Leaderpreneurship involves providing vision and inspiration to physician entrepreneurs. Physician entrepreneurs have an entrepreneurial mindset alongside their clinical mindset. They have different risk profiles, generational personas, decision-making styles, and values compared to non-entrepreneur physicians. Healthcare entrepreneurial roles include technopreneur, intrapreneur, social entrepreneur, edupreneur, medical practice entrepreneur, and more. Important lessons for physician entrepreneurs include knowing when to hold on or let go of ideas, building credibility, getting feedback from an advisory board, relentlessly testing ideas, and learning crisis management.