This document discusses principles of injecting and drug considerations for common conditions of the wrist and hand. It covers injectable conditions such as carpal tunnel syndrome, trigger finger, osteoarthritis, and Dupuytren's contracture. Injecting principles include obtaining a history, confirming the diagnosis, managing expectations, preparing the patient and equipment, using the proper needle size, following injection steps such as anesthetizing the skin and manipulating the area, and documenting the procedure. Potential complications are also reviewed. Contraindications include skin infections, deep infections, lack of previous response, and inaccessible joints.