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Imunopatogenesis TB
dr. Adianto Dwi Prasetio Z
Imunopatogenesis Mycobacterium
Tuberculosis (M.Tb)
Owen. JA, Punt J, Stranford SA, Jones PP. Kuby
Immunology 7th Ed. USA. 2013
Abbas AK, Licthman AH, Pillai S. Cellular and Molecular Immunology 7th Ed. Elsevier. USA. 2012
Imunopatogenesis Mycobacterium
Tuberculosis (M.Tb)
(Makrofag)
Owen. JA, Punt J, Stranford SA, Jones
PP. Kuby Immunology 7th Ed. USA. 2013
Abbas AK, Licthman AH, Pillai S. Cellular and Molecular Immunology 7th Ed. Elsevier. USA. 2012
Antonio Sica, Tiziana Schiopp, Alberto Mantovani, Paola Allavena. Tumourassociated macrophages are a distinct M2 polarised population
promoting tumour progression. Potential targets of anti-cancer therapy. EJC 42 (2006) 717 –727
• Abbas AK, Licthman AH, Pillai S. Cellular and Molecular Immunology 7th Ed. Elsevier. USA. 2012
• Abbas AK, Licthman AH, Pillai S. Cellular and Molecular Immunology 7th Ed. Elsevier. USA. 2012
• Abbas AK, Licthman AH, Pillai S. Cellular and Molecular Immunology 7th Ed. Elsevier. USA. 2012
Owen. JA, Punt J, Stranford SA, Jones PP. Kuby Immunology
7th Ed. USA. 2013
• Limfosit Th1- CD4 → Interferon- gamma→
rekrut dan aktivasi makrofag → fagolisosom
mikroba meningkat
• Limfosit T- CD 8 → interferon – gamma,
granzyme dan perforins → perforin
memfasilitasi granzyme masuk ke sitoplasma →
eliminasi mikroba
• Abbas AK, Licthman AH, Pillai S. Cellular and Molecular Immunology 7th Ed. Elsevier. USA. 2012
Kirman JR, Henao-Tamayo MI, Agger EM. The Memory Immune Response to Tuberculosis. Microbiol Spectrum. 2016.
4(6):TBTB2-0009-2016.
Timmermans WMC, Laar JAM, Hagen PM, Zelm MC.
Immunopathogenesis of granuloma in chronic
autoinflammatory disease. Clinical & Translation Immunology.
Australia. 2016.(5) : 5.
Zhang Q, Sugawara I. Immunology of Tuberculosis. World J Exp Med.
China. 2012. 2(4): 72
Owen. JA, Punt J, Stranford SA, Jones PP. Kuby Immunology 7th Ed. USA. 2013
Bassam HM, Mayank GV. Tuberculosis : Current Issue in Diagnosis and Management 2nd Edition. 2016
• Abbas AK, Licthman AH, Pillai S. Cellular and Molecular Immunology 7th Ed. Elsevier. USA. 2012
Bassam HM, Mayank GV. Tuberculosis : Current Issue in Diagnosis and Management 2nd Edition. 2016
Bassam HM, Mayank GV. Tuberculosis : Current Issue in Diagnosis and Management 2nd Edition. 2016
Shaler CR, Horvarth CN, Jeyenathan M, Xing Z. Within The Enemys Camp Contribution of The Granuloma to The
Dissemination, Persistence, and Transmission of Mycobacterium tuberculosis. Frontiers in Immunology. USA.
2013.
Tuberculin Test
Abbas AK, Licthman AH, Pillai S. Cellular and Molecular
Immunology 7th Ed. Elsevier. USA. 2012
Akumulasi netrofil disekitar venula
Indurasi berisi sel T,
fibrin, monosit →
muncul stelah 18 jam
→ max 24-48 jam
TERIMA KASIH

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Immunopathogenesis of Tuberculosis Caused by Mycobacterium Tuberculosis

  • 2. Imunopatogenesis Mycobacterium Tuberculosis (M.Tb) Owen. JA, Punt J, Stranford SA, Jones PP. Kuby Immunology 7th Ed. USA. 2013 Abbas AK, Licthman AH, Pillai S. Cellular and Molecular Immunology 7th Ed. Elsevier. USA. 2012
  • 3. Imunopatogenesis Mycobacterium Tuberculosis (M.Tb) (Makrofag) Owen. JA, Punt J, Stranford SA, Jones PP. Kuby Immunology 7th Ed. USA. 2013 Abbas AK, Licthman AH, Pillai S. Cellular and Molecular Immunology 7th Ed. Elsevier. USA. 2012
  • 4. Antonio Sica, Tiziana Schiopp, Alberto Mantovani, Paola Allavena. Tumourassociated macrophages are a distinct M2 polarised population promoting tumour progression. Potential targets of anti-cancer therapy. EJC 42 (2006) 717 –727
  • 5. • Abbas AK, Licthman AH, Pillai S. Cellular and Molecular Immunology 7th Ed. Elsevier. USA. 2012
  • 6. • Abbas AK, Licthman AH, Pillai S. Cellular and Molecular Immunology 7th Ed. Elsevier. USA. 2012
  • 7. • Abbas AK, Licthman AH, Pillai S. Cellular and Molecular Immunology 7th Ed. Elsevier. USA. 2012
  • 8. Owen. JA, Punt J, Stranford SA, Jones PP. Kuby Immunology 7th Ed. USA. 2013
  • 9. • Limfosit Th1- CD4 → Interferon- gamma→ rekrut dan aktivasi makrofag → fagolisosom mikroba meningkat • Limfosit T- CD 8 → interferon – gamma, granzyme dan perforins → perforin memfasilitasi granzyme masuk ke sitoplasma → eliminasi mikroba • Abbas AK, Licthman AH, Pillai S. Cellular and Molecular Immunology 7th Ed. Elsevier. USA. 2012
  • 10. Kirman JR, Henao-Tamayo MI, Agger EM. The Memory Immune Response to Tuberculosis. Microbiol Spectrum. 2016. 4(6):TBTB2-0009-2016.
  • 11. Timmermans WMC, Laar JAM, Hagen PM, Zelm MC. Immunopathogenesis of granuloma in chronic autoinflammatory disease. Clinical & Translation Immunology. Australia. 2016.(5) : 5. Zhang Q, Sugawara I. Immunology of Tuberculosis. World J Exp Med. China. 2012. 2(4): 72
  • 12. Owen. JA, Punt J, Stranford SA, Jones PP. Kuby Immunology 7th Ed. USA. 2013
  • 13. Bassam HM, Mayank GV. Tuberculosis : Current Issue in Diagnosis and Management 2nd Edition. 2016
  • 14. • Abbas AK, Licthman AH, Pillai S. Cellular and Molecular Immunology 7th Ed. Elsevier. USA. 2012
  • 15. Bassam HM, Mayank GV. Tuberculosis : Current Issue in Diagnosis and Management 2nd Edition. 2016
  • 16. Bassam HM, Mayank GV. Tuberculosis : Current Issue in Diagnosis and Management 2nd Edition. 2016
  • 17. Shaler CR, Horvarth CN, Jeyenathan M, Xing Z. Within The Enemys Camp Contribution of The Granuloma to The Dissemination, Persistence, and Transmission of Mycobacterium tuberculosis. Frontiers in Immunology. USA. 2013.
  • 18. Tuberculin Test Abbas AK, Licthman AH, Pillai S. Cellular and Molecular Immunology 7th Ed. Elsevier. USA. 2012 Akumulasi netrofil disekitar venula Indurasi berisi sel T, fibrin, monosit → muncul stelah 18 jam → max 24-48 jam