffective hematopoiesis and cytopenias.
C. Histiocytic neoplasms:
Represent proliferative lesions of histiocytes. Of special interest is a apectrum of
proliferations comprising langerhans cells (the langerhans cell histiocytoses), anemia,
thrombocytopenia, hemorrhage is present, not all leukemia have high white cell count
even though leukopoietic tissue are hyperplastic because bone marrow unable to
mobilize the cells, so the white cells will be normal or low white few immature
leukocytes, such leukemia are called aleukemic, leukopenic or subleukopenic leukemia.
Myeloid neoplasms fall into three subcategories:

6. PRESENTATION
ENDS
Copyrights © 2017 l Aliraqia University l Dentistry l Pathology l Prof.Dr. Khalil Hassan Zenad Aljeboori.
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