The document discusses the reversible helical handedness switching in peptidomimetic l-valine fibrils using vibrational circular dichroism (VCD) spectroscopy. It details the self-assembly of a low molecular mass hydrogelator, pval3, and demonstrates how VCD can monitor changes in the structure of the fibrils under different conditions. The findings provide a novel observation of handedness changes in short peptides in response to external stimuli.

1. Vibrational Circular Dichroism Shows
Reversible Helical Handedness
Switching in Peptidomimetic L‑ Valine Fibrils.
Belén Nieto-Ortega,† Vicent J. Nebot,‡ Juan F. Miravet,‡ TOC Graphics
Beatriu Escuder,‡ Juan T. López Navarrete,†
Juan Casado,† and Francisco J. Ramírez*,†
†Departamento de Química Física, Facultad de Ciencias,
Universidad de Málaga, Málaga 29071, Spain
‡Department de Química Inorgànica I Orgànica,
Universitat Jaume I, Castellón 12071, Spain
J. Phys. Chem. Lett. 2012, Vol.3, 2120 -2124 1