This document discusses causes of pain from intramuscular injections and measures to alleviate it. It notes that the most common side effect of injections given to children for immunizations is pain and apprehension. It then describes multiple pharmacological and non-pharmacological strategies that can be used before, during, and after injections to reduce pain, including use of distractions, topical anesthetics, proper needle size and technique, injection site selection and more. The goal is to improve the experience of receiving injections for both children and their parents.