This document summarizes information about Kopyrrol, an active ingredient that stimulates hair growth. Kopyrrol nourishes hair follicles, increases the growth of hair, protects against hair loss, and favors better hair anchoring. It works by supplying nutrients to hair follicles and stimulating the transition from the telogen to anagen phase of the hair growth cycle. Kopyrrol is recommended for use in hair care products at a concentration of 0.1-5% and has been shown to be safe and effective for both men and women.

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Kopyrrol
(Pyrrolidino diamino pyrimidine oxide)
An enlivening hair growth active
Rejuvenates hair follicle
Increases the growth of hair
Protects against hair loss
Favors a better hair anchoring

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Kumar Organic Products Pvt Ltd
At Kumar Organic Products, we are committed to develop and deliver our valued customers who are in
pharmaceutical and personal care industries with superior quality products at most competitive prices.
Worldwide, 85% of Men (15% women) suffer from hair loss. Day by day, the number of hair loss
sufferers is increasing in number and is more than doubled between 2008 to 2010. The importance
of hair in our lives cannot be overstated. Whether men or women lose their hair, they lose much
more than their natural, youthful appearance. People also lose their self-esteem and self-
confidence associated with healthy looking hair. The scalp and hair requires an optimal amount of
nutrients that is not always provided by the daily nutritional intake leading to Hair. Hair growth
actives have a strong presence in our everyday lives and are integrated to help prevent hair loss
and nurture hair regrowth.
KOPYRROL recovers weak follicle cells by supplying the nutrition which hair needed for growth and
increase the growth of hair and increases the volume of hair in the growth stage by working on the
deep structure of the roots. Through the bloodstream, KOPYRROL works at the level of the hair
root, which is responsible for a healthy scalp and beautiful hair. KOPYRROL is used in hair cosmetics
to combat hair loss due to premature exhaustion of the hair root.
Product Specification Molecular Structure
Trade Name KOPYRROL
INCI Name Pyrrolidinil diaminopyrimidine oxide O
Chemical Name 6-pyrrolidino 2,4-diaminopyrimidine 3-oxide
Molecular Formula C8H13N5O NH2
H2N N
CAS NO 55921-65-8
Harmonized Tariff No. 2932.00 N
Appearance Pale White crystalline powder
Assay by HPLC (on dried basis) NLT 99% N
Solubility 2% solution in ethanol/water (70:30)
Clear & Colourless
Suggested use level 0.1-5%
Storage Preserve in well closed container

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Mechanism of Hair Growth Cycle
The scalp has at an average 100,000 hairs. A healthy scalp sheds hair continuously and new hair replaces them.
Hair growth follows a series of cycle. Each cycle includes a growth phase (anagen), a transitional phase
(catagen), and a resting phase (telogen). Any changes to the normal hair growth cycle would result in hair loss. It
occurs when the old hairs are shed and no new hair is growing from beneath to replace it. However, when the
scalp is not able to produce new hair to replace the shed hair, baldness develops and the condition is
scientifically called as alopecia.
The most common type of hair loss is androgenetic alopecic (AGA) both in men (Male pattern baldness)
and women (Female pattern hair loss) and is caused by heredity hormones and genetics.
Normal Hair Growth Cycle Altered Hair Growth Cycle
Normal A: T (80:20) Decrease A: T
Multiplication of group of
Return to Anagen: The
cells at the base of the
hair follicle re-enters
hair. Typically lasts from 2
the growth phase. The
to 6 years.
older hair is shed, and
then replaced by a new
one.
The growth in the hair
The hair rests and no growth • Miniaturization of follicles
follicles stops and
is experienced which lasts 2 • Gradually Shorter Anagen Phase &
degeneration begins. This
to 3 months.
phase lasts about 2 to 3 longer telogen phase
weeks. • Empty follicles- Disruption of hair cycle
* Everyday around 100 old hairs are shed before new hair replaces them. Average hair growth rate is upto 1cm per
month
Mechanism of KOPYRROL on stimulating hair growth

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Hair Growth Activity
Efficacy of KOPYRROL

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TOXICOLOGICAL INFORMATION
Acute Toxicity:
LD50 Oral rat 820mg/kg
LD50 Oral mouse 780mg/kg
LD50 Cutaneous Rat >2000mg/kg
Chronic Exposure:
Primary irritation skin rabbit : not irritant
Primary irritation eye rabbit : not irritant
Primary irritation skin Guinea pig : not irritant
Mutagenicity:
Animal cellule ‘in vitro’ negative
Cytotoxicity:
“Salmonella Typhimurium”
Range: 100mcg/dishes – 10000 mcg/dishes negative
ECOLOGICAL INFORMATION
No information is available about the potential of this product to produce adverse
environmental effects. Local regulations and procedures should be consulted prior to
environmental release.

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Features & Benefits
Features Benefits
Potassium channel opener Transition from telogen to anagen phase of the
hair cycle. Maintains the anagen phase for a long
period of time.
Nourish the hair follicles Dilates blood vessels and increases nutrients and
oxygen supply to the hair root.
Increases matrix cell proliferation Strengthens hair from root to tip by strong
anchoring of the hair root. Works on crown of the
scalp in certain, usually younger, men.
Known for its efficacy Safe and Effective for Both Men and Women.
RECOMMENDED DOSAGE AND APPLICATIONS
Recommended dosage:
The compound generally used in the proportion of between 0.001 and 10% w/w and
preferably in the concentration of 0.1 -5% w/w.
Applications:
-Hair Tonic -Hair Cream
-Scalp Treatment -Hair Gel
-Hair Shampoo -Hair Conditioner
Regulatory Status*:
Not approved by FDA
Europe : Allowed for personal care application
USA : Allowed for personal care application
Japan : Allowed in selected product category
Rest of world : Allowed for use in most of the Asian countries
*Consult your regulatory authority for use level and restrictions.

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Formulation guidelines:
• Charge 5%w/w of KOPYRROL into the vessel and add all other ingredients(50 wt% Propylene
Glycol, 15 wt% Ethanol, 15 wt% Benzyl Alcohol, QS to 100 wt% Distilled water, 0.25 wt%
Perfume and 0.50 wt% Tween 20) one by one with stirring in the order mentioned. Continue
stirring until KOPYRROL dissolves and forms a clear solution.
• Typical use level of KOPYRROL: 0.001-1.5 wt% of finished formulation
• The finished product should be protected from prolong exposure to heat and light.
References:
• Won Seok Park et. al. Hair growth activity of cosmetic diaminopyrimidine oxide
compound invitro and in murine anagen induction. Amore pacific corporation.
• A.G.Messenger and J .Rundegren. Minoxidil: Mechanisms of action on hair growth.
British Journal of Dermatology 2004; 150: 186–194.
• Davies GC et.al., Novel and established potassium channel openers stimulate hair
growth invitro: Implications for their mode of action in hair follicles. J Invest Dermatol
2005. 124: 686-94.
Disclaimer:
The information given and the recommendations made herein are based on literature search and are believed to be accurate but no guarantee of
their accuracy is made. Information is supplied upon the condition that the receivers will make their own determination as to its suitability for their
purposes prior to use. In no event will KUMAR ORGANIC PRODUCTS LTD be responsible for the damage of any nature whatsoever resulting from the
use of or upon reliance of the information