This is the presentation I gave at the Knowledge Translation conference at Banff on September 30th. This presentation is about the wiki project we are currently undertaking at the Faculty of Rehabilitation Medicine at the UofA.
Accessibility 2.0: People, Policies and Processeslisbk
Slides for a paper by Brian Kelly, UKOLN presented at the W4A 2007 conference in Banff, Canada in May 2007.
See http://www.ukoln.ac.uk/web-focus/events/conferences/w4a-2007/
Slides from a talk by Scott Wilson in the "Web 2.0: Behind The Hype" panel session given at the Institutional Web Management Workshop 2006 on 15 June 2006.
See <http: />
Engagement, Impact, Value: Measuring and Maximising Impact Using the Social Weblisbk
Slides for a workshop session on "Engagement, Impact, Value: Measuring and Maximising Impact Using the Social Web" to be given by Brian Kelly, UKOLN at the IWMW 2010 event held at the University of Sheffield on 12-14 July 2010.
See http://iwmw.ukoln.ac.uk/iwmw2010/sessions/kelly/
What if Web 2.0 Really Does Change Everything?lisbk
Slides for a talk on "What if Web 2.0 Really Does Change Everything?" given by Brian Kelly, UKOLN at the UCISA CISG 2009 conference on 18-20 November 2009.
See http://www.ukoln.ac.uk/web-focus/events/conferences/ucisa-cisg-2009/
The 'Higher Education in a Web 2.0 World' Report: Implications For IT Service...guest6d8f50
Slides from talk on "The 'Higher Education in a Web 2.0 World' Report: Implications For IT Service Departments" given in the BUCS seminar room on 8 June 2009.
See http://www.ukoln.ac.uk/web-focus/events/seminars/bucs-200906/
What Does Openness Mean To The Openness Museum Communitylisbk
Slides used in a professional forum on "What Does Openness Mean To The Museum Community" given at the Museums and Web 2008 conference.
See http://www.ukoln.ac.uk/web-focus/events/conferences/mw-2008/openness-forum/
Accessibility 2.0: People, Policies and Processeslisbk
Slides for a paper by Brian Kelly, UKOLN presented at the W4A 2007 conference in Banff, Canada in May 2007.
See http://www.ukoln.ac.uk/web-focus/events/conferences/w4a-2007/
Slides from a talk by Scott Wilson in the "Web 2.0: Behind The Hype" panel session given at the Institutional Web Management Workshop 2006 on 15 June 2006.
See <http: />
Engagement, Impact, Value: Measuring and Maximising Impact Using the Social Weblisbk
Slides for a workshop session on "Engagement, Impact, Value: Measuring and Maximising Impact Using the Social Web" to be given by Brian Kelly, UKOLN at the IWMW 2010 event held at the University of Sheffield on 12-14 July 2010.
See http://iwmw.ukoln.ac.uk/iwmw2010/sessions/kelly/
What if Web 2.0 Really Does Change Everything?lisbk
Slides for a talk on "What if Web 2.0 Really Does Change Everything?" given by Brian Kelly, UKOLN at the UCISA CISG 2009 conference on 18-20 November 2009.
See http://www.ukoln.ac.uk/web-focus/events/conferences/ucisa-cisg-2009/
The 'Higher Education in a Web 2.0 World' Report: Implications For IT Service...guest6d8f50
Slides from talk on "The 'Higher Education in a Web 2.0 World' Report: Implications For IT Service Departments" given in the BUCS seminar room on 8 June 2009.
See http://www.ukoln.ac.uk/web-focus/events/seminars/bucs-200906/
What Does Openness Mean To The Openness Museum Communitylisbk
Slides used in a professional forum on "What Does Openness Mean To The Museum Community" given at the Museums and Web 2008 conference.
See http://www.ukoln.ac.uk/web-focus/events/conferences/mw-2008/openness-forum/
Brian Kelly and Marieke Guy, UKOLN gave the welcoming talk at the IWMW 2010 event held at the University of Sheffield on 12-14 July 2010.
See http://iwmw.ukoln.ac.uk/iwmw2010/talks/welcome/
Slides for a talk on "Demystifying the Social Web" given by Brian Kelly, UKOLN at the Readeast's "R-e-@ding: reaching out to readers in a digital world" Conference held in Flitwick on 26 November 2009.
See http://www.ukoln.ac.uk/cultural-heritage/events/readeast-2009/
Blogs, Wikis and more: Web 2.0 demystified for information professionalsMarieke Guy
Marieke Guy from UKOLN will help you find out how Web 2.0 applications are being used in libraries and information centres, and what actually works. Blogs, wikis, RSS? Podcasts, Slideshare, Flickr and del.icio.us? Social Networking, Social Bookmarking and Video Sharing are the buzz words.
Web 2.0: How Should IT Services and the Library Respond?lisbk
Slides used by Brian Kelly, UKOLN at a meeting on "Web 2.0: How Should IT Services and the Library Respond?" held at the University of Nottingham, on 16 November 2006.
Presentation about implications of Web 2.0 for education. This presentation is delivered at ACER sponsored National Education Semiar for education leaders in Indonesia held at the Shangri La hotel in Jakarta on 1st of August 2007.
Slides for talk on "Organisational Use of Twitter" given by Brian Kelly, UKOLN at a workshop on "Engagement, Impact, Value" on 24 May 2010.
See http://www.ukoln.ac.uk/web-focus/events/workshops/engagement-impact-value-201005/
Talk on "The Accessible Web" given at the Museums and the Web 2007 conference.
See http://www.ukoln.ac.uk/web-focus/events/conferences/museums-web-2007/
In this session, I will review the literature on virtual communities of practice and wikis in emergency medicine. I will propose a new model for knowledge translation to link emergency physicians from across Canada in the creation of a novel open-source and free database of shared resources that can be reused and adapted to local contexts. Finally, I will provide a glimpse of a new era in knowledge translation in the era of the Semantic Web.
Learning Objectives
1- Learn how communities of practice and wikis can support clinical practice in emergency medicine
2- Learn how a database of open-source and free knowledge tools could support your ED
3- Learn about the evolution of knowledge translation in the era of the of the Semantic Web
A presentation on an Enterprise WIki pilot as part of the dissertation towards an MSc in Knowledge Management which was presented at the IBM Connectr event in Dublin on June 3rd 2008.
Building and Sustaining a Community using the Social Weblisbk
Slides for a talk on "Building and Sustaining a Community using the Social Web" given by Brian Kelly, UKOLN at a UCISA SSG Communications Group Conference on "Using Social Media to Communicate" held at Austin Court, Birmingham on 18 January 2012.
See http://www.ukoln.ac.uk/web-focus/events/workshops/ucisa-ssg-2012/
Beyond Compliance - A Holistic Approach to Web Accessibilitylisbk
A talk on "Beyond Compliance - A Holistic Approach to Web Accessibility" given at the Techshare 2007 conference.
See http://www.ukoln.ac.uk/web-focus/events/conferences/techshare-2007/
This will share best practices in using wikis and relate to Common Core standards as teachers learn essential skills. Note that some of this session is an online demo, but bullet points of what is shared is included in the presentation.
Brian Kelly and Marieke Guy, UKOLN gave the welcoming talk at the IWMW 2010 event held at the University of Sheffield on 12-14 July 2010.
See http://iwmw.ukoln.ac.uk/iwmw2010/talks/welcome/
Slides for a talk on "Demystifying the Social Web" given by Brian Kelly, UKOLN at the Readeast's "R-e-@ding: reaching out to readers in a digital world" Conference held in Flitwick on 26 November 2009.
See http://www.ukoln.ac.uk/cultural-heritage/events/readeast-2009/
Blogs, Wikis and more: Web 2.0 demystified for information professionalsMarieke Guy
Marieke Guy from UKOLN will help you find out how Web 2.0 applications are being used in libraries and information centres, and what actually works. Blogs, wikis, RSS? Podcasts, Slideshare, Flickr and del.icio.us? Social Networking, Social Bookmarking and Video Sharing are the buzz words.
Web 2.0: How Should IT Services and the Library Respond?lisbk
Slides used by Brian Kelly, UKOLN at a meeting on "Web 2.0: How Should IT Services and the Library Respond?" held at the University of Nottingham, on 16 November 2006.
Presentation about implications of Web 2.0 for education. This presentation is delivered at ACER sponsored National Education Semiar for education leaders in Indonesia held at the Shangri La hotel in Jakarta on 1st of August 2007.
Slides for talk on "Organisational Use of Twitter" given by Brian Kelly, UKOLN at a workshop on "Engagement, Impact, Value" on 24 May 2010.
See http://www.ukoln.ac.uk/web-focus/events/workshops/engagement-impact-value-201005/
Talk on "The Accessible Web" given at the Museums and the Web 2007 conference.
See http://www.ukoln.ac.uk/web-focus/events/conferences/museums-web-2007/
In this session, I will review the literature on virtual communities of practice and wikis in emergency medicine. I will propose a new model for knowledge translation to link emergency physicians from across Canada in the creation of a novel open-source and free database of shared resources that can be reused and adapted to local contexts. Finally, I will provide a glimpse of a new era in knowledge translation in the era of the Semantic Web.
Learning Objectives
1- Learn how communities of practice and wikis can support clinical practice in emergency medicine
2- Learn how a database of open-source and free knowledge tools could support your ED
3- Learn about the evolution of knowledge translation in the era of the of the Semantic Web
A presentation on an Enterprise WIki pilot as part of the dissertation towards an MSc in Knowledge Management which was presented at the IBM Connectr event in Dublin on June 3rd 2008.
Building and Sustaining a Community using the Social Weblisbk
Slides for a talk on "Building and Sustaining a Community using the Social Web" given by Brian Kelly, UKOLN at a UCISA SSG Communications Group Conference on "Using Social Media to Communicate" held at Austin Court, Birmingham on 18 January 2012.
See http://www.ukoln.ac.uk/web-focus/events/workshops/ucisa-ssg-2012/
Beyond Compliance - A Holistic Approach to Web Accessibilitylisbk
A talk on "Beyond Compliance - A Holistic Approach to Web Accessibility" given at the Techshare 2007 conference.
See http://www.ukoln.ac.uk/web-focus/events/conferences/techshare-2007/
This will share best practices in using wikis and relate to Common Core standards as teachers learn essential skills. Note that some of this session is an online demo, but bullet points of what is shared is included in the presentation.
A presentation about the process and outcome of creating a program for people with acquired brain injury to learn how to safely and effectively use a blog and Facebook.
Social Media Unboxed Ii Best Practices For Kt In HealthcareAnita Hamilton PhD
This was an invited presentation by RTNA in Alberta. This is another one on the topic of using wikis in health care education. The findings from the focus groups was included in this presentation, and the recommendations for best practice in introducing a wiki in health care education.
Virtual Therapists: teaching tomorrows health care practitioners how to use W...Anita Hamilton PhD
This presentation was given at the Canadian Network for Innovation in Education conference in Ottawa, ON, in June 2009. The key message was that with the right educators and right tools Wikis can enhance group learning activities.
Wiki tool for Knowledge Education
Presented to the actKM conference in 2008
Collaborative learning for both content and behavioural aspects of education. Interactive web2.0 learning with high quality outcomes
1 WIKIS IN HIGHER EDUCATION: THE CONSTRUCTIVIST LEARNING PARADIGMThiyagu K
Wikis are a very versatile and easy-to-use tool that is finding increasing applications in teaching and learning. Wikis are largely used in education for both teaching and learning. Wikis can be used in the classroom to support many learning approaches. Learning approaches that could most be supported by wikis are collaborative learning and the constructivist learning paradigms. A wiki is a web page that can be viewed and modified by anybody with a web browser and access to the internet. This means that any visitor to the wiki can change its content if they desire. While the potential for mischief exists, wikis can be surprisingly robust, open-ended, collaborative group sites. This paper deals about the characteristics of wiki, wiki as a learning tool and uses of wiki in education. This paper also explains the concept of STOLEN principles for using wiki in higher education.
Co-authored with Steve Hellen.
This presentation was delivered at Educause 2007 and derivatives at SunGard Summit 2007 and AACRAO Tech 2008. This presentation introduces wiki concepts and explore their use in project management and in supporting IT systems in higher education. JHU's implementation of a new student information system extensively uses an enterprise wiki, which will be highlighted, along with use cases, examples, and lessons learned.
Note: The title has changed from its original submission ("Wiki and Project Management").
The Future for Educational Resource Repositories in a Web 2.0 Worldlisbk
Slides for a talk on "The Future for Educational Resource Repositories in a Web 2.0 World" given by Brian Kelly, UKOLN at an Edspaces workshop held at the University of Southampton on 4 November 2009.
See http://www.ukoln.ac.uk/web-focus/events/workshops/edspace-2009/
Using wikis to promote the personal and professional development of undergrad...Tünde Varga-Atkins
Cite this report as: Varga-Atkins, T; Dangerfield, P; with contributions from Bunyan, N; McKinnell, S; Ralph, M; Brigden, D and Williams D (2009) Using wikis to promote the personal and professional development of undergraduate medical students: a report for the CETL in Developing Professionalism. Liverpool: University of Liverpool.
Online technology for Occupational Therapy: Presentation for studentsAnita Hamilton PhD
This is similar to the presentation given at the WFOT congress. I used this presentation with my students who were learning about online technology with me in my 13 hour intensive "module".
Investigating the impact of curriculum on attitudes by first year occupationa...Anita Hamilton PhD
This was a presentation that I gave during the Graduate Certificate in Higher Education at Deakin University. This pilot study lead to a fourth year honours research study in 2007 by Alison Naughton.
Innovative teaching strategies for student-centred learning: Utilising Honey...Anita Hamilton PhD
Hamilton, A. (2006). Innovative teaching strategies for student-centred learning: Utilising Honey & Mumford’s Learning Styles. Poster presentation at World Federation of Occupational Therapist International congress, Sydney, NSW, Australia.
Understanding learning styles to enhance the experience of being a first year...Anita Hamilton PhD
This is a presentation I gave at the Deakin University Festival of Teaching and Learning in 2006. The presentation is about enabling students to understand their own learning styles in order to work better in groups, and ultimately with clients after they graduate.
Health Care Knowledge Transfer Using The Online EnvironmentAnita Hamilton PhD
I gave this presentation to a group of health care managers in Alberta Canada (February 2009). The goal of this presentation was to increase awareness around the possibilities that Web 2.0 tools offer the managers to enable their teams to network, collaborate and share knowledge. It was well received and I have been asked to present it again in December 2009.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...
Knowledge Translation Using A Wiki
1. Mapping our way to the Future of Knowledge Transfer Development of a Wiki in an Evidence-Based Practice Physical Therapy course Anita Hamilton, Pat Edney, Susan Armijo-Olivo Faculty of Rehabilitation Medicine, University of Alberta
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12. So, what is a wiki? … and what is the role of a wiki in health care practice knowledge transfer?
26. It is easy to see how centralized resources in a wiki, customized for a client, provide an opportunity to increase inclusion. Custom options designed around the client’s strengths and information about resources ensure continued usage by the stakeholders (client, family, friends, work). The client retains and maximizes independence, ultimately having the information at their fingertips to manage their own issues. Creating the custom wiki allowed our team to utilize our strengths. There was a lot of informal and formal collaboration which was evident by good team dynamics. The most significant benefit of the wiki besides being tailor-made is the portability. It is a resource which clients are likely to utilize in everyday life, albeit with a learning curve for somewhat less technologically inclined. Because the wiki had material that is relevant and based on evidence-based practice it expands the therapeutic relationship without the added burden of service delivery time. We could have benefited from a formal project management approach where scope, time and cost constraints enhance or limit the quality of the product. I think the wiki is a great utility, and our product shows promise.