This curriculum vitae summarizes the education and experience of James E. Nelson. He received a PhD in Molecular Biology and Genetics from Wayne State University in 1994. Since then, he has held several research and staff positions, primarily focused on nonalcoholic steatohepatitis (NASH). He has received over $5 million in grant funding and authored over 50 publications. He has also designed and conducted numerous clinical studies on NASH through the NASH Clinical Research Network.
Kyle J. Ericson is a urology resident at Cleveland Clinic who completed medical school and residencies in general surgery and urology. He has extensive research experience in prostate cancer, pulmonary hypertension, and infectious disease. He received many academic honors and has published papers in peer-reviewed journals. Ericson has taught medical students and enjoys hobbies like golf and spending time outdoors.
Katrina Welch-Reardon has extensive scientific research experience and seeks a business role in a scientific organization. She has a Ph.D. in Biological Sciences from UC Irvine and certificates in bioscience management. Her career includes roles managing admissions events, scientific writing and project management, and graduate research investigating angiogenesis. She has strong communication, organizational and leadership skills as shown through successful event planning, publishing papers, and managing teams of researchers.
This document is a curriculum vitae for Dr. Ryan D. Russell that outlines his education, appointments, honors, grants, and teaching experience. The key points are:
- Dr. Russell received his Ph.D. in Kinesiology from Louisiana State University in 2011 and is currently a Junior Research Fellow at the Menzies Institute for Medical Research in Tasmania, Australia.
This curriculum vitae summarizes Michelle Renee Tourigny's work experience and education. She has over 20 years of experience in flow cytometry and 14 years working with mouse models. Her positions include graduate research assistant, flow cytometry facility manager, and postdoctoral fellow. She received a Ph.D. in Immunology from Cornell University and has skills in flow cytometry, cell culture, mouse work, and immunological techniques.
Dr. Schally is a world renowned endocrinologist and I have had the privilege of collaborating with him on several
projects focused on growth hormone signaling and cognitive aging. We are currently investigating how modulating growth
hormone receptor activity impacts learning, memory and neurogenesis in the hippocampus of young and aged mice. I am
responsible for designing and conducting the behavioral experiments, analyzing the results and assisting in writing manuscripts.
This work has the potential to identify new therapeutic targets for cognitive decline.
Viviane Palhares Muniz has over 15 years of experience in molecular biology and biomedical research. She received her PhD from the University of Iowa in Molecular and Cellular Biology in 2012. Since then, she has worked as a postdoctoral scholar at the University of Iowa, developing mouse models to study cancer metabolism, metabolic syndrome, and pancreatic beta-cell proliferation. She has authored or co-authored over 10 publications and presented her research at several conferences. Her expertise includes developing disease models, molecular techniques, and training students.
This curriculum vitae summarizes the professional experience and qualifications of Douglas Borchman, a professor at the University of Louisville School of Medicine since 2000. It lists his education, including a B.S. in Chemistry from Wayne State University and a Ph.D. in Chemistry from Wayne State University with a minor in Biology. It details his academic appointments and awards. It also provides an overview of his teaching experience, research interests, and record of mentoring students.
This curriculum vitae summarizes the educational background and professional experience of Ryan D. Russell, Ph.D. He received a B.S. in Biomedical Science from Marquette University in 2002 and a Ph.D. in Kinesiology from Louisiana State University in 2011. His current position is as a Junior Research Fellow at the Menzies Institute for Medical Research in Tasmania, Australia, where he coordinates and runs clinical trials related to diabetes. He has extensive experience in clinical research related to exercise interventions for diabetes and microvascular health.
Kyle J. Ericson is a urology resident at Cleveland Clinic who completed medical school and residencies in general surgery and urology. He has extensive research experience in prostate cancer, pulmonary hypertension, and infectious disease. He received many academic honors and has published papers in peer-reviewed journals. Ericson has taught medical students and enjoys hobbies like golf and spending time outdoors.
Katrina Welch-Reardon has extensive scientific research experience and seeks a business role in a scientific organization. She has a Ph.D. in Biological Sciences from UC Irvine and certificates in bioscience management. Her career includes roles managing admissions events, scientific writing and project management, and graduate research investigating angiogenesis. She has strong communication, organizational and leadership skills as shown through successful event planning, publishing papers, and managing teams of researchers.
This document is a curriculum vitae for Dr. Ryan D. Russell that outlines his education, appointments, honors, grants, and teaching experience. The key points are:
- Dr. Russell received his Ph.D. in Kinesiology from Louisiana State University in 2011 and is currently a Junior Research Fellow at the Menzies Institute for Medical Research in Tasmania, Australia.
This curriculum vitae summarizes Michelle Renee Tourigny's work experience and education. She has over 20 years of experience in flow cytometry and 14 years working with mouse models. Her positions include graduate research assistant, flow cytometry facility manager, and postdoctoral fellow. She received a Ph.D. in Immunology from Cornell University and has skills in flow cytometry, cell culture, mouse work, and immunological techniques.
Dr. Schally is a world renowned endocrinologist and I have had the privilege of collaborating with him on several
projects focused on growth hormone signaling and cognitive aging. We are currently investigating how modulating growth
hormone receptor activity impacts learning, memory and neurogenesis in the hippocampus of young and aged mice. I am
responsible for designing and conducting the behavioral experiments, analyzing the results and assisting in writing manuscripts.
This work has the potential to identify new therapeutic targets for cognitive decline.
Viviane Palhares Muniz has over 15 years of experience in molecular biology and biomedical research. She received her PhD from the University of Iowa in Molecular and Cellular Biology in 2012. Since then, she has worked as a postdoctoral scholar at the University of Iowa, developing mouse models to study cancer metabolism, metabolic syndrome, and pancreatic beta-cell proliferation. She has authored or co-authored over 10 publications and presented her research at several conferences. Her expertise includes developing disease models, molecular techniques, and training students.
This curriculum vitae summarizes the professional experience and qualifications of Douglas Borchman, a professor at the University of Louisville School of Medicine since 2000. It lists his education, including a B.S. in Chemistry from Wayne State University and a Ph.D. in Chemistry from Wayne State University with a minor in Biology. It details his academic appointments and awards. It also provides an overview of his teaching experience, research interests, and record of mentoring students.
This curriculum vitae summarizes the educational background and professional experience of Ryan D. Russell, Ph.D. He received a B.S. in Biomedical Science from Marquette University in 2002 and a Ph.D. in Kinesiology from Louisiana State University in 2011. His current position is as a Junior Research Fellow at the Menzies Institute for Medical Research in Tasmania, Australia, where he coordinates and runs clinical trials related to diabetes. He has extensive experience in clinical research related to exercise interventions for diabetes and microvascular health.
This document contains a bibliography divided into sections on basic science, oncology, prognosis, burden of illness, and HIV. It lists over 100 references for studies that have used bioelectrical impedance analysis to study body composition, fluid status, and the relationship between impedance measurements and health outcomes in various patient populations.
This document summarizes an article that appeared in a journal published by Elsevier. The attached copy is provided to the author for non-commercial research and education purposes only. Other uses such as reproduction, distribution, selling, or posting to third party websites are prohibited without permission. Authors are allowed to post their version of the article to their personal or institutional websites for archiving purposes, and the document provides a link for authors to view Elsevier's full author rights and manuscript policies.
CV for Alexander M Riordan, MD Orthopaedic Surgeon at Blount Orthopaedic Associates (Glendale, Cedarburg, and Greater Milwaukee Area), Orthopaedic Hospital of Wisconsin (OHOW), and Ascension Columbia St. Mary's Milwaukee & Ozaukee (Mequon). Specialist in joint replacement (hip including anterior approach, knee, and shoulder), arthroscopy (rotator cuff, ACL, meniscus), sports injuries, and fractures.
A link between premenopausal iron deficiency and breast cancer malignancyEnrique Moreno Gonzalez
This document summarizes a study that found a link between premenopausal iron deficiency and breast cancer malignancy. The study used mouse models and human patient data to show that host iron deficiency promotes primary tumor growth and lung metastasis in mice. It also found that mild iron deficiency in young human breast cancer patients was significantly associated with lymph node invasion. The results indicate that host iron deficiency could be a contributing factor to the poorer prognosis often seen in young breast cancer patients.
The document is a resume for Mia Farrah Tazi, who has a Ph.D. in Integrated Biomedical Sciences from Ohio State University. She has extensive skills and experience in immunology, molecular biology, and cell biology. Her research has focused on cystic fibrosis and autophagy, and she has published 9 papers, given invited lectures, received grants and awards, and served in leadership roles.
This document is a CV for Mia Farrah Tazi. It summarizes her education, including anticipated completion of a Ph.D. in Integrated Biomedical Science from Ohio State University in 2015. It also outlines her extensive research experience, including multiple roles at Ohio State University and Nationwide Children's Hospital since 2010. Finally, it lists her publications, abstracts, and seminar presentations related to her work in immunology and microbial pathogenesis.
The document provides the program for a commencement ceremony for the Graduate School of Biomedical Sciences at The University of Texas Health Science Center at San Antonio. It lists the platform party members and then provides brief biographies for each graduating master's student, including their thesis title, research interests, and future plans. It recognizes 22 students who are graduating with Master of Science degrees.
This document provides a biography and curriculum vitae for Dragan Nikolic M, Ph.D. It outlines his educational background including a Ph.D. in examination of parameters affecting human adult pancreatic islet insulin secretion capacity. It details his professional experience researching human pancreatic islets and diabetes at various medical institutions in Belgrade, Serbia. It also lists his research skills, interests, memberships, publications, presentations, and computer/language skills.
The document provides a bibliography of scientific literature on bioelectrical impedance analysis and phase angle measurements. It is divided into sections on basic science, oncology, prognosis, and burden of illness. The references cover topics like the use of bioelectrical impedance and phase angle as prognostic indicators for various cancers, kidney disease, critical illness, and more. Over 100 references in total are provided spanning research from 1932 to 2009.
This document discusses possible links between vitamin D deficiency and various geriatric syndromes and common comorbidities. It begins by outlining how vitamin D receptors are present in many tissues beyond the musculoskeletal system. It then examines potential associations between vitamin D deficiency and increased risks of frailty, urinary incontinence, dementia/cognitive impairment, and depression in elderly populations. While evidence is limited and relationships are not clearly causal, several observational studies have found correlations between low vitamin D levels and higher rates of these conditions. More research is still needed, but maintaining adequate vitamin D status may help reduce risks of age-related diseases and functional decline.
10 TESIS PENGARUH UMUR, DEPRESI DAN DEMENSIA TERHADAP DISABILITAS FUNGSIONAL ...Bondan Palestin
Kelompok lansia dipandang sebagai kelompok masyarakat yang berisiko (population at risk) mengalami gangguan kesehatan. Oleh karenanya, kelompok lansia merupakan kelompok risiko tinggi yang menjadi perhatian utama dalam cabang ilmu keperawatan komunitas. Masalah keperawatan yang menonjol pada kelompok tersebut adalah meningkatnya disabilitas fungsional fisik sebagai dampak dari respon lansia terhadap proses penuaan, penyakit kronis, atau status psikososialnya. Disabilitas fungsional lansia sebagai efek dari perubahan fisiologis (umur depresi dan demensia) memungkinkan untuk dijelaskan melalui Model Sistem Neuman (MSN). Mengingat MSN memiliki banyak interrelasi konsep sehingga derivasi teori konseptual tersebut lebih bersifat kontekstual. Oleh karenanya, peneliti bermaksud agar penelitian ini dapat digunakan sebagai studi pendahuluan terhadap penelitian-penelitian mengenai disabilitas fungsional yang lebih kompleks. Gigliotti (2003) berpendapat bahwa kredibilitas MSN hanya dapat dikembangkan melalui proses derivasi dan pengujian teori antara (middle-range theory) sebagai derivat dari MSN.
This curriculum vitae outlines the education and career of Dr. Sarah A. Chambers. She received her B.A. from Harvard University and her M.D. from Columbia University. She completed her pediatric training and fellowships at Children's Hospital of New York. Dr. Chambers is currently an Assistant Professor at Albert Einstein College of Medicine, the Director of the Fetal Heart Program at Children's Hospital at Montefiore, and an attending physician at multiple hospitals in the Bronx, NY area. She has authored several publications and book chapters, and actively participates in teaching, research, and quality improvement initiatives related to pediatric cardiology and fetal echocardiography.
Survival and disposition of patients 75 years orKristina Newport
This study investigated outcomes for patients aged 75 or older who required mechanical ventilation for 7 or more days. The researchers reviewed electronic medical records from a hospital and hospice to determine mortality rates and patient dispositions. They found that of the 88 patients who met the criteria, 54.5% survived their hospitalization but only 19.32% were still alive after 1 year. Most surviving patients (93.6%) required skilled nursing care after discharge and few (3.4%) were able to return home, with none living independently. Prolonged mechanical ventilation for elderly patients was associated with high mortality, universal need for post-hospital services, and poor chance of long-term survival.
The document describes searches conducted in Scopus and CINAHL databases to find literature on how nursing interventions influence quality of life for people with lateral sclerosis or multiple sclerosis. Search terms and strategies are provided for both databases. In CINAHL, 7 relevant articles were found and their bibliographic information is listed. In Scopus, search results are presented through links to the database.
Determination the Levels of Zinc and Copper in Patients with LeukemiaHussein Alkufi
Leukemia is the most common type of blood cancer in which both of zinc and copper levels are altered resulting in many metabolic and physiological disorders.
This document discusses human disease from a bioinformatics perspective. It describes major categories of human disease and approaches to identifying disease-associated genes. It compares disease databases and describes how model organisms can elucidate disease-related genetic variation. Key tools for studying disease at the molecular level include DNA databases, genetic and physical maps, protein structure analyses, and functional genomics. Classification systems organize diseases by causes of mortality, global disease burden, and clinical codes.
This document provides a curriculum vitae for Patricia Hentosh. It outlines her education, including a Sc.D. from Harvard University in Cancer Biology and Radiation Biology, experience as a professor and researcher focused on molecular diagnostics and cancer biology, and extensive teaching experience developing and instructing graduate courses. It also lists publications, research advising, and presentations given.
This curriculum vitae summarizes the education and professional experience of Dr. Mark Kenneth Robbins. He received his Bachelor's degree from Gettysburg College in 1983, his medical doctorate from the University of North Carolina School of Medicine in 1987, and completed his residency and fellowship training in pulmonary/critical care medicine by 1994. Since then, he has held various staff physician and director roles in pulmonary/critical care medicine and lung transplant programs across several hospitals in Virginia, North Carolina, Indiana, and Idaho. He maintains active medical licenses and board certifications in internal medicine, pulmonary disease, and critical care medicine.
Liver Iron Measurement by Magnetic Susceptometry alferedo
This document discusses magnetic susceptometry for measuring liver iron concentration. It describes how magnetic susceptometry works by measuring the induced paramagnetic response of iron in the liver to an external magnetic field. It discusses modeling of the human torso, including using a water bag to cancel out background tissue signals. Different types of magnetizing fields and pickup coil configurations are presented for localized measurement of liver iron.
MRI-based Monitoring Tools for Iron Chelation by Pairash Saiviroonporn, Ph.D., Radiology Department, Faculty of Medicine Siriraj Hospital, Mahidol University
This document contains a bibliography divided into sections on basic science, oncology, prognosis, burden of illness, and HIV. It lists over 100 references for studies that have used bioelectrical impedance analysis to study body composition, fluid status, and the relationship between impedance measurements and health outcomes in various patient populations.
This document summarizes an article that appeared in a journal published by Elsevier. The attached copy is provided to the author for non-commercial research and education purposes only. Other uses such as reproduction, distribution, selling, or posting to third party websites are prohibited without permission. Authors are allowed to post their version of the article to their personal or institutional websites for archiving purposes, and the document provides a link for authors to view Elsevier's full author rights and manuscript policies.
CV for Alexander M Riordan, MD Orthopaedic Surgeon at Blount Orthopaedic Associates (Glendale, Cedarburg, and Greater Milwaukee Area), Orthopaedic Hospital of Wisconsin (OHOW), and Ascension Columbia St. Mary's Milwaukee & Ozaukee (Mequon). Specialist in joint replacement (hip including anterior approach, knee, and shoulder), arthroscopy (rotator cuff, ACL, meniscus), sports injuries, and fractures.
A link between premenopausal iron deficiency and breast cancer malignancyEnrique Moreno Gonzalez
This document summarizes a study that found a link between premenopausal iron deficiency and breast cancer malignancy. The study used mouse models and human patient data to show that host iron deficiency promotes primary tumor growth and lung metastasis in mice. It also found that mild iron deficiency in young human breast cancer patients was significantly associated with lymph node invasion. The results indicate that host iron deficiency could be a contributing factor to the poorer prognosis often seen in young breast cancer patients.
The document is a resume for Mia Farrah Tazi, who has a Ph.D. in Integrated Biomedical Sciences from Ohio State University. She has extensive skills and experience in immunology, molecular biology, and cell biology. Her research has focused on cystic fibrosis and autophagy, and she has published 9 papers, given invited lectures, received grants and awards, and served in leadership roles.
This document is a CV for Mia Farrah Tazi. It summarizes her education, including anticipated completion of a Ph.D. in Integrated Biomedical Science from Ohio State University in 2015. It also outlines her extensive research experience, including multiple roles at Ohio State University and Nationwide Children's Hospital since 2010. Finally, it lists her publications, abstracts, and seminar presentations related to her work in immunology and microbial pathogenesis.
The document provides the program for a commencement ceremony for the Graduate School of Biomedical Sciences at The University of Texas Health Science Center at San Antonio. It lists the platform party members and then provides brief biographies for each graduating master's student, including their thesis title, research interests, and future plans. It recognizes 22 students who are graduating with Master of Science degrees.
This document provides a biography and curriculum vitae for Dragan Nikolic M, Ph.D. It outlines his educational background including a Ph.D. in examination of parameters affecting human adult pancreatic islet insulin secretion capacity. It details his professional experience researching human pancreatic islets and diabetes at various medical institutions in Belgrade, Serbia. It also lists his research skills, interests, memberships, publications, presentations, and computer/language skills.
The document provides a bibliography of scientific literature on bioelectrical impedance analysis and phase angle measurements. It is divided into sections on basic science, oncology, prognosis, and burden of illness. The references cover topics like the use of bioelectrical impedance and phase angle as prognostic indicators for various cancers, kidney disease, critical illness, and more. Over 100 references in total are provided spanning research from 1932 to 2009.
This document discusses possible links between vitamin D deficiency and various geriatric syndromes and common comorbidities. It begins by outlining how vitamin D receptors are present in many tissues beyond the musculoskeletal system. It then examines potential associations between vitamin D deficiency and increased risks of frailty, urinary incontinence, dementia/cognitive impairment, and depression in elderly populations. While evidence is limited and relationships are not clearly causal, several observational studies have found correlations between low vitamin D levels and higher rates of these conditions. More research is still needed, but maintaining adequate vitamin D status may help reduce risks of age-related diseases and functional decline.
10 TESIS PENGARUH UMUR, DEPRESI DAN DEMENSIA TERHADAP DISABILITAS FUNGSIONAL ...Bondan Palestin
Kelompok lansia dipandang sebagai kelompok masyarakat yang berisiko (population at risk) mengalami gangguan kesehatan. Oleh karenanya, kelompok lansia merupakan kelompok risiko tinggi yang menjadi perhatian utama dalam cabang ilmu keperawatan komunitas. Masalah keperawatan yang menonjol pada kelompok tersebut adalah meningkatnya disabilitas fungsional fisik sebagai dampak dari respon lansia terhadap proses penuaan, penyakit kronis, atau status psikososialnya. Disabilitas fungsional lansia sebagai efek dari perubahan fisiologis (umur depresi dan demensia) memungkinkan untuk dijelaskan melalui Model Sistem Neuman (MSN). Mengingat MSN memiliki banyak interrelasi konsep sehingga derivasi teori konseptual tersebut lebih bersifat kontekstual. Oleh karenanya, peneliti bermaksud agar penelitian ini dapat digunakan sebagai studi pendahuluan terhadap penelitian-penelitian mengenai disabilitas fungsional yang lebih kompleks. Gigliotti (2003) berpendapat bahwa kredibilitas MSN hanya dapat dikembangkan melalui proses derivasi dan pengujian teori antara (middle-range theory) sebagai derivat dari MSN.
This curriculum vitae outlines the education and career of Dr. Sarah A. Chambers. She received her B.A. from Harvard University and her M.D. from Columbia University. She completed her pediatric training and fellowships at Children's Hospital of New York. Dr. Chambers is currently an Assistant Professor at Albert Einstein College of Medicine, the Director of the Fetal Heart Program at Children's Hospital at Montefiore, and an attending physician at multiple hospitals in the Bronx, NY area. She has authored several publications and book chapters, and actively participates in teaching, research, and quality improvement initiatives related to pediatric cardiology and fetal echocardiography.
Survival and disposition of patients 75 years orKristina Newport
This study investigated outcomes for patients aged 75 or older who required mechanical ventilation for 7 or more days. The researchers reviewed electronic medical records from a hospital and hospice to determine mortality rates and patient dispositions. They found that of the 88 patients who met the criteria, 54.5% survived their hospitalization but only 19.32% were still alive after 1 year. Most surviving patients (93.6%) required skilled nursing care after discharge and few (3.4%) were able to return home, with none living independently. Prolonged mechanical ventilation for elderly patients was associated with high mortality, universal need for post-hospital services, and poor chance of long-term survival.
The document describes searches conducted in Scopus and CINAHL databases to find literature on how nursing interventions influence quality of life for people with lateral sclerosis or multiple sclerosis. Search terms and strategies are provided for both databases. In CINAHL, 7 relevant articles were found and their bibliographic information is listed. In Scopus, search results are presented through links to the database.
Determination the Levels of Zinc and Copper in Patients with LeukemiaHussein Alkufi
Leukemia is the most common type of blood cancer in which both of zinc and copper levels are altered resulting in many metabolic and physiological disorders.
This document discusses human disease from a bioinformatics perspective. It describes major categories of human disease and approaches to identifying disease-associated genes. It compares disease databases and describes how model organisms can elucidate disease-related genetic variation. Key tools for studying disease at the molecular level include DNA databases, genetic and physical maps, protein structure analyses, and functional genomics. Classification systems organize diseases by causes of mortality, global disease burden, and clinical codes.
This document provides a curriculum vitae for Patricia Hentosh. It outlines her education, including a Sc.D. from Harvard University in Cancer Biology and Radiation Biology, experience as a professor and researcher focused on molecular diagnostics and cancer biology, and extensive teaching experience developing and instructing graduate courses. It also lists publications, research advising, and presentations given.
This curriculum vitae summarizes the education and professional experience of Dr. Mark Kenneth Robbins. He received his Bachelor's degree from Gettysburg College in 1983, his medical doctorate from the University of North Carolina School of Medicine in 1987, and completed his residency and fellowship training in pulmonary/critical care medicine by 1994. Since then, he has held various staff physician and director roles in pulmonary/critical care medicine and lung transplant programs across several hospitals in Virginia, North Carolina, Indiana, and Idaho. He maintains active medical licenses and board certifications in internal medicine, pulmonary disease, and critical care medicine.
Liver Iron Measurement by Magnetic Susceptometry alferedo
This document discusses magnetic susceptometry for measuring liver iron concentration. It describes how magnetic susceptometry works by measuring the induced paramagnetic response of iron in the liver to an external magnetic field. It discusses modeling of the human torso, including using a water bag to cancel out background tissue signals. Different types of magnetizing fields and pickup coil configurations are presented for localized measurement of liver iron.
MRI-based Monitoring Tools for Iron Chelation by Pairash Saiviroonporn, Ph.D., Radiology Department, Faculty of Medicine Siriraj Hospital, Mahidol University
MRI uses strong magnetic fields and radio waves to generate images of the inside of the body. It is a medical imaging technique widely used in radiology to visualize anatomy and physiological processes. MRI has many medical uses and applications across different body systems. It is generally a safe technique but there are some risks needing consideration for things like implants, projectile effects, and claustrophobia. Guidelines and certifications aim to standardize roles and ensure safe MRI practices.
Thalassemia in Viet Nam by Prof.Nguyen Anh Tri MD Ph.D Director - National institute of Hematology and Blood Transfusion President – Viet Nam Thalassemia Association
Liver biopsy is currently the reference standard for assessing liver fibrosis but it has disadvantages like being an invasive procedure that carries risk. Non-invasive alternatives to biopsy include clinical indices, imaging, serum biomarkers, and measurements of liver stiffness and portal pressure. While these alternatives are safer than biopsy, they each only assess one aspect of liver disease and cannot provide the full histological assessment of biopsy. However, within defined clinical contexts, noninvasive assessment can be an attractive alternative and contribute valuable information to patient management and treatment outcomes.
MRI is useful for evaluating various liver conditions. It is superior to CT for detecting small liver lesions and characterizing lesions. MRI can identify diffuse liver diseases affecting hepatocytes or reticuloendothelial cells, causing homogeneous or segmental changes. Cirrhosis appears as numerous low signal regenerative nodules on T2-weighted images. Hemangiomas are intensely hyperintense on T2-weighted images and enhance peripherally on contrast images. Dysplastic nodules are generally hypointense on T1-weighted images and do not enhance with contrast. MRI utilizes multiple sequences and techniques to comprehensively evaluate liver tumors, diffuse diseases, and incidental findings.
The document discusses liver cancer, including its causes, risk factors, symptoms, diagnosis, and treatment. It states that liver cancer is difficult to diagnose and treat, as the liver is an important organ involved in many bodily functions. The cancer often develops due to conditions like hepatitis or cirrhosis that damage the liver over time. Symptoms can include abdominal swelling and pain, and diagnosis involves medical imaging and biopsy. Treatment options depend on cancer stage and liver health, and may include surgery, chemotherapy, radiation, or other approaches. Maintaining a healthy lifestyle is important to prevent risk factors and protect the liver.
This document discusses non-transfusion dependent thalassemia (NTDT), including HbE/β thalassemia. It classifies HbE/β thalassemia into severe, moderate, and mild based on hemoglobin levels and clinical symptoms. It also discusses transfusion therapy for NTDT, indicating when regular transfusions should start based on hemoglobin drop, organ enlargement, and other factors. The document further discusses chelation therapy for managing iron overload in NTDT, covering various chelating agents like deferoxamine, deferiprone, and deferasirox.
1) The document discusses the structure, function, variations and synthesis of haemoglobin. It describes haemoglobin as a conjugated protein made up of iron and globin, with a molecular weight of 68,000.
2) The structure of haemoglobin includes a heme group which is an iron-porphyrin complex, and a globin protein composed of two alpha and two beta polypeptide chains. Haemoglobin's role is to transport oxygen to tissues and carbon dioxide to the lungs.
3) Variations discussed include fetal haemoglobin, sickle cell haemoglobin caused by an amino acid substitution, and thalassemias which are defects in globin chain synthesis. The document provides details on the
This document discusses liver stiffness measurement (FibroScan) for assessing liver fibrosis. It begins by describing FibroScan as a non-invasive test that measures liver stiffness using ultrasound to evaluate the velocity of shock wave propagation through liver tissue. FibroScan has several advantages over liver biopsy as it is simple, reproducible, readily available, less expensive, and can predict the full spectrum of fibrosis. The document then reviews factors that can affect liver stiffness measurements such as obesity, operator experience, acute liver injury, extrahepatic cholestasis, increased central venous pressure, and ascites. It concludes that while FibroScan is a useful test, its results must be interpreted in the overall clinical context while considering potential limitations and pitfalls
Jack Ryan Reifert has extensive experience in neuroscience research and industrial research. He received his Ph.D. in Molecular, Cellular, and Developmental Biology from UCSB, focusing on amyloid beta induced neurodegeneration and the involvement of tau. He has held postdoctoral positions at UCSB studying bacterial peptide display to inhibit ovarian cancer metastasis and at UCSD investigating wnt/β-catenin signaling in rheumatoid arthritis. Reifert has worked at several companies, contributing to FDA approval of Bendamustine and coordinating product releases. He is currently a postdoctoral fellow at UCSB studying targeted inhibition of proteases in ovarian cancer metastasis.
The document is a resume for Kenya M. Joseph detailing her education in biology from the University of North Carolina Charlotte and Queensborough Community College, as well as her research experience including examining interactions of RNA nanoparticles and cytokine expression related to smoking and stress, along with presentations and publications from this work. She has received several awards and honors for her academic and research accomplishments.
This document provides a summary of Jack Ryan Reifert's education, experience, publications, and research skills. Reifert holds a Ph.D. in Molecular, Cellular, and Developmental Biology from UCSB and a B.S. in Pharmacological Chemistry from UCSD. He has postdoctoral and research experience studying mechanisms of amyloid beta induced neurodegeneration and ovarian cancer metastasis. Reifert has authored several publications investigating topics like tau fragmentation and the mechanism of action of cancer drug Bendamustine. His research skills include tissue culture, molecular techniques, microscopy, and cytotoxicity assays.
This document provides a summary of Jack Ryan Reifert's education, experience, publications, and research skills. Reifert holds a Ph.D. in Molecular, Cellular, and Developmental Biology from UCSB and a B.S. in Pharmacological Chemistry from UCSD. He has postdoctoral research experience at UCSB studying bacterial peptide display for ovarian cancer detection and inhibition. Reifert has over 10 years of experience in neuroscience research and industrial research, and he has authored several publications in peer-reviewed journals.
Jack Ryan Reifert is seeking a post-doctoral position in molecular mechanisms of age-related human diseases. He received his Ph.D. in Molecular, Cellular, and Developmental Biology from UCSB, where his dissertation research investigated amyloid beta-induced neurodegeneration and the role of tau phosphorylation and cleavage. He has research experience in academia and industry, including publications, and is currently investigating tau fragmentation and amyloid beta signaling in neurodegeneration.
Vicky M.-H. Sung has over 20 years of experience in biomedical research. She received her Ph.D. in Molecular Microbiology and Immunology from the University of Southern California. Her resume summarizes her educational background and work experience conducting independent research projects at prestigious institutions such as Harvard Medical School, the University of California Irvine, and the University of Southern California. She has extensive expertise in areas such as viral infections, stem cell biology, and molecular biology techniques.
Amy Staebler Husak is a pharmacy resident at St. Claire Regional Medical Center in Morehead, KY. She received her PharmD from the University of Kentucky College of Pharmacy in 2014. Her resume provides extensive details on her education, experience, licensure, presentations, and involvement in professional organizations. She has focused her career and research on antimicrobial stewardship and infectious diseases.
This document summarizes the goals and programs of the UCLA Clinical & Translational Science Institute (CTSI). The CTSI aims to advance translational research through 10 program areas, including clinical and community research resources, biostatistics, and career development programs. It provides various types of funding, including KL2 and TL1 awards, to support early career researchers and train the next generation of translational scientists. The document highlights recent awardees and accomplishments of the CTSI and its collaboration with other University of California institutions.
The document is a curriculum vitae for Dr. Sachin Jogal, an Assistant Professor of Pediatrics specializing in hematology, oncology, and bone marrow transplant. It details his education, including undergraduate and medical degrees, as well as his postgraduate training and fellowships. It also lists his faculty appointments, awards, publications, presentations, committee involvement, and community service activities.
Jack Reifert has over 15 years of experience in biomedical research. He received his Ph.D. in Molecular, Cellular, and Developmental Biology from UC Santa Barbara and has worked in both academic and industry research settings. Currently he is a scientist at Serimmune Inc. where he utilizes techniques like peptide display screening and deep sequencing to identify biomarkers and therapeutic candidates for autoimmune diseases.
This document is a curriculum vitae for Dr. Aria F. Olumi. It summarizes her education, including degrees in chemistry and medicine from UC San Diego and USC. It details her medical training in surgery and urologic surgery. It also outlines her faculty appointments at Harvard Medical School and administrative roles at various hospitals. Finally, it lists publications, honors, committee service, and history of funded research projects in areas like prostate cancer and bladder dysfunction related to diabetes.
Kelvin Yaprianto is a biochemist from Indonesia who received his Bachelor of Science with Honours degree from the Walter and Eliza Hall Institute of Medical Research in Australia in 2013. He has extensive research experience investigating the roles of NF-κB family transcription factors in promoting tumor cell survival and metastasis. Currently he works as a research assistant in stem cell and cancer research at PT. Kalbe Farma Tbk. in Jakarta.
This document provides a summary of Jorge Allina's professional experience and education. It lists his positions held from 1992 to the present, including roles as a clinical research coordinator, assistant professor, and adjunct assistant professor. It also outlines his medical education and credentials. The document lists original research manuscripts and reviews authored by Jorge Allina as well as past mentees and grants received.
This document is a curriculum vitae for Dr. Brittany Pakalniskis that summarizes her education and training, licenses, professional experience, research, publications, presentations, honors, and references. She received her Bachelor's degree from Ohio State University and MD from Dartmouth Medical School. She completed residency training in Anatomic and Clinical Pathology at University of Iowa Hospitals and Clinics and fellowships in General Surgical Pathology and Cytopathology. She is licensed to practice medicine in Iowa and Washington and is board certified in Anatomic and Clinical Pathology.
This curriculum vitae summarizes the qualifications and experience of Joseph M. Devaney. He is currently a staff scientist at Children's National Health System where he develops and validates clinical genetic tests. He has over 20 years of experience in genomics and genetic diagnostics, including developing technologies for sequencing and analyzing exomes. He has authored over 90 peer-reviewed publications focused on identifying genetic variants associated with diseases.
This curriculum vitae outlines the education and career of Dr. Jeffrey C. Fink. It details his education, including degrees from Clark University and Case Western Reserve University School of Medicine. It provides a comprehensive history of his academic appointments and certifications, clinical and research activities, teaching experience, grant support, and publications. Dr. Fink currently serves as Professor of Medicine and Epidemiology and Chief of General Internal Medicine at the University of Maryland School of Medicine.
This document is a resume for Laura E. Skeeles PA-C summarizing her education, clinical rotations, certifications, employment history, volunteer experience, publications, professional memberships, and computer skills. She received her Master of Science in Physician Assistant Studies from Long Island University in 2015 and has since worked as a Physician Assistant. Her resume demonstrates extensive clinical experience in specialties such as orthopedic surgery, general surgery, neurosurgery, internal medicine, pediatrics, emergency medicine, and OB/GYN.
The document provides a curriculum vitae for M.Kalaivani. It summarizes her objective of seeking a challenging career where she can utilize her knowledge and experience. It then details her professional experience including current and previous roles as an Assistant Professor and Junior Research Fellow. It lists her educational qualifications and publications.
This curriculum vitae summarizes the professional experience and qualifications of David M. Miller. Miller is currently a Professor of Cell and Developmental Biology and Biological Sciences at Vanderbilt University. His research focuses on developmental neurobiology, synaptic remodeling, and dendrite morphogenesis using the model organism C. elegans. He has over 30 years of experience in this field and has supervised numerous graduate students and postdoctoral fellows in his lab. Miller has also received significant grant funding, including multiple NIH R01 grants, and has been recognized with awards for his research and teaching.
Tammy Butterick is an Adjunct Assistant Professor and Health Science Specialist at the University of Minnesota and Minneapolis VA Health Care System. She received her Ph.D. in Pharmacology from the University of Minnesota and has received research funding from the VA and other sources. Her research focuses on the neuroscience and neuropharmacology of obesity, specifically investigating the role of orexin A in cognitive decline, obesity, and neuroinflammation.
IU Data Visualization Class Final Project: Visualizing Missing Species Intera...James Nelson
The aim of our project is to also utilize the GloBI APIs to visualize understudied organisms and locations with minimal interaction data within the GloBI data repository.
IU Applied Machine Learning Class Final Project: ML Methods for Predicting Wi...James Nelson
The document describes a machine learning project that compares the performance of R packages for logistic regression and random forest algorithms on wine quality datasets. It loads and prepares the datasets, then explores the data through descriptive statistics. Logistic regression and random forest models are applied to the training data and evaluated on test data.
James Nelson has over 15 years of experience designing and leading laboratory, translational, and clinical research studies. He has a PhD in Molecular Biology and Genetics from Wayne State University and is currently enrolled in Indiana University's Data Science Master's Program. Nelson has extensive experience in areas such as statistical analysis, machine learning, big data technologies, bioinformatics, and data visualization. He has authored over 70 peer-reviewed publications and has been the recipient of over $7 million in NIH research grants.
This proposal outlines the commercialization pathway for an investigational in vitro diagnostic (IVD) device for nonalcoholic fatty liver disease (NAFLD). They were unable to identify a substantially equivalent predicate device, so they plan to submit a formal pre-submission to the FDA to obtain guidance on the appropriate regulatory pathway. The proposed studies funded by this proposal would support information needed for the pre-submission, including analytical validation and performance characteristics of the test. Depending on FDA feedback, the pathway may involve de novo classification, reclassification, or premarket approval.
1) A study examined the effects of a high-fat diet and parenteral iron administration on non-alcoholic fatty liver disease (NAFLD) in an obese, diabetic mouse model. 2) Mice fed a high-fat diet and administered parenteral iron showed increased liver inflammation, oxidative stress, and collagen production compared to mice on only a high-fat diet or normal diet. 3) However, mice given both a high-fat diet and parenteral iron showed less fat accumulation in the liver (steatosis) than mice on only a high-fat diet.
This document summarizes a study that will compare the effects of omega-3 polyunsaturated fatty acid supplementation to monounsaturated fatty acid supplementation for 8 weeks on nonalcoholic fatty liver disease (NAFLD). It will randomize 30 patients with NAFLD and at least 20% steatosis into the two treatment groups. The primary outcome is reduction of intrahepatic fat content as measured by magnetic resonance spectroscopy. Secondary outcomes include changes in liver enzymes, lipid profile, inflammation markers, and insulin resistance. The study personnel, design, population, visit schedule, and treatment protocols are outlined.
A Randomized, Masked, Controlled Study of Omega-3 Polyunsaturated Fatty Acid ...James Nelson
The aim of this study is to investigate the effects of an 8-week dietary supplementation with omega-3 polyunsaturated fatty acids (PUFA; i.e., fish oil) compared to monounsaturated fatty acids (MUFA; i.e., safflower oil) on intrahepatic fat content measured by magnetic resonance spectroscopy, serum aminotransferases, fasting lipids, insulin resistance, resting metabolic rate and proinflammatory cytokines in patients with non-alcoholic fatty liver disease.
Variants In The Il6 And Il1β Genes Either Alone Or In Combination With C282Y ...James Nelson
The goal of this study was to investigate if IL6 and IL1β cytokine SNPs, alone or in combination with HFE gene mutations, can affect the grade and pattern of hepatic iron deposition and serum iron markers in the well characterized NASH CRN cohort.
Serum Vitamin D Deficiency is Associated with NASH in AdultsJames Nelson
The aim of this study was to determine the relationship of serum vitamin D levels to histologic features of NAFLD, and associated demographic, clinical, and laboratory data in the well characterized NASH CRN cohort.
Twitter Dataset Analysis and Geocoding James Nelson
The aim of the project was to validate user-defined location data in a Twitter dataset of 10,000 tweets using MongoDB and the Google Maps Geocoding API.
Deep Sequencing Identifies Novel Circulating and Hepatic ncRNA Profiles in NA...James Nelson
Next-generation RNA sequencing has expedited the identification of new non-coding RNA species (ncRNAs), thus ushering in the emerging field of ncRNA biology. The goals of this study were to catalogue the spectrum of different ncRNAs in serum and liver of patients with NAFLD and to compare expression of serum exRNAs between NAFLD patients and healthy control subjects.
Serum microRNA biomarkers for prognosis of nonalcoholic fatty liver diseaseJames Nelson
Next- generation sequencing (NGS) was performed on 45 serum RNA samples using the Illumina HiScanSQ platform. The goal of this study was to determine serum miRNA profiles for use as novel diagnostic and prognostic biomarkers for the presence of NAFLD, NASH and advanced fibrosis.
Serum microRNA biomarkers for prognosis of nonalcoholic fatty liver disease
James Nelson CV 33016
1. 1
JAMES EDWARD NELSON
CURRICULUM VITAE
Home Address:
2036 218th
PL NE
Sammamish, WA 98074
Phone: (206) 794-2998
EDUCATION
Degrees
1988 BS Biology, Alma College, Alma, Michigan
1994 PhD Department of Molecular Biology and Genetics, Wayne State University School of
Medicine, Detroit, Michigan. Minor: Department of Immunology and Microbiology
Dissertation: Detailed Characterization of the Human Protamine Gene Cluster Region; Physical
Analysis, Isolation of the Transition Protein 2 Gene and Complete DNA Sequence
Analysis.
Advisor: Stephen A. Krawetz, Ph.D., Charlotte B. Failing Professor of Fetal Therapy and
Diagnosis. Department of Molecular Biology and Genetics, Obstetrics and
Gynecology and Center for Molecular Medicine and Genetics
9/03-6/04 Clinical Trials Certificate Program, University of Washington Extension-Seattle
9/15-present Data Science Master’s Program (online), Indiana University-Bloomington
Graduate Certificate (awarded upon completion of 12 credit hours) May 2016
EMPLOYMENT AND TRAINING
4/94-10/94 Research Faculty, Dept. of Molecular Biology and Genetics, Wayne State
University, Detroit, MI
11/94-8/98 Senior Fellow, Division of Medical Genetics, Markey Molecular Medicine Center,
University of Washington School of Medicine. Seattle, WA. Laboratory Director:
Mark Kay M.D., Ph.D.
8/98-8/99 Postdoctoral Fellow, Division of Pediatric Genetics, Stanford University School of
Medicine. Palo Alto, CA. Laboratory Director: Mark Kay M.D., Ph.D.
2/04-12/05 Research Coordinator, Division of Gastroenterology, University of Washington
School of Medicine. Seattle, WA. Employer: Kris Kowdley, MD
12/05-7/07 Research Scientist, Division of Gastroenterology, University of Washington School
of Medicine. Seattle, WA. Employer: Kris Kowdley, MD
7/07-1/13 Staff Scientist, Kowdley Lab Manager, Benaroya Research Institute, Seattle, WA
1/13-5/15 Research Assistant Member, Benaroya Research Institute, Seattle, WA
Career Related Coursework
2. James E. Nelson, PhD
2
1989 “A Short Course in Molecular Biology Software”, Intelligenetics Inc., Detroit, MI
1992 NIDDK Symposium, “Impact of Molecular Genetics on the Treatment of Genetic
Diseases”, Bethesda, MD
1994 “Introduction to SUNOS”, SUN microsystems Inc., Southfield, MI
1995-present “Animal Use; Laws and Regulations Training”, University of Washington
1995, 2006 “Animal Use; Specific Pathogen Free Training”, University of Washington
1995, 2006 “Mouse Hands-on Training Course”, University of Washington
2003 “Human Subjects Research Training”, University of Washington, Seattle, WA
2004 “Introduction to Microsoft Access”, UW Computer Training, Seattle, WA
2004 “Intermediate Microsoft Access”, UW Computer Training, Seattle, WA
2004 “NIH Regional Seminars in Program Funding and Grants Administration”, Seattle
2005 “Design of a Clinical Research Trial Summer Course”, UW GCRC, Seattle, WA
2005-2007 “Bloodborne Pathogens for Researchers Training”, University of Washington
2005-present “Human Research Course”, CITI Collaborative Institutional Training Initiative
2006 “Integrating Quality in Clinical Trials: Update on Clinical Trial and IRB
Management of Studies”, FDA Center for Devices and Radiological Health
(CDRH) and the Organization for Regulatory and Clinical Associates (ORCA),
Kirkland, WA
2007-present “GCP Training Course”, Clinical Research Training for Investigational Site
Personnel (CRISP) Sponsored by ClinfoSource and the UW School of Medicine
2008-present “Working with the IACUC”, CITI Collaborative Institutional Training Initiative
2008-present “Specific Pathogen Free Training”, Benaroya Research Institute
2008-present “Occupational Health and Safety Training”, Benaroya Research Institute
2008-present “Radiation Safety Training”, Benaroya Research Institute
2009 NIDDK Symposium, “Iron Overload Disorders”, Bethesda, MD
2010 Northwest Center for Public Health Practice “Online Course in Epidemiology”
2010 AASLD Basic Research Workshop – “Progenitors, Precursors, and Non-
Parenchymal Cells in Liver Fibrosis”, Boston, MA
2011 Manager Online Training, “Workplace Answers”, Benaroya Research Institute
2011 “Working with Rats”, University of Washington, Seattle, WA
2011 “Rat Hands-on Training Course”, University of Washington
2011 AASLD Basic Research Workshop – “MicroRNAs in Liver Diseases”, San
Francisco, CA
2012 EASL Monothematic Conference, “IMLI – Immune-Mediated Liver Injury,”
Birmingham, UK
2012 AASLD Basic Research Single Topic Conference – “Mitochondria and
Hepatotoxicity” Atlanta, GA
3. James E. Nelson, PhD
3
2012 “Conflict of Interest; mini-course”, CITI Collaborative Institutional Training Initiative
2013 “Writing/Designing NIH Proposals Workshop” Sponsored by the Grant Training
Center, University of Washington, Seattle, WA
2014 AASLD Basic Research Single Topic Conference – “Non coding RNAs in Liver
Function and Dysfunction”, Miami, FL
2014 “Learning R / Bioconductor for Sequence Analysis”, Fred Hutchinson Cancer
Research Center, Seattle, WA
RESEARCH SUPPORT
Completed
1994-1997 Cystic Fibrosis Foundation Postdoctoral Fellowship (Nelson)
1997-1998 NIDDK Training Grant- Postdoctoral Fellowship, Division of Gastroenterology,
University of Washington School of Medicine (Lee)
2002-2014 NIDDK [U01DK061728-12], Research Network in Nonalcoholic Steatohepatitis
(Kowdley). Role: Staff Scientist
2005-2009 NIDDK [U01DK61728-03S1], Iron Depletion Therapy for Patients with Type 2
Diabetes Mellitus and Nonalcoholic Fatty Liver Disease (Kowdley). Role: Staff
Scientist
2005-2009 NIDDK [U01DK61728-03S2], A Randomized, Masked, Controlled Study of
Omega-3 Polyunsaturated Fatty Acid vs Monounsaturated Fatty Acid Dietary
Supplementation for the Treatment of Nonalcoholic Fatty Liver Disease (Kowdley).
Role: Staff Scientist
2007-2011 NIDDK [R21DK072360], Room Temperature Susceptometry for Hepatic Iron
Measurement (Kowdley). Role: Other Significant Contributor
2009-2010 Calistoga Pharmaceuticals, Seattle, WA. Effect of Phosphoinositide 3-Kinase
P110delta Inhibition in a Murine Model of NASH (Kowdley). Role: Co-Investigator
2010-2011 NIDDK [R56DK087696], The Role of Iron in the Pathogenesis of NAFLD
(Kowdley). Role: Co-Investigator
2011-2015 NIDDK [R01DK087696-03], The Role of Iron in the Pathogenesis of NAFLD
(Kowdley). Role: Co-Investigator
2012-2013 The American College of Gastroenterology [ACG-CR-072-2012], The Relationship
Between Serum Vitamin D Levels and NASH Severity (Kowdley). Role: Co-
Investigator
2012-2014 NHLBI [R21HL112678-02], Serum Biomarkers Associated with Phenotypic
Expression of Hemochromatosis (Kowdley). Role: Co-Investigator
2013-2014 Gilead Sciences, Inc. Expression of PI3Kdelta and Activation Status of this
Pathway in Liver Tissue Samples From NASH Patients. Role: PI
2013-2014 VMMC Digestive Disease Institute, Defining the Hepatic Immune Response to
Vitamin D Deficiency in Humans and Rats with Nonalcoholic Steatohepatitis.
Role: PI
4. James E. Nelson, PhD
4
2013-2014 Benaroya Research Institute, Wilske Center for Translational Research Pioneer
Award, Serum MicroRNA Profiling in NAFLD. Role: PI
2013-2015 NIDDK [R21DK099718-01], Novel Prognostic MicroRNA Biomarkers for Primary
Sclerosing Cholangitis (Kowdley). Role: Co-Investigator
2014-2019 NIDDK [U01DK061728-14], Research Network in Non-alcoholic Steatohepatitis
(Kowdley). Role: Co-Investigator
AWARDS
1981 Eagle Scout
1988-1991 Graduate Research Assistantship I, W.S.U. School of Medicine
1991-1994 Graduate Research Assistantship II, W.S.U. School of Medicine
1992 NIH Travel Grant to attend the NIDDK Symposium on the Impact of Molecular
Genetics on the Treatment of Genetic Diseases
1993 The Institute for Genome Research T.I.G.R. Travel Grant to attend the Genome
Sequencing and Analysis Conference V
1993 Wayne State University Travel Award to attend the Genome Sequencing and
Analysis Conference V
2007 The International BioIron Society, Travel Award to attend BioIron 2007
2011 Presidential Poster of Distinction, Digestive Disease Week 2011: Relationship of
C282Y HFE Mutations, Hepatic Iron Deposition and Histologic Features in
Patients with Nonalcoholic Fatty Liver Disease.
2011 Presidential Poster of Distinction, AASLD 2011:C282Y HFE Mutations Contribute
to Decreased Circulating Hepcidin Levels and Increased Hepatocellular Iron
Deposition in Patients with Nonalcoholic Fatty Liver Disease.
2012 Presidential Poster of Distinction, AASLD 2012: The Il1β +3953 C>T
polymorphism minor allele is associated with a higher NAFLD activity score,
presence of nonalcoholic steatohepatitis and is an independent risk factor for
advanced fibrosis in subjects with nonalcoholic fatty liver disease.
PROTOCOLS AND STUDIES DESIGNED
1995 Second Generation Adenoviral Vectors for Liver-Directed Gene Therapy. Funding:
Cystic Fibrosis Foundation
1997 Minimal Adenovirus Gene Therapy Vectors. Funding: NIDDK Training Grant
Postdoctoral Fellowship
2005 Iron Depletion Therapy for Patients with Type 2 Diabetes Mellitus and Non-Alcoholic
Fatty Liver Disease. NASH CRNPilot and Feasibility Study PF6. IRB#: 07049-UW.
Funding: NIDDK U01 K061728-03S1; ClinicalTrials.gov ID NCT00230113
2005 A Randomized, Masked, Controlled Study of Omega-3 Polyunsaturated Fatty Acid vs
Monounsaturated Fatty Acid Dietary Supplementation for the Treatment of Nonalcoholic
Fatty Liver Disease. NASH CRN Pilot and Feasibility Study PF7. IRB#: 07050-UW.
5. James E. Nelson, PhD
5
Funding: NIDDK U01 DK061728-03S2; ClinicalTrials.gov ID NCT00230087
2006 Room Temperature Susceptometry for Hepatic Iron Measurement. IRB#: 07031-BRI.
Funding: NIDDK R21 DK072360
2006 Effect of Liver Transplantation on Duodenal Iron Transporter Gene Expression in a Hfe
Knockout Mouse Model. ACUC Protocol #: 4101-UW. Funding: Private
2006 Prevalence and Pattern of Hepatic Iron Deposition and Relationship to Type 2 Diabetes
and Fibrosis among Patients with NAFLD: Preliminary findings from the NASH CRN.
NASH CRN MS#2006-3
2007 The Relationship of BMI, the Metabolic Syndrome and NAFLD. NASH CRN MS#2007-4
2008 Generation of a Dietary Mouse Model for NASH. ACUC Protocol #: 07KO01- BRI.
Funding: Private
2008 Effects of Dietary and Parenteral Iron Loading in a Mouse Model of NASH. ACUC
Protocol #: 07KO02-BRI. Funding: Private
2008 The Relationship of Hyperferritinemia and NAFLD. NASH CRN MS#2008-6
2008 Effect of Pioglitazone in an Iron Loaded Murine Model of NAFLD. Submitted to
Takeda Pharmaceuticals North America, Inc.; not funded
2009 The Relationship of Hepatic Iron Phenotype, Serum Ferritin Levels and NASH
Pathogenesis. NASH CRN Ancillary Study AS40; IRB#:09002-BRI. Funding: NIDDK K24
DK002957; R56 DK087696; 1R01 DK087696
2009 Translational Research in NAFLD. IRB#: 09002-BRI. Funding: NIDDK K24 DK002957;
R56 DK087696; 1R01 DK087696
2009 The Effect of PI3-Kinase p110Δ Inhibition in a Murine Model of NASH. ACUC Protocol #:
07KO03-BRI. Funding: Calistoga Pharmaceuticals, Inc
2009 The Relationship of Serum Ferritin and hsCRP in Patients with Nonalcoholic Fatty Liver
Disease. IRB#: 09002-BRI. Funding: NIDDK K24 DK002957-08S1
2010 The Relationship between Serum Cytokines and miRNA Levels and Progression of
PSC, Presence of Ulcerative Cholitis and Cholangiocarcinoma and Therapeutic Effect of
UDCA. IRB#: 07032-BRI. Funding: NIDDK R01 DK056924-08S1
2010 Prevalence and features of iron deficiency and anemia among subjects in the NASH
CRN. NASH CRN MS#2010-10
2010 The Relationship of Hemochromatosis Gene HFE Mutations and NAFLD. NASH CRN
MS#2010-11
2011 Serum Biomarkers Associated With Phenotypic Expression of Hemochromatosis. IRB#:
11075-BRI. Funding: NHLBI R21HL116878-01
2011 Role of Vitamin D Deficiency and the Intestinal Microbiome in a Rat Model of NAFLD.
ACUC Protocol #: 07KO02-BRI. Not funded
2012 The Relationship between Serum Vitamin D Levels, NASH Diagnosis, and NAFLD
Activity Score. NASH CRN Ancillary Study AS64. IRB#: 09002-BRI. Funding: ACG-CR-
072-2012
2012 Identification of Novel Micro-RNAs in a Rat Model of Cholangiocarcinoma*. ACUC
Protocol #: 12KO01-BRI. Funding: BRI. *Co-designed with Bart Rose, MD and Yu Li,
6. James E. Nelson, PhD
6
PhD
2013 Effect of Iron Deposition in NAFLD: A Longitudinal Study. NASH CRN MS#2013-2
2013 Defining the Hepatic Immune Response to Vitamin D Deficiency in Humans and Rats
with Nonalcoholic Steatohepatitis. IRB#: 09002-BRI. Funding: VMMC Digestive Disease
Institute
2013 An Integrative Transcriptomic Approach to Define Novel Diagnostic and Prognostic
Serum Extracellular RNA (exRNA) Biomarkers for Nonalcoholic Steatohepatitis. NASH
CRN Ancillary Study AS76. IRB#: 09002-BRI. Funding: Wilske Center for Translational
Research Pioneer Award
2013 Development of a miRNA Based In Vitro Diagnostic Device for the Prognosis of NAFLD.
Submitted to the BRI Commercialization Gap Funding Program; not funded
2013 Novel Prognostic MicroRNA Biomarkers for Primary Sclerosing Cholangitis. IRB#:
07032-BRI. Funding: NIDDK R21DK099718
2014 The IL1B rs1143634 Rare Allele Increases the Risk of Nonalcoholic Steatohepatitis and
Advanced Fibrosis. NASH CRN MS#2014-3
2014 Serum Vitamin D Deficiency is Associated with Nonalcoholic Steatohepatitis in Adults.
NASH CRN MS#2014-7
SERVICE
1991-1992 Curriculum Committee, Department of Molecular Biology and Genetics, Wayne
State University School of Medicine
1992-1993 Guest Speaker Committee Department of Molecular Biology and Genetics, Wayne
State University School of Medicine
2006-2007 Member, “Working Group For Lean Alignment”, University of Washington Clinical
Research Center
2006-2011 NASH Clinical Research Network Steering Committee Representative
2012-2014 Member, Benaroya Research Institute Safety Committee
2012-2015 Member, AASLD Steatosis and Steatohepatitis Special Interest Group
2012-2015 Member, AASLD Liver Fibrosis Special Interest Group
Reviewer: BioTechniques, Journal of Virology, Gene Therapy, Human Gene Therapy,
Gastroenterology, Hepatology, Molecular Medicine, Journal of Cellular
Biochemistry, Alimentary Pharmacology & Therapeutics, Journal of Clinical
Gastroenterology, Tissue and Cell, Journal of Hepatology,
PROFESSIONAL SOCIETY MEMBERSHIPS
1995-1999 American Association for the Advancement of Science
1997-1999 American Society for Human Gene Therapy (invited membership)
2005-2015 International BioIron Society
2009-2015 American Association for the Study of Liver Disease
7. James E. Nelson, PhD
7
2010-present Northwest Institute of Genetic Medicine
2010-present Institute for Translational Health Sciences
SELECTED PRESENTATIONS
1996 “Adenoviral Vectors for Liver-Directed Gene Therapy”, Cystic Fibrosis Foundation,
Seattle WA.
1997 “Third Generation Adenoviral Vectors”, Cystic Fibrosis Foundation, Seattle WA.
1998 “Minimal Adenovirus Gene Therapy Vectors”, Division of Gastroenterology, Dept. of
Medicine, University of Washington, Seattle, WA.
1998 “The Role of Host Immune Responses in the Persistence of minAD Vectors”, Seattle
Gene Therapy Club, Seattle, WA.
1998 “Principles of Gene Therapy” Fred Hutchinson Cancer Research Center, Outreach
Program, Seattle, WA.
2007 “Iron Depletion Therapy for Patients with Type 2 Diabetes Mellitus and Non-Alcoholic
Fatty Liver Disease”. NASH Clinical Research Network Steering Committee Meeting,
Baltimore, MD
2008 “A Randomized, Masked, Controlled Study of Omega-3 Polyunsaturated Fatty Acid vs
Monounsaturated Fatty Acid Dietary Supplementation for the Treatment of Nonalcoholic
Fatty Liver Disease”. NASH Clinical Research Network Steering Committee Meeting,
Baltimore, MD
2009 “Iron in Hepatic Reticulendothelial Cells is Associated with Histologic Severity in
Nonalcoholic Fatty Liver Disease” NASH Clinical Research Network Steering Committee
Meeting, Baltimore, MD
2011 “Relationship of C282Y HFE Mutations, Hepatic Iron Deposition and Histologic Features
in Patients with Nonalcoholic Fatty Liver Disease”. International Congress of the BioIron
Society, Vancouver, Canada
2011 “Iron, Immunity and Liver Disease” Benaroya Research Institute Work-In-Progress
Seminar, Seattle WA
2013 “Reticuloendothelial Cell System Iron Staining is a Predictor of Progression to Borderline
or Definite Steatohepatitis in Patients without Fibrosis”. NASH Clinical Research
Network Steering Committee Meeting, Baltimore, MD
2014 “Development of Serum Based miRNA Biomarkers for the Diagnosis and Prognosis of
NAFLD” Benaroya Research Institute Work-In-Progress Seminar, Seattle WA
PUBLICATIONS
Original Articles
1. Nelson JE, Krawetz SA. Purification of cloned and genomic DNA by guanidine thiocyanate
/isobutyl alcohol fractionation. Anal Biochem. 1992 Nov 15;207(1):197-201.
2. Nelson JE, Krawetz SA. Linkage of human spermatid-specific basic nuclear protein genes:
definition and evolution of the P1P2TP2 locus. J Biol Chem. 1993 Feb 5;268(4):2932-6.
8. James E. Nelson, PhD
8
3. Nelson JE, Krawetz SA. Easy-read DNA sequencing gels. Biotechniques 1994
Sep;17(3):416-418.
4. De Jonckheere J, Nelson JE, Ginsburg KA, Krawetz SA. GA repeat polymorphism at the
PRM2 male fertility locus of chromosome 16. Hum Mol Genet. 1994 Oct;3(10):1915.
5. Nelson JE, Krawetz SA. Characterization of a human locus in transition. J Biol Chem. 1994;
Dec 9;269(49):31067-73.
6. Singh GB, Nelson JE, McALinden TP, Krawetz SA. ISWAC:Proposed system for the
integrated assembly of chromosomes. DNASeq. 1994;5(2):67-76.
7. Nelson JE, Krawetz SA. Mapping the clonally recombinogenic PRM1PRM2TNP2 region
of human 16p13.2. DNA Seq. 1995;5(3):163-8.
8. Wykes SM, Nelson JE, Visscher DW, Djakiew D, Krawetz SA. Coordinate expression of the
PRM1, PRM2 and TNP2 multigene locus in human testis. DNA Cell Biol. 1995
Feb;14(2):155-61.
9. Choudhary SK, Wykes, SM, Kramer JA, Anwar M, Koppitch F, Nelson JE, Krawetz SA. A
haploid expressed gene cluster exists as a single chromatin domain in human sperm. J Biol
Chem. 1995 Apr 14;270(15):8755-62.
10. Nelson JE, Krawetz SA. Computer assisted promoter analysis of human sperm specific
nucleoprotein cluster. DNA Seq. 1995;5(6):329-37
11. Nelson JE, Kay MA. Persistence of recombinant adenovirus in vivo is not dependent on
vector DNA replication. J Virol. 1997 Nov;71(11):8902-7. PMCID: PMC192362,
12. Nelson JE, Bhattacharya R, Raaka S, Lindor KD, Heathcote EJ, Chalasani N, Shaffer E,
Miskovsky E, Rulyak SJ, Kowdley KV. The C282Y HFE mutation is associated with
advanced fibrosis in non-alcoholic steatohepatitis. Hepatology 2007 Sep;46(3):723-9.
13. Bares JM, Berger J, Nelson JE, Messner DJ, Schildt S, Tung BY, Standish LJ, Kowdley KV.
Silybin treatment is associated with reduction in serum ferritin in patients with chronic
hepatitis C. J Clin Gastroenterol. 2008 Sep;42(8):937-44.
14. Patton HM, Lavine JE, Van Natta ML, Schwimmer JB, Kleiner D, Molleston J; Nonalcoholic
Steatohepatitis Clinical Research Network, [Nelson JE]. Clinical correlates of histopathology
in pediatric nonalcoholic steatohepatitis. Gastroenterology 2008 Dec;135(6):1961-1971.
PMCID: PMC2628583.
15. David K, Kowdley KV, Unalp A, Kanwal F, Brunt EM, Schwimmer JB; NASH CRNResearch
Group, [Nelson JE]. Quality of life in adults with nonalcoholic fatty liver disease: baseline
data from the nonalcoholic steatohepatitis clinical research network. Hepatology. 2009
Jun;49(6):1904-12. PMCID: PMC2692572.
16. Shah AG, Lydecker A, Murray K, Tetri BN, Contos MJ, Sanyal AJ; NASH Clinical Research
Network, [Nelson JE]. Comparison of noninvasive markers of fibrosis in patients with
nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2009 Oct;7(10):1104-12.
PMCID: PMC3079239.
17. Lavine JE, Schwimmer JB, Molleston JP, Scheimann AO, Murray KF, Abrams SH, Rosenthal
P, Sanyal AJ, Robuck PR, Brunt EM, Unalp A, Tonascia J; Nonalcoholic Steatohepatitis
Clinical Research Network Research Group [Nelson JE]. Treatment of nonalcoholic fatty
liver disease in children: TONIC trial design. Contemp Clin Trials. 2010 Jan;31(1):62-70.
PMCID: PMC2936451.
9. James E. Nelson, PhD
9
18. Nelson JE, Mugford VR, Kilcourse E, Wang RS, Kowdley KV. Relationship between gene
expression of duodenal iron transporters and iron stores in hemochromatosis subjects. Am J
Physiol Gastrointest Liver Physiol. 2010 Jan;298(1):G57-62. PMCID: PMC2806103.
19. Kistler KD, Molleston J, Unalp A, Abrams SH, Behling C, Schwimmer JB; Nonalcoholic
Steatohepatitis Clinical Research Network (NASH CRN) [Nelson JE]. Symptoms and quality
of life in obese children and adolescents with non-alcoholic fatty liver disease. Aliment
Pharmacol Ther. 2010 Feb 1;31(3):396-406. PMCID: PMC2807909.
20. Sanyal A, Chalasani N, Kleiner D, Brunt E, Robuck P, Unalp-Arida A, Tonascia J; NASH
Clinical Research Network [Nelson JE]. Pioglitazone, vitamin E, or placebo for nonalcoholic
steatohepatitis. N Engl J Med. 2010 May 6;362(18):1675-85. PMCID: PMC2928471.
21. Abdelmalek MF, Suzuki A, Guy C, Unalp-Arida A, Colvin R, Johnson RJ, Diehl AM;
Nonalcoholic Steatohepatitis Clinical Research Network [Nelson JE]. Increased fructose
consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver
disease. Hepatology. 2010 Jun;51(6):1961-71. PMCID: PMC2922495.
22. Neuschwander-Tetri BA, Clark JM, Bass NM, Van Natta ML, Unalp-Arida A, Tonascia J, Zein
CO, Brunt EM, Kleiner DE, McCullough AJ, Sanyal AJ, Diehl AM, Lavine JE, Chalasani N,
Kowdley KV; NASH Clinical Research Network [Nelson JE]. Clinical, laboratory and
histological associations in adults with nonalcoholic fatty liver disease. Hepatology. 2010
Sep;52(3):913-24. PMCID: PMC3070295.
23. Nelson JE, Wilson L, Brunt EM, Yeh MM, Kleiner DE, Ünalp A, Kowdley KV and the NASH
CRN Research Group. Relationship between pattern of hepatic iron deposition and histologic
severity in nonalcoholic fatty liver disease. Hepatology. 2011 Feb;53(2):448-57. PMCID:
PMC3058264.
24. Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, Gudnason V,
Eiriksdottir G, Garcia ME, Launer LJ, Nalls MA, Clark JM, Mitchell BD, Shuldiner AR, Butler
JL, Tomas M, Hoffmann U, Hwang SJ, Massaro JM, O'Donnell CJ, Sahani DV, Salomaa V,
Schadt EE, Schwartz SM, Siscovick DS; NASH CRN; GIANT Consortium; MAGIC
Investigators, Voight BF, Carr JJ, Feitosa MF, Harris TB, Fox CS, Smith AV, Kao WH,
Hirschhorn JN, Borecki IB; GOLD Consortium [Nelson JE]. Genome-wide association
analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct
effects on metabolic traits. PLoS Genet. 2011 Mar;7(3):e1001324. PMCID: PMC3053321.
25. Brunt EM, Kleiner DE, Wilson LA, Belt P, Neuschwander-Tetri BA; NASH Clinical Research
Network (CRN) [Nelson JE]. Nonalcoholic fatty liver disease (NAFLD) activity score and the
histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings. Hepatology. 2011
Mar;53(3):810-20. PMCID: PMC3079483.
26. Kistler KD, Brunt EM, Clark JM, Diehl AM, Sallis JF, Schwimmer JB; NASH CRN Research
Group [Nelson JE]. Physical activity recommendations, exercise intensity, and histological
severity of nonalcoholic fatty liver disease. Am J Gastroenterol. 2011 Mar;106(3):460-8.
PMCID: PMC3070294.
27. Lavine JE, Schwimmer JB, Van Natta ML, Molleston JP, Murray KF, Rosenthal P, Abrams
SH, Scheimann AO, Sanyal AJ, Chalasani N, Tonascia J, Ünalp A, Clark JM, Brunt EM,
Kleiner DE, Hoofnagle JH, Robuck PR; Nonalcoholic Steatohepatitis Clinical Research
Network [Nelson JE]. Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver
disease in children and adolescents: the TONIC randomized controlled trial. JAMA. 2011 Apr
27;305(16):1659-68. PMCID: PMC3110082.
10. James E. Nelson, PhD
10
28. Kowdley KV, Belt P, Wilson LA, Yeh MM, Neuschwander-Tetri BA, Chalasani N, Sanyal AJ,
Nelson JE; NASH Clinical Research Network. Serum ferritin is an independent predictor of
histologic severity and advanced fibrosis in patients with nonalcoholic fatty liver disease.
Hepatology. 2012 Jan;55(1):77-85. PMCID: PMC3245347.
29. Maliken BD, Avrin WF, Nelson JE, Mooney J, Kumar S, Kowdley KV. Room-temperature
susceptometry predicts biopsy-determined hepatic iron in patients with elevated serum
ferritin. Ann Heptol. 2012 Jan-Feb; 11(1): 77-84. PMCID: PMC3499026.
30. Vos MB, Colvin R, Belt P, Molleston JP, Murray KF, Rosenthal P, Schwimmer JB,Tonascia J,
Unalp A, Lavine JE; NASH CRN Research Group [Nelson JE]. Correlation of vitamin E, uric
acid, and diet composition with histologic features of pediatric NAFLD. J Pediatr
Gastroenterol Nutr. 2012 Jan;54(1):90-6. PMCID: PMC3208079.
31. Bambha K, Belt P, Abraham M, Wilson LA, Pabst M, Ferrell L, Unalp-Arida A, Bass N;
Nonalcoholic Steatohepatitis Clinical Research Network Research Group [Nelson JE].
Ethnicity and nonalcoholic fatty liver disease. Hepatology. 2012 Mar;55(3):769-80. PMCID:
PMC3278533.
32. Roth CL, Elfers C, Lattemann D, Hoofnagle A, Morton GJ, Yeh MM, Nelson JE, Kowdley KV.
Vitamin D deficiency in obese rats exacerbates NAFLD and increases hepatic resistin and
toll-like receptor activation. Hepatology 2012 Apr;55(4):1103-11.
33. Guy CD, Suzuki A, Zdanowicz M, Abdelmalek MF, Burchette J, Unalp A, Diehl AM; NASH
CRN. [Nelson JE]. Hedgehog pathway activation parallels histologic severity of injury and
fibrosis in human nonalcoholic fatty liver disease. Hepatology. 2012 Jun;55(6):1711-21.
PMCID: PMC3499103.
34. Guy CD, Suzuki A, Burchette JL, Brunt EM, Abdelmalek MF, Cardona D, McCall SJ, Ünalp A,
Belt P, Ferrell LD, Diehl AM; Nonalcoholic Steatohepatitis Clinical Research Network.
[Nelson JE]. Costaining for keratins 8/18 plus ubiquitin improves detection of hepatocyte
injury in nonalcoholic fatty liver disease. Hum Pathol. 2012 Jun;43(6):790-800. PMCID:
PMC3288773.
35. Loomba R, Abraham M, Unalp A, Wilson L, Lavine J, Doo E, Bass NM; Nonalcoholic
Steatohepatitis Clinical Research Network [Nelson JE]. Association between diabetes, family
history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis. Hepatology. 2012
Sep;56(3):943-51. PMCID: PMC3407289.
36. Bell LN, Wang J, Muralidharan S, Chalasani S, Fullenkamp AM, Wilson LA, Sanyal AJ,
Kowdley KV, Neuschwander-Tetri BA, Brunt EM, McCullough AJ, Bass NM, Diehl AM, Unalp-
Arida A, Chalasani N; Nonalcoholic Steatohepatitis Clinical Research Network [Nelson JE].
Relationship between adipose tissue insulin resistance and liver histology in nonalcoholic
steatohepatitis: a pioglitazone versus vitamin E versus placebo for the treatment of
nondiabetic patients with nonalcoholic steatohepatitis trial follow-up study. Hepatology. 2012
Oct;56(4):1311-8. PMCID: PMC3432683.
37. Nelson JE, Brunt EM, Kowdley KV. Lower serum hepcidin and greater parenchymal iron in
nonalcoholic fatty liver disease patients with C282Y HFE genotypes. Hepatology 2012
Nov;56(5):1730-1740. PMCID: PMC3462887.
38. Maliken BD, Nelson JE, Yeh MM, Klintworth H, Beauchamp M, Kowdley KV. Hepatic
reticuloendothelial system cell iron deposition is associated with increased apoptosis in
nonalcoholic fatty liver disease. Hepatology. 2013 May;57(5):1806-13. PMCID:
PMC3637923.
11. James E. Nelson, PhD
11
39. Hoofnagle JH, Van Natta ML, Kleiner DE, Clark JM, Kowdley KV, Loomba R, Neuschwander
Tetri BA, Sanyal AJ, Tonascia J; the Non-alcoholic Steatohepatitis Clinical Research Network
[Nelson JE]. Vitamin E and changes in serum alanine aminotransferase levels in patients
with non-alcoholic steatohepatitis. Aliment Pharmacol Ther. 2013 Jul;38(2):134-43. PMCID:
PMC3775262.
40. Noureddin M, Yates KP, Vaughn IA, Neuschwander-Tetri BA, Sanyal AJ, McCullough A,
Merriman R, Hameed B, Doo E, Kleiner DE, Behling C, Loomba R; NASH CRN [Nelson JE].
Clinical and histological determinants of nonalcoholic steatohepatitis and advanced fibrosis in
elderly patients. Hepatology. 2013 Nov;58(5):1644-54.
41. Bambha K, Wilson LA, Unalp A, Loomba R, Neuschwander-Tetri BA, Brunt EM, Bass NM;
for the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) [Nelson JE].
Coffee consumption in NAFLD patients with lower insulin resistance is associated with lower
risk of severe fibrosis. Liver Int. 2014 Sep;34(8):1250-8.PMID: 24267865.
42. Handa P, Maliken BD, Nelson JE, Morgan-Stevenson V, Dhillon BK, Klintworth HM,
Beauchamp M, Yeh MM, Elfers CT, Roth CL, Kowdley KV. Reduced adiponectin signaling
due to weight gain results in nonalcoholic steatohepatitis through impaired mitochondrial
biogenesis. Hepatology. 2014 Jul;60(1):133-45. PMID: 24464605
43. Utzschneider KM, Largajolli A, Bertoldo A, Marcovina S, Nelson JE, Yeh MM, Kowdley KV,
Kahn SE. Serum ferritin is associated with nonalcoholic fatty liver disease and decreased Β-
cell function in non-diabetic men and women. J Diabetes Complications. 2014 Mar-
Apr;28(2):177-84. PMCID: PMC3943487.
44. Kratz M, Marcovina S, Nelson JE, Yeh MM, Kowdley KV, Callahan HS, Song X, Di C,
Utzschneider KM. Dairy fat intake is associated with glucose tolerance, hepatic and systemic
insulin sensitivity, and liver fat but not β-cell function in humans. Am J Clin Nutr. 2014;
99:1385-96. PMCID: PMC4021783.
45. Siddique A*, Nelson JE*, Aouizerat B, Yeh MM, Kowdley KV; for the NASH Clinical
Research Network. Iron deficiency in patients with nonalcoholic fatty liver disease is
associated with obesity, female sex, and low serum hepcidin. Clin Gastroenterol Hepatol.
2014 Jul;12(7):1170-8. PMCID: PMC4028425. *These authors contributed equally.
46. Corey KE, Vuppalanchi R, Wilson LA, Cummings OW, Chalasani N; NASH CRN [Nelson
JE]. NASH resolution is associated with improvements in HDL and triglyceride levels but not
improvement in LDL or non-HDL-C levels. Aliment Pharmacol Ther. 2015 Feb;41(3):301-9.
47. Neuschwander-Tetri BA, Loomba R, Sanyal AJ, Lavine JE, Van Natta ML, Abdelmalek MF,
Chalasani N, Dasarathy S, Diehl AM, Hameed B, Kowdley KV, McCullough A, Terrault N,
Clark JM, Tonascia J, Brunt EM, Kleiner DE, Doo E; NASH Clinical Research Network CRN
[Nelson JE]. Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-
alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. Lancet.
2015 Mar 14;385(9972):956-65.
48. Corey KE, Vuppalanchi R, Vos M, Kohli R, Molleston JP, Wilson L, Unalp-Arida A, Cummings
OW, Lavine JE, Chalasani N; Nonalcoholic Steatohepatitis Clinical Research Network
[Nelson JE]. Improvement in liver histology is associated with reduction in dyslipidemia in
children with nonalcoholic fatty liver disease. J Pediatr Gastroenterol Nutr. 2015
Mar;60(3):360-7.
49. Handa P, Morgan-Stevenson V, Maliken BD, Nelson JE, Washington S, Westerman M, Yeh
MM, Kowdley KV. Iron overload results in hepatic oxidative stress, immune cell activation,
12. James E. Nelson, PhD
12
and hepatocellular ballooning injury, leading to nonalcoholic steatohepatitis in genetically
obese mice. Am J Physiol Gastrointest Liver Physiol. 2016 Jan 15;310(2):G117-27.
50. Nelson JE, Roth C, Wilson L, Yates K, Whalen E, Aouizerat B, Morgan-Stevenson V,
Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV; for the NASH Clinical
Research Network. Vitamin D deficiency is associated with increased risk of nonalcoholic
steatohepatitis in adults with nonalcoholic fatty liver disease: possible role for MAPK and NF-
κB? Am J Gastroenterol. 2016 Mar 22. [Epub ahead of print]
51. Nelson JE, Aouizerat B, Wilson L, Yeh MM, Kowdley KV; for the NASH Clinical Research
Network. Association of IL1B and IL6 Polymorphisms with Steatohepatitis and Parenchymal
Damage in Caucasians with Nonalcoholic Fatty Liver Disease. In revision for Liver
International.
52. Kanwar P, Nelson JE, Yates K, Unalp-Arida A, Kowdley KV; for the NASH Clinical Research
Network Relationship of obesity, metabolic syndrome and insulin resistance to NASH. In
Revision for Ann Heptol.
53. Handa P, Gupta R, Dhillon BK, Nelson JE, Maliken BD, Yeh MM, Kowdley KV. Iron,
inflammation and oxidative stress-mediated regulation of hepcidin gene expression in
patients with nonalcoholic steatohepatitis. Submitted to Clinical Gastroenterology and
Hepatology.
Manuscripts in Preparation
1. Nelson JE, Whalen E, Morgan-Stevenson V, Sendler E, Gersuk V, Yeh MM, Krawetz S,
Kowdley KV. Integrated transcriptomics define novel molecular networks and prognostic
serum extracellular RNA biomarkers for nonalcoholic steatohepatitis. In preparation for
submission to Science Translational Medicine.
2. Rose JB, Correa-Gallego C, Li Y, Nelson JE, Alseidi A, Helton S, Allen PJ, D’Angelica MI,
DeMatteo RP, Fong Y, Kingham TP, Kowdley KV, Jarnagin WR, Rocha FG. The Role of
Biliary Carcinoembryonic Antigen-related Cellular Adhesion Molecule 6 (CEACAM6) as a
Biomarker in Cholangiocarcinoma. In preparation for submission to Clinical Cancer
Research.
Invited Reviews and Letters
1. Nelson JE, Kowdley KV. Iron and hepatitis C. Curr Hepatol Rep. 2005 3(4):140-147.
2. Nelson JE, Kowdley KV. Non-HFE Hemochromatosis: genetics, pathogenesis and clinical
management. Curr Gastroenterol Rep. 2005 7:71–80.
3. Nelson JE, Kowdley KV. Letter to the editor: Reply Valenti et.al., Hepatology 2008
May;47(5):1795-6.
4. Nelson JE, Kowdley KV. IKKε: A potential therapuetic target for obesity (and nonalcoholic
fatty liver disease)? Hepatology. 2010 Jan;51(1):336-8.
5. Nelson JE, Kowdley KV. Letter to the editor: Author Reply Manco et.al.,The wide spectrum
of hepatic iron overload. Hepatology. 2011 Mar;53(3):1057-8; author reply 1058-9
6. Maliken BD, Nelson JE, Kowdley KV. The hepcidin circuits act: balancing iron and
inflammation. Hepatology. 2011 May; 53(5): 1764-1766.
7. Nelson JE, Klintworth H, Kowdley KV. Iron metabolism in nonalcoholic fatty liver disease.
Curr Gastroenterol Rep. 2012 Feb;14(1):8-16.
13. James E. Nelson, PhD
13
8. Nelson JE, Kowdley KV. Letter to the editor: Author Reply Paul et.al., Interaction of serum
ferritin and body mass index in patients with chronic hepatitis B: Improved prediction of
cirrhosis. Hepatology. 2013 May;57(5):2095.
9. Shah N, Nelson JE, Kowdley KV. MicroRNAs in Liver Disease: Bench to Bedside. J Clin Exp
Hepatol. 2013 Sep;3(3):231-42.
Book Chapters
1. Nelson, JE, Khidir, M. and Krawetz, SA. Purification of DNA with guanidine thiocyanate and
isobutyl alcohol fractionation. CELL BIOLOGY: A LABORATORY HANDBOOK (ed. J.E.
Celis) Academic Press Inc. 1994 (1);674-679.
2. Nelson JE, Trinder D, Kowdley KV. Hemochromatosis. Molecular Pathology of Liver
Diseases, Molecular Pathology Library 5 (ed., S.P.S. Monga) Springer Science LLC. 2010;
665-676.
Abstracts
1. Nelson, JE, Twomey, TA and Krawetz, SA. (1990) Resources for the human genome
project. Cold Spring Harbor Genome Mapping and Sequencing:128.
2. Nelson JE, Krawetz SA. (1992) Analysis and evolution of the human protamine locus. Fisher
Scientific Winternational Symposium "Gene Expression during Gametogenesis" # 2.
3. Nelson, JE and Krawetz, SA. (1992) Characterization of the human protamine locus. Great
Lakes Mammalian Development Meeting.
4. Nelson JE, Krawetz SA. (1993) High resolution analysis of the human P1P2 TP2 locus.
Genome Sequencing and Analysis Conference V:41.
5. Nelson JE, Krawetz SA. (1994) Analysis of the highly repetitive human P1P2 TP2 locus.
Great Lakes Mammalian Development Meeting.
6. Wykes SM, Nelson JE, Visscher DW, Djakiew D, Krawetz SA. (1994) Expression of the
human PRM1, PRM2 and TNP2 testis specific genes. Great Lakes Mammalian Development
Meeting.
7. Choudhary SK, Nelson JE, Krawetz SA. (1994) Locus activation of the human protamine
domain. Great Lakes Mammalian Development Meeting.
8. Nelson JE, Kay MA (1996) Minimal adenoviral vectors for gene therapy. Cold Spring Harbor
Gene Therapy Meeting:227.
9. Nelson JE, Bhattacharya R, Raaka S, Lindor KD, Heathcote EJ, Chalasani N, Shaffer E,
Miskovsky E, Rulyak SJ, Kowdley KV (2005) Association of HFE mutations and advanced
fibrosis in patients with NASH. International Congress of the BioIron Society.
10. Nelson JE, Bhattacharya R, Raaka S, Lindor KD, Heathcote EJ, Chalasani N, Shaffer E,
Miskovsky E, Rulyak SJ, Kowdley KV (2005) Association of HFE mutations and advanced
fibrosis in patients with NASH. Presented at AASLD 2005. Hepatology, 42:1066.
11. Nelson JE, Raaka S, Li W, Kowdley KV (2007) Murine liver transplantation model in Hfe
knockout mice: preliminary results on expression of Hamp and duodenal iron transport
genes. International Congress of the BioIron Society.
12. Nelson JE, Yates K, Ünalp A, Kowdley KV for the NASH CRN Research Group: (2007)
Relationship of BMI, metabolic syndrome, and NASH in adults. Presented at AASLD.
14. James E. Nelson, PhD
14
Hepatology, 2007;46: 742A, 2007, Supplement 1.
13. Nelson JE, Belt P, Wilson LA, Yeh MM, Kowdley KV, for the NASH CRN Research
Group. (2008) Serum ferritin is associated with the presence of NASH, increased ALT, AST
and histologic severity among patients with NAFLD. Presented at AASLD. Hepatology,
2007;48:1126A, 2008, Supplement 1.
14. Nelson JE, Maliken B, Saunders C, Stevenson J, Richards TL, Kowdley KV. (2009) A
randomized, masked, controlled study of omega-3 polyunsaturated fatty acid vs
monounsaturated fatty acid diet supplementation for the treatment of nonalcoholic fatty liver
disease. Presented at DDW. Gastroenterology, 2009;136: A847-A848, 2009, Supplement 1.
15. Nelson JE, Utzschneider K, Maliken B, Alexander J, Kowdley KV. (2009) Iron depletion
therapy for patients with metabolic syndrome and non-alcoholic fatty liver disease:
preliminary findings. International Congress of the BioIron Society.
16. Nelson JE, Raaka S, Mugford VR, Kilcourse E, Kowdley KV. (2009) Differences in gene
expression of duodenal iron transporters among hemochromatosis subjects with and without
iron overload. International Congress of the BioIron Society.
17. Nelson JE, Wilson L, Brunt EM, Yeh MM, Kleiner D, Ünalp-Arida A, Kowdley, KV for the
NASH CRN. (2009) Hepatic iron deposition in reticuloendothelial cells but not hepatocytes is
associated with more severe NASH: results from the NASH Clinical Research Network.
International Congress of the BioIron Society.
18. Maliken BD, Nelson JE, Dhillon BK, Yeh MM, Beauchamp M, Roth C, Kowdley KV. (2010)
Combining genetic and dietary factors in creation of a novel murine model of nonalcoholic
steatohepatitis (NASH). Presented at DDW. Gastroenterology, May 2010;138(5):S-801,
Supplement 1.
19. Dhillon BK, Nelson JE, Maliken BD, Yeh MM, Beauchamp M, Roth C, Kowdley KV. (2010)
Hepatic hepcidin expression in an obese diabetic model of nonalcoholic steatohepatitis (NASH)
Presented at DDW. Gastroenterology, May 2010;138(5):S-801, Supplement 1.
20. Nelson JE, Mooney J, Avrin W, Kowdley KV. (2010) Room temperature susceptometry for
hepatic iron measurement. Presented at AASLD. Hepatology, 2010;52:500A, 2010,
Supplement 1.
21. Nelson JE, Yeh M, Kowdley KV. (2011) Relationship of C282Y HFE Mutations, Hepatic Iron
Deposition and Histologic Features in Patients with Nonalcoholic Fatty Liver Disease.
Presented at Digestive Disease Week. Gastroenterology, 2011;140:S-938-S-939. Suppl 1.
Presidential Poster of Distinction & Invited Video Presentation;SU1852.
22. Nelson JE, Belt P, Wilson L, Yeh M, Tetri BA, Chalasani NP, Sanyal AJ, Kowdley, KV.
(2011) Elevated serum ferritin values above the upper limit of normal are associated with
laboratory and histologic evidence of increased NASH severity, but not the presence of
diabetes or metabolic syndrome among patients in the NASH CRN. Presented at Digestive
Disease Week. Gastroenterology, 2011;140:S-727. Suppl 1.
23. Siddique A, Nelson JE, Yeh M, Kowdley KV. (2011) The relationship between obesity,
metabolic syndrome and iron deficiency in NAFLD. Presented at Digestive Disease Week.
Gastroenterology, 2011;140:S-703. Suppl 1.
24. Nelson JE, Mooney J, Avrin W, Kowdley KV (2011) Room temperature susceptometry for
hepatic iron measurement. Presented at International Congress of the BioIron Society.
15. James E. Nelson, PhD
15
25. Nelson JE, Belt P, Wilson L, Yeh M, Tetri BA, Chalasani NP, Sanyal AJ, Kowdley, KV.
(2011). Elevated serum ferritin values above the upper limit of normal are associated with
laboratory and histologic evidence of increased NASH severity, but not the presence of
diabetes or metabolic syndrome among patients in the NASH CRN. Presented at
International Congress of the BioIron Society.
26. Siddique A, Nelson JE, Yeh M, Kowdley KV. (2011). The relationship between obesity,
metabolic syndrome and iron deficiency in NAFLD. Presented at International Congress of
the BioIron Society.
27. Maliken BD, Nelson JE, Dhillon B, Yeh MM, Kowdley KV. (2011) Hyperferritinemia in
nonalcoholic fatty liver disease: the effects of obesity-related chronic inflammation and
increased body iron stores. Presented at International Congress of the BioIron Society.
28. Roth CL, Elfers C, Lattemann D, Hoofnagle A, Morton GJ, Yeh MM, Nelson JE, Kowdley KV.
(2011) Vitamin D deficiency contributes to insulin resistance and NAFLD in obese rats. The
Endocrine Society’s 93rd
Annual Meeting, Boston, poster P3-392.
29. Nelson JE, Yeh MM, Dhillon BK, Kowdley KV. (2011) C282Y HFE mutations contribute to
decreased circulating hepcidin levels and increased hepatocellular iron deposition in patients
with nonalcoholic fatty liver disease. Presented at AASLD. Presidential Poster of Distinction.
Hepatology, 2011;54(4):1113A. Supplement.
30. Dhillon BK, Nelson JE, Maliken BD, Yeh MM, Kowdley KV. (2011). Liver hepcidin gene
expression in patients with NAFLD is induced by both hepatic necroinflammation and iron
stores. Presented at AASLD. Hepatology, 2011;54(4):1142A. Supplement.
31. Maliken BD, Klintworth H, Yeh MM, Nelson JE, Kowdley KV. (2011). Hepatic iron deposition
is associated with increased apoptosis and oxidative stress among patients with NAFLD.
Presented at AASLD. Hepatology, 2011;54(4):1126A, 2011, Supplement.
32. Maliken BD, Nelson JE, Dhillon BK, Beauchamp, M, Yeh MM, Kowdley KV. (2011) Use of
ferritin/CRP ratio to distinguish iron overload in NAFLD patients with hyperferritinemia: the
effects of obesity-related chronic inflammation and increased body iron stores. Presented at
AASLD. Hepatology, 2011;54(4):1145A, 2011, Supplement.
33. Nelson JE, Maliken BD, Klintworth H, Yeh MM, Kowdley KV. (2012). A high fat diet and
parenteral iron causes increased inflammation and oxidative stress but less steatosis in an
obese, diabetic mouse model of NAFLD. Presented at EASL Monothematic Conference on
"Immune Mediated Liver Injury" Stratford-upon-Avon, UK, January 19-21, 2012.
34. Handa P, Maliken BD, Nelson JE, Yeh MM, Kowdley KV. (2012). Obesity causes
adiponectin depletion and non-alcoholic steatohepatitis in Lepr db/db
mice fed an unsaturated
fat-rich diet. Presented at FASEB Liver Biology: Fundamental Mechanisms & Translational
Applications, Snowmass, CO.
35. Roth CL, Elfers CT, Figlewicz DP, Melhorn SJ, Morton GJ, Hoofnagle A, Yeh MM, Nelson
JE, Kowdley KV. (2012). Vitamin D deficiency activates hepatic toll-like receptors and
exacerbates NAFLD in obese rats. European Society for Pediatric Endocrinology. Hormone
Research, 2012;78. Suppl.1.
36. Nelson JE, Yeh MM, Kowdley KV. (2012) The Il1β +3953 C>T polymorphism minor allele is
associated with a higher NAFLD activity score, presence of nonalcoholic steatohepatitis and
is an independent risk factor for advanced fibrosis in subjects with nonalcoholic fatty liver
disease. Presidential Poster of Distinction. Hepatology, 2012;56(4):883A. Supplement.
16. James E. Nelson, PhD
16
37. Nelson JE, Maliken BD, Yeh MM, Klintworth H, Beauchamp M, Kowdley KV. (2012) Hepatic
iron grade and pattern affects oxidative stress and apoptosis in NAFLD. Hepatology,
2012;56(4):890A. Supplement.
38. Handa P, Nelson JE, Maliken BD, Chua J, Yeh MM, Kowdley KV. (2012) Parenteral iron
and a high fat diet cause increased inflammation, oxidative stress and apoptosis but
decreased steatosis in an obese, diabetic mouse model of NAFLD. Hepatology,
2012;56(4):859A. Supplement.
39. Handa P, Nelson JE, Maliken BD, Yeh MM, Kowdley KV. (2012) A high unsaturated fat diet
leads to NF-κB activation and increased hepatic macrophage and T cell accrual accompanies
NF-κB activation in a diabetic, obese mouse model of NAFLD. Hepatology, 2012;56(4):865A.
Supplement.
40. Rose JB, Correa-Gallego C, Nelson JE, Alseidi A, Helton S, Allen PJ, D'Angelica M,
DeMatteo RP, Fong Y, Kingham PT, Kowdley K, Jarnagin WR, Rocha FG. (2013) Role of
biliary CEACAM6 as a biomarker for cholangiocarcinoma. ASCO GI Meeting, San Francisco,
CA. J Clin Onc. Feb 2013;31(4):177.
41. Rose JB, Correa-Gallego C, Nelson JE, Alseidi A, Helton S, Allen PJ, D'Angelica M,
DeMatteo RP, Fong Y, Kingham PT, Kowdley K, Jarnagin WR, Rocha FG. (2013) Role of
biliary CEACAM6 as a biomarker for cholangiocarcinoma. SSO Annual Meeting in National
Harbor, MD. Ann Surg Onc. Mar 2013;20(1):S21.
42. Nelson JE, Maliken BD, Yeh MM, Klintworth H, Beauchamp M, Kowdley KV. (2013) Hepatic
reticuloendothelial system cell iron deposition is associated with increased apoptosis in
nonalcoholic fatty liver disease. Presented at International Congress of the BioIron Society,
London UK, April 15-18, 2013.
43. Nelson JE, Yeh MM, Kowdley KV. (2013) Variants in the IL6 and IL1β genes modify the
hepatic iron phenotype of patients with nonalcoholic fatty liver disease. Presented at
International Congress of the BioIron Society, London UK, April 15-18, 2013.
44. Li Y, Shah N, Nelson JE, Lindor KD, Talwalkar J, Kowdley KV. (2013) Serum MicroRNA:
Novel prognostic biomarkers in primary sclerosing cholangitis patients treated with high-dose
ursodeoxycholic acid. Presented at DDW. Gastroenterology, 2013;144(5):S254,
Supplement 1.
45. Nelson JE, Kleiner DE, Aouizerat BE, Kowdley KV. (2013) Variants in the Il6 and Il1β Genes
either Alone or in Combination with C282Y HFE Mutations Modify the Hepatic Iron
Phenotype of Patients with Nonalcoholic Fatty Liver Disease. Poster presented at the
AASLD, 2013. Hepatology, 2013;58(4):490A, Supplement.
46. Kowdley KV, Kleiner DE, Wilson L, Belt PH, Nelson JE. (2013) Reticuloendothelial cell
system iron staining is a predictor of progression to borderline or definite steatohepatitis in
patients without fibrosis. Poster presented at the AASLD, 2013. Hepatology,
2013;58(4):516A, Supplement.
47. Handa P, Morgan-Stevenson V, Nelson JE, Maliken BD, Yeh MM, Kowdley KV. (2013)
Dietary iron overload results in hepatic reticuloendothelial system cell iron accumulation,
oxidative stress, mitochondrial dysfunction, immune cell activation, and nonalcoholic
steatohepatitis in obese, diabetic mice. Poster presented at the AASLD, 2013. Hepatology,
2013;58(4):555A, Supplement.
48. Handa P, Morgan-Stevenson V, Nelson JE, Maliken BD, Yeh MM, Elfers CT, Roth C,
17. James E. Nelson, PhD
17
Kowdley KV. (2013) A high-fat diet results in nonalcoholic steatohepatitis, and adipose tissue
hypoxia, macrophage infiltration and inflammatory M1 activation in obese diabetic mice.
Poster presented at the AASLD, 2013. Hepatology, 2013;58(4):969A, Supplement.
49. Nelson JE, Sendler E, Krawetz SA, Kowdley KV. (2014) Deep sequencing identifies novel
circulating and hepatic ncRNA profiles in nonalcoholic fatty liver disease patients. Presented
at AASLD Basic Research Single Topic Conference – “Non coding RNAs in Liver Function
and Dysfunction”, Miami, FL
50. Nelson JE, Sendler E, Krawetz SA, Kowdley KV. (2014) Serum microRNAbiomarkers for
prognosis of nonalcoholic fatty liver disease. Presented at AASLD Basic Research Single
Topic Conference – “Non coding RNAs in Liver Function and Dysfunction”, Miami, FL
51. Handa P, Morgan-Stevenson V, Maliken BD, Li Y, Nelson JE, Yeh MM, Kowdley KV. High
fat diet impairs hepatic microRNAs related to inflammation and macrophage infiltration
contributing to nonalcoholic steatohepatitis in a mouse model with metabolic syndrome.
Presented at AASLD Poster Session. Hepatology, October 2014;60(S1):499A.
52. Handa P, Morgan-Stevenson V, Maliken BD, Nelson JE, Yeh MM, Kowdley KV. Chronic
dietary iron overload in genetically obese mice causes nonalcoholic steatosis, whereas acute
iron excess leads to increased inflammation and reduced steatosis. Presented at AASLD
Poster Session. Hepatology, October 2014;60(S1):520A.
53. Handa P, Morgan-Stevenson V, Maliken BD, Nelson JE, Yeh MM, Kowdley KV. Iron excess
exacerbates proinflammatory and fibrogenic gene expression in genetically obese mice and
in primary human hepatic stellate cells in response to TNF-α or TGF-β. Presented at AASLD
Poster Session. Hepatology, October 2014;60(S1):583A.
54. Nelson JE, Wilson L, Roth C, Yeh MM, Kowdley KV. Serum vitamin D deficiency is
associated with nonalcoholic steatohepatitis in adults. Presented at AASLD Poster Session.
Hepatology, October 2014;60(S1):608A.
55. Karnik S, Charlton M, Nash M, Sulfab M, Barry V, Huntzicker EG, French D, Breckenridge D,
Corkey B, Notte G, Nelson JE, Kowdley KV, Tumas D. Inhibition of MAP3K5, apoptosis
signal-regulating kinase 1, with an oral small molecule inhibitor blocks hepatic fibrosis and
steatosis in murine models of NASH and PSC. Presented at AASLD Poster Session.
Hepatology, October 2014;60(S1):570A.
SEQUENCES DEPOSITED INTO INTERNATIONAL DATA BANKS
GenBank and EMBL
1. Nelson JE, Krawetz SA. (1992) LO3378; Homo sapiens (chromosome 16), sperm-specific
basic nuclear protein gene, TNP2
2. Nelson JE, Krawetz SA. (1994) HSU15422; Homo sapiens (chromosome 16), 40 kb of the
human 16p13.13-16p13.2 region containing the protamine gene cluster
COMMUNITY SERVICE
2008-2009 Coach, Eastlake Flag Football, Sammamish, WA
2009-present Member, PTSA, Margaret Mead Elementary School, Sammamish, WA
18. James E. Nelson, PhD
18
2009-2013 Den Leader, Cubscout Pack 551, Sammamish, WA
2011-2013 Cubmaster, Cubscout Pack 551, Sammamish, WA
2011-present Judge, “Science Fair”, Margaret Mead Elementary School, Sammamish, WA
2012-2015 Coach, Eastlake Little League Softball, Sammamish, WA
2015 Coach, Boys and Girls Basketball Program, Sammamish, WA
2015-present Coach, Bellevue Blast Select Softball, Sammamish, WA