This document discusses integrating knowledge from pharmacogenomics databases to enable personalized medicine approaches. It describes using ontologies to integrate data on drugs, diseases, pathways, and genotypes from multiple sources. Queries over this integrated knowledge can discover disease and drug pathways and relationships between genotypes and drugs/diseases. The goal is to identify aberrant pathways underlying a disease and personalized treatment options based on a patient's gene expression profile. Future work includes expanding to interaction networks and experimental validation.