2. Global Operations
World’s #1 glass manufacturer
Approximately 51,500 employees
US $13 billion net sales
200 consolidated subsidiaries in 30 countries
4. Global Product Reach
Chemicals Products and Other
• Caustic soda – soaps
• Sodium bicarbonate
– household detergents
• Sodium hypochlorite
– fungicides, bleach
• Urethanes – automobile seats
• Fluorinated resin films
– solar cells/architectural/agricultural
• Fluorinated resins/elastomers
– coatings/additives/auto/electronics
• Fluorinated water/oil repellents
– textile/non-woven/paper
• Fluorinated intermediates
– pharmaceuticals/agrochemicals
• Fluorinated solvents
– precision cleaning
• Reinforced fluorinated compounds
– auto/electronics/other apps
• Silica gel – personal care products/
chromatography/catalysts support
5. Global Operation of Fine Chemicals Business
Headquarters
Tokyo
Sales and Marketing in Europe
Amsterdam
Sales and Marketing in USA
Exton, PA
6. All Manufacturing Plants are in Japan
cGMP sites (API)
EPA approved (AI)
R&D labs
Pilot plant
Commercial factory
7. Factory for Fine Chemicals – Chiba Factory
CMP (cGMP) Plant
Location
Chiba, Japan
Operation Started
January 2003
(Production & Analysis Site)
Purpose
cGMP multipurpose for
pharma
API & intermediates
8. CMP Major Equipment
Main Points
Ultra-Low temperature reaction(-100 degrees C)
2 line of GL, SUS and HC
Capacity Number Material
Temperature
(degrees)
Reactors
1000~6000L 2 GL -30~180
1000~3000L 7 SUS -100~270
100~1000L 2 HC -100~270
Distillation tower 2500L - SUS -
Centrifuges Φ48 - -
Dryers 1000~1200L - -
Filter Dryers 2000L - SUS -
10. Factory for Fine chemicals – Chiba Factory
FMP (Fluoro Multi Purpose) Plant
Operation Started
FMP1:1984 FMP2:2000
Purpose
Multi-purpose plant
High pressure gas & dangerous goods
Scale-up from lab to production scale
Handling special fluorine raw materials (TFE etc.)
11. Factory for Fine Chemicals – Chiba Factory
Capacity Number Material
Temperature
(degrees)
Reactors
150~480L 2 GL -30~180
60~2400L 7 SUS ~400
550~2400L 3 HC -10~270
8.8L 1 Inconel 500
- Inconel 350
Distillation
tower
150~2400L - SUS -
12. Inspection Record in Chiba Factory
Plant A Plant B
Year License of Manufacturing
Classification:
Biological product
License of
Manufacturing
Classification:
General API
Pre-approval Inspection
General API
2007 Pre-approval
Inspection/PMDA
2008 3
2009 GMP Inspection
/PMDA
3
GMP Inspection for
renewal/Chiba Local
Government
3
2010 2 3 GMP certification for export/
Chiba Local Government
Pre-approval Inspection/TGA
2011 2 4 Pre-approval
Inspection/FDA
2012 2 1 GMP Inspection/PMDA
(Document Inspection)
13. Audit Record in Chiba Factory
Number of Visitors Purpose
Year Japan Overseas QA EMS / BCP Tour
2007 7 2 5
2008 4 1 3
2009 4 2 2
2010 4 5 6 1 2
2011 3 2 4 1
2012 5 1 5 1
14. Factory for Fine Chemicals
– AGC Seimi Chemical
Location
Chigasaki-shi
Kanagawa-ken, Japan
Established
December 18, 1947
Stockholder
Asahi Glass Co.,Ltd.
Purpose
Selective fluorination by electrolytic reaction
Raw materials and intermediates by GMP
15. Ultra low temperature reaction
(-80 degrees C)
Lab to Production scale (MT)
Factory for Fine Chemicals
– AGC Seimi Chemical
16. Capacity Number Material
Temperature
(degrees)
Reactors
100~3000L 12 GL -
100~1000L 11 SUS -50~180
200~500L 4 HC -80~200
160~1500L 2 ETFE -30~120
Distillation
tower
300~1500L - - -
Centrifuges Φ20~36
Dryers 500~800L
Factory for Fine Chemicals
– AGC Seimi Chemical
18. Factory for Fine Chemicals
– AGC Wakasa Chemical
Capacity Number Material
Temperature
(degrees)
Reactors
100~5000L 23 GL -30~150
100~6000L 16 SUS -50~210
300L 1 HC -50~150
Distillation
tower
75~1000L - - -
Centrifuges Φ20~48B
Dryers 200~4000L
Filter Dryers 300~1700L
19. Kaminaka Factory
Location
Kaminaka Mikata
Fukui, Japan
Site area
28,400m2
Established
December 2012
Purpose
Multi purpose plant for intermediates and ingredients for
agrochemicals
Capacity up to 3,000MT per year
Factory for Fine Chemicals
– AGC Wakasa Chemical
21. Factory for Fine Chemicals
– AGC Wakasa Chemical
Capacity Numbers Material
Temperature
(degrees C)
Reactors
3000~8000L 12 GL -30~150
5000~10000L 11 SUS -50~150
7000L 2 HC -50~150
Centrifuges Φ48B
Dryers 3000~4000L
22. Location
Kashima Complex
Ibaraki, Japan
Site area
67,000m2
Established
November, 1968
Purpose
Propylene + Chlorine, C-3 Specialty Chemicals
Capacity up to 3,000MT per year
Factory for C-3 Products – Kashima Chemical
24. Location
Yokohama Kanagawa, Japan
Main Functions
Intellectual Property Investigation
Research for new routes / Development
Study of manufacturing optimums
Scale up
Original API Research
Research Center for Fine Chemicals