This document describes an implantable drug delivery system. Implantable devices are small, sterile solid masses made through compression, molding or extrusion of purified drugs. They are implanted under the skin through minor surgery or injection and provide continuous release of drugs like insulin, steroids, antibiotics over long periods of time. Implantable devices have advantages like controlled drug delivery, improved patient compliance, targeted delivery and bypassing first-pass metabolism but also have disadvantages like requiring minor surgery, inability to easily discontinue therapy and potential device failures. The document goes on to describe different mechanisms of drug release including rate-programmed, feedback-regulated and activation-modulated systems.

1. IMPLANTABLE DRUG DELIVERY SYSTEM
1
Dr. Rajendra gode institute of pharmacy,amravati
By= Shreyash ingole
B.Pharm (7th sem)
Roll no= 85

2. Index 2
A). Introduction
B). Advantages
C). Disadvantages
D). Mechanism of action

3. Diagrametical view of implantable 3

4. A) Introduction 4
i. Implantable are,
a) small
b) sterile
c) solid mass
ii. It consisting of highly purified drug made by,
Compression, Molding or extrusion.
iii. Implantable are implanted into the Subcutaneous membrane of skin
by a minor surgical incision or injected through a large bore needle.

5. s
5
iv. Implantable are developed with a view to provide continuous release
of drug into the bloodstream, over long period of time.
V. Well suitable for drug delivery requirement of
a) Insulin
b) Steroid
c) Heparine
d) Antibiotics ………. etc

6. B) Advantages 6
i. Controlled drug delivery for long period of time.
ii. Improve patient compliance.
iii. Targeted drug delivery.
iv. By passes 1st pass metabolism.
v. Decreased side effect.
vi. Improved stability of drug.
vii. Improve bioavability of drug.
viii. Suitable for avoid pregnancy.

7. C) Disadvantage 7
i. Painful ( Minor surgery ).
ii. Therapy cannot be simply discontinued.
iii. Reaction between host and implant.
iv. Chances of device failure.
v. Limited to potent drug ( particular amount of drug required to cure
or treat the disorder )

8. D) Mechanism of action 8
Classification
1) Rate programmed
drug delivery system
2) Feedback
regulated process
3) Activation
modulated drug
delivery

9. 1) Rate programmed drug delivery system 9
i). Defn = Release of drug from the device is pre programmed at a specific
rate profile.
ii). It divided into three type,
a) Polymer membrane permeation.
b) Matrix diffusion.
c) Matrix hybrid type.

10. a) Polymer membrane permeation 10
i. Drug formulation is encapsulated within a compartment that is
enclosed by rate controlling polymeric membrane.
ii. Drug release by the diffusion through porous membrane/
semipermeable polymeric membrane.
EX= Norplant subdermal implant, ocusert system

11. b) Matrix diffusion 11
i. Drug reservoir is prepared by homogeneously dispersing drug
particle at rate controlling polymeric matrix.
ii. This membrane either made up of lipophilic or hydrophilic.
EX= Nitro-DUR TDDS

12. c) Matrix hybrid type 12
i. It is a hybrid of membrane permeation and matrix diffusion CDDS.
ii. In this dispersion of drug in to the matrix and this matrix is
covered by semipermeable polymer membrane.

13. 2) Feedback regulated process 13
i). The release of drug is activated by a triggering system,such as
biochemical molecule in the body through some feedback mechanism, and
release of drug depend upon the triggering agent.
ii). It is divided into two types,
a) Bio-erosion regulated drug delivery system.
b) Bio-responsive drug delivery system.

14. a) Bio-erosion regulated drug delivery system 14
i. This system consist of a drug dispersed into a bio degradable
polymer matrix like polyvinyl methyl ether and is coated with
immobilized enzyme.

15. b) Bio-responsive drug delivery system 15
i. The drug reservoir is contained in a device enclosed by a
bioresponsive polymer membrane whose permeability to drug
molecule is controlled by concentration of some biochemical agent in
tissue where the system is to be implanted.

16. 3) Activation modulated drug delivery 16
i. The release of drug molecule from delivery system is activated by
some Physical,chemical or biochemical process facilitated by an
external energy supplier.
ii. It can divided into four type,
a) Hydration activated drug delivery system
b) Osmotic pressure activated drug delivery device
c) Vapour pressure activated drug delivery system
d) Hydrolysis activated drug delivery system

17. a) Hydration activated drug delivery system 17
i. Drug reservoir is homogeneously dispersed in a swellable hydrophilic
polymeric matrix
ii. After hydration drug molecule are released through the microscopic
water filled pore channels in the swollen polymeric matrix.
EX = Norgestomet releasing HYDRON implant

18. b) Osmotic pressure activated drug delivery device 18
Fig (1) osmotic pressure implantable

19. 19
i. The drug solution is released a specified opening through orifice, at
constant rate under a controlled of concentration gradient of
osmotic pressure.
ii. It have some sensor to sense and after sensesion it release a drug.
iii. It have flexiable diaphragram to help the release of drug

20. c) Vapour pressure activated drug delivery system 20
Fig (2) vapour pressure implantable system

21. 21
i. This system contain infusate chamber, in which drug can reserve.
ii. Bellows seprated the infusate chamber and vapour pressure
chamber.
iii. The vapour chamber contain a vaporizable fluids which vapouries at
body tempreture and creates a vapour pressure.
iv. Under pressure the bellows move upward and drug solution release
out.

22. d) Hydrolysis activated drug delivery system 22
i. These system is made by a bio erodible polymer such poly(lactide-
glycolide)
ii. Release of drug is activated by hydrolysis of polymer base by tissue
fluid at the implantable site.

23. Thank you