This document discusses modeling cyber-physical systems for engineering complex software. It proposes using geometric algebra and grammar of graphics to provide better visualization of cyber-physical systems. The key points are:
1) Cyber-physical systems integrate computation, networking, and physical processes. They are complex software systems that connect various sub-systems.
2) Geometric algebra and grammar of graphics can provide a mathematical approach to model the dynamics of cyber-physical systems. This allows better visualization of interconnected elements, feedback processes, and emergent behaviors.
3) Geometric algebra represents geometric objects algebraically rather than through equations. This provides a unified language for engineering disciplines and aspects of computer science like graphics.
Applications of Artificial Neural Networks in Civil EngineeringPramey Zode
An artificial brain-like network based on certain mathematical algorithms developed using a numerical computing environment is called as an ‘Artificial Neural Network (ANN)’. Many civil engineering problems which need understanding of physical processes are found to be time consuming and inaccurate to evaluate using conventional approaches. In this regard, many ANNs have been seen as a reliable and practical alternative to solve such problems. Literature review reveals that ANNs have already being used in solving numerous civil engineering problems. This study explains some cases where ANNs have been used and its future scope is also discussed.
ANALYSIS OF SYSTEM ON CHIP DESIGN USING ARTIFICIAL INTELLIGENCEijesajournal
Automation is a powerful word that lies everywhere. It shows that without automation, application will not get developed. In a semiconductor industry, artificial intelligence played a vital role for implementing the chip based design through automation .The main advantage of applying the machine learning & deep learning technique is to improve the implementation rate based upon the capability of the society. The main objective of the proposed system is to apply the deep learning using data driven approach for controlling the system. Thus leads to a improvement in design, delay ,speed of operation & costs. Through this system, huge volume of data’s that are generated by the system will also get control.
Artificial intelligence in civil engineering seminar reportDhanushS51
Artificial intelligence is a branch of computer science, involved in the research,
design, and application of intelligent computer. Traditional methods for modeling
and optimizing complex structure systems require huge amounts of computing
resources, and artificial intelligence based solutions can often provide valuable
alternatives for efficiently solving problems in civil engineering. This seminar
summarizes recently developed methods and theories in the developing direction for
applications of artificial intelligence in civil engineering. The field of artificial
intelligence, or AI, attempts to understand intelligent entities as well as construct
them to make the operation reasonably simple and easy, correct and precise.
Artificial neural networks are typical examples of a modern interdisciplinary
subject. Sophisticated modeling technique that can be used for solving many
complex problems serves as an analytical tool for qualified prognoses of the results.
Using the concept of the artificial neural networks and the results of the performed
numerical analyses make the field of civil engineering more accurate, precise and
efficient especially in the fields of smart materials and many more.
ADVANCED CIVIL ENGINEERING OPTIMIZATION BY ARTIFICIAL INTELLIGENT SYSTEMS: RE...Journal For Research
Artificial intelligence is the ability of computer systems to perform tasks which otherwise need human brain. Those tasks include visual perception, decision-making, speech recognition and translation between languages. Large amount computing resources is required to traditionally design and optimize complex civil structure in traditional method. This can be effectively eased by using intelligent systems. This paper lists out some of the methods and theories in the application of artificial intelligent systems in the field of civil engineering.
Applications of Artificial Neural Networks in Civil EngineeringPramey Zode
An artificial brain-like network based on certain mathematical algorithms developed using a numerical computing environment is called as an ‘Artificial Neural Network (ANN)’. Many civil engineering problems which need understanding of physical processes are found to be time consuming and inaccurate to evaluate using conventional approaches. In this regard, many ANNs have been seen as a reliable and practical alternative to solve such problems. Literature review reveals that ANNs have already being used in solving numerous civil engineering problems. This study explains some cases where ANNs have been used and its future scope is also discussed.
ANALYSIS OF SYSTEM ON CHIP DESIGN USING ARTIFICIAL INTELLIGENCEijesajournal
Automation is a powerful word that lies everywhere. It shows that without automation, application will not get developed. In a semiconductor industry, artificial intelligence played a vital role for implementing the chip based design through automation .The main advantage of applying the machine learning & deep learning technique is to improve the implementation rate based upon the capability of the society. The main objective of the proposed system is to apply the deep learning using data driven approach for controlling the system. Thus leads to a improvement in design, delay ,speed of operation & costs. Through this system, huge volume of data’s that are generated by the system will also get control.
Artificial intelligence in civil engineering seminar reportDhanushS51
Artificial intelligence is a branch of computer science, involved in the research,
design, and application of intelligent computer. Traditional methods for modeling
and optimizing complex structure systems require huge amounts of computing
resources, and artificial intelligence based solutions can often provide valuable
alternatives for efficiently solving problems in civil engineering. This seminar
summarizes recently developed methods and theories in the developing direction for
applications of artificial intelligence in civil engineering. The field of artificial
intelligence, or AI, attempts to understand intelligent entities as well as construct
them to make the operation reasonably simple and easy, correct and precise.
Artificial neural networks are typical examples of a modern interdisciplinary
subject. Sophisticated modeling technique that can be used for solving many
complex problems serves as an analytical tool for qualified prognoses of the results.
Using the concept of the artificial neural networks and the results of the performed
numerical analyses make the field of civil engineering more accurate, precise and
efficient especially in the fields of smart materials and many more.
ADVANCED CIVIL ENGINEERING OPTIMIZATION BY ARTIFICIAL INTELLIGENT SYSTEMS: RE...Journal For Research
Artificial intelligence is the ability of computer systems to perform tasks which otherwise need human brain. Those tasks include visual perception, decision-making, speech recognition and translation between languages. Large amount computing resources is required to traditionally design and optimize complex civil structure in traditional method. This can be effectively eased by using intelligent systems. This paper lists out some of the methods and theories in the application of artificial intelligent systems in the field of civil engineering.
A Machine Learning-Driven proactive Decision making approach for adaptive Arc...Karthik Vaidyanathan
This was the presentation given at the International Conference on Software Architecture (ICSA 2019), Hamburg, Germany based on our paper on "Machine Learning Driven proactive Decision-making approach for adaptive Architectures". The paper was accepted as a part of the New and Emerging Ideas Track (NEMI). The complete presentation of the paper can be found here : https://www.researchgate.net/publication/331374199_A_Machine_Learningdriven_Approach_for_Proactive_Decision_Making_in_Adaptive_Architectures
Augmented Collective Digital Twins for Self-Organising Cyber-Physical SystemsRoberto Casadei
Context. Self-organising and collective computing
approaches are increasingly applied to large-scale cyber-physical
systems (CPS), enabling them to adapt and cooperate in dynamic
environments. Also, in CPS engineering, digital twins are often
leveraged to provide synchronised logical counterparts of physical
entities, whereas in sensor networks the different-but-related
concept of virtual device is used e.g. to abstract groups of sensors.
Vision. We envision the design concept of “augmented collective
digital twin” that captures digital twins at a collective level
extended with purely virtual devices. We argue that this concept
can foster the engineering of self-organising CPS by providing a
holistic, declarative, and integrated system view.
Method. From a review and proposed taxonomy of logical
devices comprehending both digital twins and virtual devices,
we reinterpret a meta-model for self-organising CPSs and discuss
how it can support augmented collective digital twins. We illus-
trate the approach in a crowd-aware navigation scenario, where
virtual devices are opportunistically integrated into the system
to enhance spatial coverage, improving navigation capabilities.
Conclusion. By integrating physical and virtual devices, the
novel notion of augmented collective digital twin paves the way
to self-improving system functionality and intelligent use of
resources in self-organising CPSs.
TOWARD ORGANIC COMPUTING APPROACH FOR CYBERNETIC RESPONSIVE ENVIRONMENTijasa
The developpment of the Internet of Things (IoT) concept revives Responsive Environments (RE) technologies. Nowadays, the idea of a permanent connection between physical and digital world is technologically possible. The capillar Internet relates to the Internet extension into daily appliances such as they become actors of Internet like any hu-man. The parallel development of Machine-to-Machine
communications and Arti cial Intelligence (AI) technics start a new area of cybernetic. This paper presents an approach for Cybernetic Organism (Cyborg) for RE based on Organic Computing (OC). In such approach, each appli-ance is a part of an autonomic system in order to control a physical environment.The underlying idea is that such systems must have self-x properties in order to adapt their behavior to
external disturbances with a high-degree of autonomy.
6th eCAS workshop on Engineering Collective Adaptive SystemsRoberto Casadei
This is the presentation introducing the 6th eCAS workshop on Engineering Collective Adaptive Systems. It recaps its scope, provides data regarding this edition, provides an overview of the program and related initiatives.
Recent articles published in VLSI design & Communication SystemsVLSICS Design
International Journal of VLSI design & Communication Systems (VLSICS) is a bi monthly open access peer-reviewed journal that publishes articles which contribute new results in all areas of VLSI Design & Communications. The goal of this journal is to bring together researchers and practitioners from academia and industry to focus on advanced VLSI Design & communication concepts and establishing new collaborations in these areas.
Authors are solicited to contribute to this journal by submitting articles that illustrate research results, projects, surveying works and industrial experiences that describe significant advances in the VLSI design & Communications.
A Machine Learning-Driven proactive Decision making approach for adaptive Arc...Karthik Vaidyanathan
This was the presentation given at the International Conference on Software Architecture (ICSA 2019), Hamburg, Germany based on our paper on "Machine Learning Driven proactive Decision-making approach for adaptive Architectures". The paper was accepted as a part of the New and Emerging Ideas Track (NEMI). The complete presentation of the paper can be found here : https://www.researchgate.net/publication/331374199_A_Machine_Learningdriven_Approach_for_Proactive_Decision_Making_in_Adaptive_Architectures
Augmented Collective Digital Twins for Self-Organising Cyber-Physical SystemsRoberto Casadei
Context. Self-organising and collective computing
approaches are increasingly applied to large-scale cyber-physical
systems (CPS), enabling them to adapt and cooperate in dynamic
environments. Also, in CPS engineering, digital twins are often
leveraged to provide synchronised logical counterparts of physical
entities, whereas in sensor networks the different-but-related
concept of virtual device is used e.g. to abstract groups of sensors.
Vision. We envision the design concept of “augmented collective
digital twin” that captures digital twins at a collective level
extended with purely virtual devices. We argue that this concept
can foster the engineering of self-organising CPS by providing a
holistic, declarative, and integrated system view.
Method. From a review and proposed taxonomy of logical
devices comprehending both digital twins and virtual devices,
we reinterpret a meta-model for self-organising CPSs and discuss
how it can support augmented collective digital twins. We illus-
trate the approach in a crowd-aware navigation scenario, where
virtual devices are opportunistically integrated into the system
to enhance spatial coverage, improving navigation capabilities.
Conclusion. By integrating physical and virtual devices, the
novel notion of augmented collective digital twin paves the way
to self-improving system functionality and intelligent use of
resources in self-organising CPSs.
TOWARD ORGANIC COMPUTING APPROACH FOR CYBERNETIC RESPONSIVE ENVIRONMENTijasa
The developpment of the Internet of Things (IoT) concept revives Responsive Environments (RE) technologies. Nowadays, the idea of a permanent connection between physical and digital world is technologically possible. The capillar Internet relates to the Internet extension into daily appliances such as they become actors of Internet like any hu-man. The parallel development of Machine-to-Machine
communications and Arti cial Intelligence (AI) technics start a new area of cybernetic. This paper presents an approach for Cybernetic Organism (Cyborg) for RE based on Organic Computing (OC). In such approach, each appli-ance is a part of an autonomic system in order to control a physical environment.The underlying idea is that such systems must have self-x properties in order to adapt their behavior to
external disturbances with a high-degree of autonomy.
6th eCAS workshop on Engineering Collective Adaptive SystemsRoberto Casadei
This is the presentation introducing the 6th eCAS workshop on Engineering Collective Adaptive Systems. It recaps its scope, provides data regarding this edition, provides an overview of the program and related initiatives.
Recent articles published in VLSI design & Communication SystemsVLSICS Design
International Journal of VLSI design & Communication Systems (VLSICS) is a bi monthly open access peer-reviewed journal that publishes articles which contribute new results in all areas of VLSI Design & Communications. The goal of this journal is to bring together researchers and practitioners from academia and industry to focus on advanced VLSI Design & communication concepts and establishing new collaborations in these areas.
Authors are solicited to contribute to this journal by submitting articles that illustrate research results, projects, surveying works and industrial experiences that describe significant advances in the VLSI design & Communications.
Bindu Baburajan Is Widely Recognized For Her Legal ProficiencyJohn Harvey
Bindu Baburajan is an experienced attorney specializing in real estate/foreclosure, Fair Labor Standards Act or Wage and Hour Law, criminal defense, DUI defense, personal injury, employment litigation, family law, bankruptcy law, & Commercial/Business Litigation.
Jodat Law Group, P.A. is an established law firm serving Bradenton, Brandon, Ellenton, Englewood, North Port, Palmetto, Port Charlotte, Sarasota, Sun City, St. Petersburg, Tampa and Venice since 1994. We represent the rights of people with personal injuries caused in auto accidents and other negligence.
A Survey of Building Robust Business Models in Pervasive ComputingOsama M. Khaled
Pervasive computing is one of the most challenging and difficult computing domains nowadays. It includes many architectural challenges like context awareness, adaptability, mobility, availability, and scalability. There are currently few approaches which provide methodologies to build suitable architectural models that are more suited to the nature of the pervasive domain. This area still needs a lot of enhancements in order to let the software business analyst (BA) cognitively handle pervasive applications by using suitable tasks and tools. Accordingly, any proposed research topic that would attempt to define a development methodology can greatly help BAs in modeling pervasive applications with high efficiency. In this survey paper we address some of the most significant and current software engineering practices that are proving to be most effective in building pervasive systems.
For citation:
Osama M. Khaled and Hoda M. Hosny. A Survey of Building Robust Business Models in Pervasive Computing. An accepted paper in the 2014 World Congress in Computer Science Computer Engineering and Applied Computing
Meetup #3 - Cyber-physical view of the Internet of EverythingFrancesco Rago
The Internet of Everything (IoE) is built on the connections among people, processes, data, and internet of things. However, it is not about these four dimensions in isolation. Each amplifies the capabilities of the other three. It is in the intersection of all of these elements that the true power of Internet of Everything is realized.
We will examine the Cyber-physical view to explore Specification, Hybrid and Heterogeneous Models, Conceptual frameworks, Multiform Time, and much more.
Data Structures in the Multicore Age : NotesSubhajit Sahu
Highlighted notes of article while studying Concurrent Data Structures, CSE:
Data Structures in the Multicore Age
Nir Shivit
Communications of the ACM, March 2011, Vol. 54 No. 3, Pages 76-84
10.1145/1897852.1897873
Nir Shavit is a professor of computer science at Tel-Aviv
University and a member of the Scalable Synchronization
Group at Oracle Labs. He is a recipient of the 2004 ACM/
EATCS Gödel Prize.
Tools and Techniques for Designing, Implementing, & Evaluating Ubiquitous Com...ijceronline
Interactive systems in the mobile, ubiquitous and virtual environments are at a stage of development where designers and developers are keen to find out more about design, use, and usability of these systems. Ubiquitous Computing is the design, implementation and usability that highlight the theories, techniques, tools and best practices in these environments. This paper shows that usable and useful systems that can be achieved in ways that will improve usability to enhance user experience. Research on the usability issues for young children, teenagers, adults and the elderly is presented with different techniques for the mobile, ubiquitous and virtual environments. Interactive frameworks in the portable, omnipresent, and virtual situations are at a phase of advancement where creators and engineers are quick to discover more about the outline, use, and ease of use of these frameworks. The objective of this research paper is to assess the tools and techniques for designing, implementing, and evaluating ubiquitous computing systems used by developers so as to formulate practical solutions that address the functionality of these systems. Ideal systems ensure that designers are able to develop and predict usability of systems at all the stages of virtual environments. This is particularly essential as it increases the experience of the users. This requires one to use the best tool and techniques backed by theories to practice the same. However this varies across different fields such as ubiquitous and mobile environments. In addition all the computing tools have to share visionary tools that allow them to network while at the same time they are processing and distinctively modeling the user interface. Some of the main methods that are used for smart devices include tools such as tabs, boards and pads. Various tools are usually used in the design of the works of the computer. The need to select appropriate techniques that will allow for the efficient use of the chosen techniques for the devices is thus a necessity. This implies that the selection of such tools should be based on set out effective techniques that have been tested so that the required output is achieved.
UBIQUITOUS COMPUTING Its Paradigm, Systems & Middlewarevivatechijri
This paper offers a survey of ubiquitous computing research which is the developing a scope that
gears communication technologies into routine life accomplishments. This study paper affords a types of the
studies that extents at the ubiquitous computing exemplar. In this paper, we present collective structure principles
of ubiquitous systems and scrutinize important developments in context-conscious ubiquitous structures. In toting,
this studies work affords a novel structure of ubiquitous computing system and an evaluation of sensors needed
for applications in ubiquitous computing. The goal of this studies work are 3-fold: i) help as a parameter for
researchers who're first-hand to ubiquitous computing and want to subsidize to this research expanse, ii) provide
a unique machine architecture for ubiquitous computing system, and iii) offer auxiliary studies ways necessary
for exceptional-of-provider assertion of ubiquitous computing..
Computation of Neural Network using C# with Respect to BioinformaticsSarvesh Kumar
Neural network is the emerging field in the era of globalization which is fully based on the concept of soft-computing technique and bioinformatics. In the competitive market of new development process, Bioinformatics play the vital role to give the process of integration aspect as multidisciplinary subject like- biological Science, medicine science, computer science, engineering, chemical science, physical science as well as mathematical science who gives the experiences of artificial activities of human behaviour in the form of software. Now a days neural Network and its multidimensional approach give the idea for solving bioinformatics problems to handle imprecision, uncertainty in large and complex search spaces. This paper gives the emphasis on multidimensional approaches of neural network with soft computing paradigm using C# in bioinformatics with integrative research methodology. The overall process of multidimensional approaches of bioinformatics neurons can also be understood with the help of flow chart and diagram is the major concerned.
Improved Strategy for Distributed Processing and Network Application Developm...Editor IJCATR
The complexity of software development abstraction and the new development in multi-core computers have shifted the burden of distributed software performance from network and chip designers to software architectures and developers. We need to look at software development strategies that will integrate parallelization of code, concurrency factors, multithreading, distributed resources allocation and distributed processing. In this paper, a new software development strategy that integrates these factors is further experimented on parallelism. The strategy is multidimensional aligns distributed conceptualization along a path. This development strategy mandates application developers to reason along usability, simplicity, resource distribution, parallelization of code where necessary, processing time and cost factors realignment as well as security and concurrency issues in a balanced path from the originating point of the network application to its retirement.
Improved Strategy for Distributed Processing and Network Application DevelopmentEditor IJCATR
The complexity of software development abstraction and the new development in multi-core computers have shifted the
burden of distributed software performance from network and chip designers to software architectures and developers. We need to
look at software development strategies that will integrate parallelization of code, concurrency factors, multithreading, distributed
resources allocation and distributed processing. In this paper, a new software development strategy that integrates these factors is
further experimented on parallelism. The strategy is multidimensional aligns distributed conceptualization along a path. This
development strategy mandates application developers to reason along usability, simplicity, resource distribution, parallelization of
code where necessary, processing time and cost factors realignment as well as security and concurrency issues in a balanced path from
the originating point of the network application to its retirement.
With the surge in modern research focus towards Pervasive Computing, lot of techniques and challenges
needs to be addressed so as to effectively create smart spaces and achieve miniaturization. In the process of
scaling down to compact devices, the real things to ponder upon are the Information Retrieval challenges.
In this work, we discuss the aspects of multimedia which makes information access challenging. An
Example Pattern Recognition scenario is presented and the mathematical techniques that can be used to
model uncertainty are also presented for developing a system that can sense, compute and communicate in
a way that can make human life easy with smart objects assisting from around his surroundings.
Analysis and assessment software for multi-user collaborative cognitive radi...IJECEIAES
Computer simulations are without a doubt a useful methodology that allows to explore research queries and develop prototypes at lower costs and timeframes than those required in hardware processes. The simulation tools used in cognitive radio networks (CRN) are undergoing an active process. Currently, there is no stable simulator that enables to characterize every element of the cognitive cycle and the available tools are a framework for discrete-event software. This work presents the spectral mobility simulator in CRN called “App MultiColl-DCRN”, developed with MATLAB’s app designer. In contrast with other frameworks, the simulator uses real spectral occupancy data and simultaneously analyzes features regarding spectral mobility, decision-making, multi-user access, collaborative scenarios and decentralized architectures. Performance metrics include bandwidth, throughput level, number of failed handoffs, number of total handoffs, number of handoffs with interference, number of anticipated handoffs and number of perfect handoffs. The assessment of the simulator involves three scenarios: the first and second scenarios present a collaborative structure using the multi-criteria optimization and compromise solution (VIKOR) decision-making model and the naïve Bayes prediction technique respectively. The third scenario presents a multi-user structure and uses simple additive weighting (SAW) as a decision-making technique. The present development represents a contribution in the cognitive radio network field since there is currently no software with the same features.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
2. T. V. Gopal / International Journal of Engineering Issues
74
between the design and use of the complex software in a given context needs to be minimized in a well-engineered and
verifiable manner.
Software Engineering depends on strong abstractions. Abstraction enables more focus on the concepts apart from
particular instances of the concepts. Abstraction facilitates the postponement of some structural considerations and many
algorithmic details for a later expansion. It reduces the amount of complexity [8] that must be dealt with at any given
point. Design is a process of proceeding from abstraction to concrete representations. Various models help to
communicate different aspects of the system by masking some of the complexity and revealing some relationships. In
the absence of generic principles the construction of evolving complex software is based on a series of claims that are
very difficult to verify and validate.
Any given principle is a proposal formulated in a prescriptive way. It should not be directly associated with, or
arise from, a particular technology, a very specific method, or a Unique technique. It should not be an activity of
software engineering. The principle should not dictate a compromise (or a proportioning) between two actions or
concepts. A principle of software engineering should include concepts connected to the engineering discipline. It must
be possible to test the formulation of a principle in practice, or to check its consequences.
The context for constructing the complex software is a Cyber – Physical System [5]. Cyber-Physical Systems
(CPS) are integrations of computation, networking, and physical processes. CPS facilitates the necessary abstractions for
modeling and designing the integrated whole. Cyber-physical systems (CPS) are physical and well-engineered systems
that are monitored, coordinated, controlled and integrated by a computing and communication core with complex
software connecting the various sub-systems.
“We all realize that we're kind of surrounded with technology: there's little device here recording us, there's tables,
chairs, spoons, light bulbs. Each of these things seem pretty mechanical, pretty inert in a certain sense, not very
interactive, you know, a hammer, roads. But each one of these technologies actually requires many other technologies to
make and produce. So your little thing in your pocket that you use for a phone might require thousands of other
technologies to create it and support it and keep it going, and each of those technologies may require hundreds of
thousands of subtechnologies below it. And that network of different technologies and the co-dependency that each of
those technologies have on each other forms a virtual organism, a super organism.
We can keep stepping back and realize that all these technologies are in some ways co-dependent and related and
connected to each other in some way and that largest of all the networks of all these technologies together I call the
Technium.” – Kevin Kelly
The author defines the technium as a Cyber – Physical Systems. CPS represent a conglomeration of technologies in
embedded systems, distributed systems, dependable systems, real-time systems, communication systems with advances
in energy-efficient networking, microcontrollers, sensors and actuators.
II. THE DYNAMICS OF CYBER – PHYSICAL SYSTEMS
Classical mechanics studies the mechanical parts that move. The techniques used to study the dynamics of such
parts are also applicable to other physical systems, including circuits, chemical processes, and biological processes. It is
thus possible to arrive at a set of principles across multiple engineering disciplines to engineer mechanical parts.
Mechanical parts are easiest for most people to visualize and are also easily engineered. The motion of mechanical parts
can often be represented using differential equations, or equivalently, integral equations. Such representations work well
for motion that is amenable for precise definition using the notions of linearity, time invariance, and continuity.
However, discrete events are necessary for other motions. Continuous components evolve smoothly, while discrete
components evolve abruptly. Finite state machines are used to represent discrete dynamics.
Theory of Computation in its present form begins with the Finite State Machines and culminates in the Turing
Machine. Finite state machines describe the class of regular languages, have no memory and has limited number of
states. Turing Machines describe a much larger class of languages and have a much larger computational power. There
are obvious differences between a Turing machine and a real computer [1]. The computer is finite in size, prone to
3. T. V. Gopal / International Journal of Engineering Issues
75
failures and it is made from decaying matter. There are many emerging models of computation such as Spintronics that
attempt to harness the matter that forms the substrate for the computation. The concept of an automaton is changing to
include the theories related to cybernetics along with the present automata theory.
The physical system is given by a differential or an integral equation [10] that relates input signals (force or torque)
to output signals (position, orientation, velocity, or rotational velocity). Such a physical system can be viewed as a
component in a larger system. Cyber – Physical systems include both continuous and discrete components.
Computation needs to be organized as a network of interconnected components of some kind, each of which is free
to run when it pleases, propagating information around the network as proves possible. The consequence that the
structure of the CPS [7] does not impose a temporal ordering. Instead each component in the CPS functions as it pleases,
and allows the order of operations to be determined by the needs of the solution and not on the structure of the problem
description. Constructing well-engineered software for CPS thus needs different foundational principles.
III. VECTORS, GEOMETRY AND ALGEBRA
Visualization of the solution is the key to success in CPS. Drawing is a proven method across engineering
disciplines to facilitate accurate and clear communication of the proposed solution. However, present day software
engineering has evolved many diagrammatic representations based on the automata theory that are highly restrictive.
Also, the notations for the diagrams are usually not interoperable with other engineering disciplines. The control
switches between propagation of arbitrary partial information and search for alternative paths of execution only when a
contradictions are discovered. The primary concern is “evaluation” to quickly discover any contradiction to ensure faster
execution by choosing the most optimal paths of computation. The over-rigid notions of computational timing and
constraint make the methods archaic for CPS [4,9].
Time is nature’s way of keeping everything from happening at once. Space is nature’s way of keeping everything
from happening in the same place. Physics has limitations imposed by the very nature of physical reality. Mathematics
may provide both natural and artificial solutions warranted by the complex software. However, the mathematics applied
to physics must be limited, simply by the limits imposed by physics.
The foundational point of using Calculus is for an easy mathematical approach for the most reasonable estimation
of Time and Space complexity [6] for a computation. “Algebra” connotes “relationships”. “Linear Algebra” indicates
“line-like relationships” that are predictable. There are many algebras. Boolean Algebra that made computation with
numbers happen using machines that are physically realizable using the logic using the symbols 0 ad 1.
Vectors are "numbers with direction". For the physical phenomena, such as velocity and displacement, vectors are
very useful representations. Geometry and Trigonometry are very difficult to apply in many contexts. Vector algebra
was invented in order to solve two-dimensional and three-dimensional problems without the use of cumbersome
geometry. The calculus of real numbers, vector calculus and complex analysis eventually paved way for Geometric
Calculus. This calculus serves better to understand the intricacies of electrodynamics [11]. Geometric algebra [2] and its
extension to geometric calculus unify, simplify, and generalize many areas of mathematics that involve geometric ideas.
They also provide a unified mathematical language for physics, engineering, and the geometrical aspects of computer
science such as those found in graphics, robotics and computer vision.
The following aspects [3] of Evolving Complex Software Systems thus become more amenable to analysis and design.
Interconnected and interdependent elements and dimensions
Feedback processes promote and inhibit change within systems
System characteristics and behaviors emerge from simple rules of interaction
Nonlinearity
Sensitivity to initial conditions
4. T. V. Gopal / International Journal of Engineering Issues
76
Phase space – the ‘space of the possible’
Attractors, chaos and the ‘edge of chaos’
Adaptive agents
Self-organization
Co-evolution
IV. GEOMETRIC ALGEBRA
A vector is “anything that can be represented by arrows that add head-to-tail.” Such objects have magnitude (how long is
the arrow) and direction (which way does it point). Real numbers have two analogous properties: a magnitude (absolute
value) and a sign (plus or minus). Higher-dimensional objects in real vector spaces also have these properties: for
example, a surface element is a plane with a magnitude (area) and an orientation (clockwise or counterclockwise). If we
associate real scalars with zero-dimensional spaces, then we can say that scalars, vectors, planes and so on, have three
features in common:
An attitude: exactly which subspace is represented?
A weight: an amount, or a length, area, volume and so on.
An orientation: positive or negative, forward or backward, clockwise or counterclockwise. No matter what the
dimension of the space, there are always only two orientations.
Geometric objects (points, lines, planes, circles and so on) are represented by members of an algebra, a geometric
algebra, rather than by equations relating coordinates. Geometric operations on the objects (rotate, translate, intersect,
project, construct the circle through three points, and so on) are then represented by algebraic operations on the objects.
Geometric algebra is coordinate-free i.e coordinates are needed only when specific objects or operations are under
consideration. The author opines that Geometric Algebra provides a better visualization of the CPS and the pertinent
dynamics. Grammar of Graphics [13] is chosen to lend expressions to the Geometric Algebra of the CPS.
V. GRAMMAR OF GRAPHICS
A grammar provides the fundamental principles or rules of an art or science. A good grammar will allow us to gain
insight into the composition of complicated graphics, and reveal unexpected connections between seemingly different
graphics. A grammar provides a strong foundation for understanding a diverse range of graphics. A grammar may also
help guide us on what a well-formed or correct graphic looks like, but there will still be many grammatically correct but
nonsensical graphics [6]. The proposed block schematic for visualizing a Cyber – Physical System is given in Figure 1.
Component Geometric Algebra
Algebraic Operations
[with Uncertainty]
Aesthetics
Cyber – Physical System
Grammar Based Representation of the
Cyber – Physical System
5. T. V. Gopal / International Journal of Engineering Issues
77
Figure 1. Proposed Block Schematic for Visualizing a Cyber – Physical System
The Uncertainty factored in the algebraic operations indicated in Figure 1 above is a combination of Variability, Noise,
Incompleteness, Indeterminacy, Bias, Error, Accuracy, Precision, Reliability, Validity, Quality and Integrity. The
Aesthetic Attributes pertaining to Figure 1 are indicated in the Table 1.
Table 1. The Aesthetic Attributes
Form Surface Motion Sound Text
Position
Size
Shape
Rotation
Resolution
Color
Texture
Blur
Transparency
Direction
Speed
Acceleration
Tone
Volume
Rhythm
Voice
Label
Positioning of the Components may be a separate layer [12] based on the Calculus of Geometry [3].
VI. CONCLUSIONS
This paper proposes a mathematical approach to architect the automata that model the Cyber – Physical Systems and
hence paving way for better visualization and representation for the 14 Grand Challenges in Engineering [14] mentioned
below.
1. Make solar energy economical
2. Provide energy from fusion
3. Develop carbon sequestration methods
4. Manage the nitrogen cycle
5. Provide access to clean water
6. Restore and improve urban infrastructure
7. Advance health informatics and practice of Medicine
8. Engineer better medicines
9. Reverse-engineer the brain
10. Prevent nuclear terror
11. Secure cyberspace with methods better than the traditional practices
12. Enhance virtual reality
13. Advance personalized learning
14. Engineer the tools of scientific discovery
ACKNOWLEDGEMENTS
The author places on record his sincere thanks to Anna University, Chennai, the members of the Steering Committee of
the Series of Annual Conferences on Theory and Applications of Models of Computation [TAMC] and the Conference
Chairs of the IEEE Series of Conferences on Norbert Wiener in the 21st
Century.
6. T. V. Gopal / International Journal of Engineering Issues
78
REFERENCES
[1] DAVID, Evans. Introduction to Computing Explorations in Language, Logic, and Machines. CreateSpace
Independent Publishing Platform, 2011.
[2] DORAN, Chris et LASENBY, A. N. Geometric algebra for physicists. Cambridge : Cambridge University
Press, 2003.
[3] GOPAL T,V. The Physics of Evolving Complex Software Systems. International Journal of Engineering
Issues, Vol. 2015, no. 1, p. 33-39.
[4] GLOTFELTER, Paul, EICHELBERGER, Travis, et MARTIN, Patrick J. PhysiCloud: A cloud-computing
framework for programming cyber-physical systems. Report supported by US National Science Foundation
through grant CNS-1239221, 2015.
[5] IVAN, Ruchkin, BRADLEY, Schmerl, et DAVID, Garlan. Analytic Dependency Loops in Architectural
Models of Cyber-Physical Systems. In: 8th International Workshop on Model-based Architecting of Cyber-
Physical and Embedded Systems (ACES-MB). Ottawa, Canada, 2015.
[6] IVOR, Grattan-Guinness. The Scope and Limitations of Algebras: Some Historical and Philosophical
Considerations. Theology and Science, 2011, Vol. 9, no. 1, p 137 – 147.
[7] LEE, Edward Ashford et SESHIA, Sanjit A. Introduction to embedded systems. Morrisville, NC :
LeeSeshia.org., 2011.
[8] MAINZER, Klaus. Thinking in complexity. Berlin : Springer-Verlag, 2014.
[9] RAGUNATHAN (Raj) Rajkumar et al. Cyber-Physical Systems: The Next Computing Revolution. In: Design
Automation Conference 2010, Anaheim, California, USA.
[10] RAJARAMAN, V. Analog computation and simulation. New Delhi : Prentice-Hall of India, 1974.
[11] TERJE, G, Vold. An Introduction to Geometric Calculus and its Application to Electrodynamics. American
Journal of Physics, 2013, Vol. 61, no, 6, p 505 – 513..
[12] WICKHAM Hadley. A Layered Grammar of Graphics. Report Supported by the National Science Foundation
under grant 0706949, 2008.
[13] WILKINSON, Leland et WILLS, Graham, 2005, The grammar of graphics. New York : Springer.
[14] WILLIAM Perry et al. Grand Challenges in Engineering. Report by National Academy of Engineering, 2008.