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ISB - Ion Source & Biotechnologies

"We semplify mass spectrometry world"

                       Simone Cristoni, Ph.D.
                         Founder & CEO
                     Cell: +39-340-963-9745
               Email: simone.cristoni@isbiolab.com


   ISB-Headquarters & Laboratories: Insubrias BioBiopark, Via Roberto Lepetit 34
   Gerenzano (VA) – Italy.   Tel. 02/96474438; Fax 02/700410252.
Company Overview

            Founded on September 5th, 2006


                   ISB Core Business

Development and Engineering of new Ionization Sources for
                 Mass Spectrometry


  3 Italian government grants have financed ISB start-up
                   and its initial growth
Core Business




SERVICES                       APPLICATIONS (kits)       IONIZATION SOURCES
ISB offers an extensive        ISB has developed a       ISB has patented two
array of services, ranging     series of standardized    innovative      ionization
from    development      of    analytical methods that   sources     for      mass
customized       analytical    can be directly used in   spectrometry allowing for
methods, to the analysis       our      laboratory  or   a considerable reduction
of specific proteins and       transferred     to  the   of analysis times and
biomolecules.                  customer.                 costs.
Multidisciplinary Scientific Team

• Lorenzo Zingaro - Chemist;

• Vincenza Valveri - Biologist;

• Cristina Canton - Pharmacologist;

• Vincenza Flora Dibari - Bioinformatics;

ISB experienced and multidisciplinary technical team is
complemented by a talented group of PhD and
undergraduate students recruited through collaborations with
the University of Milan.
Strategic Location

Insubrias BioPark

is one of the eight technological parks and bio-incubators of the Italian
biotechnology sector. It is located in Gerenzano, Varese. The BioPark
covers an area of 52,000sm; 15,000sm of which include office space
and laboratories, equipped with the most advanced technologies in the
bio-medical sector.




The BioPark is located in a beautiful green area in a geographical and economical
strategic position aiming at creating an effective network of partners in the territory. It was
created by the cooperation of Italian and Swiss entrepreneurship found in the historical
area called Insubriac Region, shared by Lombardia, Piemonte and Cantone Ticino.
Regio Insubria and Insubrias BioPark


A            "Euroregion”,
complying      with    the
Madrid Agreement by
the Council of Europe
which      since     1995
promotes            cross-
boundary cooperation in
the Italian-Swiss region
of the three pre-Alpine
lakes regions including
Lake      Como,      Lake
Lugano       and     Lake
Maggiore.


       Insubrias BioPark
Mission
• Make mass spectrometry easy: Produce highly
  innovative and ready to use kits for clinical analysis
  based on proprietary Ionization Sources for mass
  spectrometry.

• Assay Development Program: develop a custom
  tailored research and development program using a
  strong in-house technological expertise.

• Services Program: provide state-of-the-art services to
  our customers based on innovative proprietary
  technologies.
Why ionization source
Ionization source is a key component of mass
spectrometry influencing the following key factors:

• Sensitivity: it is a function of ionization efficiency and
  chemical noise produced by ion charged solvent
  clusters.

• Quantitative Accuracy: Matrix effect dependent.

• Throughput: a source that exhibits high sensitivity and
  low matrix effect can in principle increase the
  throughput.
Company structure
ISB ionization sources portfolio


• Surface Activated Chemical Ionization (SACI; Cristoni
  S. et al. Mass Spectrom Rev. 2007 Sep-Oct;26(5):645-
  56);

• Universal Soft Ionization Source (USIS; Cristoni S.
  International Patent n. WO/2007/131682);
Mass analyzers



• HCT ultra Ion Trap (Bruker Daltonics);

• ORBITRAP high resolution mass spectrometry
  (Thermoelecton);
Surface Activated Chemical Ionization
                     (SACI)




Cristoni et al. Mass Spectrom Rev. 2007 Sep-Oct;26(5):645-
                            56.
SACI
                         Benefits


• Increased sensitivity operating in full scan (chemical
  noise reduction).

• Lower matrix effect.

• Operates in ion exchange chromatographic conditions.
SACI
                                                   Chemical noise reduction
                            Figure 1 – Analysis of Cocaine and Morphine, HCT & APCI


Signal Intensity




                                                                                                Retention time (minutes)




                            Figure 2 – Analysis of Cocaine and Morphine, HCT & SACI




                                                                                      Cocaine



                                                                 Morphine
         Signal Intensity




                                                                                                    Retention time (minutes)
SACI
                     Limitations



• Compound dependent (It is particularly suitable for
  peptide and protein analysis).

• Not very effective for Biomarker Discovery.
Universal Soft Ionization Source
            (USIS)




        Reference patent
USIS
                         Benefits
• Increased sensitivity operating in full scan (chemical
  noise reduction).

• Lower matrix effect.

• Operates in ion exchange chromatographic conditions.

• Can ionize all kind of polar and not polar compounds.

• Ideal for full scan profiling (e.g. Bacterial
  Characterization through metabolite profiling).
USIS
        Applications




Polar                  Low polar
USIS
                    Limitations




• The detectable m/z ratio depends on the mass
  analyzer.
Future development




• USIS for breath analysis.

• Deposit of other provisional patents to improuves
  ionization source performances.
ISB
Contacts


              Contact us:
          Dr. Simone Cristoni
        Tel: +39-02-96474438
        Cel: +39-340-9639745
e-mail: simone.cristoni@isbiolab.com
 Web page: http://www.isbiolab.com

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Isb presentation

  • 1. ISB - Ion Source & Biotechnologies "We semplify mass spectrometry world" Simone Cristoni, Ph.D. Founder & CEO Cell: +39-340-963-9745 Email: simone.cristoni@isbiolab.com ISB-Headquarters & Laboratories: Insubrias BioBiopark, Via Roberto Lepetit 34 Gerenzano (VA) – Italy. Tel. 02/96474438; Fax 02/700410252.
  • 2. Company Overview Founded on September 5th, 2006 ISB Core Business Development and Engineering of new Ionization Sources for Mass Spectrometry 3 Italian government grants have financed ISB start-up and its initial growth
  • 3. Core Business SERVICES APPLICATIONS (kits) IONIZATION SOURCES ISB offers an extensive ISB has developed a ISB has patented two array of services, ranging series of standardized innovative ionization from development of analytical methods that sources for mass customized analytical can be directly used in spectrometry allowing for methods, to the analysis our laboratory or a considerable reduction of specific proteins and transferred to the of analysis times and biomolecules. customer. costs.
  • 4. Multidisciplinary Scientific Team • Lorenzo Zingaro - Chemist; • Vincenza Valveri - Biologist; • Cristina Canton - Pharmacologist; • Vincenza Flora Dibari - Bioinformatics; ISB experienced and multidisciplinary technical team is complemented by a talented group of PhD and undergraduate students recruited through collaborations with the University of Milan.
  • 5. Strategic Location Insubrias BioPark is one of the eight technological parks and bio-incubators of the Italian biotechnology sector. It is located in Gerenzano, Varese. The BioPark covers an area of 52,000sm; 15,000sm of which include office space and laboratories, equipped with the most advanced technologies in the bio-medical sector. The BioPark is located in a beautiful green area in a geographical and economical strategic position aiming at creating an effective network of partners in the territory. It was created by the cooperation of Italian and Swiss entrepreneurship found in the historical area called Insubriac Region, shared by Lombardia, Piemonte and Cantone Ticino.
  • 6. Regio Insubria and Insubrias BioPark A "Euroregion”, complying with the Madrid Agreement by the Council of Europe which since 1995 promotes cross- boundary cooperation in the Italian-Swiss region of the three pre-Alpine lakes regions including Lake Como, Lake Lugano and Lake Maggiore. Insubrias BioPark
  • 7. Mission • Make mass spectrometry easy: Produce highly innovative and ready to use kits for clinical analysis based on proprietary Ionization Sources for mass spectrometry. • Assay Development Program: develop a custom tailored research and development program using a strong in-house technological expertise. • Services Program: provide state-of-the-art services to our customers based on innovative proprietary technologies.
  • 8. Why ionization source Ionization source is a key component of mass spectrometry influencing the following key factors: • Sensitivity: it is a function of ionization efficiency and chemical noise produced by ion charged solvent clusters. • Quantitative Accuracy: Matrix effect dependent. • Throughput: a source that exhibits high sensitivity and low matrix effect can in principle increase the throughput.
  • 10. ISB ionization sources portfolio • Surface Activated Chemical Ionization (SACI; Cristoni S. et al. Mass Spectrom Rev. 2007 Sep-Oct;26(5):645- 56); • Universal Soft Ionization Source (USIS; Cristoni S. International Patent n. WO/2007/131682);
  • 11. Mass analyzers • HCT ultra Ion Trap (Bruker Daltonics); • ORBITRAP high resolution mass spectrometry (Thermoelecton);
  • 12. Surface Activated Chemical Ionization (SACI) Cristoni et al. Mass Spectrom Rev. 2007 Sep-Oct;26(5):645- 56.
  • 13. SACI Benefits • Increased sensitivity operating in full scan (chemical noise reduction). • Lower matrix effect. • Operates in ion exchange chromatographic conditions.
  • 14. SACI Chemical noise reduction Figure 1 – Analysis of Cocaine and Morphine, HCT & APCI Signal Intensity Retention time (minutes) Figure 2 – Analysis of Cocaine and Morphine, HCT & SACI Cocaine Morphine Signal Intensity Retention time (minutes)
  • 15. SACI Limitations • Compound dependent (It is particularly suitable for peptide and protein analysis). • Not very effective for Biomarker Discovery.
  • 16. Universal Soft Ionization Source (USIS) Reference patent
  • 17. USIS Benefits • Increased sensitivity operating in full scan (chemical noise reduction). • Lower matrix effect. • Operates in ion exchange chromatographic conditions. • Can ionize all kind of polar and not polar compounds. • Ideal for full scan profiling (e.g. Bacterial Characterization through metabolite profiling).
  • 18. USIS Applications Polar Low polar
  • 19. USIS Limitations • The detectable m/z ratio depends on the mass analyzer.
  • 20. Future development • USIS for breath analysis. • Deposit of other provisional patents to improuves ionization source performances.
  • 21. ISB Contacts Contact us: Dr. Simone Cristoni Tel: +39-02-96474438 Cel: +39-340-9639745 e-mail: simone.cristoni@isbiolab.com Web page: http://www.isbiolab.com