SlideShare a Scribd company logo
Signal & Image Processing : An International Journal (SIPIJ) Vol.7, No.1, February 2016
DOI : 10.5121/sipij.2016.7105 43
INHIBITION AND SET-SHIFTING TASKS IN
CENTRAL EXECUTIVE FUNCTION OF
WORKING MEMORY: AN EVENT-RELATED
POTENTIAL (ERP) STUDY
Pankaj,1
Jamuna Rajeswaran,1*
Divya Sadana1
1
Deptartment of Clinical Psychology, National Institute of Mental Health and
Neurosciences (NIMHANS), Bangalore, India 560 029
ABSTRACT
Understanding of neuro-dynamics of a complex higher cognitive process, Working Memory (WM) is
challenging. In WM, information processing occurs through four subsystems: phonological loop, visual
sketch pad, memory buffer and central executive function (CEF). CEF plays a principal role in WM. In this
study, our objective was to understand the neurospatial correlates of CEF during inhibition and set-shifting
processes. Thirty healthy educated subjects were selected. Event-Related Potential (ERP) related to visual
inhibition and set-shifting task was collected using 32 channel EEG system. Activation of those ERPs
components was analyzed using amplitudes of positive and negative peaks. Experiment was controlled
using certain parametric constraints to judge behavior, based on average responses in order to establish
relationship between ERP and local area of brain activation and represented using standardized low
resolution brain electromagnetic tomography. The average score of correct responses was higher for
inhibition task (87.5%) as compared to set-shifting task (59.5%). The peak amplitude of neuronal activity
for inhibition task was lower compared to set-shifting task in fronto-parieto-central regions. Hence this
proposed paradigm and technique can be used to measure inhibition and set-shifting neuronal processes in
understanding pathological central executive functioning in patients with neuro-psychiatric disorders.
KEYWORDS
Working Memory (WM), Central Executive Function (CEF), Inhibition Task, Set-Shifting Task, Event
Related Potential (ERP), sLORETA
1. INTRODUCTION
Working memory (WM) is a part of the higher cognitive mental functions (HMFs) [1]. Baddeley
and Hitch generated the first model of WM that represents the role of CEF [2]. WM has a
temporary storage system that involves small packets of spatially distributed information
processing systems [3]. It involves a four subsystem i.e., phonological loop, visual sketch pad,
memory buffer and central executive function (CEF) [4]. They integrate to perform the following
cognitive functions i.e., temporary storage, learning, reasoning, comprehension, manipulation and
updating. This involves various parts of the sensory-motor cortices in the frontoparietal lobes,
where the experience is recorded and integrated and subsequently brought to the conscious
domain [5]. The information of CEF drifts through these circuits and it is coordinated by neurons
in the prefrontal cortex [6]. The CEF is studied as a component of Baddeley’s WM model. It’s
further divided in four sub components, inhibition, set-shifting, dual-tasking and updating [7].
Signal & Image Processing : An International Journal (SIPIJ) Vol.7, No.1, February 2016
44
Electroencephalography (EEG) measures the electrical activity of the brain from the electrodes on
the scalp [8]. Event-related potentials (ERPs) are averaged EEG responses to a specific time-
locked stimuli involving complex mental processing. ERPs are used to assess brain function and
observe electro-physiological manifestations of cognitive activities in both the time domain and
spatial extents. In general, ERPs are typically described in terms of components based on polarity
and latency. ERPs provide good temporal resolution to certify studies of any cognitive processes
in real time. When the subjects were made to perform tasks involving revision of various
memories in short-term which were presented as a specific train of stimulus sequence, the
responses could be measured and spatiotemporally correlated real-time using ERP [9]. EEG
records the correct and incorrect responses of both the inhibition and set-shifting tasks and the
ERPs associated with cognitive process and control potentials in brain are derived from this
signal.
Overall, the ERPs associated with the task are correlated with CEF activity. CEF of inhibition and
set-shifting tasks is manifest in the P200 (or P2), P300 (or P3) and N200 (OR N2) components of
the human ERP and EEG maps show peak activity in the fronto-parietal cortices [10]. This study
was aimed at understanding the brain dynamics of CEF and to find the spatial neural correlates in
CEF during inhibition and set-shifting tasks. For this we designed a paradigm to study the CEF of
WM and modelled the EEG signal to find out neural spatial domains during the aforementioned
tasks.
2. MATERIAL AND METHODS
2.1. Subjects:
We recruited 30 educated healthy subjects (male: female=15:15, right handed, age: 28±5.9years)
in NIMHANS (National Institute of Mental Health and Neuroscience, Bangalore, India) for the
Event Related Potential (ERP) study. All 30 participants were selected for study after assessing
them with clinical interview and normal or corrected vision (Visual Acuity < +1.5/-1.5). A written
informed consent was obtained after explaining the tasks and recording procedure. Subjects with
history of any neurological and mental disorders and use of substances such as alcohol and
tobacco prior to session were excluded. Individuals with frequent headaches or migraine problem
were excluded from the study. Completion of tasks was mandatory for inclusion in the analysis.
Four participants were excluded due to bad electroencephalography (EEG) signal.
2.2. EEG Data Acquisitions
Electroencephalography was recorded using 32 channels Ag-AgCl electrodes arranged to the
revised 10-20 system (to improve spatial sampling) and mounted in uniform fit, highly elastic cap
(ECI, Electro Cap Int®, USA). EEG signal were acquired by SynAmps amplifier™ and recorded
by NeuroScan™ (version 4.4) software. We used mastoid electrodes as reference. Electro-
oculographic (EOG) activity was recorded by the electrodes of on the outer canthus of each eye
for horizontal and below the left eye for vertical movements. Impedance of input signal of
electrode was kept below less than 5kΩ (sampling rate: 1kHz). This study contains one hour EEG
session. Before the start of the tasks, 3 minutes rest state EEG recording was done. Both the task
paradigms were designed using “Stim2” software (Compumedics®
, Neuroscan™). A button box
with millisecond accuracy measured the reaction time (RT) for these computerized tasks.
2.3. Paradigm for the Tasks
The following two types of tasks were performed followed to eye open and eye close at relax
resting condition and measure the CEF process.
Signal & Image Processing : An International Journal (SIPIJ) Vol.7, No.1, February 2016
45
2.3.1 Inhibition task:
The ‘inhibition task’, subject was shown four geometric different shapes such as a triangle, circle,
plus and square in four quadrants of the monitor (Figure 1). The geometric shapes were presented
randomly in four quadrants checker board that were positioned in the center of the screen with a
white background. The shapes are presented for 800ms at intervals of 200ms. In the four
geometric shapes, if triangle ( ) geometric shape comes with black color, then the subject was
instructed to press the button 1 or else to continue to press the button 2 of the response box. The
participant was instructed to respond as quickly and accurately as possible. The whole inhibition
WM task had 160 rounds and 3 minutes of completion.
Figure 1. Experimental design for inhibition task. “S” - stimulus, which presented for 800ms, “R” - rest
period kept for 200ms, “Target” – Targeted stimuli.
2.3.2 Set-shifting task:
In the Set-shifting task, subjects were shown a set of patterns on a monitor (Figure 2). The set-
shifting task consisted of three pictures in a row and fourth picture column was left empty. There
were four options (1, 2, 3, 4) given to the subject below the pattern. Subject chooses the one of
the right option. All pictures were positioned in the center of the screen in a white back ground.
The subject were instructed to press the key either “1” or “2” or “3” or “4” with their response. In
the task, three patterns (similar, pair, process) were present and among them each pattern had a
set of 10 stimuli of similar type which were presented successively. The stimuli were presented
for 4000ms at intervals of 1000ms. The participant was instructed to respond as quickly and
accurately as possible. The whole set-shifting WM task had 30 rounds and 3minutes of
completion.
Figure 2. Experimental design for set-shifting task. “S” - stimulus, which presented for 4000ms, “R” - rest
period kept for 1000ms.
3. DATA ANALYSIS:
3.1 Pre-processing and Artifact Removal from EEG signal
Raw EEG data analysis was performed on Neuroscan™ and MATLAB®
software. The data was
down-sampled to 250Hz. A cut-off frequency of 0.01 to 60 Hz done by 4th
order band pass
Butterworth FIR filter [9] and after 50Hz notch filter was applied for power line interference [11]
[12]. Preprocessing was done by eye movement artifact correction, muscle artifact correction and
Signal & Image Processing : An International Journal (SIPIJ) Vol.7, No.1, February 2016
46
singular value decomposition (SVD) for artifact free data and created linear derivation (LDR)
EEG file. The artifact free EEG was epoched to a particular time window for both CEF tasks. In
‘inhibition’ task, EEG file were epoched to a window of 100ms pre-stimulus to 700ms post-
stimulus by selecting trigger and in set-shifting task. Low pass filter of 1Hz was applied on these
epoched data and were corrected to baseline. High amplitude artifacts were rejected using the
artifact rejection criteria of +/-75µV. After artifact rejection, these epochs were averaged in both
time and frequency domain. After this, EEG data was taken for further analysis.
3.2 Post Processing for EEG and ERP Signal:
ERPs were calculated from the epoched EEG data obtained by time domain averaging.
Smoothening was applied on this averaged data. In the electrodes where ERP components were
present as per the visual inspection, the ERP components (N200, P200, P300) were identified for
inhibition task and set-shifting task. The designated time window for identification of the ERPs,
which we considered in the whole experimental tasks were as follows: a) N200 - most negatively
deflecting potential occurring 150ms to 250ms after the stimulus, , b) P200 - most positively
deflecting potential occurring 150ms to 250ms after the stimulus and c) P300 - most positively
deflecting potential occurring 250ms to 350ms after the stimulus. The group averaged EEG files
contain all the ERP components to which 2D maps were generated and collected to get the
activation areas during both the CEF - Working Memory tasks. We computed the activation value
of amplitude in frontal cluster (F3, F7, Fz, F4, F8) and parietal cluster (P3, P7, Pz, P4, P8).
The neural activity for inhibition and set-shifting process of central executive function were
mapped using “spectopo” functions of EEGLAB on 2D head view. Then the signal was computed
for three dimensional cortical distributions on realistic head model with MNI152 template using
standardized low resolution brain electromagnetic tomography (sLORETA). This was followed
by an appropriate standardization of the current density, producing images of electric neuronal
activity without localization bias [13]. sLORETA images represent the electric activity at each
voxel in neuroanatomic Talairach space as the squared standardized magnitude of the estimated
current density. It was found that in all noise free simulations, although the image was blurred,
sLORETA had exact, zero error localization when reconstructing single sources, that is, the
maximum of the current density power estimate coincided with the exact dipole location. In all
noisy simulations, it had the lowest localization errors when compared with the minimum norm
solution and the Dale method [14].
3.3 Statistics data Analysis:
Electrophysiological variables included N200, P200 and P300 peak amplitudes and latencies for
Fz and Pz electrodes for both tasks. N200 to P300 latency ratio for inhibition process (Table 1)
and P200 to P300 latency ratio for set-shifting process (Table 2) were used for paired T-test
statistics. All ERP value found highly significant (>0.05).
Table 1. Inhibition task Paired T-test
Paired T-test inhibition task
frontal electrode stimulus distracter p value t value DF SED
P300 P300 0.0001 17.43 58 0.34
N200 N200 0.0001 4.83 58 0.23
parietal electrode stimulus distracter p value t value DF SED
P300 P300 0.0001 9.7 58 0.91
N200 N200 0.0482 0.76 58 0.23
Signal & Image Processing : An International Journal (SIPIJ) Vol.7, No.1, February 2016
47
Table 2. Set-shifting data Paired T-test
Paired T-test set-shifting task
frontal electrode value 1 value 2 p value t value DF SED
similar P300 pair P300 0.2086 1.27 58 0.61
similar P300 process P300 0.0001 5.18 58 0.56
pair P300 process P300 0.009 2.7 58 0.79
similar P200 pair P200 0.0004 3.73 58 0.18
similar P200 process P200 0.9705 0.03 58 0.215
pair P200 process P200 0.0019 3.25 58 0.212
parietal electrode value 1 value 2 p value t value DF SED
similar P300 pair P300 0.0001 4.32 58 0.421
similar P300 process P300 0.0001 5.69 58 0.554
pair P300 process P300 0.0441 2.05 58 0.648
similar P200 pair P200 0.0001 21.46 58 0.208
similar P200 process P200 0.0001 6.73 58 0.292
pair P200 process P200 0.0001 21.46 58 0.307
4. RESULTS:
4.1 Response accuracy:
The participants were performed well in CEF tasks. Accuracy and response time were analyzed in
inhibition and set-shifting working memory paradigm. Comparative curves were plotted in
between the inhibition and set-shifting task. We found that average score of correct response was
higher in ‘inhibition task’ (87.5%) in comparison to ‘set-shifting task’ (59.5%).
4.2 ERP Peaks in Inhibition and Set-Shifting Task:
(a) (b)
Figure 3 Event related Potentials in (a) Inhibition task (b) Set-shifting task.
Signal & Image Processing : An International Journal (SIPIJ) Vol.7, No.1, February 2016
48
Figure 3 represents the average ERPs for the N200, P200, P300 components. We measured the
amplitudes for fronto-central (Fz) and parieto-central (Pz) electrode. These electrodes were
significantly attenuated compared. We found that Fz electrode have less amplitude value than Pz
electrode. In comparison of both tasks, inhibition process had less amplitude than set-shifting
process.
4.3 EEG ERP results:
We found that lower peak amplitude activity of brain area in inhibition process than set-shifting
process, which reveals that inhibition process utilize less activation of brain areas to perform
tasks. In order to show this, we examined the frontal and parietal activity of brain in same tasks.
We found that brain uses the fronto-parietal connectivity when it performs CEF of WM related
tasks. We also found that the midline frontal (FZ, F4, F6) and parietal (PZ, P4, P6) electrodes
were activated at the same time with prominent pattern of negative potentials and other had
positive potentials in both tasks.
Figure 4 (a). Neuronal activation in EEGLab®
head-view (3D & 2D) for Inhibition task.
Figure 4 (b). Neuronal activation in EEGLab®
head-view (3D & 2D) for Set-shifting task.
Figure 5(a) . Neuronal activation in MNI template for Inhibition task computed from EEG signal.
Figure 5 (b). Neuronal activation in MNI template for Set-shifting task computed from EEG signal.
Most significant results were found in both tasks. After the post processing we got 3D and 2D
head-views in EEGLAB [Figure 4 (a,b)] and sLORETA [Figure 5 (a,b)]. In EEGLAB we
Signal & Image Processing : An International Journal (SIPIJ) Vol.7, No.1, February 2016
49
measured the activation on 100, 200 and 300 ms after the stumuli come. In both head-views we
found the Inhibition process have less activation on fronto-parietal lobs than set-shifting process.
5. DISCUSSION
Till today, a lot of research has been done on both central executive function of working memory
but little efforts have been made to find the behavioural and neural connections between the two
processes. This study examined the brain activation pattern. We find out ERPs and behavioural
interpretations, during the inhibition and set-shifting tasks. In this study our objective was to
understand the brain dynamics for CEF of WM functions and find out neural spatial domain in
central executive function during inhibition and set-shifting process. The behavioural results
showed that among the population of normal individuals, inhibition process score was high in
comparison to set-shifting task.
These behavioural changes were accompanied by a number of changes in transient ERPs and task
related EEG activations. This study is mainly focused on finding the EEG correlation between
components of CEF. In EEG findings, by using time domain analysis [15] and bivalent 2-D and
3-D cartoon maps, positive and negative potentials were observed across the pre-frontal, frontal,
central and parietal electrodes, during both the tasks.
Electric potential distribution on the basis of the scalp recording was measured by sLORETA that
compute the cortical three- dimensional smoothest of all possible neural current density
distribution, where neighbouring voxels have maximally similar activity. Low Resolution
Electromagnetic Tomography (LORETA) is used for source localization, based on R. D. Pascual-
Marqui and its virtual MR anatomical images are based on Montreal Neurological Institute (MNI)
of McGill University. LORETA is a linear distribution method and it calculates the current
density voxel by voxel in the brain as a linear, weighted sum of scalp electrical potential.
Computations were made in a realistic head model using the MNI 152 template with the three
dimensional solution space restricted to cortical grey matter.
The EEG method is the dipole source with fixed location and orientation method and it is
distributed in the whole brain volume or cortical surface. There are six parameters that specify the
dipole, three special coordinates (x,y,z) and three dipole components (orientation, angle, and
strength). In the LORETA, the electrode potentials and matrix X are considered to be related as
X=LS
Where S is the actual current density and L is Ne×3m matrix representation the forward
transmission coefficients form each source to the array of sensors. There are number of sensors
Ne, extra cranial measurements in the surface of brain and Nv, voxels in the brain. In the real
world applications where more concentrated focal source methods fail and choose smoothness of
the inverse solution as
S=LT
(LLT
)X
The sloreta uses the minimum norm solution is to create a space solution with zero contribution
from the source. However, the variance of the current density estimate is based only on the
measurement noise, in contrast to sLORETA , which takes into account the actual source variance
as well.
Time domain analysis of EEG and ERPs: After averaging in time domain 2-D head maps were
taken to represent the surface potential distribution patterns. Central executive WM tasks were
Signal & Image Processing : An International Journal (SIPIJ) Vol.7, No.1, February 2016
50
analyzed at both the retrieval and encoding phases in epochs of 800 and 1000ms. Result was seen
throughout the whole brain electrodes. In the encoding and retrieval phase of the CEF of WM
activation patterns were seen [16].
ERPs comparison studies for inhibition and set-shifting process: Visually evoked potentials
(P100) were present throughout the CEF WM task [17]. Delay in early N200 latencies in Fz of
encoding showed that visual attention took time. In late P300 peaks in Pz of retrieval phase
showed that matching system of visually attend objects. We also found the increase in the
amplitude of the frontal visual N200 has been observed in a number of studies, this response
shows the Inhibition and attention performance. These delays in ERPs are also observed in 2D
and 3D maps in EEGLAB. So we can conclude that functioning of inhibition process is found in
fronto-parietal area of brain.
In both encoding and retrieval phase of CEF WM all desired ERPs were found. Visually evoked
potentials (P100) were seen in parietal area suggesting the stimulus representation extrastriate
cortex (BA 6 and 18) [18]. N100 component was seen in frontal and pre-frontal electrodes
showing the unpredictability of stimulus. N200 component was present in parietal electrodes.
Encoding phase showing delayed N200 latencies but in retrieval phase N200 latencies were
shorter due to attending the visual stimuli. Early-latency visual ERPs are enhanced when stimuli
are presented in an attended visual field. Reaction times are also shorter to stimuli presented in an
attended visual field than to those presented in an unattended visual field. In retrieval phase,
delayed P200 latency of Fz electrodes suggesting for a matching system that compares sensory
inputs with the stored memory. P200 latencies were present in both phases but most prominently
it was elicited in retrieval phase.
ERPs analysis is suggested for activation network during CEF of WM. In Encoding phase initial
activations occurred in the visual cortex where stimuli were attended for the visual search. The
information from the stimuli was coded to the Fz and Pz electrodes as the late P300 peaks were
present in the parietal electrodes suggesting the demand of focusing. Likewise, all the ERP
patterns were seen in the retrieval phase. The only difference was the delayed P200 latencies
suggesting for a matching system related to make comparison of present stimulus with the
previous ones. This whole ERPs analysis is consistent with EEGLAB and sLORETA maps
achieved in the time domain analysis. So, a network of activation patterns from frontal to parietal
area in the both inhibition and set-shifting process of Central Executive Function of Working
Memory.
6. CONCLUSION
Findings from this study will give a better understanding of CEF and brain activity in inhibition
and set-shifting process. Our findings demonstrate a paradigm combined with a technique to be
used to measure of inhibition and set-shifting neuronal processes. This would help in under-
standing the alteration of central executive function in patient with neurological and psychiatric
disorder.
ACKNOWLEDGMENT
Preparation of this paper was supported by Department of clinical Neuro-psychology, National
Institute of Mental Health and Neuroscience (NIMHANS), Bangalore, India. We are grateful to
Ganne Chaitanya, Deepak Ullal and Rajnikant Panda for providing thoughtful remarks and
suggestions regarding EEG and ERP analysis.
Signal & Image Processing : An International Journal (SIPIJ) Vol.7, No.1, February 2016
51
REFERENCES
[1] Baddeley, A. (1992). Working memory. Science, 255(5044), 556-559.
[2] Baddeley, A. D., & Hitch, G. J. (1974). Working memory. The psychology of learning and motivation
[3] Baddeley, A. D. (1983). Working memory. Philosophical Transactions of the Royal Society B:
Biological Sciences, 302(1110), 311-324.
[4] Baddeley, A. (1996). The fractionation of working memory. Proceedings of the National Academy of
Sciences, 93(24), 13468-13472.
[5] Miyake, A., Friedman, N. P., Emerson, M. J., Witzki, A. H., Howerter, A., & Wager, T. D. (2000).
The unity and diversity of executive functions and their contributions to complex “frontal lobe” tasks:
A latent variable analysis.Cognitive psychology, 41(1), 49-100.
[6] Collette, F., & Van der Linden, M. (2002). Brain imaging of the central executive component of
working memory. Neuroscience & Biobehavioral Reviews, 26(2), 105-125.
[7] Delorme, A., & Makeig, S. (2004). EEGLAB: an open source toolbox for analysis of single-trial EEG
dynamics including independent component analysis. Journal of neuroscience methods, 134(1), 9-21.
[8] Teplan, M. (2002). Fundamentals of EEG measurement. Measurement science review, 2(2), 1-11.
[9] Klingberg, T., O'Sullivan, B. T., & Roland, P. E. (1997). Bilateral activation of fronto-parietal
networks by incrementing demand in a working memory task. Cerebral Cortex, 7(5), 465-471.
[10] Kalpana, R., Chitra, M.,Kalsi, N., & Panda, R. (2013). ANALYSIS OF BRAIN COGNITIVE STATE
FOR ARITHMETIC TASK AND MOTOR TASK USING ELECTROENCE PHALOGRAPHY
SIGNAL. Signal & Image Processing, 4(4), 51.
[11] Pal, P. R., Khobragade, P., & Panda, R. (2011, January). Expert system design for classification of
brain waves and epileptic-seizure detection. In Students' Technology Symposium (TechSym), 2011
IEEE (pp. 187-192). IEEE.
[12] Garrett, D., Peterson, D., Anderson, C. W., & Thaut, M. H. (2003). Comparison of linear, nonlinear,
and feature selection methods for EEG signal classification.Neural Systems and Rehabilitation
Engineering, IEEE Transactions on, 11(2), 141-144.
[13] Pascual-Marqui, R. D. (2002). Standardized low-resolution brain electromagnetic tomography
(sLORETA): technical details. Methods Find Exp Clin Pharmacol, 24(Suppl D), 5-12.
[14] Dale, A. M., Liu, A. K., Fischl, B. R., Buckner, R. L., Belliveau, J. W., Lewine, J. D., & Halgren, E.
(2000). Dynamic statistical parametric mapping: combining fMRI and MEG for high-resolution
imaging of cortical activity. Neuron, 26(1), 55-67.
[15] Kenemans, J. L., Molenaar, P., Verbaten, M. N., & Slangen, J. L. (1991). Removal of the ocular
artifact from the EEG: a comparison of time and frequency domain methods with simulated and real
data. Psychophysiology,28(1), 114-121.
[16] Kusak, G., Grune, K., Hagendorf, H., & Metz, A. M. (2000). Updating of working memory in a
running memory task: an event-related potential study. International Journal of
Psychophysiology, 39(1), 51-65.
[17] Luck, S. J., Heinze, H. J., Mangun, G. R., & Hillyard, S. A. (1990). Visual event-related potentials
index focused attention within bilateral stimulus arrays. II. Functional dissociation of P1 and N1
components. Electroencephalography and clinical neurophysiology, 75(6), 528-542.
Signal & Image Processing : An International Journal (SIPIJ) Vol.7, No.1, February 2016
52
[18] Mueller, A., Candrian, G., Kropotov, J. D., Ponomarev, V. A., & Baschera, G. M. (2010).
Classification of ADHD patients on the basis of independent ERP components using a machine
learning system. Nonlinear biomedical physics,4(Suppl 1), S1.
AUTHORS
*The Corresponding author for this paper is Dr. Jamuna Rajeswaran
Mr. Pankaj, received M.Tech degree in Cognitive Neuroscience from Centre for
Converging Technologies, University of Rajasthan, India, in 2015. He has more than one
year of research experience on clinical psychology, Neuro-imaging and EEG signal
processing on cognition at National Institute of Mental Health and Neurosciences,
Bangalore, India. He has clinical research experience with many National institutes. He
also got Mani Bhomik research-fellowship (2015) in National Institute of Advanced
Studies (NIAS), Indian Institute of Science campus, Bangalore, India.
Dr. Jamuna Rajeswaran, Additional Professor, Consultant & Head Neuropsychology
Unit, National Institute of Mental Health and Neurosciences, Bangalore, India. She
completed her M.Phil and PhD from Dept. of Clinical Psychology, National Institute of
Mental Health and Neurosciences, Bangalore, India.
Dr. Divya Sadana, Senior Research Fellow, Department of Clinical psychology,
National Institute of Mental Health and Neurosciences, Bangalore, India. She completed
her M.Phil and PhD from Dept. of Clinical Psychology, National Institute of Mental
Health and Neurosciences, Bangalore, India.

More Related Content

What's hot

CURRENT STATUS AND FUTURE RESEARCH DIRECTIONS IN MONITORING VIGILANCE OF INDI...
CURRENT STATUS AND FUTURE RESEARCH DIRECTIONS IN MONITORING VIGILANCE OF INDI...CURRENT STATUS AND FUTURE RESEARCH DIRECTIONS IN MONITORING VIGILANCE OF INDI...
CURRENT STATUS AND FUTURE RESEARCH DIRECTIONS IN MONITORING VIGILANCE OF INDI...
ijsc
 
SUITABLE MOTHER WAVELET SELECTION FOR EEG SIGNALS ANALYSIS: FREQUENCY BANDS D...
SUITABLE MOTHER WAVELET SELECTION FOR EEG SIGNALS ANALYSIS: FREQUENCY BANDS D...SUITABLE MOTHER WAVELET SELECTION FOR EEG SIGNALS ANALYSIS: FREQUENCY BANDS D...
SUITABLE MOTHER WAVELET SELECTION FOR EEG SIGNALS ANALYSIS: FREQUENCY BANDS D...
sipij
 
Segmentation
SegmentationSegmentation
Segmentation
Kavitha A
 
EMG Diagnosis using Neural Network Classifier with Time Domain and AR Features
EMG Diagnosis using Neural Network Classifier with Time Domain and AR FeaturesEMG Diagnosis using Neural Network Classifier with Time Domain and AR Features
EMG Diagnosis using Neural Network Classifier with Time Domain and AR Features
IDES Editor
 
Eyeblink artefact removal from eeg using independent
Eyeblink artefact removal from eeg using independentEyeblink artefact removal from eeg using independent
Eyeblink artefact removal from eeg using independent
eSAT Publishing House
 
Jennie Si: "Computing with Neural Spikes"
Jennie Si: "Computing with Neural Spikes" Jennie Si: "Computing with Neural Spikes"
Jennie Si: "Computing with Neural Spikes"
ieee_cis_cyprus
 
Improved target recognition response using collaborative brain-computer inter...
Improved target recognition response using collaborative brain-computer inter...Improved target recognition response using collaborative brain-computer inter...
Improved target recognition response using collaborative brain-computer inter...
Kyongsik Yun
 
Minimizing Musculoskeletal Disorders in Lathe Machine Workers
Minimizing Musculoskeletal Disorders in Lathe Machine WorkersMinimizing Musculoskeletal Disorders in Lathe Machine Workers
Minimizing Musculoskeletal Disorders in Lathe Machine Workers
Waqas Tariq
 
EEG SIGNAL IDENTIFICATION USING SINGLE-LAYER NEURAL NETWORK
EEG SIGNAL IDENTIFICATION USING SINGLE-LAYER NEURAL NETWORKEEG SIGNAL IDENTIFICATION USING SINGLE-LAYER NEURAL NETWORK
EEG SIGNAL IDENTIFICATION USING SINGLE-LAYER NEURAL NETWORK
IJCI JOURNAL
 
FYP
FYPFYP
Neurally Driven Prosthetics
Neurally Driven ProstheticsNeurally Driven Prosthetics
Neurally Driven Prosthetics
Marshall Benson
 
The 5th WBA Hackathon Orientation -- Cerenaut Part
The 5th WBA Hackathon Orientation  -- Cerenaut PartThe 5th WBA Hackathon Orientation  -- Cerenaut Part
The 5th WBA Hackathon Orientation -- Cerenaut Part
The Whole Brain Architecture Initiative
 
Classification of emotions induced by horror and relaxing movies using single-...
Classification of emotions induced by horror and relaxing movies using single-...Classification of emotions induced by horror and relaxing movies using single-...
Classification of emotions induced by horror and relaxing movies using single-...
IJECEIAES
 
Mirror-neuron-draft-4-21
Mirror-neuron-draft-4-21Mirror-neuron-draft-4-21
Mirror-neuron-draft-4-21
Megan Dempsey
 
脳とAIの接点から何を学びうるのか@第5回WBAシンポジウム: 銅谷賢治
脳とAIの接点から何を学びうるのか@第5回WBAシンポジウム: 銅谷賢治脳とAIの接点から何を学びうるのか@第5回WBAシンポジウム: 銅谷賢治
脳とAIの接点から何を学びうるのか@第5回WBAシンポジウム: 銅谷賢治
The Whole Brain Architecture Initiative
 
A New Approach to Denoising EEG Signals - Merger of Translation Invariant Wav...
A New Approach to Denoising EEG Signals - Merger of Translation Invariant Wav...A New Approach to Denoising EEG Signals - Merger of Translation Invariant Wav...
A New Approach to Denoising EEG Signals - Merger of Translation Invariant Wav...
CSCJournals
 
NCP_Thesis_Francesca_Bocca.pdf
NCP_Thesis_Francesca_Bocca.pdfNCP_Thesis_Francesca_Bocca.pdf
NCP_Thesis_Francesca_Bocca.pdf
Francesca Bocca-Aldaqre
 
main
mainmain
IRJET- Depression Prediction System using Different Methods
IRJET- Depression Prediction System using Different MethodsIRJET- Depression Prediction System using Different Methods
IRJET- Depression Prediction System using Different Methods
IRJET Journal
 
Grounded Cognition: Mirror Neurons
Grounded Cognition: Mirror NeuronsGrounded Cognition: Mirror Neurons
Grounded Cognition: Mirror Neurons
Kristina Rebrova
 

What's hot (20)

CURRENT STATUS AND FUTURE RESEARCH DIRECTIONS IN MONITORING VIGILANCE OF INDI...
CURRENT STATUS AND FUTURE RESEARCH DIRECTIONS IN MONITORING VIGILANCE OF INDI...CURRENT STATUS AND FUTURE RESEARCH DIRECTIONS IN MONITORING VIGILANCE OF INDI...
CURRENT STATUS AND FUTURE RESEARCH DIRECTIONS IN MONITORING VIGILANCE OF INDI...
 
SUITABLE MOTHER WAVELET SELECTION FOR EEG SIGNALS ANALYSIS: FREQUENCY BANDS D...
SUITABLE MOTHER WAVELET SELECTION FOR EEG SIGNALS ANALYSIS: FREQUENCY BANDS D...SUITABLE MOTHER WAVELET SELECTION FOR EEG SIGNALS ANALYSIS: FREQUENCY BANDS D...
SUITABLE MOTHER WAVELET SELECTION FOR EEG SIGNALS ANALYSIS: FREQUENCY BANDS D...
 
Segmentation
SegmentationSegmentation
Segmentation
 
EMG Diagnosis using Neural Network Classifier with Time Domain and AR Features
EMG Diagnosis using Neural Network Classifier with Time Domain and AR FeaturesEMG Diagnosis using Neural Network Classifier with Time Domain and AR Features
EMG Diagnosis using Neural Network Classifier with Time Domain and AR Features
 
Eyeblink artefact removal from eeg using independent
Eyeblink artefact removal from eeg using independentEyeblink artefact removal from eeg using independent
Eyeblink artefact removal from eeg using independent
 
Jennie Si: "Computing with Neural Spikes"
Jennie Si: "Computing with Neural Spikes" Jennie Si: "Computing with Neural Spikes"
Jennie Si: "Computing with Neural Spikes"
 
Improved target recognition response using collaborative brain-computer inter...
Improved target recognition response using collaborative brain-computer inter...Improved target recognition response using collaborative brain-computer inter...
Improved target recognition response using collaborative brain-computer inter...
 
Minimizing Musculoskeletal Disorders in Lathe Machine Workers
Minimizing Musculoskeletal Disorders in Lathe Machine WorkersMinimizing Musculoskeletal Disorders in Lathe Machine Workers
Minimizing Musculoskeletal Disorders in Lathe Machine Workers
 
EEG SIGNAL IDENTIFICATION USING SINGLE-LAYER NEURAL NETWORK
EEG SIGNAL IDENTIFICATION USING SINGLE-LAYER NEURAL NETWORKEEG SIGNAL IDENTIFICATION USING SINGLE-LAYER NEURAL NETWORK
EEG SIGNAL IDENTIFICATION USING SINGLE-LAYER NEURAL NETWORK
 
FYP
FYPFYP
FYP
 
Neurally Driven Prosthetics
Neurally Driven ProstheticsNeurally Driven Prosthetics
Neurally Driven Prosthetics
 
The 5th WBA Hackathon Orientation -- Cerenaut Part
The 5th WBA Hackathon Orientation  -- Cerenaut PartThe 5th WBA Hackathon Orientation  -- Cerenaut Part
The 5th WBA Hackathon Orientation -- Cerenaut Part
 
Classification of emotions induced by horror and relaxing movies using single-...
Classification of emotions induced by horror and relaxing movies using single-...Classification of emotions induced by horror and relaxing movies using single-...
Classification of emotions induced by horror and relaxing movies using single-...
 
Mirror-neuron-draft-4-21
Mirror-neuron-draft-4-21Mirror-neuron-draft-4-21
Mirror-neuron-draft-4-21
 
脳とAIの接点から何を学びうるのか@第5回WBAシンポジウム: 銅谷賢治
脳とAIの接点から何を学びうるのか@第5回WBAシンポジウム: 銅谷賢治脳とAIの接点から何を学びうるのか@第5回WBAシンポジウム: 銅谷賢治
脳とAIの接点から何を学びうるのか@第5回WBAシンポジウム: 銅谷賢治
 
A New Approach to Denoising EEG Signals - Merger of Translation Invariant Wav...
A New Approach to Denoising EEG Signals - Merger of Translation Invariant Wav...A New Approach to Denoising EEG Signals - Merger of Translation Invariant Wav...
A New Approach to Denoising EEG Signals - Merger of Translation Invariant Wav...
 
NCP_Thesis_Francesca_Bocca.pdf
NCP_Thesis_Francesca_Bocca.pdfNCP_Thesis_Francesca_Bocca.pdf
NCP_Thesis_Francesca_Bocca.pdf
 
main
mainmain
main
 
IRJET- Depression Prediction System using Different Methods
IRJET- Depression Prediction System using Different MethodsIRJET- Depression Prediction System using Different Methods
IRJET- Depression Prediction System using Different Methods
 
Grounded Cognition: Mirror Neurons
Grounded Cognition: Mirror NeuronsGrounded Cognition: Mirror Neurons
Grounded Cognition: Mirror Neurons
 

Viewers also liked

A BINARY TO RESIDUE CONVERSION USING NEW PROPOSED NON-COPRIME MODULI SET
A BINARY TO RESIDUE CONVERSION USING NEW PROPOSED NON-COPRIME MODULI SETA BINARY TO RESIDUE CONVERSION USING NEW PROPOSED NON-COPRIME MODULI SET
A BINARY TO RESIDUE CONVERSION USING NEW PROPOSED NON-COPRIME MODULI SET
sipij
 
An Innovative Moving Object Detection and Tracking System by Using Modified R...
An Innovative Moving Object Detection and Tracking System by Using Modified R...An Innovative Moving Object Detection and Tracking System by Using Modified R...
An Innovative Moving Object Detection and Tracking System by Using Modified R...
sipij
 
A STUDY OF SPECKLE NOISE REDUCTION FILTERS
A STUDY OF SPECKLE NOISE REDUCTION FILTERS A STUDY OF SPECKLE NOISE REDUCTION FILTERS
A STUDY OF SPECKLE NOISE REDUCTION FILTERS
sipij
 
A FLUXGATE SENSOR APPLICATION: COIN IDENTIFICATION
A FLUXGATE SENSOR APPLICATION: COIN IDENTIFICATIONA FLUXGATE SENSOR APPLICATION: COIN IDENTIFICATION
A FLUXGATE SENSOR APPLICATION: COIN IDENTIFICATION
sipij
 
Recognition of historical records
Recognition of historical recordsRecognition of historical records
Recognition of historical records
sipij
 
TARGET LOCALIZATION IN WIRELESS SENSOR NETWORKS BASED ON RECEIVED SIGNAL STRE...
TARGET LOCALIZATION IN WIRELESS SENSOR NETWORKS BASED ON RECEIVED SIGNAL STRE...TARGET LOCALIZATION IN WIRELESS SENSOR NETWORKS BASED ON RECEIVED SIGNAL STRE...
TARGET LOCALIZATION IN WIRELESS SENSOR NETWORKS BASED ON RECEIVED SIGNAL STRE...
sipij
 
Optimized Biometric System Based on Combination of Face Images and Log Transf...
Optimized Biometric System Based on Combination of Face Images and Log Transf...Optimized Biometric System Based on Combination of Face Images and Log Transf...
Optimized Biometric System Based on Combination of Face Images and Log Transf...
sipij
 
A Hybrid Architecture for Tracking People in Real-Time Using a Video Surveill...
A Hybrid Architecture for Tracking People in Real-Time Using a Video Surveill...A Hybrid Architecture for Tracking People in Real-Time Using a Video Surveill...
A Hybrid Architecture for Tracking People in Real-Time Using a Video Surveill...
sipij
 
Stem calyx recognition of an apple using shape descriptors
Stem   calyx recognition of an apple using shape descriptorsStem   calyx recognition of an apple using shape descriptors
Stem calyx recognition of an apple using shape descriptors
sipij
 
Efficient pu mode decision and motion estimation for h.264 avc to hevc transc...
Efficient pu mode decision and motion estimation for h.264 avc to hevc transc...Efficient pu mode decision and motion estimation for h.264 avc to hevc transc...
Efficient pu mode decision and motion estimation for h.264 avc to hevc transc...
sipij
 
Automatic meal inspection system using lbp hf feature for central kitchen
Automatic meal inspection system using lbp hf feature for central kitchenAutomatic meal inspection system using lbp hf feature for central kitchen
Automatic meal inspection system using lbp hf feature for central kitchen
sipij
 
DESIGN REALIZATION AND PERFORMANCE EVALUATION OF AN ACOUSTIC ECHO CANCELLATIO...
DESIGN REALIZATION AND PERFORMANCE EVALUATION OF AN ACOUSTIC ECHO CANCELLATIO...DESIGN REALIZATION AND PERFORMANCE EVALUATION OF AN ACOUSTIC ECHO CANCELLATIO...
DESIGN REALIZATION AND PERFORMANCE EVALUATION OF AN ACOUSTIC ECHO CANCELLATIO...
sipij
 
Objective Quality Assessment of Image Enhancement Methods in Digital Mammogra...
Objective Quality Assessment of Image Enhancement Methods in Digital Mammogra...Objective Quality Assessment of Image Enhancement Methods in Digital Mammogra...
Objective Quality Assessment of Image Enhancement Methods in Digital Mammogra...
sipij
 
MULTIPLE OBJECTS TRACKING IN SURVEILLANCE VIDEO USING COLOR AND HU MOMENTS
MULTIPLE OBJECTS TRACKING IN SURVEILLANCE VIDEO USING COLOR AND HU MOMENTSMULTIPLE OBJECTS TRACKING IN SURVEILLANCE VIDEO USING COLOR AND HU MOMENTS
MULTIPLE OBJECTS TRACKING IN SURVEILLANCE VIDEO USING COLOR AND HU MOMENTS
sipij
 
FUZZY CLUSTERING BASED GLAUCOMA DETECTION USING THE CDR
FUZZY CLUSTERING BASED GLAUCOMA DETECTION USING THE CDR FUZZY CLUSTERING BASED GLAUCOMA DETECTION USING THE CDR
FUZZY CLUSTERING BASED GLAUCOMA DETECTION USING THE CDR
sipij
 
AN MINIMUM RECONFIGURATION PROBABILITY ROUTING ALGORITHM FOR RWA IN ALL-OPTIC...
AN MINIMUM RECONFIGURATION PROBABILITY ROUTING ALGORITHM FOR RWA IN ALL-OPTIC...AN MINIMUM RECONFIGURATION PROBABILITY ROUTING ALGORITHM FOR RWA IN ALL-OPTIC...
AN MINIMUM RECONFIGURATION PROBABILITY ROUTING ALGORITHM FOR RWA IN ALL-OPTIC...
sipij
 
A R EVIEW P APER : N OISE M ODELS IN D IGITAL I MAGE P ROCESSING
A R EVIEW P APER : N OISE M ODELS IN D IGITAL I MAGE P ROCESSINGA R EVIEW P APER : N OISE M ODELS IN D IGITAL I MAGE P ROCESSING
A R EVIEW P APER : N OISE M ODELS IN D IGITAL I MAGE P ROCESSING
sipij
 
WECPOSTER5 crop
WECPOSTER5 cropWECPOSTER5 crop
WECPOSTER5 crop
Vince Netto
 
Antibiotics -simplified-
Antibiotics -simplified-Antibiotics -simplified-
Antibiotics -simplified-
Mohamed Alasmar
 
Surveillance and disease control approaches for pigs and their application to...
Surveillance and disease control approaches for pigs and their application to...Surveillance and disease control approaches for pigs and their application to...
Surveillance and disease control approaches for pigs and their application to...
ILRI
 

Viewers also liked (20)

A BINARY TO RESIDUE CONVERSION USING NEW PROPOSED NON-COPRIME MODULI SET
A BINARY TO RESIDUE CONVERSION USING NEW PROPOSED NON-COPRIME MODULI SETA BINARY TO RESIDUE CONVERSION USING NEW PROPOSED NON-COPRIME MODULI SET
A BINARY TO RESIDUE CONVERSION USING NEW PROPOSED NON-COPRIME MODULI SET
 
An Innovative Moving Object Detection and Tracking System by Using Modified R...
An Innovative Moving Object Detection and Tracking System by Using Modified R...An Innovative Moving Object Detection and Tracking System by Using Modified R...
An Innovative Moving Object Detection and Tracking System by Using Modified R...
 
A STUDY OF SPECKLE NOISE REDUCTION FILTERS
A STUDY OF SPECKLE NOISE REDUCTION FILTERS A STUDY OF SPECKLE NOISE REDUCTION FILTERS
A STUDY OF SPECKLE NOISE REDUCTION FILTERS
 
A FLUXGATE SENSOR APPLICATION: COIN IDENTIFICATION
A FLUXGATE SENSOR APPLICATION: COIN IDENTIFICATIONA FLUXGATE SENSOR APPLICATION: COIN IDENTIFICATION
A FLUXGATE SENSOR APPLICATION: COIN IDENTIFICATION
 
Recognition of historical records
Recognition of historical recordsRecognition of historical records
Recognition of historical records
 
TARGET LOCALIZATION IN WIRELESS SENSOR NETWORKS BASED ON RECEIVED SIGNAL STRE...
TARGET LOCALIZATION IN WIRELESS SENSOR NETWORKS BASED ON RECEIVED SIGNAL STRE...TARGET LOCALIZATION IN WIRELESS SENSOR NETWORKS BASED ON RECEIVED SIGNAL STRE...
TARGET LOCALIZATION IN WIRELESS SENSOR NETWORKS BASED ON RECEIVED SIGNAL STRE...
 
Optimized Biometric System Based on Combination of Face Images and Log Transf...
Optimized Biometric System Based on Combination of Face Images and Log Transf...Optimized Biometric System Based on Combination of Face Images and Log Transf...
Optimized Biometric System Based on Combination of Face Images and Log Transf...
 
A Hybrid Architecture for Tracking People in Real-Time Using a Video Surveill...
A Hybrid Architecture for Tracking People in Real-Time Using a Video Surveill...A Hybrid Architecture for Tracking People in Real-Time Using a Video Surveill...
A Hybrid Architecture for Tracking People in Real-Time Using a Video Surveill...
 
Stem calyx recognition of an apple using shape descriptors
Stem   calyx recognition of an apple using shape descriptorsStem   calyx recognition of an apple using shape descriptors
Stem calyx recognition of an apple using shape descriptors
 
Efficient pu mode decision and motion estimation for h.264 avc to hevc transc...
Efficient pu mode decision and motion estimation for h.264 avc to hevc transc...Efficient pu mode decision and motion estimation for h.264 avc to hevc transc...
Efficient pu mode decision and motion estimation for h.264 avc to hevc transc...
 
Automatic meal inspection system using lbp hf feature for central kitchen
Automatic meal inspection system using lbp hf feature for central kitchenAutomatic meal inspection system using lbp hf feature for central kitchen
Automatic meal inspection system using lbp hf feature for central kitchen
 
DESIGN REALIZATION AND PERFORMANCE EVALUATION OF AN ACOUSTIC ECHO CANCELLATIO...
DESIGN REALIZATION AND PERFORMANCE EVALUATION OF AN ACOUSTIC ECHO CANCELLATIO...DESIGN REALIZATION AND PERFORMANCE EVALUATION OF AN ACOUSTIC ECHO CANCELLATIO...
DESIGN REALIZATION AND PERFORMANCE EVALUATION OF AN ACOUSTIC ECHO CANCELLATIO...
 
Objective Quality Assessment of Image Enhancement Methods in Digital Mammogra...
Objective Quality Assessment of Image Enhancement Methods in Digital Mammogra...Objective Quality Assessment of Image Enhancement Methods in Digital Mammogra...
Objective Quality Assessment of Image Enhancement Methods in Digital Mammogra...
 
MULTIPLE OBJECTS TRACKING IN SURVEILLANCE VIDEO USING COLOR AND HU MOMENTS
MULTIPLE OBJECTS TRACKING IN SURVEILLANCE VIDEO USING COLOR AND HU MOMENTSMULTIPLE OBJECTS TRACKING IN SURVEILLANCE VIDEO USING COLOR AND HU MOMENTS
MULTIPLE OBJECTS TRACKING IN SURVEILLANCE VIDEO USING COLOR AND HU MOMENTS
 
FUZZY CLUSTERING BASED GLAUCOMA DETECTION USING THE CDR
FUZZY CLUSTERING BASED GLAUCOMA DETECTION USING THE CDR FUZZY CLUSTERING BASED GLAUCOMA DETECTION USING THE CDR
FUZZY CLUSTERING BASED GLAUCOMA DETECTION USING THE CDR
 
AN MINIMUM RECONFIGURATION PROBABILITY ROUTING ALGORITHM FOR RWA IN ALL-OPTIC...
AN MINIMUM RECONFIGURATION PROBABILITY ROUTING ALGORITHM FOR RWA IN ALL-OPTIC...AN MINIMUM RECONFIGURATION PROBABILITY ROUTING ALGORITHM FOR RWA IN ALL-OPTIC...
AN MINIMUM RECONFIGURATION PROBABILITY ROUTING ALGORITHM FOR RWA IN ALL-OPTIC...
 
A R EVIEW P APER : N OISE M ODELS IN D IGITAL I MAGE P ROCESSING
A R EVIEW P APER : N OISE M ODELS IN D IGITAL I MAGE P ROCESSINGA R EVIEW P APER : N OISE M ODELS IN D IGITAL I MAGE P ROCESSING
A R EVIEW P APER : N OISE M ODELS IN D IGITAL I MAGE P ROCESSING
 
WECPOSTER5 crop
WECPOSTER5 cropWECPOSTER5 crop
WECPOSTER5 crop
 
Antibiotics -simplified-
Antibiotics -simplified-Antibiotics -simplified-
Antibiotics -simplified-
 
Surveillance and disease control approaches for pigs and their application to...
Surveillance and disease control approaches for pigs and their application to...Surveillance and disease control approaches for pigs and their application to...
Surveillance and disease control approaches for pigs and their application to...
 

Similar to INHIBITION AND SET-SHIFTING TASKS IN CENTRAL EXECUTIVE FUNCTION OF WORKING MEMORY: AN EVENT-RELATED POTENTIAL (ERP) STUDY

ANALYSIS OF BRAIN COGNITIVE STATE FOR ARITHMETIC TASK AND MOTOR TASK USING EL...
ANALYSIS OF BRAIN COGNITIVE STATE FOR ARITHMETIC TASK AND MOTOR TASK USING EL...ANALYSIS OF BRAIN COGNITIVE STATE FOR ARITHMETIC TASK AND MOTOR TASK USING EL...
ANALYSIS OF BRAIN COGNITIVE STATE FOR ARITHMETIC TASK AND MOTOR TASK USING EL...
sipij
 
The Preface Layer for Auditing Sensual Interacts of Primary Distress Conceali...
The Preface Layer for Auditing Sensual Interacts of Primary Distress Conceali...The Preface Layer for Auditing Sensual Interacts of Primary Distress Conceali...
The Preface Layer for Auditing Sensual Interacts of Primary Distress Conceali...
IIRindia
 
Classification of EEG Signal for Epileptic Seizure DetectionusingEMD and ELM
Classification of EEG Signal for Epileptic Seizure DetectionusingEMD and ELMClassification of EEG Signal for Epileptic Seizure DetectionusingEMD and ELM
Classification of EEG Signal for Epileptic Seizure DetectionusingEMD and ELM
IJTET Journal
 
Classification of EEG Signals for Brain-Computer Interface
Classification of EEG Signals for Brain-Computer InterfaceClassification of EEG Signals for Brain-Computer Interface
Classification of EEG Signals for Brain-Computer Interface
Azoft
 
EEG Mouse:A Machine Learning-Based Brain Computer Interface_interface
EEG Mouse:A Machine Learning-Based Brain Computer Interface_interfaceEEG Mouse:A Machine Learning-Based Brain Computer Interface_interface
EEG Mouse:A Machine Learning-Based Brain Computer Interface_interface
Willy Marroquin (WillyDevNET)
 
018 bci gamma band
018   bci gamma band018   bci gamma band
018 bci gamma band
Sezin Tunaboylu
 
EEG S IGNAL Q UANTIFICATION B ASED ON M ODUL L EVELS
EEG S IGNAL  Q UANTIFICATION  B ASED ON M ODUL  L EVELS EEG S IGNAL  Q UANTIFICATION  B ASED ON M ODUL  L EVELS
EEG S IGNAL Q UANTIFICATION B ASED ON M ODUL L EVELS
sipij
 
International Journal of Engineering Research and Development (IJERD)
International Journal of Engineering Research and Development (IJERD)International Journal of Engineering Research and Development (IJERD)
International Journal of Engineering Research and Development (IJERD)
IJERD Editor
 
Implementation and Evaluation of Signal Processing Techniques for EEG based B...
Implementation and Evaluation of Signal Processing Techniques for EEG based B...Implementation and Evaluation of Signal Processing Techniques for EEG based B...
Implementation and Evaluation of Signal Processing Techniques for EEG based B...
Damian Quinn
 
Personalization_Effect_Emotion_Recognition
Personalization_Effect_Emotion_RecognitionPersonalization_Effect_Emotion_Recognition
Personalization_Effect_Emotion_Recognition
Roula Kollia
 
Recognition of emotional states using EEG signals based on time-frequency ana...
Recognition of emotional states using EEG signals based on time-frequency ana...Recognition of emotional states using EEG signals based on time-frequency ana...
Recognition of emotional states using EEG signals based on time-frequency ana...
IJECEIAES
 
HUMAN EMOTION ESTIMATION FROM EEG AND FACE USING STATISTICAL FEATURES AND SVM
HUMAN EMOTION ESTIMATION FROM EEG AND FACE USING STATISTICAL FEATURES AND SVMHUMAN EMOTION ESTIMATION FROM EEG AND FACE USING STATISTICAL FEATURES AND SVM
HUMAN EMOTION ESTIMATION FROM EEG AND FACE USING STATISTICAL FEATURES AND SVM
csandit
 
56x35_oct10
56x35_oct1056x35_oct10
56x35_oct10
Benson Ng
 
A0510107
A0510107A0510107
A0510107
IOSR Journals
 
Brain research journal regional differences nova
Brain research journal regional differences   nova Brain research journal regional differences   nova
Brain research journal regional differences nova
Vladimír Krajča
 
Eeg time series data analysis in focal cerebral ischemic rat model
Eeg time series data analysis in focal cerebral ischemic rat modelEeg time series data analysis in focal cerebral ischemic rat model
Eeg time series data analysis in focal cerebral ischemic rat model
ijbesjournal
 
Transfer learning for epilepsy detection using spectrogram images
Transfer learning for epilepsy detection using spectrogram imagesTransfer learning for epilepsy detection using spectrogram images
Transfer learning for epilepsy detection using spectrogram images
IAESIJAI
 
Robot Motion Control Using the Emotiv EPOC EEG System
Robot Motion Control Using the Emotiv EPOC EEG SystemRobot Motion Control Using the Emotiv EPOC EEG System
Robot Motion Control Using the Emotiv EPOC EEG System
journalBEEI
 
MHEALTH APPLICATIONS DEVELOPED BY THE MINISTRY OF HEALTH FOR PUBLIC USERS INK...
MHEALTH APPLICATIONS DEVELOPED BY THE MINISTRY OF HEALTH FOR PUBLIC USERS INK...MHEALTH APPLICATIONS DEVELOPED BY THE MINISTRY OF HEALTH FOR PUBLIC USERS INK...
MHEALTH APPLICATIONS DEVELOPED BY THE MINISTRY OF HEALTH FOR PUBLIC USERS INK...
hiij
 
Spike removal through multiscale wavelet and entropy analysis of ocular motor...
Spike removal through multiscale wavelet and entropy analysis of ocular motor...Spike removal through multiscale wavelet and entropy analysis of ocular motor...
Spike removal through multiscale wavelet and entropy analysis of ocular motor...
Giuseppe Fineschi
 

Similar to INHIBITION AND SET-SHIFTING TASKS IN CENTRAL EXECUTIVE FUNCTION OF WORKING MEMORY: AN EVENT-RELATED POTENTIAL (ERP) STUDY (20)

ANALYSIS OF BRAIN COGNITIVE STATE FOR ARITHMETIC TASK AND MOTOR TASK USING EL...
ANALYSIS OF BRAIN COGNITIVE STATE FOR ARITHMETIC TASK AND MOTOR TASK USING EL...ANALYSIS OF BRAIN COGNITIVE STATE FOR ARITHMETIC TASK AND MOTOR TASK USING EL...
ANALYSIS OF BRAIN COGNITIVE STATE FOR ARITHMETIC TASK AND MOTOR TASK USING EL...
 
The Preface Layer for Auditing Sensual Interacts of Primary Distress Conceali...
The Preface Layer for Auditing Sensual Interacts of Primary Distress Conceali...The Preface Layer for Auditing Sensual Interacts of Primary Distress Conceali...
The Preface Layer for Auditing Sensual Interacts of Primary Distress Conceali...
 
Classification of EEG Signal for Epileptic Seizure DetectionusingEMD and ELM
Classification of EEG Signal for Epileptic Seizure DetectionusingEMD and ELMClassification of EEG Signal for Epileptic Seizure DetectionusingEMD and ELM
Classification of EEG Signal for Epileptic Seizure DetectionusingEMD and ELM
 
Classification of EEG Signals for Brain-Computer Interface
Classification of EEG Signals for Brain-Computer InterfaceClassification of EEG Signals for Brain-Computer Interface
Classification of EEG Signals for Brain-Computer Interface
 
EEG Mouse:A Machine Learning-Based Brain Computer Interface_interface
EEG Mouse:A Machine Learning-Based Brain Computer Interface_interfaceEEG Mouse:A Machine Learning-Based Brain Computer Interface_interface
EEG Mouse:A Machine Learning-Based Brain Computer Interface_interface
 
018 bci gamma band
018   bci gamma band018   bci gamma band
018 bci gamma band
 
EEG S IGNAL Q UANTIFICATION B ASED ON M ODUL L EVELS
EEG S IGNAL  Q UANTIFICATION  B ASED ON M ODUL  L EVELS EEG S IGNAL  Q UANTIFICATION  B ASED ON M ODUL  L EVELS
EEG S IGNAL Q UANTIFICATION B ASED ON M ODUL L EVELS
 
International Journal of Engineering Research and Development (IJERD)
International Journal of Engineering Research and Development (IJERD)International Journal of Engineering Research and Development (IJERD)
International Journal of Engineering Research and Development (IJERD)
 
Implementation and Evaluation of Signal Processing Techniques for EEG based B...
Implementation and Evaluation of Signal Processing Techniques for EEG based B...Implementation and Evaluation of Signal Processing Techniques for EEG based B...
Implementation and Evaluation of Signal Processing Techniques for EEG based B...
 
Personalization_Effect_Emotion_Recognition
Personalization_Effect_Emotion_RecognitionPersonalization_Effect_Emotion_Recognition
Personalization_Effect_Emotion_Recognition
 
Recognition of emotional states using EEG signals based on time-frequency ana...
Recognition of emotional states using EEG signals based on time-frequency ana...Recognition of emotional states using EEG signals based on time-frequency ana...
Recognition of emotional states using EEG signals based on time-frequency ana...
 
HUMAN EMOTION ESTIMATION FROM EEG AND FACE USING STATISTICAL FEATURES AND SVM
HUMAN EMOTION ESTIMATION FROM EEG AND FACE USING STATISTICAL FEATURES AND SVMHUMAN EMOTION ESTIMATION FROM EEG AND FACE USING STATISTICAL FEATURES AND SVM
HUMAN EMOTION ESTIMATION FROM EEG AND FACE USING STATISTICAL FEATURES AND SVM
 
56x35_oct10
56x35_oct1056x35_oct10
56x35_oct10
 
A0510107
A0510107A0510107
A0510107
 
Brain research journal regional differences nova
Brain research journal regional differences   nova Brain research journal regional differences   nova
Brain research journal regional differences nova
 
Eeg time series data analysis in focal cerebral ischemic rat model
Eeg time series data analysis in focal cerebral ischemic rat modelEeg time series data analysis in focal cerebral ischemic rat model
Eeg time series data analysis in focal cerebral ischemic rat model
 
Transfer learning for epilepsy detection using spectrogram images
Transfer learning for epilepsy detection using spectrogram imagesTransfer learning for epilepsy detection using spectrogram images
Transfer learning for epilepsy detection using spectrogram images
 
Robot Motion Control Using the Emotiv EPOC EEG System
Robot Motion Control Using the Emotiv EPOC EEG SystemRobot Motion Control Using the Emotiv EPOC EEG System
Robot Motion Control Using the Emotiv EPOC EEG System
 
MHEALTH APPLICATIONS DEVELOPED BY THE MINISTRY OF HEALTH FOR PUBLIC USERS INK...
MHEALTH APPLICATIONS DEVELOPED BY THE MINISTRY OF HEALTH FOR PUBLIC USERS INK...MHEALTH APPLICATIONS DEVELOPED BY THE MINISTRY OF HEALTH FOR PUBLIC USERS INK...
MHEALTH APPLICATIONS DEVELOPED BY THE MINISTRY OF HEALTH FOR PUBLIC USERS INK...
 
Spike removal through multiscale wavelet and entropy analysis of ocular motor...
Spike removal through multiscale wavelet and entropy analysis of ocular motor...Spike removal through multiscale wavelet and entropy analysis of ocular motor...
Spike removal through multiscale wavelet and entropy analysis of ocular motor...
 

Recently uploaded

GraphRAG for LifeSciences Hands-On with the Clinical Knowledge Graph
GraphRAG for LifeSciences Hands-On with the Clinical Knowledge GraphGraphRAG for LifeSciences Hands-On with the Clinical Knowledge Graph
GraphRAG for LifeSciences Hands-On with the Clinical Knowledge Graph
Neo4j
 
Crafting Excellence: A Comprehensive Guide to iOS Mobile App Development Serv...
Crafting Excellence: A Comprehensive Guide to iOS Mobile App Development Serv...Crafting Excellence: A Comprehensive Guide to iOS Mobile App Development Serv...
Crafting Excellence: A Comprehensive Guide to iOS Mobile App Development Serv...
Pitangent Analytics & Technology Solutions Pvt. Ltd
 
Y-Combinator seed pitch deck template PP
Y-Combinator seed pitch deck template PPY-Combinator seed pitch deck template PP
Y-Combinator seed pitch deck template PP
c5vrf27qcz
 
Demystifying Knowledge Management through Storytelling
Demystifying Knowledge Management through StorytellingDemystifying Knowledge Management through Storytelling
Demystifying Knowledge Management through Storytelling
Enterprise Knowledge
 
Poznań ACE event - 19.06.2024 Team 24 Wrapup slidedeck
Poznań ACE event - 19.06.2024 Team 24 Wrapup slidedeckPoznań ACE event - 19.06.2024 Team 24 Wrapup slidedeck
Poznań ACE event - 19.06.2024 Team 24 Wrapup slidedeck
FilipTomaszewski5
 
AppSec PNW: Android and iOS Application Security with MobSF
AppSec PNW: Android and iOS Application Security with MobSFAppSec PNW: Android and iOS Application Security with MobSF
AppSec PNW: Android and iOS Application Security with MobSF
Ajin Abraham
 
"Choosing proper type of scaling", Olena Syrota
"Choosing proper type of scaling", Olena Syrota"Choosing proper type of scaling", Olena Syrota
"Choosing proper type of scaling", Olena Syrota
Fwdays
 
Northern Engraving | Nameplate Manufacturing Process - 2024
Northern Engraving | Nameplate Manufacturing Process - 2024Northern Engraving | Nameplate Manufacturing Process - 2024
Northern Engraving | Nameplate Manufacturing Process - 2024
Northern Engraving
 
Session 1 - Intro to Robotic Process Automation.pdf
Session 1 - Intro to Robotic Process Automation.pdfSession 1 - Intro to Robotic Process Automation.pdf
Session 1 - Intro to Robotic Process Automation.pdf
UiPathCommunity
 
Northern Engraving | Modern Metal Trim, Nameplates and Appliance Panels
Northern Engraving | Modern Metal Trim, Nameplates and Appliance PanelsNorthern Engraving | Modern Metal Trim, Nameplates and Appliance Panels
Northern Engraving | Modern Metal Trim, Nameplates and Appliance Panels
Northern Engraving
 
Introduction of Cybersecurity with OSS at Code Europe 2024
Introduction of Cybersecurity with OSS  at Code Europe 2024Introduction of Cybersecurity with OSS  at Code Europe 2024
Introduction of Cybersecurity with OSS at Code Europe 2024
Hiroshi SHIBATA
 
GNSS spoofing via SDR (Criptored Talks 2024)
GNSS spoofing via SDR (Criptored Talks 2024)GNSS spoofing via SDR (Criptored Talks 2024)
GNSS spoofing via SDR (Criptored Talks 2024)
Javier Junquera
 
High performance Serverless Java on AWS- GoTo Amsterdam 2024
High performance Serverless Java on AWS- GoTo Amsterdam 2024High performance Serverless Java on AWS- GoTo Amsterdam 2024
High performance Serverless Java on AWS- GoTo Amsterdam 2024
Vadym Kazulkin
 
Connector Corner: Seamlessly power UiPath Apps, GenAI with prebuilt connectors
Connector Corner: Seamlessly power UiPath Apps, GenAI with prebuilt connectorsConnector Corner: Seamlessly power UiPath Apps, GenAI with prebuilt connectors
Connector Corner: Seamlessly power UiPath Apps, GenAI with prebuilt connectors
DianaGray10
 
"Frontline Battles with DDoS: Best practices and Lessons Learned", Igor Ivaniuk
"Frontline Battles with DDoS: Best practices and Lessons Learned",  Igor Ivaniuk"Frontline Battles with DDoS: Best practices and Lessons Learned",  Igor Ivaniuk
"Frontline Battles with DDoS: Best practices and Lessons Learned", Igor Ivaniuk
Fwdays
 
inQuba Webinar Mastering Customer Journey Management with Dr Graham Hill
inQuba Webinar Mastering Customer Journey Management with Dr Graham HillinQuba Webinar Mastering Customer Journey Management with Dr Graham Hill
inQuba Webinar Mastering Customer Journey Management with Dr Graham Hill
LizaNolte
 
Leveraging the Graph for Clinical Trials and Standards
Leveraging the Graph for Clinical Trials and StandardsLeveraging the Graph for Clinical Trials and Standards
Leveraging the Graph for Clinical Trials and Standards
Neo4j
 
zkStudyClub - LatticeFold: A Lattice-based Folding Scheme and its Application...
zkStudyClub - LatticeFold: A Lattice-based Folding Scheme and its Application...zkStudyClub - LatticeFold: A Lattice-based Folding Scheme and its Application...
zkStudyClub - LatticeFold: A Lattice-based Folding Scheme and its Application...
Alex Pruden
 
Dandelion Hashtable: beyond billion requests per second on a commodity server
Dandelion Hashtable: beyond billion requests per second on a commodity serverDandelion Hashtable: beyond billion requests per second on a commodity server
Dandelion Hashtable: beyond billion requests per second on a commodity server
Antonios Katsarakis
 
A Deep Dive into ScyllaDB's Architecture
A Deep Dive into ScyllaDB's ArchitectureA Deep Dive into ScyllaDB's Architecture
A Deep Dive into ScyllaDB's Architecture
ScyllaDB
 

Recently uploaded (20)

GraphRAG for LifeSciences Hands-On with the Clinical Knowledge Graph
GraphRAG for LifeSciences Hands-On with the Clinical Knowledge GraphGraphRAG for LifeSciences Hands-On with the Clinical Knowledge Graph
GraphRAG for LifeSciences Hands-On with the Clinical Knowledge Graph
 
Crafting Excellence: A Comprehensive Guide to iOS Mobile App Development Serv...
Crafting Excellence: A Comprehensive Guide to iOS Mobile App Development Serv...Crafting Excellence: A Comprehensive Guide to iOS Mobile App Development Serv...
Crafting Excellence: A Comprehensive Guide to iOS Mobile App Development Serv...
 
Y-Combinator seed pitch deck template PP
Y-Combinator seed pitch deck template PPY-Combinator seed pitch deck template PP
Y-Combinator seed pitch deck template PP
 
Demystifying Knowledge Management through Storytelling
Demystifying Knowledge Management through StorytellingDemystifying Knowledge Management through Storytelling
Demystifying Knowledge Management through Storytelling
 
Poznań ACE event - 19.06.2024 Team 24 Wrapup slidedeck
Poznań ACE event - 19.06.2024 Team 24 Wrapup slidedeckPoznań ACE event - 19.06.2024 Team 24 Wrapup slidedeck
Poznań ACE event - 19.06.2024 Team 24 Wrapup slidedeck
 
AppSec PNW: Android and iOS Application Security with MobSF
AppSec PNW: Android and iOS Application Security with MobSFAppSec PNW: Android and iOS Application Security with MobSF
AppSec PNW: Android and iOS Application Security with MobSF
 
"Choosing proper type of scaling", Olena Syrota
"Choosing proper type of scaling", Olena Syrota"Choosing proper type of scaling", Olena Syrota
"Choosing proper type of scaling", Olena Syrota
 
Northern Engraving | Nameplate Manufacturing Process - 2024
Northern Engraving | Nameplate Manufacturing Process - 2024Northern Engraving | Nameplate Manufacturing Process - 2024
Northern Engraving | Nameplate Manufacturing Process - 2024
 
Session 1 - Intro to Robotic Process Automation.pdf
Session 1 - Intro to Robotic Process Automation.pdfSession 1 - Intro to Robotic Process Automation.pdf
Session 1 - Intro to Robotic Process Automation.pdf
 
Northern Engraving | Modern Metal Trim, Nameplates and Appliance Panels
Northern Engraving | Modern Metal Trim, Nameplates and Appliance PanelsNorthern Engraving | Modern Metal Trim, Nameplates and Appliance Panels
Northern Engraving | Modern Metal Trim, Nameplates and Appliance Panels
 
Introduction of Cybersecurity with OSS at Code Europe 2024
Introduction of Cybersecurity with OSS  at Code Europe 2024Introduction of Cybersecurity with OSS  at Code Europe 2024
Introduction of Cybersecurity with OSS at Code Europe 2024
 
GNSS spoofing via SDR (Criptored Talks 2024)
GNSS spoofing via SDR (Criptored Talks 2024)GNSS spoofing via SDR (Criptored Talks 2024)
GNSS spoofing via SDR (Criptored Talks 2024)
 
High performance Serverless Java on AWS- GoTo Amsterdam 2024
High performance Serverless Java on AWS- GoTo Amsterdam 2024High performance Serverless Java on AWS- GoTo Amsterdam 2024
High performance Serverless Java on AWS- GoTo Amsterdam 2024
 
Connector Corner: Seamlessly power UiPath Apps, GenAI with prebuilt connectors
Connector Corner: Seamlessly power UiPath Apps, GenAI with prebuilt connectorsConnector Corner: Seamlessly power UiPath Apps, GenAI with prebuilt connectors
Connector Corner: Seamlessly power UiPath Apps, GenAI with prebuilt connectors
 
"Frontline Battles with DDoS: Best practices and Lessons Learned", Igor Ivaniuk
"Frontline Battles with DDoS: Best practices and Lessons Learned",  Igor Ivaniuk"Frontline Battles with DDoS: Best practices and Lessons Learned",  Igor Ivaniuk
"Frontline Battles with DDoS: Best practices and Lessons Learned", Igor Ivaniuk
 
inQuba Webinar Mastering Customer Journey Management with Dr Graham Hill
inQuba Webinar Mastering Customer Journey Management with Dr Graham HillinQuba Webinar Mastering Customer Journey Management with Dr Graham Hill
inQuba Webinar Mastering Customer Journey Management with Dr Graham Hill
 
Leveraging the Graph for Clinical Trials and Standards
Leveraging the Graph for Clinical Trials and StandardsLeveraging the Graph for Clinical Trials and Standards
Leveraging the Graph for Clinical Trials and Standards
 
zkStudyClub - LatticeFold: A Lattice-based Folding Scheme and its Application...
zkStudyClub - LatticeFold: A Lattice-based Folding Scheme and its Application...zkStudyClub - LatticeFold: A Lattice-based Folding Scheme and its Application...
zkStudyClub - LatticeFold: A Lattice-based Folding Scheme and its Application...
 
Dandelion Hashtable: beyond billion requests per second on a commodity server
Dandelion Hashtable: beyond billion requests per second on a commodity serverDandelion Hashtable: beyond billion requests per second on a commodity server
Dandelion Hashtable: beyond billion requests per second on a commodity server
 
A Deep Dive into ScyllaDB's Architecture
A Deep Dive into ScyllaDB's ArchitectureA Deep Dive into ScyllaDB's Architecture
A Deep Dive into ScyllaDB's Architecture
 

INHIBITION AND SET-SHIFTING TASKS IN CENTRAL EXECUTIVE FUNCTION OF WORKING MEMORY: AN EVENT-RELATED POTENTIAL (ERP) STUDY

  • 1. Signal & Image Processing : An International Journal (SIPIJ) Vol.7, No.1, February 2016 DOI : 10.5121/sipij.2016.7105 43 INHIBITION AND SET-SHIFTING TASKS IN CENTRAL EXECUTIVE FUNCTION OF WORKING MEMORY: AN EVENT-RELATED POTENTIAL (ERP) STUDY Pankaj,1 Jamuna Rajeswaran,1* Divya Sadana1 1 Deptartment of Clinical Psychology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India 560 029 ABSTRACT Understanding of neuro-dynamics of a complex higher cognitive process, Working Memory (WM) is challenging. In WM, information processing occurs through four subsystems: phonological loop, visual sketch pad, memory buffer and central executive function (CEF). CEF plays a principal role in WM. In this study, our objective was to understand the neurospatial correlates of CEF during inhibition and set-shifting processes. Thirty healthy educated subjects were selected. Event-Related Potential (ERP) related to visual inhibition and set-shifting task was collected using 32 channel EEG system. Activation of those ERPs components was analyzed using amplitudes of positive and negative peaks. Experiment was controlled using certain parametric constraints to judge behavior, based on average responses in order to establish relationship between ERP and local area of brain activation and represented using standardized low resolution brain electromagnetic tomography. The average score of correct responses was higher for inhibition task (87.5%) as compared to set-shifting task (59.5%). The peak amplitude of neuronal activity for inhibition task was lower compared to set-shifting task in fronto-parieto-central regions. Hence this proposed paradigm and technique can be used to measure inhibition and set-shifting neuronal processes in understanding pathological central executive functioning in patients with neuro-psychiatric disorders. KEYWORDS Working Memory (WM), Central Executive Function (CEF), Inhibition Task, Set-Shifting Task, Event Related Potential (ERP), sLORETA 1. INTRODUCTION Working memory (WM) is a part of the higher cognitive mental functions (HMFs) [1]. Baddeley and Hitch generated the first model of WM that represents the role of CEF [2]. WM has a temporary storage system that involves small packets of spatially distributed information processing systems [3]. It involves a four subsystem i.e., phonological loop, visual sketch pad, memory buffer and central executive function (CEF) [4]. They integrate to perform the following cognitive functions i.e., temporary storage, learning, reasoning, comprehension, manipulation and updating. This involves various parts of the sensory-motor cortices in the frontoparietal lobes, where the experience is recorded and integrated and subsequently brought to the conscious domain [5]. The information of CEF drifts through these circuits and it is coordinated by neurons in the prefrontal cortex [6]. The CEF is studied as a component of Baddeley’s WM model. It’s further divided in four sub components, inhibition, set-shifting, dual-tasking and updating [7].
  • 2. Signal & Image Processing : An International Journal (SIPIJ) Vol.7, No.1, February 2016 44 Electroencephalography (EEG) measures the electrical activity of the brain from the electrodes on the scalp [8]. Event-related potentials (ERPs) are averaged EEG responses to a specific time- locked stimuli involving complex mental processing. ERPs are used to assess brain function and observe electro-physiological manifestations of cognitive activities in both the time domain and spatial extents. In general, ERPs are typically described in terms of components based on polarity and latency. ERPs provide good temporal resolution to certify studies of any cognitive processes in real time. When the subjects were made to perform tasks involving revision of various memories in short-term which were presented as a specific train of stimulus sequence, the responses could be measured and spatiotemporally correlated real-time using ERP [9]. EEG records the correct and incorrect responses of both the inhibition and set-shifting tasks and the ERPs associated with cognitive process and control potentials in brain are derived from this signal. Overall, the ERPs associated with the task are correlated with CEF activity. CEF of inhibition and set-shifting tasks is manifest in the P200 (or P2), P300 (or P3) and N200 (OR N2) components of the human ERP and EEG maps show peak activity in the fronto-parietal cortices [10]. This study was aimed at understanding the brain dynamics of CEF and to find the spatial neural correlates in CEF during inhibition and set-shifting tasks. For this we designed a paradigm to study the CEF of WM and modelled the EEG signal to find out neural spatial domains during the aforementioned tasks. 2. MATERIAL AND METHODS 2.1. Subjects: We recruited 30 educated healthy subjects (male: female=15:15, right handed, age: 28±5.9years) in NIMHANS (National Institute of Mental Health and Neuroscience, Bangalore, India) for the Event Related Potential (ERP) study. All 30 participants were selected for study after assessing them with clinical interview and normal or corrected vision (Visual Acuity < +1.5/-1.5). A written informed consent was obtained after explaining the tasks and recording procedure. Subjects with history of any neurological and mental disorders and use of substances such as alcohol and tobacco prior to session were excluded. Individuals with frequent headaches or migraine problem were excluded from the study. Completion of tasks was mandatory for inclusion in the analysis. Four participants were excluded due to bad electroencephalography (EEG) signal. 2.2. EEG Data Acquisitions Electroencephalography was recorded using 32 channels Ag-AgCl electrodes arranged to the revised 10-20 system (to improve spatial sampling) and mounted in uniform fit, highly elastic cap (ECI, Electro Cap Int®, USA). EEG signal were acquired by SynAmps amplifier™ and recorded by NeuroScan™ (version 4.4) software. We used mastoid electrodes as reference. Electro- oculographic (EOG) activity was recorded by the electrodes of on the outer canthus of each eye for horizontal and below the left eye for vertical movements. Impedance of input signal of electrode was kept below less than 5kΩ (sampling rate: 1kHz). This study contains one hour EEG session. Before the start of the tasks, 3 minutes rest state EEG recording was done. Both the task paradigms were designed using “Stim2” software (Compumedics® , Neuroscan™). A button box with millisecond accuracy measured the reaction time (RT) for these computerized tasks. 2.3. Paradigm for the Tasks The following two types of tasks were performed followed to eye open and eye close at relax resting condition and measure the CEF process.
  • 3. Signal & Image Processing : An International Journal (SIPIJ) Vol.7, No.1, February 2016 45 2.3.1 Inhibition task: The ‘inhibition task’, subject was shown four geometric different shapes such as a triangle, circle, plus and square in four quadrants of the monitor (Figure 1). The geometric shapes were presented randomly in four quadrants checker board that were positioned in the center of the screen with a white background. The shapes are presented for 800ms at intervals of 200ms. In the four geometric shapes, if triangle ( ) geometric shape comes with black color, then the subject was instructed to press the button 1 or else to continue to press the button 2 of the response box. The participant was instructed to respond as quickly and accurately as possible. The whole inhibition WM task had 160 rounds and 3 minutes of completion. Figure 1. Experimental design for inhibition task. “S” - stimulus, which presented for 800ms, “R” - rest period kept for 200ms, “Target” – Targeted stimuli. 2.3.2 Set-shifting task: In the Set-shifting task, subjects were shown a set of patterns on a monitor (Figure 2). The set- shifting task consisted of three pictures in a row and fourth picture column was left empty. There were four options (1, 2, 3, 4) given to the subject below the pattern. Subject chooses the one of the right option. All pictures were positioned in the center of the screen in a white back ground. The subject were instructed to press the key either “1” or “2” or “3” or “4” with their response. In the task, three patterns (similar, pair, process) were present and among them each pattern had a set of 10 stimuli of similar type which were presented successively. The stimuli were presented for 4000ms at intervals of 1000ms. The participant was instructed to respond as quickly and accurately as possible. The whole set-shifting WM task had 30 rounds and 3minutes of completion. Figure 2. Experimental design for set-shifting task. “S” - stimulus, which presented for 4000ms, “R” - rest period kept for 1000ms. 3. DATA ANALYSIS: 3.1 Pre-processing and Artifact Removal from EEG signal Raw EEG data analysis was performed on Neuroscan™ and MATLAB® software. The data was down-sampled to 250Hz. A cut-off frequency of 0.01 to 60 Hz done by 4th order band pass Butterworth FIR filter [9] and after 50Hz notch filter was applied for power line interference [11] [12]. Preprocessing was done by eye movement artifact correction, muscle artifact correction and
  • 4. Signal & Image Processing : An International Journal (SIPIJ) Vol.7, No.1, February 2016 46 singular value decomposition (SVD) for artifact free data and created linear derivation (LDR) EEG file. The artifact free EEG was epoched to a particular time window for both CEF tasks. In ‘inhibition’ task, EEG file were epoched to a window of 100ms pre-stimulus to 700ms post- stimulus by selecting trigger and in set-shifting task. Low pass filter of 1Hz was applied on these epoched data and were corrected to baseline. High amplitude artifacts were rejected using the artifact rejection criteria of +/-75µV. After artifact rejection, these epochs were averaged in both time and frequency domain. After this, EEG data was taken for further analysis. 3.2 Post Processing for EEG and ERP Signal: ERPs were calculated from the epoched EEG data obtained by time domain averaging. Smoothening was applied on this averaged data. In the electrodes where ERP components were present as per the visual inspection, the ERP components (N200, P200, P300) were identified for inhibition task and set-shifting task. The designated time window for identification of the ERPs, which we considered in the whole experimental tasks were as follows: a) N200 - most negatively deflecting potential occurring 150ms to 250ms after the stimulus, , b) P200 - most positively deflecting potential occurring 150ms to 250ms after the stimulus and c) P300 - most positively deflecting potential occurring 250ms to 350ms after the stimulus. The group averaged EEG files contain all the ERP components to which 2D maps were generated and collected to get the activation areas during both the CEF - Working Memory tasks. We computed the activation value of amplitude in frontal cluster (F3, F7, Fz, F4, F8) and parietal cluster (P3, P7, Pz, P4, P8). The neural activity for inhibition and set-shifting process of central executive function were mapped using “spectopo” functions of EEGLAB on 2D head view. Then the signal was computed for three dimensional cortical distributions on realistic head model with MNI152 template using standardized low resolution brain electromagnetic tomography (sLORETA). This was followed by an appropriate standardization of the current density, producing images of electric neuronal activity without localization bias [13]. sLORETA images represent the electric activity at each voxel in neuroanatomic Talairach space as the squared standardized magnitude of the estimated current density. It was found that in all noise free simulations, although the image was blurred, sLORETA had exact, zero error localization when reconstructing single sources, that is, the maximum of the current density power estimate coincided with the exact dipole location. In all noisy simulations, it had the lowest localization errors when compared with the minimum norm solution and the Dale method [14]. 3.3 Statistics data Analysis: Electrophysiological variables included N200, P200 and P300 peak amplitudes and latencies for Fz and Pz electrodes for both tasks. N200 to P300 latency ratio for inhibition process (Table 1) and P200 to P300 latency ratio for set-shifting process (Table 2) were used for paired T-test statistics. All ERP value found highly significant (>0.05). Table 1. Inhibition task Paired T-test Paired T-test inhibition task frontal electrode stimulus distracter p value t value DF SED P300 P300 0.0001 17.43 58 0.34 N200 N200 0.0001 4.83 58 0.23 parietal electrode stimulus distracter p value t value DF SED P300 P300 0.0001 9.7 58 0.91 N200 N200 0.0482 0.76 58 0.23
  • 5. Signal & Image Processing : An International Journal (SIPIJ) Vol.7, No.1, February 2016 47 Table 2. Set-shifting data Paired T-test Paired T-test set-shifting task frontal electrode value 1 value 2 p value t value DF SED similar P300 pair P300 0.2086 1.27 58 0.61 similar P300 process P300 0.0001 5.18 58 0.56 pair P300 process P300 0.009 2.7 58 0.79 similar P200 pair P200 0.0004 3.73 58 0.18 similar P200 process P200 0.9705 0.03 58 0.215 pair P200 process P200 0.0019 3.25 58 0.212 parietal electrode value 1 value 2 p value t value DF SED similar P300 pair P300 0.0001 4.32 58 0.421 similar P300 process P300 0.0001 5.69 58 0.554 pair P300 process P300 0.0441 2.05 58 0.648 similar P200 pair P200 0.0001 21.46 58 0.208 similar P200 process P200 0.0001 6.73 58 0.292 pair P200 process P200 0.0001 21.46 58 0.307 4. RESULTS: 4.1 Response accuracy: The participants were performed well in CEF tasks. Accuracy and response time were analyzed in inhibition and set-shifting working memory paradigm. Comparative curves were plotted in between the inhibition and set-shifting task. We found that average score of correct response was higher in ‘inhibition task’ (87.5%) in comparison to ‘set-shifting task’ (59.5%). 4.2 ERP Peaks in Inhibition and Set-Shifting Task: (a) (b) Figure 3 Event related Potentials in (a) Inhibition task (b) Set-shifting task.
  • 6. Signal & Image Processing : An International Journal (SIPIJ) Vol.7, No.1, February 2016 48 Figure 3 represents the average ERPs for the N200, P200, P300 components. We measured the amplitudes for fronto-central (Fz) and parieto-central (Pz) electrode. These electrodes were significantly attenuated compared. We found that Fz electrode have less amplitude value than Pz electrode. In comparison of both tasks, inhibition process had less amplitude than set-shifting process. 4.3 EEG ERP results: We found that lower peak amplitude activity of brain area in inhibition process than set-shifting process, which reveals that inhibition process utilize less activation of brain areas to perform tasks. In order to show this, we examined the frontal and parietal activity of brain in same tasks. We found that brain uses the fronto-parietal connectivity when it performs CEF of WM related tasks. We also found that the midline frontal (FZ, F4, F6) and parietal (PZ, P4, P6) electrodes were activated at the same time with prominent pattern of negative potentials and other had positive potentials in both tasks. Figure 4 (a). Neuronal activation in EEGLab® head-view (3D & 2D) for Inhibition task. Figure 4 (b). Neuronal activation in EEGLab® head-view (3D & 2D) for Set-shifting task. Figure 5(a) . Neuronal activation in MNI template for Inhibition task computed from EEG signal. Figure 5 (b). Neuronal activation in MNI template for Set-shifting task computed from EEG signal. Most significant results were found in both tasks. After the post processing we got 3D and 2D head-views in EEGLAB [Figure 4 (a,b)] and sLORETA [Figure 5 (a,b)]. In EEGLAB we
  • 7. Signal & Image Processing : An International Journal (SIPIJ) Vol.7, No.1, February 2016 49 measured the activation on 100, 200 and 300 ms after the stumuli come. In both head-views we found the Inhibition process have less activation on fronto-parietal lobs than set-shifting process. 5. DISCUSSION Till today, a lot of research has been done on both central executive function of working memory but little efforts have been made to find the behavioural and neural connections between the two processes. This study examined the brain activation pattern. We find out ERPs and behavioural interpretations, during the inhibition and set-shifting tasks. In this study our objective was to understand the brain dynamics for CEF of WM functions and find out neural spatial domain in central executive function during inhibition and set-shifting process. The behavioural results showed that among the population of normal individuals, inhibition process score was high in comparison to set-shifting task. These behavioural changes were accompanied by a number of changes in transient ERPs and task related EEG activations. This study is mainly focused on finding the EEG correlation between components of CEF. In EEG findings, by using time domain analysis [15] and bivalent 2-D and 3-D cartoon maps, positive and negative potentials were observed across the pre-frontal, frontal, central and parietal electrodes, during both the tasks. Electric potential distribution on the basis of the scalp recording was measured by sLORETA that compute the cortical three- dimensional smoothest of all possible neural current density distribution, where neighbouring voxels have maximally similar activity. Low Resolution Electromagnetic Tomography (LORETA) is used for source localization, based on R. D. Pascual- Marqui and its virtual MR anatomical images are based on Montreal Neurological Institute (MNI) of McGill University. LORETA is a linear distribution method and it calculates the current density voxel by voxel in the brain as a linear, weighted sum of scalp electrical potential. Computations were made in a realistic head model using the MNI 152 template with the three dimensional solution space restricted to cortical grey matter. The EEG method is the dipole source with fixed location and orientation method and it is distributed in the whole brain volume or cortical surface. There are six parameters that specify the dipole, three special coordinates (x,y,z) and three dipole components (orientation, angle, and strength). In the LORETA, the electrode potentials and matrix X are considered to be related as X=LS Where S is the actual current density and L is Ne×3m matrix representation the forward transmission coefficients form each source to the array of sensors. There are number of sensors Ne, extra cranial measurements in the surface of brain and Nv, voxels in the brain. In the real world applications where more concentrated focal source methods fail and choose smoothness of the inverse solution as S=LT (LLT )X The sloreta uses the minimum norm solution is to create a space solution with zero contribution from the source. However, the variance of the current density estimate is based only on the measurement noise, in contrast to sLORETA , which takes into account the actual source variance as well. Time domain analysis of EEG and ERPs: After averaging in time domain 2-D head maps were taken to represent the surface potential distribution patterns. Central executive WM tasks were
  • 8. Signal & Image Processing : An International Journal (SIPIJ) Vol.7, No.1, February 2016 50 analyzed at both the retrieval and encoding phases in epochs of 800 and 1000ms. Result was seen throughout the whole brain electrodes. In the encoding and retrieval phase of the CEF of WM activation patterns were seen [16]. ERPs comparison studies for inhibition and set-shifting process: Visually evoked potentials (P100) were present throughout the CEF WM task [17]. Delay in early N200 latencies in Fz of encoding showed that visual attention took time. In late P300 peaks in Pz of retrieval phase showed that matching system of visually attend objects. We also found the increase in the amplitude of the frontal visual N200 has been observed in a number of studies, this response shows the Inhibition and attention performance. These delays in ERPs are also observed in 2D and 3D maps in EEGLAB. So we can conclude that functioning of inhibition process is found in fronto-parietal area of brain. In both encoding and retrieval phase of CEF WM all desired ERPs were found. Visually evoked potentials (P100) were seen in parietal area suggesting the stimulus representation extrastriate cortex (BA 6 and 18) [18]. N100 component was seen in frontal and pre-frontal electrodes showing the unpredictability of stimulus. N200 component was present in parietal electrodes. Encoding phase showing delayed N200 latencies but in retrieval phase N200 latencies were shorter due to attending the visual stimuli. Early-latency visual ERPs are enhanced when stimuli are presented in an attended visual field. Reaction times are also shorter to stimuli presented in an attended visual field than to those presented in an unattended visual field. In retrieval phase, delayed P200 latency of Fz electrodes suggesting for a matching system that compares sensory inputs with the stored memory. P200 latencies were present in both phases but most prominently it was elicited in retrieval phase. ERPs analysis is suggested for activation network during CEF of WM. In Encoding phase initial activations occurred in the visual cortex where stimuli were attended for the visual search. The information from the stimuli was coded to the Fz and Pz electrodes as the late P300 peaks were present in the parietal electrodes suggesting the demand of focusing. Likewise, all the ERP patterns were seen in the retrieval phase. The only difference was the delayed P200 latencies suggesting for a matching system related to make comparison of present stimulus with the previous ones. This whole ERPs analysis is consistent with EEGLAB and sLORETA maps achieved in the time domain analysis. So, a network of activation patterns from frontal to parietal area in the both inhibition and set-shifting process of Central Executive Function of Working Memory. 6. CONCLUSION Findings from this study will give a better understanding of CEF and brain activity in inhibition and set-shifting process. Our findings demonstrate a paradigm combined with a technique to be used to measure of inhibition and set-shifting neuronal processes. This would help in under- standing the alteration of central executive function in patient with neurological and psychiatric disorder. ACKNOWLEDGMENT Preparation of this paper was supported by Department of clinical Neuro-psychology, National Institute of Mental Health and Neuroscience (NIMHANS), Bangalore, India. We are grateful to Ganne Chaitanya, Deepak Ullal and Rajnikant Panda for providing thoughtful remarks and suggestions regarding EEG and ERP analysis.
  • 9. Signal & Image Processing : An International Journal (SIPIJ) Vol.7, No.1, February 2016 51 REFERENCES [1] Baddeley, A. (1992). Working memory. Science, 255(5044), 556-559. [2] Baddeley, A. D., & Hitch, G. J. (1974). Working memory. The psychology of learning and motivation [3] Baddeley, A. D. (1983). Working memory. Philosophical Transactions of the Royal Society B: Biological Sciences, 302(1110), 311-324. [4] Baddeley, A. (1996). The fractionation of working memory. Proceedings of the National Academy of Sciences, 93(24), 13468-13472. [5] Miyake, A., Friedman, N. P., Emerson, M. J., Witzki, A. H., Howerter, A., & Wager, T. D. (2000). The unity and diversity of executive functions and their contributions to complex “frontal lobe” tasks: A latent variable analysis.Cognitive psychology, 41(1), 49-100. [6] Collette, F., & Van der Linden, M. (2002). Brain imaging of the central executive component of working memory. Neuroscience & Biobehavioral Reviews, 26(2), 105-125. [7] Delorme, A., & Makeig, S. (2004). EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. Journal of neuroscience methods, 134(1), 9-21. [8] Teplan, M. (2002). Fundamentals of EEG measurement. Measurement science review, 2(2), 1-11. [9] Klingberg, T., O'Sullivan, B. T., & Roland, P. E. (1997). Bilateral activation of fronto-parietal networks by incrementing demand in a working memory task. Cerebral Cortex, 7(5), 465-471. [10] Kalpana, R., Chitra, M.,Kalsi, N., & Panda, R. (2013). ANALYSIS OF BRAIN COGNITIVE STATE FOR ARITHMETIC TASK AND MOTOR TASK USING ELECTROENCE PHALOGRAPHY SIGNAL. Signal & Image Processing, 4(4), 51. [11] Pal, P. R., Khobragade, P., & Panda, R. (2011, January). Expert system design for classification of brain waves and epileptic-seizure detection. In Students' Technology Symposium (TechSym), 2011 IEEE (pp. 187-192). IEEE. [12] Garrett, D., Peterson, D., Anderson, C. W., & Thaut, M. H. (2003). Comparison of linear, nonlinear, and feature selection methods for EEG signal classification.Neural Systems and Rehabilitation Engineering, IEEE Transactions on, 11(2), 141-144. [13] Pascual-Marqui, R. D. (2002). Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. Methods Find Exp Clin Pharmacol, 24(Suppl D), 5-12. [14] Dale, A. M., Liu, A. K., Fischl, B. R., Buckner, R. L., Belliveau, J. W., Lewine, J. D., & Halgren, E. (2000). Dynamic statistical parametric mapping: combining fMRI and MEG for high-resolution imaging of cortical activity. Neuron, 26(1), 55-67. [15] Kenemans, J. L., Molenaar, P., Verbaten, M. N., & Slangen, J. L. (1991). Removal of the ocular artifact from the EEG: a comparison of time and frequency domain methods with simulated and real data. Psychophysiology,28(1), 114-121. [16] Kusak, G., Grune, K., Hagendorf, H., & Metz, A. M. (2000). Updating of working memory in a running memory task: an event-related potential study. International Journal of Psychophysiology, 39(1), 51-65. [17] Luck, S. J., Heinze, H. J., Mangun, G. R., & Hillyard, S. A. (1990). Visual event-related potentials index focused attention within bilateral stimulus arrays. II. Functional dissociation of P1 and N1 components. Electroencephalography and clinical neurophysiology, 75(6), 528-542.
  • 10. Signal & Image Processing : An International Journal (SIPIJ) Vol.7, No.1, February 2016 52 [18] Mueller, A., Candrian, G., Kropotov, J. D., Ponomarev, V. A., & Baschera, G. M. (2010). Classification of ADHD patients on the basis of independent ERP components using a machine learning system. Nonlinear biomedical physics,4(Suppl 1), S1. AUTHORS *The Corresponding author for this paper is Dr. Jamuna Rajeswaran Mr. Pankaj, received M.Tech degree in Cognitive Neuroscience from Centre for Converging Technologies, University of Rajasthan, India, in 2015. He has more than one year of research experience on clinical psychology, Neuro-imaging and EEG signal processing on cognition at National Institute of Mental Health and Neurosciences, Bangalore, India. He has clinical research experience with many National institutes. He also got Mani Bhomik research-fellowship (2015) in National Institute of Advanced Studies (NIAS), Indian Institute of Science campus, Bangalore, India. Dr. Jamuna Rajeswaran, Additional Professor, Consultant & Head Neuropsychology Unit, National Institute of Mental Health and Neurosciences, Bangalore, India. She completed her M.Phil and PhD from Dept. of Clinical Psychology, National Institute of Mental Health and Neurosciences, Bangalore, India. Dr. Divya Sadana, Senior Research Fellow, Department of Clinical psychology, National Institute of Mental Health and Neurosciences, Bangalore, India. She completed her M.Phil and PhD from Dept. of Clinical Psychology, National Institute of Mental Health and Neurosciences, Bangalore, India.