On Wednesday 15 January 2020 the OECD hosted a second webinar in the series of Adverse Outcome Pathways (AOPs). It focused on the importance of weight of evidence in the process of developing AOPs, the types and lines of evidences assembled, examples demonstrating the lines of evidence and understanding why quantitative AOPs are developed. The AOP framework is a collaborative tool that applies an innovative approach for collecting mechanistic knowledge from various sources that can eventually support chemical safety assessment. Magda Sachana from the OECD Environment Directorate introduced the presenters and scope of the webinar.

1. Webinar on Adverse Outcome Pathways: assembling and
evaluating weight of evidence (WoE) and quantitative
understanding
Wednesday 15 January 2020
@ 1 pm (CET, Paris time) / 7 am (EST)

2. • Why WoE is important for AOP development?
• What types/lines of evidence are assembled?
• Are there examples demonstrating the lines of evidence?
• Why quantitative AOPs are developed?
Scope of the Webinar

3. Presenters
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Bette Meek Kristie Sullivan Dan Villeneuve
University of Ottawa Physicians Committee for
Responsible Medicine
US EPA
Introduction to WoE
forAOPs
Examples of implementing
WoE inanAOP
Quantitative understanding of
relationships
and whythat’s important

4. CONCLUDING REMARKS

5. • WoE evaluation provides transparency and confidence on
assembling scientific knowledge in AOPs.
• Quantitative AOPs further enhance the confidence of their
use in the regulatory arena.
• Data generated in your lab can be an important line of
evidence needed to strengthen the development and use
of AOPs.
Concluding remarks:

6. Register for our webinar on Adverse Outcome Pathway
Knowledge Base (AOP-KB) and AOP developing tips
When: Thursday 30 January 2020 @ 1 pm
(CET, Paris time) / 7 am (EST)
Where: The convenience of your computer
When: Thursday 30 January 2020 @ 1 pm (CET, Paris
time) / 7 am (EST)
Register here

7. QUESTIONS

8. • Adverse Outcome Pathways
http://www.oecd.org/chemicalsafety/testing/adverse-outcome-
pathways-molecular-screening-and-toxicogenomics.htm
• Future webinar announcements / Recordings of past webinars:
– Webinar Series on Testing and Assessment Methodologies
http://www.oecd.org/chemicalsafety/testing/webinars-on-testing-and-
assessment-methodologies.htm
– Webinar Series on Emerging Science to Improve Chemical Safety
http://www.oecd.org/chemicalsafety/testing/webinars-on-emerging-
science.htm
• Online training material
https://learning.aopkb.org/
Useful links - OECD website

9. Nathalie.Delrue@oecd.org
Magdalini.Sachana@oecd.org
2, rue André Pascal -
75775 Paris Cedex 16,
France
http://www.oecd.org/chemicalsafety/
Thanks For Watching
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