The document discusses ILC Dover's drum transfer system for safely transferring powders from drums. It notes that manually transferring powders from drums poses challenges like heavy lifting, contamination risks, and dust exposure. ILC Dover's system uses a modular, single-use design to lift drums, contain powders, and connect to downstream equipment while protecting workers. Key features include a drum enclosure, lifter, and flexible sleeves that allow adaptable connections to vessels and equipment in a way that contains powders below exposure limits.
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A fundamental consideration for handling and discharge arrangements for cereal products in the chain from field to end of process is that of controlling the generation of fugitive material (dust) into the atmosphere. The need to control dust levels is driven by a number of factors such as the long term health of operators, plant hygiene or plant operational safety (ATEX/DSEAR).
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The encapsulation technology is implemented for ingredients such as vitamins, minerals, sweeteners, phytonutrients, antioxidants, enzymes, probiotics and essential oils, which are highly volatile.
To Read More : https://bit.ly/3tYLY3w
Considerations for reducing risk and increasing containment performanceChargePoint Technology
“High Containment Powder Handling - Considerations for Reducing Risk and Increasing Performance” provides insights for end users on how to increase the containment performance at their facilities by utilising the latest containment technology available.
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Measuring the Impact of the Use of Smartphone Applications in Supporting the Culture of Academic Advising and Guidance of Students in the Educational Technology Department – College of Basic Education
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Dos módulos, 20 y 27 de Junio
informes: hola@bico.mx
@BiCo
FB. BiCo
www.bico.mx
Tel. (81)8348.4195
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Flexibility and modularity. Because food powders and granules feature varying densities and flow characteristics, the conveyor must be modular, and capable of running a variety of different dry materials, such as the sugar, ground coffee, and powdered milk that make up cappuccino mixes.
Machines voor speciale doeleinden
Verwerking van vaste stoffen
Werktuigbouwkunde
Vullen
Ontladen
Doseren
Wegwerp techniek
Transporteren en vullen
Monstername
Vacuümverlader
Vul station
Losplaats
Insluiting
Poedertransport
Stortgoed
Grote zak vullen
Grote zak lossen
afvoerpoort voor groter zak
grote zak losstation
vultrechter voor grote zakken
grote zak station
grote zak vulstation
grote zak navulling
grote zak aansluitsysteem
grote zak los station chemie
grote zak los station pharma
grote zak los systeem
productieplanning
bulk materiaal transportband
grote zak snijder
batterij techniek
poederdosering
Grote zak opslag
Doseren van bulkmateriaal
logistiek van bulkmateriaal
Poeder behandeling
Transporteren van poeder
Batterij productie planning
Containminatie batterij
Pneumatisch transport
Pneumatisch transport techniek
Pneumatisch transport systemen
Poeder transport
Pneumatisch transport systeem
Poeder behandeling
bulk materiaal transport
Vacuüm transport
Transport en vullen
Poeder transport systeem
Machines voor speciale doeleinden
Grondstoffen behandeling
mechanical engineering
Special purpose machines
Solids Handling
mechanical engineering
Filling
discharging
dispensing
Disposable technoglide
Conveying and filling
Sampling
Vacuum forderer
Filling station
Discharging station
Containment
Powder transport
Bulk solids
big bag filling
big bag discharging
discharge gate for big bag
big bag discharge station
filling funnel for big bags
big bag station
big bag filling station
big bag refill
Big Bags Connection System
Big Bag Discharge Station Chemistry
Big Bag Discharge Station Pharma
Big Bag Discharge System
production planning
bulk material conveyor belt
big bag slider
battery technology
powder dosing
big bag silo
Dosing bulk material
bulk material logistics
powder handling
Transfer powder
Battery production planning
Containment Batterie
pneumatic conveying
pneumatic conveying technology
pneumatic conveying systems
Powder conveying
pneumatic conveying system
Powder handling
Bulk material transport
Vacuum conveying
Conveying and filling
Powder Transport System
Special purpose machines
Solids Handling
mechanical engineering
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As technology leader in industrial de-dusting we offer complete and tailor-made solutions in the area of dust removal technology and product recovery.
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Closed processing with single-use technologies is a critical enabler for efficient and robust manufacturing for novel modalities as well as continuous biomanufacturing processing. It can also reduce the dependence on classified clean rooms for traditional modalities. This approach helps to mitigate the risk of contamination by adventitious agents while enhancing operator safety.
In this presentation, we discuss the implementation of closed processing for downstream applications and present the design and performance testing of a single use manufacturing-scale tangential flow filtration system to be able to operate in both functionally and fully closed mode.
In this webinar, you will learn:
• The context of closed processing
• Differences between closed and functionally closed processing
• The drivers for adoption
• Its practical implementation to a TFF step
2. One of the simplest, most convenient and most cost-effective ways to ship, receive,
and store bulk powder ingredients, including active pharmaceutical ingredients
(APIs), intermediates, excipients, and ingredients for buffers and media, is in drums.
The contents of these will need to be transferred before use, and this process can be
challenging. Integrated drum transfer solutions make the process simpler, cleaner,
and faster, improving safety for both workers and patients, as well as protecting any
remaining ingredients for storage.
The Challenges Of Drum Transfer
A great many powder ingredients for pharmaceutical manufacturing are delivered
in large drums, from media ingredients to the APIs themselves. The ingredients
then need to be taken out of the drums and transferred into other containers for the
next step in their use – this includes:
Milling — sifting or particle size reduction
Subdividing — dividing into measured amounts
Repackaging — for customer use
Charging —– transferring to vessels for the next step of processing
Whatever the application for powder transfer, the first challenge faced is handling
the drums. Full drums can be very heavy to lift, and may need to be lifted high
to charge containers or equipment. Unless drums are handled carefully, this puts
workers at risk of injury. Manual handling can also be a slow process, which can
cause delays.
Once the drums are opened, the next challenge is containing the spread of powder
and avoiding contamination. Transferring powder from one container to another
without containment, whether by pouring or scooping, can create plumes of dust.
This may settle on surfaces, including other drums, bags, and packages, and
could cause cross-contamination with other products manufactured in the same
facility. To avoid putting patients at risk from side effects or allergic reactions, areas
where powders are handled will need regular cleaning. Any spills can also lead
to cross-contamination, and could waste expensive ingredients, thereby increasing
production costs and creating challenges for inventory reconciliation.
Dust in the air puts workers at risk, as even inert powders, when inhaled, can
cause lung damage, and active ingredients can cause lung, skin, and eye irritation
or damage, or trigger allergic reactions. Companies transferring materials from
drums need to ensure that their containment levels are within national and regional
3. exposure limits. These will differ according to the content of the drums; for
example, the exposure levels may be for dust for inert buffers and media, and
for toxicity limits for APIs, such as cytotoxics.
Processes may only use part of a drum of powder, and to avoid waste, members
of staff need to be able to return excess powder to the container, seal the drum,
and remove it from the transfer area without affecting the product’s purity.
Creating Solutions
Options for solving powder containment issues need to transfer
the ingredients from the drums to the applications efficiently
and cost-effectively without compromising safety. The
options can be divided into open processing and closed
processing approaches.
Open processing approaches
In an open processing suite, the workers are protected
from powder during drum transfer by wearing personal
protective equipment (PPE), and overall contamination
levels are reduced by using air extraction. However, in
open processing systems, powders can still get into
the air and so the whole of the processing suite requires
regular deep cleaning. Open processing does not reach
the ISPE Containment Community of Practice’s Risk
Based Manufacture of Pharmaceutical Products (Risk-
MaPP) guidelines for manufacturing hazardous compounds.
Closed processing approaches
Closed processing approaches are more effective than open
approaches at containing powders during transfer from the drum,
reducing cross-contamination and allowing manufacturers to meet
cGMP guidelines. One approach is to use a rigid isolator with panels for
operator access, airlocks, and transfer ports. However, their rigid design can
cause ergonomic issues for workers who are shorter or taller than average. Rigid
isolators can be costly to set up and run — the capital outlay is high, and they
need regular cleaning. If needs change or technologies advance, rigid isolators
are difficult to adapt or retrofit.
Disposable single use isolators provide a greater degree of adaptability in set
up and use. The capital investment and cleaning costs are much lower, and
fer
y
en
drum,
to meet
th panels for
Open
processing
does not reach the
ISPE Containment
Community of Practice’s
Risk Based Manufacture of
Pharmaceutical Products
(Risk-MaPP) guidelines
for manufacturing
hazardous
compounds.
4. validation is quicker, as the system uses single-use consumables that can be disposed
of after use. The nature of single use items is that they are flexible, improving the
ergonomics over rigid isolators and making it easier to create seals and connections
between different pieces of equipment. If changes in processes are needed, for
example, production levels go up or down, the required levels of stringency change, or if
a production line created for one product needs to be used
for another one because of project failures or changes
in scheduling, changing the single use enclosures and
bags is a simple process, and may not even need to be
revalidated. Single use systems are also generally easier
to use than rigid systems, so the error rates are lower and
there is less need for time-consuming training.
Using a drum transfer system
While both rigid and single use isolators contain the
powder, protect workers, and reduce the risk of cross-
contamination, they do not necessarily meet the first
challenge, that of handling the heavy drums. ILC Dover’s
drum transfer system has been created to have all the
advantages of single use products, with the added
capability of lifting the drum into place.
The system is made up of a drum enclosure frame
and drum lifter, with options for a variety of different
single use modules, including flexible enclosures that
can allow operator access, drum sleeves linking the drum to the rest of the system,
attachment rings providing secure connections, and a number of different outlets and
transfer sleeves. The drum is connected via disposable drum sleeves and lifted into
place. The outlet sleeve connects to process equipment such as vessels or mills via a
transfer sleeve, or links directly to DoverPacs, allowing completely contained transfer
of product, protecting workers, and reducing product loss. Any excess powder remains
in the drum and can be sealed using the drum liner, ensuring that it remains clean for
its next use.
ILC Dover’s system is completely modular so it can be adapted to existing processes
and equipment, for example, the O-ring canister (see Figure 1 and Figure 2) designed
to introduce the drum to the enclosure is patented and is standard throughout the
company’s product range. The film used for the single use modules is specifically
designed to meet the product contact regulations in the regulatory guidelines. It’s also
Figure 1: ILC Dover’s patented O-ring canister
as used on a drum transfer system
5. One of the applications for the ILC Dover drum
transfer system is in the charging of vessels for the
next step of cGMP (current good manufacturing
practice) processing (see Figure 3 and Figure 4).
This application uses ILC Dover’s disposable conical
transfer sleeve to connect the drum transfer system
and the process vessel. The sleeve is able to connect
securely with standard process equipment and
vessels, and incorporates the DoverLoc, a molded
clamp that secures the liner where it connects to
the drum, minimizing cleaning.
For a clean and secure transfer of powders from the
drum to the process vessel:
Remove the drum lid
Open the inner drum liner
Attach the liner
Position the stainless steel cone on the drum
lifter over the drum
Pull the liner through the cone and attach it with a clamp on the cone
Invert the drum and attach the drum transfer liner to the vessel nozzle
Open the clamp to allow gravity feed of the powder into the vessel for processing
In containment verification studies of the ILC Dover drum transfer station, the test results
showed that the system was able to provide containment of powders below the target
concentration of 1.0 μg/m3
when transferring powder from a drum to a vessel.
Case study:
Charging to vessels
Figure 3: Inlet and outlet
Figure 4: Reactor charge using drum transfer system
6. robust, flexible, and highly transparent, which means that
it can be lowered or raised as required for ergonomics, and
labels and scales remain clearly visible.
Because the frame is lightweight and portable, it can
be moved from place to place, reducing the need for
duplication of equipment. It can even be folded up and
stored away as required, allowing cost-effective use of
valuable space.
ILC Dover’s drum transfer system has been validated
through its real-world use in a range of customer processes
involving contained transfer of materials from drums to
pharmaceutical applications. The company also provides
engineering and service support, including training for
operators.
About DoverPac®
Containment Systems
DoverPac®
Containment Systems, an ILC Dover brand, is the global pioneer
of disposable process and powder containment systems. Launched from a
partnership with multi-national pharmaceutical companies to develop high
containment for API production and oral solid dosage processing, DoverPac®
is the global standard for containment, reliability, and service. We’ve been
providing proven Flexible Containment solutions since 1997 and have over
300,000 installed to date. ILC Dover has state-of-the-art manufacturing facilities
dedicated to the production of the DoverPac®
line including custom designed
sealing equipment capable of producing reliable 3D and 2D heat seals, and an
ISO Class 7 Clean Room. A staff of experienced design engineers permits us
to customize products and create systems to fit your needs while optimizing
worker ergonomics and productivity. Decades of work with NASA give us the
experience to provide the detailed documentation packages, critical quality
data, and certifications required.
Figure 2: Close-up of
ILC Dover’s O-ring canister
Figure 2: Close-up of
ILC Dover’s O-ring canister
7. To correspond directly with the author contact:
Chris Rombach
Biopharm Product Manager
302-335-3911 x792
rombac@ilcdover.com
ILC Dover
www.doverpac.com
customer_service@ilcdover.com