Manuscripts should be carefully checked for grammatical and punctuation errors. All papers undergo peer review. Please note that all articles published in this journal represent the opinions of the authors and do not necessarily reflect the official policy of the Journal of Indo-American Journal of Pharma and Bio Sciences of the journalism research.
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
This document describes the development and validation of a new reverse phase high performance liquid chromatography (RP-HPLC) method for the estimation of paracetamol in pharmaceutical dosage forms. Some key points:
- An isocratic RP-HPLC method was developed using a mobile phase of acetonitrile and potassium dihydrogen orthophosphate buffer at a ratio of 15:85, pH 2.5.
- The method was validated for parameters such as linearity, accuracy, precision, limit of detection, limit of quantification, and robustness as per ICH guidelines.
- The method showed good linearity in the range of 25-60 μg/ml with a correlation coefficient of 0.999
Traditional Kashmiri Recipe “Shangri-Kahwa” as a Stimulant Drink and Effectiv...SriramNagarajan15
The popular recipe “Shangri-kahwa” is an age old home remedy for respiratory and various other problems in almost whole of Kashmir. It is prepared from important spices like liquorice, clove, cinnamon, and cardamom, which have documented health benefits. Information about its use and method of preparation was obtained from group discussions held in some villages of Baramullah district of Jammu and Kashmir. People in these villages believe that Shangri-kahwa is cost effective, delicious, made from easily available ingredients and can be prepared easily at home. Being residents of this area, the authors are aware of the popularity of this magical drink used as a first line of treatment for various ailments at home, particularly during cold days. This recipe is extremely famous in these villages both as a refreshing and stimulant drink, as well as believed to be highly efficacious in respiratory illnesses. It is cost effective and highly palatable. The ingredients of Shangri-kahwa are being used extensively in Unani system of medicine and Ayurveda for almost same indications as the recipe is used. This study was carried out to highlight the effectiveness and focus the attention of the researchers towards this attractive and effective dosage form used as home remedy in Kashmir.
Spectrophotometric Estimation of Rosuvastatin Calcium in Bulk and Pharmaceuti...pharmaindexing
This document describes the development and validation of an RP-HPLC method for the simultaneous estimation of Lamivudine and Zidovudine in tablet dosage forms. The method utilizes a C18 column with a mobile phase of ammonium acetate buffer pH 4.0, acetonitrile and THF in a 60:30:10 ratio at a flow rate of 1 mL/min. Lamivudine and Zidovudine were well separated with retention times of 3.793 minutes and 2.547 minutes, respectively. The method was validated per ICH guidelines and demonstrated to be linear, precise, accurate, specific and robust for the simultaneous analysis of these two drugs in tablets.
A novel validated RP-HPLC method was developed for the estimation of Liraglutide in bulk and parenteral dosage forms. The method utilized a C18 column, mobile phase of methanol and phosphate buffer with UV detection at 246 nm. The method was validated per ICH guidelines and found to be accurate, precise, specific and linear over a concentration range of 20-80 μg/ml. The method was successfully applied to a liraglutide injection sample with 99.84% assay results. In summary, a novel HPLC method was developed and validated for the analysis of liraglutide in bulk and parenteral dosage forms.
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
This document describes the development and validation of a new reverse phase high performance liquid chromatography (RP-HPLC) method for the estimation of paracetamol in pharmaceutical dosage forms. Some key points:
- An isocratic RP-HPLC method was developed using a mobile phase of acetonitrile and potassium dihydrogen orthophosphate buffer at a ratio of 15:85, pH 2.5.
- The method was validated for parameters such as linearity, accuracy, precision, limit of detection, limit of quantification, and robustness as per ICH guidelines.
- The method showed good linearity in the range of 25-60 μg/ml with a correlation coefficient of 0.999
Traditional Kashmiri Recipe “Shangri-Kahwa” as a Stimulant Drink and Effectiv...SriramNagarajan15
The popular recipe “Shangri-kahwa” is an age old home remedy for respiratory and various other problems in almost whole of Kashmir. It is prepared from important spices like liquorice, clove, cinnamon, and cardamom, which have documented health benefits. Information about its use and method of preparation was obtained from group discussions held in some villages of Baramullah district of Jammu and Kashmir. People in these villages believe that Shangri-kahwa is cost effective, delicious, made from easily available ingredients and can be prepared easily at home. Being residents of this area, the authors are aware of the popularity of this magical drink used as a first line of treatment for various ailments at home, particularly during cold days. This recipe is extremely famous in these villages both as a refreshing and stimulant drink, as well as believed to be highly efficacious in respiratory illnesses. It is cost effective and highly palatable. The ingredients of Shangri-kahwa are being used extensively in Unani system of medicine and Ayurveda for almost same indications as the recipe is used. This study was carried out to highlight the effectiveness and focus the attention of the researchers towards this attractive and effective dosage form used as home remedy in Kashmir.
Spectrophotometric Estimation of Rosuvastatin Calcium in Bulk and Pharmaceuti...pharmaindexing
This document describes the development and validation of an RP-HPLC method for the simultaneous estimation of Lamivudine and Zidovudine in tablet dosage forms. The method utilizes a C18 column with a mobile phase of ammonium acetate buffer pH 4.0, acetonitrile and THF in a 60:30:10 ratio at a flow rate of 1 mL/min. Lamivudine and Zidovudine were well separated with retention times of 3.793 minutes and 2.547 minutes, respectively. The method was validated per ICH guidelines and demonstrated to be linear, precise, accurate, specific and robust for the simultaneous analysis of these two drugs in tablets.
A novel validated RP-HPLC method was developed for the estimation of Liraglutide in bulk and parenteral dosage forms. The method utilized a C18 column, mobile phase of methanol and phosphate buffer with UV detection at 246 nm. The method was validated per ICH guidelines and found to be accurate, precise, specific and linear over a concentration range of 20-80 μg/ml. The method was successfully applied to a liraglutide injection sample with 99.84% assay results. In summary, a novel HPLC method was developed and validated for the analysis of liraglutide in bulk and parenteral dosage forms.
Analytical Method Development and Validation of Tolvaptan in Bulk and Tablet ...pharmaindexing
This document describes the development and validation of a reverse phase high performance liquid chromatographic (RP-HPLC) method for the estimation of Tolvaptan in pharmaceutical dosage forms. A C18 column was used with a mobile phase of sodium dihydrogen phosphate and acetonitrile. The method was validated per ICH guidelines and showed good linearity, accuracy, precision, specificity, and robustness. Recovery of Tolvaptan from formulations ranged from 99.74-99.87% indicating the method is accurate for quantifying Tolvaptan in tablets.
RP-HPLC method development and validation of ritonavir in bulk and pharmaceut...SriramNagarajan17
This document describes the development and validation of an RP-HPLC method for the quantification of the HIV protease inhibitor ritonavir (RIT) in bulk and pharmaceutical dosage forms. A simple isocratic RP-HPLC method was developed using a C18 column, mobile phase of 0.02M potassium dihydrogen phosphate buffer and acetonitrile (70:30 v/v), and detection at 237 nm. The method was validated per ICH guidelines and showed good linearity from 25-150 μg/mL, precision <0.5% RSD, accuracy of 99.3-100.6% recovery, and ability to quantify RIT in pharmaceutical tablets without interference from excipients.
Development and Validation of Reverse Phase Liquid Chromatography Method for ...IOSR Journals
This document describes the development and validation of a reverse phase liquid chromatography method for the estimation of losartan in bulk drug samples. The method utilizes an Acquity BEH C18 column with a mobile phase of buffer and acetonitrile at a ratio of 50:50 delivered isocratically at 0.3 mL/min. Losartan was detected at 230 nm. The method was validated per ICH guidelines and found to be linear, precise, accurate, specific and stability-indicating for the quantification of losartan in the range of 25-75 μg/mL. The method validation shows the method is suitable for the routine analysis of losartan in bulk drug materials.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
Method Development and Validation on Etomidate injection by RP-HPLCpharmaindexing
This document describes the development and validation of a high performance liquid chromatography (HPLC) method for the analysis of etomidate injection. The method uses a Waters HPLC system with a Develosil-ODS-UG column and a mobile phase of acetonitrile and phosphate buffer at a ratio of 40:60. The method was validated per ICH guidelines and found to be accurate, precise, linear, robust and sensitive for quantifying etomidate in injections. The method was then applied to analyze etomidate levels in marketed injection formulations.
This document describes the development and validation of a reverse phase HPLC method for the simultaneous estimation of metformin and linagliptin in pure form and pharmaceutical formulations. The method utilizes a C18 column, mobile phase of phosphate buffer and acetonitrile (60:40) at a flow rate of 1 mL/min. Metformin and linagliptin were well separated with retention times of 3.048 and 4.457 minutes respectively. The method was validated per ICH guidelines and showed good linearity, accuracy, precision and recovery for both drugs. The method can be used to simultaneously quantify metformin and linagliptin in tablet formulations.
RP-HPLC Assay Method Validation for the estimation of new Anti-retroviral dru...SriramNagarajan15
A reverse phase HPLC method was developed and validated for the quantification of lamivudine in bulk and tablet formulations. The method used an ODS column with a mobile phase of acetate buffer and acetonitrile (50:50) at a flow rate of 1.5 mL/min. Lamivudine had a retention time of 1.85 minutes when detected at 272 nm. The method was linear over a concentration range of 10-50 μg/mL with a correlation coefficient of 0.999. Accuracy and precision studies demonstrated recoveries between 98-102% and %RSD below 2%, respectively. The method was found to be robust, specific, and suitable for the routine analysis of lamivudine in
The document describes the development and validation of a reverse phase HPLC method for the estimation of the anti-retroviral drug lamivudine in bulk and tablet formulations. An ODS column with a mobile phase of acetate buffer and acetonitrile was used to achieve separation of lamivudine. The method was validated as per ICH guidelines and was found to be linear, precise, accurate and robust. The developed method can be used for the routine analysis of lamivudine in pharmaceutical dosage forms.
RP-HPLC Assay Method Validation for the estimation of new Anti-retroviral dru...SriramNagarajan15
A Reverse phase HPLC method was developed for estimation of the Lamivudine in bulk and tablet formulation by using ODS column (250mm×4.6mm, 5µm) and Acetate buffer: acetonitrile (50:50) as mobile phase, at a flow rate of 1.5ml/min. The detection was carried at the 272nm the retention time of the Lamivudine is 1.850. The developed method was validated for the various parameters as per the ICH guidelines like accuracy precision, linearity and range, Robustnes. Linearity was obtained in the concentration range of 10µg/ml to 50µg/ml with correlation coefficient of 0.999. The accuracy of the method was assessed by recovery studies at three different concentration levels. The percentage recovery of Lamivudine was found to be in the range of 98% -102%. The method was found to be precise as indicated by the repeatability, inter-day, intra-day analysis, showing %RSD less than 2. Key words: RP-HPLC, Lamivudine, Pharmaceutical dosage form.
The document describes the development and validation of a reverse phase HPLC method for the estimation of the anti-retroviral drug lamivudine in bulk and tablet formulations. An ODS column with a mobile phase of acetate buffer and acetonitrile was used to achieve separation of lamivudine. The method was validated as per ICH guidelines and was found to be linear, precise, accurate and robust. The developed method can be used for the routine analysis of lamivudine in pharmaceutical dosage forms.
Stability indicating method development and validation for the estimation of ...SriramNagarajan18
Stability indicating method development and validation for the estimation of Doxorubicin by using RP-HPLC method in a bulk and pharmaceutical dosage form
IOSRPHR(www.iosrphr.org) IOSR Journal of Pharmacyiosrphr_editor
A simple reverse phase liquid chromatographic method was developed and validated for the simultaneous estimation of lornoxicam and paracetamol from their pharmaceutical dosage forms. The method utilized a C18 column with a mobile phase of potassium dihydrogen phosphate (pH 7.3) and acetonitrile (70:30) and detected compounds at 257nm. The method was linear over 20-60μg/ml for paracetamol and 0.2-1.8μg/ml for lornoxicam. Retention times were 2.33 minutes for paracetamol and 7.61 minutes for lornoxicam. The method was validated per ICH guidelines and demonstrated good precision, accuracy, reproducibility
IOSRPHR(www.iosrphr.org) IOSR Journal of Pharmacyiosrphr_editor
A simple reverse phase liquid chromatographic method was developed and validated for the simultaneous estimation of lornoxicam and paracetamol from their pharmaceutical dosage forms. The method utilized a C18 column with a mobile phase of potassium dihydrogen phosphate (pH 7.3) and acetonitrile (70:30) and detected compounds at 257nm. The method was linear over 20-60μg/ml for paracetamol and 0.2-1.8μg/ml for lornoxicam. Retention times were 2.33 minutes for paracetamol and 7.61 minutes for lornoxicam. The method was validated per ICH guidelines and demonstrated good precision, accuracy, reproducibility
ISSN 2321 – 9602
It appears that you are providing information about the publication process of IAJAVS International Journal of Advanced Veterinary and Animal Science. it seems to prioritize a fast publication schedule while maintaining rigorous peer review of the journals in research.
Indo-American Journal of Agricultural and Veterinary Sciences appears to be a reputable journal that values both the speed of publication and the quality of research in the fields of agriculture and veterinary sciences. Researchers interested in submitting their work to this journal of the journalism research.
Analytical Method Development and Validation of Tolvaptan in Bulk and Tablet ...pharmaindexing
This document describes the development and validation of a reverse phase high performance liquid chromatographic (RP-HPLC) method for the estimation of Tolvaptan in pharmaceutical dosage forms. A C18 column was used with a mobile phase of sodium dihydrogen phosphate and acetonitrile. The method was validated per ICH guidelines and showed good linearity, accuracy, precision, specificity, and robustness. Recovery of Tolvaptan from formulations ranged from 99.74-99.87% indicating the method is accurate for quantifying Tolvaptan in tablets.
RP-HPLC method development and validation of ritonavir in bulk and pharmaceut...SriramNagarajan17
This document describes the development and validation of an RP-HPLC method for the quantification of the HIV protease inhibitor ritonavir (RIT) in bulk and pharmaceutical dosage forms. A simple isocratic RP-HPLC method was developed using a C18 column, mobile phase of 0.02M potassium dihydrogen phosphate buffer and acetonitrile (70:30 v/v), and detection at 237 nm. The method was validated per ICH guidelines and showed good linearity from 25-150 μg/mL, precision <0.5% RSD, accuracy of 99.3-100.6% recovery, and ability to quantify RIT in pharmaceutical tablets without interference from excipients.
Development and Validation of Reverse Phase Liquid Chromatography Method for ...IOSR Journals
This document describes the development and validation of a reverse phase liquid chromatography method for the estimation of losartan in bulk drug samples. The method utilizes an Acquity BEH C18 column with a mobile phase of buffer and acetonitrile at a ratio of 50:50 delivered isocratically at 0.3 mL/min. Losartan was detected at 230 nm. The method was validated per ICH guidelines and found to be linear, precise, accurate, specific and stability-indicating for the quantification of losartan in the range of 25-75 μg/mL. The method validation shows the method is suitable for the routine analysis of losartan in bulk drug materials.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
Method Development and Validation on Etomidate injection by RP-HPLCpharmaindexing
This document describes the development and validation of a high performance liquid chromatography (HPLC) method for the analysis of etomidate injection. The method uses a Waters HPLC system with a Develosil-ODS-UG column and a mobile phase of acetonitrile and phosphate buffer at a ratio of 40:60. The method was validated per ICH guidelines and found to be accurate, precise, linear, robust and sensitive for quantifying etomidate in injections. The method was then applied to analyze etomidate levels in marketed injection formulations.
This document describes the development and validation of a reverse phase HPLC method for the simultaneous estimation of metformin and linagliptin in pure form and pharmaceutical formulations. The method utilizes a C18 column, mobile phase of phosphate buffer and acetonitrile (60:40) at a flow rate of 1 mL/min. Metformin and linagliptin were well separated with retention times of 3.048 and 4.457 minutes respectively. The method was validated per ICH guidelines and showed good linearity, accuracy, precision and recovery for both drugs. The method can be used to simultaneously quantify metformin and linagliptin in tablet formulations.
RP-HPLC Assay Method Validation for the estimation of new Anti-retroviral dru...SriramNagarajan15
A reverse phase HPLC method was developed and validated for the quantification of lamivudine in bulk and tablet formulations. The method used an ODS column with a mobile phase of acetate buffer and acetonitrile (50:50) at a flow rate of 1.5 mL/min. Lamivudine had a retention time of 1.85 minutes when detected at 272 nm. The method was linear over a concentration range of 10-50 μg/mL with a correlation coefficient of 0.999. Accuracy and precision studies demonstrated recoveries between 98-102% and %RSD below 2%, respectively. The method was found to be robust, specific, and suitable for the routine analysis of lamivudine in
The document describes the development and validation of a reverse phase HPLC method for the estimation of the anti-retroviral drug lamivudine in bulk and tablet formulations. An ODS column with a mobile phase of acetate buffer and acetonitrile was used to achieve separation of lamivudine. The method was validated as per ICH guidelines and was found to be linear, precise, accurate and robust. The developed method can be used for the routine analysis of lamivudine in pharmaceutical dosage forms.
RP-HPLC Assay Method Validation for the estimation of new Anti-retroviral dru...SriramNagarajan15
A Reverse phase HPLC method was developed for estimation of the Lamivudine in bulk and tablet formulation by using ODS column (250mm×4.6mm, 5µm) and Acetate buffer: acetonitrile (50:50) as mobile phase, at a flow rate of 1.5ml/min. The detection was carried at the 272nm the retention time of the Lamivudine is 1.850. The developed method was validated for the various parameters as per the ICH guidelines like accuracy precision, linearity and range, Robustnes. Linearity was obtained in the concentration range of 10µg/ml to 50µg/ml with correlation coefficient of 0.999. The accuracy of the method was assessed by recovery studies at three different concentration levels. The percentage recovery of Lamivudine was found to be in the range of 98% -102%. The method was found to be precise as indicated by the repeatability, inter-day, intra-day analysis, showing %RSD less than 2. Key words: RP-HPLC, Lamivudine, Pharmaceutical dosage form.
The document describes the development and validation of a reverse phase HPLC method for the estimation of the anti-retroviral drug lamivudine in bulk and tablet formulations. An ODS column with a mobile phase of acetate buffer and acetonitrile was used to achieve separation of lamivudine. The method was validated as per ICH guidelines and was found to be linear, precise, accurate and robust. The developed method can be used for the routine analysis of lamivudine in pharmaceutical dosage forms.
Stability indicating method development and validation for the estimation of ...SriramNagarajan18
Stability indicating method development and validation for the estimation of Doxorubicin by using RP-HPLC method in a bulk and pharmaceutical dosage form
IOSRPHR(www.iosrphr.org) IOSR Journal of Pharmacyiosrphr_editor
A simple reverse phase liquid chromatographic method was developed and validated for the simultaneous estimation of lornoxicam and paracetamol from their pharmaceutical dosage forms. The method utilized a C18 column with a mobile phase of potassium dihydrogen phosphate (pH 7.3) and acetonitrile (70:30) and detected compounds at 257nm. The method was linear over 20-60μg/ml for paracetamol and 0.2-1.8μg/ml for lornoxicam. Retention times were 2.33 minutes for paracetamol and 7.61 minutes for lornoxicam. The method was validated per ICH guidelines and demonstrated good precision, accuracy, reproducibility
IOSRPHR(www.iosrphr.org) IOSR Journal of Pharmacyiosrphr_editor
A simple reverse phase liquid chromatographic method was developed and validated for the simultaneous estimation of lornoxicam and paracetamol from their pharmaceutical dosage forms. The method utilized a C18 column with a mobile phase of potassium dihydrogen phosphate (pH 7.3) and acetonitrile (70:30) and detected compounds at 257nm. The method was linear over 20-60μg/ml for paracetamol and 0.2-1.8μg/ml for lornoxicam. Retention times were 2.33 minutes for paracetamol and 7.61 minutes for lornoxicam. The method was validated per ICH guidelines and demonstrated good precision, accuracy, reproducibility
ISSN 2321 – 9602
It appears that you are providing information about the publication process of IAJAVS International Journal of Advanced Veterinary and Animal Science. it seems to prioritize a fast publication schedule while maintaining rigorous peer review of the journals in research.
Indo-American Journal of Agricultural and Veterinary Sciences appears to be a reputable journal that values both the speed of publication and the quality of research in the fields of agriculture and veterinary sciences. Researchers interested in submitting their work to this journal of the journalism research.
ISSN 2347-2251
Manuscripts should be carefully checked for grammatical and punctuation errors. All papers undergo peer review. Please note that all articles published in this journal represent the opinions of the authors and do not necessarily reflect the official policy of the Journal of Indo-American Journal of Pharma and Bio Sciences of the journals to publish paper.
Scientific development is an ever-evolving journey, driven by the exchange of data and ideas among researchers across the globe.One such remarkable publication dedicated to facilitating this exchange within the fields of Pharmacy and Bio Sciences is the Indo-American Journal of Pharma and Bio Sciences of the published research.
It appears that you have provided information about the "Indo-American Journal of Agricultural and Veterinary Sciences" . This journal seems to be an international online publication in English, published quarterly. It emphasizes fast publication while maintaining a rigorous peer-review process of the published research.
The document summarizes a study on the effects of feed additives HammecoTox and Zeolitis on rats experiencing experimental fumonisin toxicosis. Rats were divided into 4 groups, with groups 2-4 experiencing fumonisin toxicosis and groups 3-4 additionally receiving one of the feed additives. Clinical signs of toxicosis emerged by day 14 in group 2 rats. Hematological analysis on day 14 found increased white blood cells and shifts in leukocyte composition in group 2, indicating inflammation and reduced immunity. After 21 days of feed additive treatment, groups 3 and 4 showed stabilization of hematological parameters and signs of organ recovery compared to group 2. Both additives were found effective in counter
The Indo-American Journal of Agricultural and Veterinary Sciences appears to be a scholarly journal focused on publishing research within the fields of agriculture and veterinary sciences of the journal publishers.
ISSN 2347-2251
Manuscripts should be carefully checked for grammatical and punctuation errors. All papers undergo peer review. Please note that all articles published in this journal represent the opinions of the authors and do not necessarily reflect the official policy of the Journal of Indo-American Journal of Pharma and Bio Sciences of the journal for research.
It seems like you're providing information about the publication process of the International Journal of Advanced Publication Practices. This information outlines the fast publication schedule and peer-review process by the journal of the appears to prioritize a fast and efficient publication process while maintaining the quality and integrity of the research it publishes of the original research papers.
Indo-American Journal of Agricultural and Veterinary Sciences .It sounds like the journal you're referring to has a broad scope covering various aspects of Agricultural Sciences and Veterinary Medicine. The topics listed indicate a comprehensive range of fields within these discipline and submitting manuscripts to this journal can explore research and review articles of the journalism research.
This document summarizes a study that evaluated the knowledge, attitudes, and practices of oncology health professionals in Australia regarding complementary and alternative medicine (CAM). The study surveyed 99 oncology physicians, nurses, and pharmacists. It found that the professionals had moderate knowledge of CAMs but felt unprepared to advise patients due to a lack of expertise. While they acknowledged potential benefits of CAMs, they also expressed safety concerns. Fewer than 40% of patients were open to discussing CAMs with their providers, hindered by a lack of scientific evidence and guidelines. The study reveals a need for more CAM education for oncology clinicians to improve patient-provider discussions and decision-making regarding CAM use.
This document discusses adaptive filtering techniques, specifically the Least Mean Square (LMS) and Recursive Least Squares (RLS) algorithms. It describes the basic structure and operation of adaptive filters, including their use of error signals as feedback to optimize transfer functions. The LMS algorithm is commonly used due to its computational simplicity, while RLS provides faster convergence but with higher complexity. The document proposes a modified Delayed LMS (DLMS) adaptive filter architecture to reduce adaptation delay by feeding error computations forward through pipeline stages. Simulation results show this DLMS design achieves lower area, delay and power compared to conventional LMS and RLS filters.
Scientific development is an ever-evolving journey, driven by the exchange of data and ideas among researchers across the globe.One such remarkable publication dedicated to facilitating this exchange within the fields of Pharmacy and Bio Sciences is the Indo-American Journal of Pharma and Bio Sciences of the journals to publish paper.
It appears that you have provided information about the "Indo-American Journal of Agricultural and Veterinary Sciences" . This journal seems to be an international online publication in English, published quarterly. It emphasizes fast publication while maintaining a rigorous peer-review process of the journal for research.
Indo-American Journal of Agricultural and Veterinary Sciences". It appears to be an international online journal that publishes research and review articles in English on topics related to agriculture and veterinary sciences is the journal of the research publish journal.
The Indo-American Journal of Agricultural and Veterinary Sciences appears to be a scholarly journal focused on publishing research within the fields of agriculture and veterinary sciences of the journals in research.
The Indo-American Journal of Pharma and Bio Sciences is an online international journal that publishes articles quarterly.It's important to note that the specific policies, guidelines, and the editorial board of IAJPB may change over time, so it's advisable to visit the journal's official website or contact the journal of the materials science journal.
The Indo-American Journal of Pharma and Bio Sciences is an online international journal that publishes articles quarterly.It's important to note that the specific policies, guidelines, and the editorial board of IAJPB may change over time, so it's advisable to visit the journal's official website or contact the journal of the research on journaling.
ISSN 2347-2251
Manuscripts should be carefully checked for grammatical and punctuation errors. All papers undergo peer review. Please note that all articles published in this journal represent the opinions of the authors and do not necessarily reflect the official policy of the Journal of Indo-American Journal of Pharma and Bio Sciences of the all journal.
Indo-American Journal of Agricultural and Veterinary Sciences appears to be a reputable journal that values both the speed of publication and the quality of research in the fields of agriculture and veterinary sciences. Researchers interested in submitting their work to this journal of the journal research paper.
Part 2 Deep Dive: Navigating the 2024 Slowdownjeffkluth1
Introduction
The global retail industry has weathered numerous storms, with the financial crisis of 2008 serving as a poignant reminder of the sector's resilience and adaptability. However, as we navigate the complex landscape of 2024, retailers face a unique set of challenges that demand innovative strategies and a fundamental shift in mindset. This white paper contrasts the impact of the 2008 recession on the retail sector with the current headwinds retailers are grappling with, while offering a comprehensive roadmap for success in this new paradigm.
Top mailing list providers in the USA.pptxJeremyPeirce1
Discover the top mailing list providers in the USA, offering targeted lists, segmentation, and analytics to optimize your marketing campaigns and drive engagement.
Taurus Zodiac Sign: Unveiling the Traits, Dates, and Horoscope Insights of th...my Pandit
Dive into the steadfast world of the Taurus Zodiac Sign. Discover the grounded, stable, and logical nature of Taurus individuals, and explore their key personality traits, important dates, and horoscope insights. Learn how the determination and patience of the Taurus sign make them the rock-steady achievers and anchors of the zodiac.
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Understanding User Needs and Satisfying ThemAggregage
https://www.productmanagementtoday.com/frs/26903918/understanding-user-needs-and-satisfying-them
We know we want to create products which our customers find to be valuable. Whether we label it as customer-centric or product-led depends on how long we've been doing product management. There are three challenges we face when doing this. The obvious challenge is figuring out what our users need; the non-obvious challenges are in creating a shared understanding of those needs and in sensing if what we're doing is meeting those needs.
In this webinar, we won't focus on the research methods for discovering user-needs. We will focus on synthesis of the needs we discover, communication and alignment tools, and how we operationalize addressing those needs.
Industry expert Scott Sehlhorst will:
• Introduce a taxonomy for user goals with real world examples
• Present the Onion Diagram, a tool for contextualizing task-level goals
• Illustrate how customer journey maps capture activity-level and task-level goals
• Demonstrate the best approach to selection and prioritization of user-goals to address
• Highlight the crucial benchmarks, observable changes, in ensuring fulfillment of customer needs
The Evolution and Impact of OTT Platforms: A Deep Dive into the Future of Ent...ABHILASH DUTTA
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A NOVEL VALIDATED RP-HPLC METHOD FOR ESTIMATION
OFPROPIOMAZINE IN BULK AND PHARMACEUTICAL
DOSAGE FORMS
M. Lakshmi Surekha*, Bharghava Bhushan Rao P1
, R. Sunitha2
, Padma R3
, Jhansi Rani M4
Ajay Kumar Ch5
ABSTRACT
A simple, rapid, accurate, precise and reproducible RP-HPLC method was developed for the
estimation of Propiomazine in liquid dosage forms. The method was carried out using Inertsil
ODS 3V(150mm x 4.6 mm), 5µm column in an binary mode with mobile phase comprising
gradient mixture of pH 3.0 Potassium Di-Hydrogen phosphate and Acetonitrile. The flow rate
was 1.2 ml/min and detection was carried out at 260 nm using a UV detector. The retention time
for Propiomazine was found to be at 3.76 min and 9.74 min. The method for Propiomazine
showed linearity in the concentration range of 153.7- 461µg/ml (R2
=1.000) and for
Propiomazine showed linearity in the concentration range of 12.6-37.8µg/ml (r2
=0.9997). The
recovery studies for Propiomazine also carried out and %RSD for reproducibility was found to
be below 2%. The method was simple, sensitive and specific. Hence method can be used for the
quantification of Propiomazine in pharmaceutical dosage form.
Key Words: Propiomazine; RP-HPLC; ICH validation; PDA Detector.
Introduction
Propiomazine is a member of the class of
phenothiazines that is 10H-phenothiazine
substituted by a 2-(dimethylamino)propyl
group at nitrogen atom and a propanoyl
group at position 2.It is a member of
phenothiazines, an aromatic ketone and a
tertiary amino compound. It derives from
a hydride of a 10H-phenothiazine.
*2345A.M. Reddy Memorial College of Pharmacy, petlurivaripalem, Andhra Pradesh 522601. India.
1 Professor, V V Institute of Pharmaceutical Sciences, Gudlavalleru, A.P.
*Corresponding author
Dr.M.Lakshmi Surekha
Professor & Head
A.M.Reddy Memorial College of Pharmacy,
Dept .of Pharmaceutical Analysis,
Uppalapadu, Narasaraopet, Guntur (Dt),
Andhra Pradesh, India.
3. Fig.01.Chemical Structure of Propiomazine.
Propiomazine, an atypical antipsychotic
agent, is used to treat both negative and
positive symptoms of schizophrenia, acute
mania with bipolar disorder, agitation, and
psychotic symptoms in dementia. Future
uses may include the treatment of
obsessive-compulsive disorder and severe
behavioral disorders in autism.
Structurally and pharmacologically similar
to clozapine, propiomazine binds to
alpha(1), dopamine, histamine H1,
muscarinic, and serotonin type 2 (5-HT2)
receptors.
Mechanism of action
Propiomazine acts as an antagonist of
dopamine 1, 2, and 4 receptors, serotonin
(5-HT) receptor types 2A and 2C,
muscarinic receptors 1 through 5,
alpha(1)-receptors, and histamine H1-
receptors. Its main use as a sedative is due
to its antihistamine effect.
Method Development and optimization of
Propiomazine:
Preparation of solutions:
Diluent: Based up on the solubility of the
drug diluent was selected, Methanol
taken in the ratioof 50:50.
Preparation of standard stock solutions:
Accurately weighed 10mg of
Propiomazine transferred in 10ml
volumetric flask 3/4th
of diluent was added
and sonicated for 10 mins. Flask was
made up with diluent and labelled as
standard stock solution (1000ug/ml).
Preparation of standard working
solution: One ml of Propiomazine from
stock solution was pipette out and taken
into a 10ml volumetric flask and make up
with diluents (100ug/ml).
4. Determination of wavelength:
Standard working solution was scanned between 200-400nm in double beam UV-Visible
spectrophotometer. Maximum absorbance (λmax) for the Propiomazine was determined by UV
spectrophotometer and observed that maximum absorbance at 247nm.
Fig.2 Propiomazine UV-Visible Spectrum
Chromatographic condition:
Stationary Phase : INERTSIL ODS 3V (5um 4.6×250nm)
Wavelength : 247nm
Flow rate : 1.0ml/min
Temperature : 300
C
Injection volume : 20ul
Run time : 5 min
Mobile phase : Acetonitrile: water (80:20)
Diluent : Methanol :Water
5. Fig.3 Typical Chromatogram of Propiomazine
RESULTS AND DISSCUSSION
Method validation:
Linearity: The concentration range of 10-50 µg/ml for Propiomazine and all the standard
solutions were filtered and injected.
Fig.03 Calibration curve of Propiozamine
Table 1 Linearity data of Propiomazine
Linearity
level
Concentration
(µg/ml)
Peak Area
Mean
Set 1 Set 2
1 10 531665 533356 531088
2 20 1106624 1106424 1106524
3 30 1650303 1652426 1651364
3000000
2500000
2000000
1500000
1000000
500000
0
y = 541030x
R² = 0.999
0 20 40 60
6. 4 40 2201066 2201266 2201166
5 50 2693870 2683944 2688907
Table: 2 Precision data of Propiomazine
S.NO
Concentration
(µg/ml)
Amount
(µg/ml)
% of
Amount
Avg S.D %RSD
1
30
30.1 100.3
100.2 0.90 0.89
2 30.1 100.3
3 30 100
4 30.1 100.3
5 30.1 100.3
6 30 100
Accuracy
Accuracy was done by recovery studies
Accuracy: Three concentrations of 50%,
100% and 150% are prepared and injected.
Preparation of 50% Spiked solution:
3.0ml of sample stock solution was taken
into a 10ml volumetric flask, to that 1.5ml
from each standard solution was pipette
out and make up the markwith diluents.
Preparation of 100% Spiked solution:
3.0ml of sample stock solution was taken
into a 10ml volumetric flask, to that 3.0ml
from each standard solution was pipette
out and make up the markwith diluents.
Preparation of 150% Spiked solution:
3.0ml of sample stock solution was taken
into a 10ml volumetric flask, to that 4.5ml
from each standard solution was pipette
out and make up the markwith diluents.
7. Table 3 Accuracy data
Percentage
level
Amount
(µg/ml)
Amount
added
(µg/ml)
Amo
unt
foun
d
Amount
Recovery
%
Recover
y
Avg
%
S.D %RSD
50
30
15
44.9 14.9 99.3
100.6 1.1 1.09
45.2 15.2 101.3
45.2 15.2 101.3
100 30
60.1 30.1 100.3
100.7 0.40 0.41
60.3 30.3 101
60.3 30.3 101
150 45
74.8 44.8 99.5
99 0.93
0.93
74.1 44.1 98
74.9 44.9 99.7
Limit of detection & Limit of quantification:
The limit of detection and the limit of quantification were calculated by using the average value
of slope and the standard deviation of intercept and the results are listed in the table.4
Table 4.Data of LOD and LOQ
SNO Parameters Propiomazine
1 LOD 0.15
2 LOQ 0.48
8. Robustness:
Robustness was done by changing the column temperature (±50
C), flow rate (±10O
C), changing
the wavelength (± 5nm), and organic compounds of mobile phase (±5%). All the system
suitability parameters must be met as per the method.
1. The tailing factor of Propiomazine maleate should be not more than 2 for variation in
flow and wavelength.
2. The % RSD of asymmetry and retention time for fexofendine should be not more than
2%for variation in flow and wavelength.Small deliberate change in the method is made like Flow
minus, Flow plus, Wavelength minus, Wavelength plus, Temperature minus, Temperature plus.
The % RSD of the above conditions is calculated shown Table 5.
Table 5 Robustness studies of Propiomazine maleate
Parameter Conditions Variation %RSD
Wavelength
Variation 245
250 2
240 0.55
Column oven
temperature
Variation
30ºc
25ºc 1.3
35ºc 0.95
Flow rate
Variation 1ml/min
0.9ml/min 0.22
1.1ml/min 0.39
7. SUMMARY AND CONCLUSION
Propiomazine was determined by RP-
HPLC method, optimisation of
chromatographic parameters was done.
Parameters were optimised by altering the
mobile phase ratio and flow rate at a
wavelength of 247 nm. The trails for
optimisation were conducted by using
different mobile phases which include
Acetonitrile: Watere (90:10), ACN: Water
(80:20), Methanol: Water (90:10), ACN:
Water (75:25). Out of all trails, 75:25 ratio
of ACN: Water (80:20) at 0.7ml/min flow
rate was selected for this proposed method
and its shows good system suitability
values which include, tailing factor,
retention time, no. of theoretical
plates.The calibration was performed by
using external calibration method. The
stock solution of Propiomazine was
prepared and dilution was made by using
mobile phase and absorbance was
measured at 247 nm.Serial dilutions 10 to
50 µg/ml of Propiomazine were prepared
and injected and the chromatograms are
recorded. The calibration curve using peak
area Vs concentration was plotted. The
correlation co efficient was calculated as
0.999, the system precision was done both
intraday and interday and the % RSD is
below 2.
The recovery studies were passed out to
confirm the accuracy of the method by
added standard drug to a previously
analysed formulation. The average
percentage recovery was appeared as
101%. LOD and LOQ were calculated and
were in within limits.Robustness was
performed by deliberate changes in the
optimised condition such as flow rate,
temperature, wave length, and
chromatograms were noted.Twenty tablets
are accurately weighed; powdered and
9. equivalent quantity i.e. 50 mg of
Propiomazine tablet powder was taken and
diluted by using diluent. The percentage of
Propiomazine present in the formulation
was occurred to be 101%.
Here by concluded that the method
showed tremendous sensitivity,
reproducibility, accuracy andrepeatability,
which is proved the low percentage
relative standard deviation. The results of
recovery studies, determines that there is
no interference from the excipients used in
formulation. RP-HPLC method can be
effectively applied for the routine analysis
of Propiomazine pure and tablet
formulation in quality control analysis.
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