This document discusses the challenges of leading in an age of disruption driven by exponential technological change. It makes three key points: 1) Exponential technologies are driving massive disruption across all industries at an accelerating pace, but many leaders are still focused on short-term gains rather than making bold investments to drive long-term disruption. 2) To thrive, leaders need to embrace new technologies, lifelong learning, and define a clear purpose to guide their leadership through periods of uncertainty and change. 3) Defining one's purpose can help effective leadership by informing priorities and connecting with employees navigating disruption together towards a shared goal.