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AGC Chemicals Americas, Inc.
Your Global Source for Fine Chemicals
–
Global Operations
World’s #1 glass manufacturer
Approximately 51,500 employees
US $13 billion net sales
200 consolidated subsidiaries in 30 countries
50%
Glass
25%
Electronics
25%
Chemicals/Other
Global Sales #1 global
supplier of flat
and auto glass
Largest global
glass supplier to:
NISSAN
HONDA
TOYOTA
World’s #1
supplier of ETFE
Global Product Reach
Global Product Reach
Chemicals Products and Other
• Caustic soda – soaps
• Sodium bicarbonate
– household detergents
• Sodium hypochlorite
– fungicides, bleach
• Urethanes – automobile seats
• Fluorinated resin films
– solar cells/architectural/agricultural
• Fluorinated resins/elastomers
– coatings/additives/auto/electronics
• Fluorinated water/oil repellents
– textile/non-woven/paper
• Fluorinated intermediates
– pharmaceuticals/agrochemicals
• Fluorinated solvents
– precision cleaning
• Reinforced fluorinated compounds
– auto/electronics/other apps
• Silica gel – personal care products/
chromatography/catalysts support
Global Operation of Fine Chemicals Business
 Headquarters
Tokyo
 Sales and Marketing in Europe
Amsterdam
 Sales and Marketing in USA
Exton, PA
All Manufacturing Plants are in Japan
 cGMP sites (API)
 EPA approved (AI)
 R&D labs
 Pilot plant
 Commercial factory
Factory for Fine Chemicals – Chiba Factory
CMP (cGMP) Plant
Location
Chiba, Japan
Operation Started
January 2003
(Production & Analysis Site)
Purpose
 cGMP multipurpose for
pharma
 API & intermediates
CMP Major Equipment
Main Points
 Ultra-Low temperature reaction(-100 degrees C)
 2 line of GL, SUS and HC
Capacity Number Material
Temperature
(degrees)
Reactors
1000~6000L 2 GL -30~180
1000~3000L 7 SUS -100~270
100~1000L 2 HC -100~270
Distillation tower 2500L - SUS -
Centrifuges Φ48 - -
Dryers 1000~1200L - -
Filter Dryers 2000L - SUS -
CMP Major Equipment
Factory for Fine chemicals – Chiba Factory
FMP (Fluoro Multi Purpose) Plant
Operation Started
FMP1:1984 FMP2:2000
Purpose
 Multi-purpose plant
 High pressure gas & dangerous goods
 Scale-up from lab to production scale
 Handling special fluorine raw materials (TFE etc.)
Factory for Fine Chemicals – Chiba Factory
Capacity Number Material
Temperature
(degrees)
Reactors
150~480L 2 GL -30~180
60~2400L 7 SUS ~400
550~2400L 3 HC -10~270
8.8L 1 Inconel 500
- Inconel 350
Distillation
tower
150~2400L - SUS -
Inspection Record in Chiba Factory
Plant A Plant B
Year License of Manufacturing
Classification:
Biological product
License of
Manufacturing
Classification:
General API
Pre-approval Inspection
General API
2007 Pre-approval
Inspection/PMDA
2008 3
2009 GMP Inspection
/PMDA
3
GMP Inspection for
renewal/Chiba Local
Government
3
2010 2 3 GMP certification for export/
Chiba Local Government
Pre-approval Inspection/TGA
2011 2 4 Pre-approval
Inspection/FDA
2012 2 1 GMP Inspection/PMDA
(Document Inspection)
Audit Record in Chiba Factory
Number of Visitors Purpose
Year Japan Overseas QA EMS / BCP Tour
2007 7 2 5
2008 4 1 3
2009 4 2 2
2010 4 5 6 1 2
2011 3 2 4 1
2012 5 1 5 1
Factory for Fine Chemicals
– AGC Seimi Chemical
Location
Chigasaki-shi
Kanagawa-ken, Japan
Established
December 18, 1947
Stockholder
Asahi Glass Co.,Ltd.
Purpose
 Selective fluorination by electrolytic reaction
 Raw materials and intermediates by GMP
 Ultra low temperature reaction
 (-80 degrees C)
 Lab to Production scale (MT)
Factory for Fine Chemicals
– AGC Seimi Chemical
Capacity Number Material
Temperature
(degrees)
Reactors
100~3000L 12 GL -
100~1000L 11 SUS -50~180
200~500L 4 HC -80~200
160~1500L 2 ETFE -30~120
Distillation
tower
300~1500L - - -
Centrifuges Φ20~36
Dryers 500~800L
Factory for Fine Chemicals
– AGC Seimi Chemical
Obama Factory
Location
Obama Fukui, Japan
Established
April 1998
Factory for Fine Chemicals
– AGC Wakasa Chemical
Factory for Fine Chemicals
– AGC Wakasa Chemical
Capacity Number Material
Temperature
(degrees)
Reactors
100~5000L 23 GL -30~150
100~6000L 16 SUS -50~210
300L 1 HC -50~150
Distillation
tower
75~1000L - - -
Centrifuges Φ20~48B
Dryers 200~4000L
Filter Dryers 300~1700L
Kaminaka Factory
Location
Kaminaka Mikata
Fukui, Japan
Site area
28,400m2
Established
December 2012
Purpose
 Multi purpose plant for intermediates and ingredients for
agrochemicals
 Capacity up to 3,000MT per year
Factory for Fine Chemicals
– AGC Wakasa Chemical
Kaminaka Plant Pictures
Factory for Fine Chemicals
– AGC Wakasa Chemical
Capacity Numbers Material
Temperature
(degrees C)
Reactors
3000~8000L 12 GL -30~150
5000~10000L 11 SUS -50~150
7000L 2 HC -50~150
Centrifuges Φ48B
Dryers 3000~4000L
Location
Kashima Complex
Ibaraki, Japan
Site area
67,000m2
Established
November, 1968
Purpose
 Propylene + Chlorine, C-3 Specialty Chemicals
 Capacity up to 3,000MT per year
Factory for C-3 Products – Kashima Chemical
C3 Compounds (Kashima Chemical)
Location
Yokohama Kanagawa, Japan
Main Functions
 Intellectual Property Investigation
 Research for new routes / Development
 Study of manufacturing optimums
 Scale up
 Original API Research
Research Center for Fine Chemicals
 Building blocks with “F” components
 Heterocyclic compounds
 Fluoroalkylation
 General organic reaction
 Friedel-Crafts
 Grignard
 Cross coupling
 Oxidation / Reduction
 Sulfur chemistry
 Ultra-low temperature
reaction(~ -100℃)
 C3 compounds
Our Technology
 Fluorination technology
 Electrophilic fluorination
 Nucleophilic fluorination
 Halogen exchange
 Diazo-fluorination
 “PERFECT”process
 Electrolytic chemical
fluorination
Our Strength
 Proven track record
 Commercial production
 Advanced technology
 R&D focused
 Serving the following markets:
 Agrochemicals
 Pharmaceuticals
 Co-catalysts
AGC Chemicals Americas, Inc.
Intelligent resins
Custom compounds
Smart chemistry solutions
Rev 01
2/13

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Fine Chemicals and Fluoronated Specialty Chemicals

  • 1. AGC Chemicals Americas, Inc. Your Global Source for Fine Chemicals –
  • 2. Global Operations World’s #1 glass manufacturer Approximately 51,500 employees US $13 billion net sales 200 consolidated subsidiaries in 30 countries
  • 3. 50% Glass 25% Electronics 25% Chemicals/Other Global Sales #1 global supplier of flat and auto glass Largest global glass supplier to: NISSAN HONDA TOYOTA World’s #1 supplier of ETFE Global Product Reach
  • 4. Global Product Reach Chemicals Products and Other • Caustic soda – soaps • Sodium bicarbonate – household detergents • Sodium hypochlorite – fungicides, bleach • Urethanes – automobile seats • Fluorinated resin films – solar cells/architectural/agricultural • Fluorinated resins/elastomers – coatings/additives/auto/electronics • Fluorinated water/oil repellents – textile/non-woven/paper • Fluorinated intermediates – pharmaceuticals/agrochemicals • Fluorinated solvents – precision cleaning • Reinforced fluorinated compounds – auto/electronics/other apps • Silica gel – personal care products/ chromatography/catalysts support
  • 5. Global Operation of Fine Chemicals Business  Headquarters Tokyo  Sales and Marketing in Europe Amsterdam  Sales and Marketing in USA Exton, PA
  • 6. All Manufacturing Plants are in Japan  cGMP sites (API)  EPA approved (AI)  R&D labs  Pilot plant  Commercial factory
  • 7. Factory for Fine Chemicals – Chiba Factory CMP (cGMP) Plant Location Chiba, Japan Operation Started January 2003 (Production & Analysis Site) Purpose  cGMP multipurpose for pharma  API & intermediates
  • 8. CMP Major Equipment Main Points  Ultra-Low temperature reaction(-100 degrees C)  2 line of GL, SUS and HC Capacity Number Material Temperature (degrees) Reactors 1000~6000L 2 GL -30~180 1000~3000L 7 SUS -100~270 100~1000L 2 HC -100~270 Distillation tower 2500L - SUS - Centrifuges Φ48 - - Dryers 1000~1200L - - Filter Dryers 2000L - SUS -
  • 10. Factory for Fine chemicals – Chiba Factory FMP (Fluoro Multi Purpose) Plant Operation Started FMP1:1984 FMP2:2000 Purpose  Multi-purpose plant  High pressure gas & dangerous goods  Scale-up from lab to production scale  Handling special fluorine raw materials (TFE etc.)
  • 11. Factory for Fine Chemicals – Chiba Factory Capacity Number Material Temperature (degrees) Reactors 150~480L 2 GL -30~180 60~2400L 7 SUS ~400 550~2400L 3 HC -10~270 8.8L 1 Inconel 500 - Inconel 350 Distillation tower 150~2400L - SUS -
  • 12. Inspection Record in Chiba Factory Plant A Plant B Year License of Manufacturing Classification: Biological product License of Manufacturing Classification: General API Pre-approval Inspection General API 2007 Pre-approval Inspection/PMDA 2008 3 2009 GMP Inspection /PMDA 3 GMP Inspection for renewal/Chiba Local Government 3 2010 2 3 GMP certification for export/ Chiba Local Government Pre-approval Inspection/TGA 2011 2 4 Pre-approval Inspection/FDA 2012 2 1 GMP Inspection/PMDA (Document Inspection)
  • 13. Audit Record in Chiba Factory Number of Visitors Purpose Year Japan Overseas QA EMS / BCP Tour 2007 7 2 5 2008 4 1 3 2009 4 2 2 2010 4 5 6 1 2 2011 3 2 4 1 2012 5 1 5 1
  • 14. Factory for Fine Chemicals – AGC Seimi Chemical Location Chigasaki-shi Kanagawa-ken, Japan Established December 18, 1947 Stockholder Asahi Glass Co.,Ltd. Purpose  Selective fluorination by electrolytic reaction  Raw materials and intermediates by GMP
  • 15.  Ultra low temperature reaction  (-80 degrees C)  Lab to Production scale (MT) Factory for Fine Chemicals – AGC Seimi Chemical
  • 16. Capacity Number Material Temperature (degrees) Reactors 100~3000L 12 GL - 100~1000L 11 SUS -50~180 200~500L 4 HC -80~200 160~1500L 2 ETFE -30~120 Distillation tower 300~1500L - - - Centrifuges Φ20~36 Dryers 500~800L Factory for Fine Chemicals – AGC Seimi Chemical
  • 17. Obama Factory Location Obama Fukui, Japan Established April 1998 Factory for Fine Chemicals – AGC Wakasa Chemical
  • 18. Factory for Fine Chemicals – AGC Wakasa Chemical Capacity Number Material Temperature (degrees) Reactors 100~5000L 23 GL -30~150 100~6000L 16 SUS -50~210 300L 1 HC -50~150 Distillation tower 75~1000L - - - Centrifuges Φ20~48B Dryers 200~4000L Filter Dryers 300~1700L
  • 19. Kaminaka Factory Location Kaminaka Mikata Fukui, Japan Site area 28,400m2 Established December 2012 Purpose  Multi purpose plant for intermediates and ingredients for agrochemicals  Capacity up to 3,000MT per year Factory for Fine Chemicals – AGC Wakasa Chemical
  • 21. Factory for Fine Chemicals – AGC Wakasa Chemical Capacity Numbers Material Temperature (degrees C) Reactors 3000~8000L 12 GL -30~150 5000~10000L 11 SUS -50~150 7000L 2 HC -50~150 Centrifuges Φ48B Dryers 3000~4000L
  • 22. Location Kashima Complex Ibaraki, Japan Site area 67,000m2 Established November, 1968 Purpose  Propylene + Chlorine, C-3 Specialty Chemicals  Capacity up to 3,000MT per year Factory for C-3 Products – Kashima Chemical
  • 24. Location Yokohama Kanagawa, Japan Main Functions  Intellectual Property Investigation  Research for new routes / Development  Study of manufacturing optimums  Scale up  Original API Research Research Center for Fine Chemicals
  • 25.  Building blocks with “F” components  Heterocyclic compounds  Fluoroalkylation  General organic reaction  Friedel-Crafts  Grignard  Cross coupling  Oxidation / Reduction  Sulfur chemistry  Ultra-low temperature reaction(~ -100℃)  C3 compounds Our Technology  Fluorination technology  Electrophilic fluorination  Nucleophilic fluorination  Halogen exchange  Diazo-fluorination  “PERFECT”process  Electrolytic chemical fluorination
  • 26. Our Strength  Proven track record  Commercial production  Advanced technology  R&D focused  Serving the following markets:  Agrochemicals  Pharmaceuticals  Co-catalysts
  • 27.
  • 28. AGC Chemicals Americas, Inc. Intelligent resins Custom compounds Smart chemistry solutions Rev 01 2/13