The document describes the relationship between the hypothalamus and pituitary gland. It discusses how the hypothalamus regulates the pituitary through releasing and inhibiting factors that control secretion of anterior pituitary hormones. The pituitary has anterior and posterior lobes, with the anterior secreting hormones that regulate growth, metabolism, and reproduction and the posterior secreting vasopressin and oxytocin which regulate water balance and milk letdown. The hypothalamus and pituitary form a complex regulatory system that controls many other endocrine glands.
The document discusses the hypothalamus and its key roles in regulating the endocrine system. The hypothalamus links the nervous system to the endocrine system through the pituitary gland. It produces hormones that stimulate or inhibit hormone production in the pituitary. The hypothalamus also controls the pituitary and directly secretes hormones to regulate body processes like growth, metabolism, and reproduction. Some of the major hormones it regulates include growth hormone, thyroid stimulating hormone, and gonadotropins. Disorders like acromegaly and gigantism can result from issues with growth hormone regulation.
The document discusses the endocrine system, which controls the body through hormones rather than neurotransmitters like the nervous system. It describes the main endocrine glands that secrete hormones, including the pituitary gland and hypothalamus, which regulate other glands. The pituitary gland has an anterior and posterior lobe; the anterior lobe secretes trophic hormones that stimulate other glands, while the posterior lobe secretes oxytocin and ADH synthesized in the hypothalamus. Hormones allow for slower responses than the nervous system but can target distant organs.
This document provides information about the endocrine system from Chapter 13 of an anatomy textbook. It begins with an overview of the endocrine system compared to the nervous system. It then discusses the major endocrine glands like the pituitary, thyroid, and adrenals. The pituitary is described as the master gland that regulates other endocrine glands through releasing and inhibiting hormones. The chapter outlines the seven hormones produced by the anterior pituitary and their actions, as well as the hormones of the posterior pituitary and thyroid. In summary, the document provides a high-level overview of the key concepts about the endocrine system and its major glands and hormones.
Pituitary gland one of the most important glands for health and normal biological functions inside the body.
This is a very influential gland releases hormones that affect your growth as well as influencing the activities of other glands. For this reason the pituitary gland is often referred to as the master gland.Pituitary secretion is controlled by either hormonal or nervous signals from hypothalamus.
Division in Two Lobes
1-Anterior pituitary (adenohypophysis)
- cells secrete peptide/protein hormones
2-Posterior pituitary (neurohypophysis)
- is an extension of the hypothalamus
- is composed largely of the axons of the hypothalamic neurons
The pituitary gland is located at the base of the brain and is composed of an anterior and posterior lobe. The anterior lobe secretes hormones that regulate other endocrine glands, while the posterior lobe stores and releases hormones from the hypothalamus. The pituitary is linked to and regulated by the hypothalamus via the pituitary stalk. It plays a central role in feedback systems controlling many physiological processes.
Endocrinal functions of hypothalamus and pituitary glandFarhan Ali
The hypothalamic-pituitary unit forms a unique component of the endocrine system that regulates growth, lactation, fluid homeostasis, and the functions of the thyroid gland, adrenal glands, and gonads. The hypothalamus and pituitary gland are anatomically and functionally related through the hypothalamo-hypophyseal tract and hypothalamo-hypophyseal portal system, which allow the hypothalamus to control the anterior and posterior pituitary glands. The hypothalamus regulates various endocrine functions through its control of the anterior and posterior pituitary glands.
The document summarizes the hormones of the pituitary gland. It discusses that the pituitary gland, also known as the master gland, controls other endocrine glands by secreting hormones. These hormones include growth hormone, thyroid stimulating hormone, adrenocorticotropic hormone, prolactin, luteinizing hormone, follicle stimulating hormone, oxytocin, and vasopressin. It provides details on the function and regulation of each hormone. Common diseases associated with hormonal imbalances are also mentioned.
This document summarizes key aspects of insulin and glucagon synthesis and function. It notes that insulin is synthesized as preproinsulin in the pancreatic islets of Langerhans and undergoes processing to form insulin and C-peptide. Insulin regulates glucose and lipid metabolism by promoting glucose uptake and glycogen/lipid synthesis. Glucagon is synthesized in the alpha cells and increases glucose production through glycogenolysis and gluconeogenesis. It also stimulates lipolysis. Somatostatin is synthesized in pancreatic D cells and acts as a paracrine inhibitor of other islet cell hormones.
The document discusses the hypothalamus and its key roles in regulating the endocrine system. The hypothalamus links the nervous system to the endocrine system through the pituitary gland. It produces hormones that stimulate or inhibit hormone production in the pituitary. The hypothalamus also controls the pituitary and directly secretes hormones to regulate body processes like growth, metabolism, and reproduction. Some of the major hormones it regulates include growth hormone, thyroid stimulating hormone, and gonadotropins. Disorders like acromegaly and gigantism can result from issues with growth hormone regulation.
The document discusses the endocrine system, which controls the body through hormones rather than neurotransmitters like the nervous system. It describes the main endocrine glands that secrete hormones, including the pituitary gland and hypothalamus, which regulate other glands. The pituitary gland has an anterior and posterior lobe; the anterior lobe secretes trophic hormones that stimulate other glands, while the posterior lobe secretes oxytocin and ADH synthesized in the hypothalamus. Hormones allow for slower responses than the nervous system but can target distant organs.
This document provides information about the endocrine system from Chapter 13 of an anatomy textbook. It begins with an overview of the endocrine system compared to the nervous system. It then discusses the major endocrine glands like the pituitary, thyroid, and adrenals. The pituitary is described as the master gland that regulates other endocrine glands through releasing and inhibiting hormones. The chapter outlines the seven hormones produced by the anterior pituitary and their actions, as well as the hormones of the posterior pituitary and thyroid. In summary, the document provides a high-level overview of the key concepts about the endocrine system and its major glands and hormones.
Pituitary gland one of the most important glands for health and normal biological functions inside the body.
This is a very influential gland releases hormones that affect your growth as well as influencing the activities of other glands. For this reason the pituitary gland is often referred to as the master gland.Pituitary secretion is controlled by either hormonal or nervous signals from hypothalamus.
Division in Two Lobes
1-Anterior pituitary (adenohypophysis)
- cells secrete peptide/protein hormones
2-Posterior pituitary (neurohypophysis)
- is an extension of the hypothalamus
- is composed largely of the axons of the hypothalamic neurons
The pituitary gland is located at the base of the brain and is composed of an anterior and posterior lobe. The anterior lobe secretes hormones that regulate other endocrine glands, while the posterior lobe stores and releases hormones from the hypothalamus. The pituitary is linked to and regulated by the hypothalamus via the pituitary stalk. It plays a central role in feedback systems controlling many physiological processes.
Endocrinal functions of hypothalamus and pituitary glandFarhan Ali
The hypothalamic-pituitary unit forms a unique component of the endocrine system that regulates growth, lactation, fluid homeostasis, and the functions of the thyroid gland, adrenal glands, and gonads. The hypothalamus and pituitary gland are anatomically and functionally related through the hypothalamo-hypophyseal tract and hypothalamo-hypophyseal portal system, which allow the hypothalamus to control the anterior and posterior pituitary glands. The hypothalamus regulates various endocrine functions through its control of the anterior and posterior pituitary glands.
The document summarizes the hormones of the pituitary gland. It discusses that the pituitary gland, also known as the master gland, controls other endocrine glands by secreting hormones. These hormones include growth hormone, thyroid stimulating hormone, adrenocorticotropic hormone, prolactin, luteinizing hormone, follicle stimulating hormone, oxytocin, and vasopressin. It provides details on the function and regulation of each hormone. Common diseases associated with hormonal imbalances are also mentioned.
This document summarizes key aspects of insulin and glucagon synthesis and function. It notes that insulin is synthesized as preproinsulin in the pancreatic islets of Langerhans and undergoes processing to form insulin and C-peptide. Insulin regulates glucose and lipid metabolism by promoting glucose uptake and glycogen/lipid synthesis. Glucagon is synthesized in the alpha cells and increases glucose production through glycogenolysis and gluconeogenesis. It also stimulates lipolysis. Somatostatin is synthesized in pancreatic D cells and acts as a paracrine inhibitor of other islet cell hormones.
The endocrine system regulates bodily functions through hormone secretion. The major endocrine glands include the hypothalamus, pituitary gland, pineal gland, thyroid gland, thymus, adrenal gland, pancreas and gonads. Hormones are either water-soluble and act through cell surface receptors or lipid-soluble and act inside target cells. The hypothalamus controls the pituitary gland which regulates the thyroid, adrenals and gonads. The thyroid regulates metabolism through thyroid hormones. The parathyroid regulates calcium levels. The adrenals secrete cortisol to regulate stress response and aldosterone to regulate blood pressure and electrolytes.
The pituitary gland and hypothalamus act as a unit to regulate other endocrine glands. The pituitary gland sits in the sphenoid bone below the hypothalamus and is attached by a stalk. It consists of the anterior and posterior pituitary lobes. The hypothalamus influences hormone release from both lobes through releasing and inhibiting hormones. The anterior pituitary secretes hormones that regulate growth, metabolism, and reproductive functions through feedback loops with target glands. The posterior pituitary stores and releases oxytocin and vasopressin secreted by the hypothalamus.
The anterior pituitary gland, also called the adenohypophysis, is divided into two parts: the pars anterior and the tiny pars intermedia. The pars anterior contains five major cell types that secrete different hormones: somatotrophs secrete growth hormone, corticotrophs secrete ACTH, thyrotrophs secrete TSH, lactotrophs secrete prolactin, and gonadotrophs secrete LH and FSH. The hypothalamus controls hormone secretion in the anterior pituitary through releasing and inhibiting hormones that travel via the hypophyseal portal system and stimulate or suppress hormone production.
The pituitary gland is a small gland located at the base of the brain that regulates several important bodily functions. It is divided into anterior and posterior lobes. The anterior lobe secretes hormones that control other endocrine glands and regulate processes like growth, metabolism, and reproduction. These include growth hormone, thyroid stimulating hormone, and adrenocorticotropic hormone. The posterior lobe stores and releases oxytocin and vasopressin, which are produced in the hypothalamus and help regulate water balance and milk release. Disorders of the pituitary can impact hormone levels and cause wide-ranging symptoms.
Hypothalamic, Pituitary and Parathyroid hormonesEneutron
Hypothalamic and pituitary hormones regulate target endocrine glands. Hypothalamic hormones such as TRH and GHRH act on the pituitary to stimulate secretion of pituitary hormones including TSH, GH, and gonadotropins. These pituitary hormones then act on target glands like the thyroid and gonads. There is feedback regulation between peripheral hormones and the hypothalamus and pituitary to control hormone levels. Hormones have various therapeutic uses including treatment of hormone deficiencies and regulating hormone secretion.
The document discusses the endocrine system and hormones. It defines hormones as regulatory substances released by cells to regulate other cells. Hormones can travel through different systems like endocrine, neuroendocrine, and paracrine systems. The key glands of the endocrine system include the hypothalamus, pituitary gland, thyroid gland, parathyroid gland, adrenal glands, pancreas, and gonads. Hormones maintain homeostasis, growth and development, metabolism, and reproduction. The document discusses the different types of hormones like proteins/peptides, steroids, and amines as well as their synthesis and mechanisms of action.
Pathophysiology of parathyroid hormone 2018patriqche
The correct answer is a. Primary hyperparathyroidism. The key findings that point to this diagnosis are:
- Increased serum calcium
- Decreased serum phosphorus
- Increased PTH
- Normal PTHrP
- Hypercalciuria and microhematuria
These lab findings are classic for primary hyperparathyroidism which results from overproduction of PTH by the parathyroid glands.
PHYSIOLOGY
OF
THYROID
HORMONES
Understand the significance of the conversion of tetraiodothyronine (T4) to triiodothyronine (T3) and reverse T3 (rT3) in extrathyroidal tissues.
Understand how thyroid hormones produce their cellular effects.
Describe the physiological effects of thyroid hormones in the body.
Outline the mechanisms for regulation of thyroid hormone.
Correlate knowledge to hypo- and hypersecretion of thyroid hormones
The parathyroid glands are small endocrine glands located on the thyroid gland that secrete parathyroid hormone (PTH) to regulate calcium levels. Primary hyperparathyroidism is usually caused by a solitary parathyroid adenoma. Pre-operative localization with sestamibi scanning is accurate for adenomas. Surgical treatment involves either unilateral or bilateral neck exploration to remove the abnormal gland(s), with minimally invasive radioguided parathyroidectomy being an option for localized disease.
The document provides an overview of the endocrine system, including its functions, major glands, hormones, and mechanisms of action. The endocrine system maintains homeostasis through chemical signaling via hormones, which are secreted into the bloodstream and target distant cells. Hormones are classified based on their structure as steroids, peptides, or amines and act by binding to specific receptors on target cells.
The document discusses the endocrine system, which controls many body functions by releasing hormones into the blood. It describes several endocrine glands such as the pituitary gland, thyroid gland, pancreas, adrenal glands, gonads and ovaries. It also discusses endocrine emergencies like diabetes mellitus and the role of insulin in facilitating glucose entry into cells.
The diencephalon is divided into the thalamus and hypothalamus. It forms the roof and lateral walls of the third ventricle. The thalamus is a relay station for sensory pathways and integrates many functions. The hypothalamus regulates autonomic and endocrine systems and maintains homeostasis. Lesions in different diencephalon structures can cause sensory deficits, movement disorders, and endocrine/metabolic issues.
The pineal gland is a small organ attached to the brain that secretes melatonin. Melatonin helps coordinate circadian rhythm and inhibits growth of sex organs before puberty. The thymus gland is an organ in the chest that produces thymosin and helps educate T-lymphocytes to fight infections. Both glands play important roles in the immune, endocrine, and developmental systems.
The document summarizes the physiology of the adrenal glands, which consist of an outer cortex and inner medulla. The cortex produces mineralocorticoids like aldosterone and glucocorticoids like cortisol. It is regulated by the renin-angiotensin system and HPA axis in response to stress. The medulla produces epinephrine and norepinephrine which increase heart rate and metabolism through beta receptors and constrict blood vessels through alpha receptors. Conditions like Cushing's and Addison's disease result from excess or deficiency of these hormones.
This document discusses the pituitary gland. It begins with an introduction to the functional anatomy and hormones of the anterior pituitary gland. It then describes the gross anatomy and development of the pituitary gland. The document outlines the parts of the pituitary gland including the adenohypophysis and neurohypophysis. It details the histological structure and blood supply of the pituitary gland. The relationship between the hypothalamus and pituitary is examined, including the hypothalamic-pituitary portal system. Finally, the major anterior pituitary hormones are identified as the growth hormone family, glycoprotein hormone family, and pro-opiomelanocortin peptides family.
Adrenocortical hormones by Dr Prafull TureraoPhysiology Dept
The adrenal glands produce three main classes of hormones - glucocorticoids, mineralocorticoids, and adrenal sex steroids. Glucocorticoids such as cortisol are produced in the zona fasciculata and have wide-ranging metabolic effects throughout the body. Their production is regulated by the hypothalamic-pituitary-adrenal axis. Mineralocorticoids like aldosterone are produced in the zona glomerulosa and regulate sodium and potassium balance primarily through their actions in the kidneys. Hyperaldosteronism can result from tumors or other causes that overstimulate aldosterone production.
The endocrine system is made up of ductless glands that secrete hormones directly into the bloodstream to exert chemical control over the body and maintain homeostasis. The hypothalamus acts as the control center of the endocrine system by secreting releasing and inhibiting hormones that stimulate or inhibit hormone production and secretion by the pituitary gland, which then controls other endocrine glands. Examples of releasing hormones include thyrotropin-releasing hormone, gonadotropin-releasing hormone, adrenocorticotropic hormone, growth hormone-releasing hormone, oxytocin, and vasopressin. Inhibiting hormones include growth hormone inhibiting hormone and prolactin release inhibiting hormone.
The document summarizes the hormones of the hypothalamic-pituitary axis. It describes the major classes of hormones, their functions, regulation, and pharmacological applications. The hypothalamus controls the pituitary gland, which secretes hormones like growth hormone, prolactin, thyroid-stimulating hormone, and adrenocorticotropic hormone to regulate other endocrine glands. Gonadotropin-releasing hormone controls the release of follicle-stimulating hormone and luteinizing hormone from the pituitary. The posterior pituitary secretes oxytocin and vasopressin/antidiuretic hormone in response to physiological signals.
The endocrine system regulates whole body function through hormones. Hormones are released by endocrine glands and circulate through the bloodstream to target sites. Key endocrine glands include the hypothalamus, pituitary, thyroid, parathyroid, adrenals, pancreas, ovaries/testes. The pituitary gland regulates other glands through releasing hormones like TSH, FSH, LH, ACTH, and GH. Thyroid hormones T3 and T4 regulate metabolism, and calcitonin regulates calcium levels. The parathyroid secretes PTH which increases calcium absorption and resorption from bones.
The document discusses the pituitary gland and its functions. It begins by describing the location and structure of the pituitary gland, noting that it is divided into the anterior and posterior pituitary. It then explains the origin and structure of each lobe. The document goes on to describe the hormones produced by the anterior pituitary, including growth hormone, prolactin, follicle-stimulating hormone, luteinizing hormone, thyroid-stimulating hormone, adrenocorticotropic hormone, and melanocyte-stimulating hormone. It also discusses the hormones of the posterior pituitary, antidiuretic hormone and oxytocin, and their functions. Finally, it briefly mentions the pineal gland and its hormone melatonin.
The endocrine system regulates bodily functions through hormone secretion. The major endocrine glands include the hypothalamus, pituitary gland, pineal gland, thyroid gland, thymus, adrenal gland, pancreas and gonads. Hormones are either water-soluble and act through cell surface receptors or lipid-soluble and act inside target cells. The hypothalamus controls the pituitary gland which regulates the thyroid, adrenals and gonads. The thyroid regulates metabolism through thyroid hormones. The parathyroid regulates calcium levels. The adrenals secrete cortisol to regulate stress response and aldosterone to regulate blood pressure and electrolytes.
The pituitary gland and hypothalamus act as a unit to regulate other endocrine glands. The pituitary gland sits in the sphenoid bone below the hypothalamus and is attached by a stalk. It consists of the anterior and posterior pituitary lobes. The hypothalamus influences hormone release from both lobes through releasing and inhibiting hormones. The anterior pituitary secretes hormones that regulate growth, metabolism, and reproductive functions through feedback loops with target glands. The posterior pituitary stores and releases oxytocin and vasopressin secreted by the hypothalamus.
The anterior pituitary gland, also called the adenohypophysis, is divided into two parts: the pars anterior and the tiny pars intermedia. The pars anterior contains five major cell types that secrete different hormones: somatotrophs secrete growth hormone, corticotrophs secrete ACTH, thyrotrophs secrete TSH, lactotrophs secrete prolactin, and gonadotrophs secrete LH and FSH. The hypothalamus controls hormone secretion in the anterior pituitary through releasing and inhibiting hormones that travel via the hypophyseal portal system and stimulate or suppress hormone production.
The pituitary gland is a small gland located at the base of the brain that regulates several important bodily functions. It is divided into anterior and posterior lobes. The anterior lobe secretes hormones that control other endocrine glands and regulate processes like growth, metabolism, and reproduction. These include growth hormone, thyroid stimulating hormone, and adrenocorticotropic hormone. The posterior lobe stores and releases oxytocin and vasopressin, which are produced in the hypothalamus and help regulate water balance and milk release. Disorders of the pituitary can impact hormone levels and cause wide-ranging symptoms.
Hypothalamic, Pituitary and Parathyroid hormonesEneutron
Hypothalamic and pituitary hormones regulate target endocrine glands. Hypothalamic hormones such as TRH and GHRH act on the pituitary to stimulate secretion of pituitary hormones including TSH, GH, and gonadotropins. These pituitary hormones then act on target glands like the thyroid and gonads. There is feedback regulation between peripheral hormones and the hypothalamus and pituitary to control hormone levels. Hormones have various therapeutic uses including treatment of hormone deficiencies and regulating hormone secretion.
The document discusses the endocrine system and hormones. It defines hormones as regulatory substances released by cells to regulate other cells. Hormones can travel through different systems like endocrine, neuroendocrine, and paracrine systems. The key glands of the endocrine system include the hypothalamus, pituitary gland, thyroid gland, parathyroid gland, adrenal glands, pancreas, and gonads. Hormones maintain homeostasis, growth and development, metabolism, and reproduction. The document discusses the different types of hormones like proteins/peptides, steroids, and amines as well as their synthesis and mechanisms of action.
Pathophysiology of parathyroid hormone 2018patriqche
The correct answer is a. Primary hyperparathyroidism. The key findings that point to this diagnosis are:
- Increased serum calcium
- Decreased serum phosphorus
- Increased PTH
- Normal PTHrP
- Hypercalciuria and microhematuria
These lab findings are classic for primary hyperparathyroidism which results from overproduction of PTH by the parathyroid glands.
PHYSIOLOGY
OF
THYROID
HORMONES
Understand the significance of the conversion of tetraiodothyronine (T4) to triiodothyronine (T3) and reverse T3 (rT3) in extrathyroidal tissues.
Understand how thyroid hormones produce their cellular effects.
Describe the physiological effects of thyroid hormones in the body.
Outline the mechanisms for regulation of thyroid hormone.
Correlate knowledge to hypo- and hypersecretion of thyroid hormones
The parathyroid glands are small endocrine glands located on the thyroid gland that secrete parathyroid hormone (PTH) to regulate calcium levels. Primary hyperparathyroidism is usually caused by a solitary parathyroid adenoma. Pre-operative localization with sestamibi scanning is accurate for adenomas. Surgical treatment involves either unilateral or bilateral neck exploration to remove the abnormal gland(s), with minimally invasive radioguided parathyroidectomy being an option for localized disease.
The document provides an overview of the endocrine system, including its functions, major glands, hormones, and mechanisms of action. The endocrine system maintains homeostasis through chemical signaling via hormones, which are secreted into the bloodstream and target distant cells. Hormones are classified based on their structure as steroids, peptides, or amines and act by binding to specific receptors on target cells.
The document discusses the endocrine system, which controls many body functions by releasing hormones into the blood. It describes several endocrine glands such as the pituitary gland, thyroid gland, pancreas, adrenal glands, gonads and ovaries. It also discusses endocrine emergencies like diabetes mellitus and the role of insulin in facilitating glucose entry into cells.
The diencephalon is divided into the thalamus and hypothalamus. It forms the roof and lateral walls of the third ventricle. The thalamus is a relay station for sensory pathways and integrates many functions. The hypothalamus regulates autonomic and endocrine systems and maintains homeostasis. Lesions in different diencephalon structures can cause sensory deficits, movement disorders, and endocrine/metabolic issues.
The pineal gland is a small organ attached to the brain that secretes melatonin. Melatonin helps coordinate circadian rhythm and inhibits growth of sex organs before puberty. The thymus gland is an organ in the chest that produces thymosin and helps educate T-lymphocytes to fight infections. Both glands play important roles in the immune, endocrine, and developmental systems.
The document summarizes the physiology of the adrenal glands, which consist of an outer cortex and inner medulla. The cortex produces mineralocorticoids like aldosterone and glucocorticoids like cortisol. It is regulated by the renin-angiotensin system and HPA axis in response to stress. The medulla produces epinephrine and norepinephrine which increase heart rate and metabolism through beta receptors and constrict blood vessels through alpha receptors. Conditions like Cushing's and Addison's disease result from excess or deficiency of these hormones.
This document discusses the pituitary gland. It begins with an introduction to the functional anatomy and hormones of the anterior pituitary gland. It then describes the gross anatomy and development of the pituitary gland. The document outlines the parts of the pituitary gland including the adenohypophysis and neurohypophysis. It details the histological structure and blood supply of the pituitary gland. The relationship between the hypothalamus and pituitary is examined, including the hypothalamic-pituitary portal system. Finally, the major anterior pituitary hormones are identified as the growth hormone family, glycoprotein hormone family, and pro-opiomelanocortin peptides family.
Adrenocortical hormones by Dr Prafull TureraoPhysiology Dept
The adrenal glands produce three main classes of hormones - glucocorticoids, mineralocorticoids, and adrenal sex steroids. Glucocorticoids such as cortisol are produced in the zona fasciculata and have wide-ranging metabolic effects throughout the body. Their production is regulated by the hypothalamic-pituitary-adrenal axis. Mineralocorticoids like aldosterone are produced in the zona glomerulosa and regulate sodium and potassium balance primarily through their actions in the kidneys. Hyperaldosteronism can result from tumors or other causes that overstimulate aldosterone production.
The endocrine system is made up of ductless glands that secrete hormones directly into the bloodstream to exert chemical control over the body and maintain homeostasis. The hypothalamus acts as the control center of the endocrine system by secreting releasing and inhibiting hormones that stimulate or inhibit hormone production and secretion by the pituitary gland, which then controls other endocrine glands. Examples of releasing hormones include thyrotropin-releasing hormone, gonadotropin-releasing hormone, adrenocorticotropic hormone, growth hormone-releasing hormone, oxytocin, and vasopressin. Inhibiting hormones include growth hormone inhibiting hormone and prolactin release inhibiting hormone.
The document summarizes the hormones of the hypothalamic-pituitary axis. It describes the major classes of hormones, their functions, regulation, and pharmacological applications. The hypothalamus controls the pituitary gland, which secretes hormones like growth hormone, prolactin, thyroid-stimulating hormone, and adrenocorticotropic hormone to regulate other endocrine glands. Gonadotropin-releasing hormone controls the release of follicle-stimulating hormone and luteinizing hormone from the pituitary. The posterior pituitary secretes oxytocin and vasopressin/antidiuretic hormone in response to physiological signals.
The endocrine system regulates whole body function through hormones. Hormones are released by endocrine glands and circulate through the bloodstream to target sites. Key endocrine glands include the hypothalamus, pituitary, thyroid, parathyroid, adrenals, pancreas, ovaries/testes. The pituitary gland regulates other glands through releasing hormones like TSH, FSH, LH, ACTH, and GH. Thyroid hormones T3 and T4 regulate metabolism, and calcitonin regulates calcium levels. The parathyroid secretes PTH which increases calcium absorption and resorption from bones.
The document discusses the pituitary gland and its functions. It begins by describing the location and structure of the pituitary gland, noting that it is divided into the anterior and posterior pituitary. It then explains the origin and structure of each lobe. The document goes on to describe the hormones produced by the anterior pituitary, including growth hormone, prolactin, follicle-stimulating hormone, luteinizing hormone, thyroid-stimulating hormone, adrenocorticotropic hormone, and melanocyte-stimulating hormone. It also discusses the hormones of the posterior pituitary, antidiuretic hormone and oxytocin, and their functions. Finally, it briefly mentions the pineal gland and its hormone melatonin.
The document discusses the endocrine system and several endocrine glands. It provides details on the pituitary gland, including that it is the master gland of the body located in the skull. It regulates other glands by producing hormones like growth hormone, TSH, ACTH, and gonadotropins. The document also discusses the thyroid gland located in the neck, which regulates metabolism through production of T3 and T4 hormones. The pancreas is described as having both exocrine and endocrine functions, with its endocrine role being regulation of glucose through insulin secretion.
The document discusses the pituitary gland and pituitary diseases. It begins by providing an overview of the pituitary gland, noting that it is located at the base of the brain and controls other endocrine glands by releasing hormones into the bloodstream. It then discusses specific pituitary diseases including anterior and posterior pituitary hypofunction, as well as pituitary hyperfunction. Anterior pituitary hypofunction can be caused by tumors, vascular issues, or trauma/infection and results in hormone deficiencies. Posterior pituitary hypofunction impacts antidiuretic hormone and causes diabetes insipidus. Pituitary hyperfunction includes excess secretion of hormones like prolactin, growth hormone, ACTH, and TSH, leading to conditions such as acromegaly, Cushing
This document summarizes key concepts about the endocrine system and hormone function. It describes the major endocrine glands like the hypothalamus, pituitary gland, thyroid gland, parathyroid gland, adrenal glands, pancreas and reproductive organs. It explains the different classes of hormones, the mechanisms of hormone action, and feedback loops involved in hormonal regulation. Key hormone types and their functions are defined, including examples like insulin, glucagon, estrogen and mechanisms of hormonal disorders.
The document summarizes the major hormone systems in the human body, including the hypothalamic-pituitary axis and peripheral endocrine glands. It describes the roles and mechanisms of action of key hormones like thyroid hormones, insulin, estrogen and progesterone. It also discusses hormone-related diseases that can arise from deficiencies or excesses of hormones, such as hyperthyroidism, hypothyroidism, and diabetes.
The pituitary gland, also known as the hypophysis, is located at the base of the brain and is divided into the anterior and posterior pituitary. The posterior pituitary stores and releases two hormones, antidiuretic hormone and oxytocin, which are produced in the hypothalamus. The anterior pituitary produces six hormones that are regulated by hypothalamic releasing and inhibiting hormones: growth hormone, adrenocorticotropic hormone, thyroid stimulating hormone, prolactin, follicle stimulating hormone, and luteinizing hormone. These hormones control important metabolic and reproductive functions throughout the body.
This document provides an overview of the endocrine system. It describes that the endocrine system uses hormones to regulate body functions more slowly than the nervous system. The key endocrine glands discussed are the pituitary gland, thyroid gland, parathyroid gland, adrenal glands, pancreas, ovaries and testes. For each gland, the document outlines the hormones produced, their actions in the body, and how their secretion is controlled by feedback mechanisms in the endocrine and nervous systems.
The document summarizes the key aspects of the endocrine system. It discusses the two main control systems - the nervous system and the endocrine system. It then focuses on the endocrine system, describing the endocrine glands and hormones. The mechanisms of hormone action and classifications of hormones are explained. Finally, it provides overviews of specific endocrine glands including the pituitary gland, thyroid gland, parathyroid glands, and adrenal glands.
Here is detailed description of pituitary gland, its hormone and its functions in human body. Pituitary gland is also called master gland. This assignment will tell you about the location, size, principle, weight and different lobes of hormones. The study is taken from different internet sources and published paper. Hope it will help you and will give you the knowledge which you want.
The document summarizes key aspects of the endocrine system. It describes the main differences between the nervous and endocrine systems. It then discusses the pituitary gland and its role in regulating other endocrine glands like the thyroid, adrenals, and gonads through the release of hormones. The document also explains the functions of important hormones including growth hormone, thyroid hormones, insulin, glucagon, progesterone, estrogen, and cortisol.
The document discusses several endocrine disorders and conditions involving hormone imbalances. It covers disorders of the pituitary gland like gigantism and acromegaly caused by excess growth hormone, as well as diabetes insipidus caused by excess antidiuretic hormone. Disorders of the thyroid like Graves' disease, and of the adrenal glands like Cushing's syndrome and Addison's disease are also outlined. The effects and roles of various hormones produced by these and other endocrine glands like the pancreas and gonads are described.
1. Hormones are chemical messengers that influence the functional activity of target tissues when carried through the bloodstream. The endocrine system secretes hormones internally via glands like the pituitary, thyroid, and adrenals, while the nervous system uses electrical signals.
2. Hormones bind to receptors on target cells and initiate intracellular responses like increasing cyclic AMP levels, which then modify the cell's actions. For example, thyroid stimulating hormone increases thyroid hormone production.
3. Hormone dysfunction can cause diseases. Too much or too little of hormones like growth hormone, thyroid hormones, insulin, and cortisol lead to disorders like acromegaly, hypothyroidism, diabetes, and Cushing
The endocrine system regulates physiological activities through hormones secreted by glands. There are four types of chemical messengers: endocrine messengers (hormones), paracrine messengers (act locally), autocrine messengers (control source cells), and neurocrine messengers (neurotransmitters and neurohormones). The pituitary gland located at the base of the brain regulates many other glands. It has an anterior and posterior lobe; the anterior lobe secretes hormones that regulate other glands while the posterior lobe stores hormones from the hypothalamus. Major hormones discussed include prolactin, growth hormone, thyroid stimulating hormone, and antidiuretic hormone.
Role of hypothalamus and Pituitary-1.pptxMr SACHIN
The document summarizes the roles of the hypothalamus and pituitary gland. It describes how the hypothalamus regulates body functions like temperature and hunger through both nervous and endocrine connections. The hypothalamus communicates with the pituitary gland via the hypothalamic-pituitary axis, releasing regulatory factors that stimulate hormone production in the anterior and posterior pituitary. The anterior pituitary produces hormones that target various organs, while the posterior pituitary stores hormones produced in the hypothalamus like ADH and oxytocin.
The document summarizes the key aspects of the endocrine system in 3 paragraphs or less.
The endocrine system communicates regulatory messages within the body using hormones, which are chemical signals secreted into the bloodstream. It works alongside the nervous system, with some chemicals serving as both hormones and neurotransmitters. Hormones bind to receptors to elicit physiological responses through various signaling pathways and feedback loops.
The major glands of the endocrine system and their hormones are described. The hypothalamus and pituitary gland form a key regulatory axis, with the hypothalamus controlling the pituitary which releases hormones that target other glands. Glands release hormones that control processes like metabolism, development, and responses to stress.
The document summarizes the key aspects of the endocrine system in 3 paragraphs or less.
The endocrine system communicates regulatory messages within the body using hormones, which are chemical signals secreted into the bloodstream. It works alongside the nervous system, with some chemicals serving as both hormones and neurotransmitters. Hormones bind to receptors to elicit physiological responses through feedback loops.
Major glands of the endocrine system include the hypothalamus and pituitary gland in the brain, which regulate other glands. The thyroid and parathyroid glands control calcium and metabolism. The pancreas regulates blood sugar through insulin and glucagon. The adrenal glands and gonads produce hormones for stress response and sexual development
The document discusses the neuroendocrine system, which involves the nervous system and endocrine system working together to control and regulate various functions in the body. It describes the major endocrine glands - the hypothalamus and pituitary gland, thyroid gland, parathyroid gland, adrenal gland, and pancreas. It explains how each gland secretes specific hormones that help regulate processes like metabolism, growth, and electrolyte balance. The concentration of hormones in the blood depends on the rates of secretion from the glands and removal by the liver and kidneys. Hormones act by binding to receptors on target tissues.
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
Histololgy of Female Reproductive System.pptxAyeshaZaid1
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Giloy, also known as Guduchi or Amrita in classical Ayurvedic texts, is a revered herb renowned for its myriad health benefits. It is categorized as a Rasayana, meaning it has rejuvenating properties that enhance vitality and longevity. Giloy is celebrated for its ability to boost the immune system, detoxify the body, and promote overall wellness. Its anti-inflammatory, antipyretic, and antioxidant properties make it a staple in managing conditions like fever, diabetes, and stress. The versatility and efficacy of Giloy in supporting health naturally highlight its importance in Ayurveda. At Planet Ayurveda, we provide a comprehensive range of health services and 100% herbal supplements that harness the power of natural ingredients like Giloy. Our products are globally available and affordable, ensuring that everyone can benefit from the ancient wisdom of Ayurveda. If you or your loved ones are dealing with health issues, contact Planet Ayurveda at 01725214040 to book an online video consultation with our professional doctors. Let us help you achieve optimal health and wellness naturally.
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Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
2. Objectives
• Describe the physiologic and anatomic
relationships between the
hypothalamus and pituitary.
• Identify the hypothalamic releasing
and inhibitory factors controlling the
secretion of each of the anterior
pituitary hormones.
• Know the posterior & anterior pituitary
hormones, their functions and
conditions that result from deficiency
and oversecretion
3. Hypothalamus and pituitary
This consortium forms the most
complex and dominant portion of the
entire endocrine system
Output of this unit regulates the
function of the thyroid gland, adrenal
gland and also shares in control of
somatic growth, lactation, milk
secretion and water metabolism
5. Hypothalamic function
Plays a key role in the regulation of
pituitary function
It receives afferents from
◦ Thalamus
◦ Limbic system
◦ reticular formation
◦ Eyes
◦ Neocortex
7. Embryological development of the pituitary
1. The hypophysis is an amalgam of two tissues.
2. Early in gestation a finger of ectoderm grows upward from the
roof of the mouth.
3. This protrusion is called Rathke's pouch and will develop into the
anterior pituitary or adenohypophysis.
4. Another finger of ectodermal tissue envaginates ventrally from the
developing brain.
5. This extension of the ventral brain will become the posterior
pituitary or neurohypophysis.
6. The two tissues grow into one another and become tightly
apposed
9. Anatomy
Pituitary lies in the sella turcica of
sphenoid bone below hypothalamus at
base of brain
Blood supply is from the superior and
inferior hypophyseal arteries
There is a portal system from the
median eminence
Pituitary has two lobes the anterior
and the posterior
10. Anterior
pituitary/Adenohypophysis
Traditionally cells are divided into
chromophobes and chromophils
Chromophobes contain and secrete
IL6
Chromophils are further divided into
basophils and acidophils
Acidophils secrete GH and Prolactin
while basophils secrete ACTH, TSH,
LH, and FSH
Histology
11. Neuroendocrine roles
The neurohypophysis is an extension
of the hypothalamus.
◦ neurohypophysis (posterior or neural
pituitary).
◦ It composed of bundles of axons from
hypothalamic neurosecretory neurons
intermixed with glial cells.
2 hormones ADH and oxytocin are
synthesised in the hypothalamus, stored
and secreted by posterior pituitary
12.
13. cntd
Close connections with the ANS allow
coordination btwn ANS and pituitary
function
Therefore pituitary function can be
influenced by pain, sleep, emotion,
light and possibly thought
HP axis is under the influence of blood
borne substances and neural input
14. Hypophysiotropic hormones
These are hormones secreted by the
hypothalamus which influence pituitary
function
They are either releasing or inhibiting
factors
The hormones include CRH, TRH,
GHRH, GnRH, Dopamine, serotonin
15. Anterior pituitary is exposed to higher
concentration of these hormones than
blood
Most are peptides except dopamine
It was once believed that each factor
was responsible for release of one
pitiutary hormone.
However, this is not the case
16.
17. TRH increases prolactin release and
somatostatin can inhibit release of
TSH in addition to GH
Dopamine (PIF) inhibit prolactin
secretion
20. Post Pituitary
It is responsible for secretion of
vasopressin and oxytocin
These are nonapeptides or
octapeptides depending on whether
cysteine or cystine is considered
The structures of the two hormones
are similar, with 2 different amino acid
residues
They are synthesised in the
hypothalamus
21. Post Pituitary
Vasopressin is synthesised mainly in
the SON and oxytocin is synthesised
mainly in the PVN, although both
nuclei produce each hormone
Due to the similarity in structure
vasopressin has 20% of the activity of
oxytocin and oxytocin has 0.5% to 1%
of the activity of vasopressin
23. What would happen to the
secretion of posterior pituitary
hormones if there was
transection of the connection
between the hypothalamus and
pituitary gland?
24. Arginine vasopressin(ADH)
Basically involved in the regulation of
water balance and blood pressure
Acts on 3 receptors V1 (V1a, V1b), V2
and (V3)
V2 is through the mediation of cAMP
and V1 (IP3 and DAG)
25. Physiological effects of ADH
Increases permeability of collecting
ducts to water
Increases urea reabsorption in the
inner medullary collecting duct
Increase sodium absorption in TAL by
activating the NaK-2 Cl transporter
26.
27. Physiological effects of ADH
Vasoconstriction
Increases glycogenolysis in the liver
Depresses the cardiovascular centres
Increases ACTH secretion from
corticotrophes (stress)
Increases synthesis of factor VIII and
vWF
28.
29. Increasing permeability of
collecting ducts to water
Through V2 receptors(cAMP)
Involves insertion of water channels in
the luminal membrane known as
aquaporins
There are several types of aquaporins:
1, 2, 3, 6 and 7 are found in the
kidney, 4 in the brain and 5 in salivary
glands
Vasopressin acts to increase the
concentration of aquaporin 2 on
membranes
30. Stimuli which increase the
secretion of vasopressin
Increased osmotic pressure of
plasma
Decreased ECF volume(at least
20 %), (via cardiopulmonary
receptors)
Angiotensin II,
Pain, emotion,stress
31. Stimuli which increase the
secretion of vasopressin include
Nausea and vomiting
Standing,
Adrenergic stimuli
Nicotine,
Morphine,
Carbamazepine
Exercise
35. Syndrome of Inappropriate ADH
secretion (SIADH)
Due to inappropriately elevated ADH
that cause water retention in excess of
Na+
Excess water causes dilutional
hyponatremia
36. Causes of SIADH
Malignancy eg lung ,
gastrointestinal,renal
Trauma –head injury , post surgery
Cerebrum diseases eg infections like
meningitis
Stimulation of volume receptors like in
artificial ventilation
Drug induced eg
thiazides,chlorpropamide
Infections eg pneumonia
37. (SIADH)
Diseases in the lung also decrease
tonic inhibition of ADH secretion
leading to an increase in ADH
secretion
This will result in hyponatremia
Excessive ECF volume will be lowered
by the ‘escape phenomenon’
It is treated using demeclocycline
38. Features of the syndrome
Hyponatremia (Na+ < 135 mmol/L)
Hypotonicity ( osmolality
<280moSm/kg )
Urine osmolality (>100moSm/kg)
Increased urinary Na+
excretion(>40mmol/L)
39. Diabetes Insipidus
Is due to deficient secretion of ADH
The symptoms are polyuria and
polydipsia
It can be neurogenic or nephrogenic
40. Nephrogenic DI
One interesting form of this condition is
inherited X – Linked receessive
Gene for V2 is located on the X
chromosome
It can also be due to lithium or
hypercalcemia or hypokalemia
It does not respond to desmopressin (a
vasopressin analogue)
It can be treated using thiazide diuretics
41. Nephrogenic DI
It can be treated using thiazide
diuretics
How do thiazides act???
42. Oxytocin
Is derived from oxy- meaning rapid
and tocia meaning labour
Acts on oxytocin receptors(PLC)
which uses Ca ++ as a second
messenger
43. Actions of Oxytocin
On the mammary gland: it is important for
the milk let down reflex
Augmentation of labour by increasing
uterine contractions
Ejaculation in males
May be involved in luteolysis
May be responsible for propulsion of
sperms in the female during or after
intercourse
44. Secretion can be increased by
Suckling
Stimulation of female external
genitalia and cervix
Thought of the baby, (tender thoughts)
Cervical dilatation
45. Pregnancy
Progesterone decreases synthesis of
oxytocin receptors
Towards labour estrogen increases
the synthesis of oxytocin receptors in
the myometrium
46. Side effects of oxytocin overdose
Water intoxication
Neonatal jaundice
Uterine overstimulation-uterine rupture
Hypotension (transient)
47. Secretion decreased by
Pain or physical discomfort
Breast feeding under embarrassing
circumstances
Fear and anger
49. Anterior Pituitary
Hormones secreted by the gland
appear to divide into 3 groups
A) ACTH Related peptides
e.g. ACTH, B endorphin, B
Lipotropin , B MSH
B) Glycoproteins
eg FSH, TSH and LH
C) Somatomammotropins
50. Glycoproteins
They have two subunits an alpha and
beta
Alpha subunits are identical or closely
similar and they do not have biological
activity
Beta chains confer hormone specificity
Beta chains alone have little biological
activity
53. GH
Secreted by somatomammotrophs of
pituitary
Wide range of metabolic activity which
may involve every type of cell
Some of its effects are mediated by
somatomedins
GH release is controlled by GHRH
and GHIH (somatostatin)
55. Structure
Gene for GH is on chr 17
hGH has intrinsic lactogenic activity
GH is bound to a protein in plasma
that is a large fragment of EC domain
of receptors
Concentration of fragment is an index
of number of GH receptor in the
tissues
About half of GH is protein bound and
the T1/2 is 6 – 20 mins
56.
57. Effects of GH
In liver
◦ RNA synthesis is increased
◦ Increased protein synthesis
◦ Increased gluconeogenesis, glycogenolysis
◦ Increased somatomedin
◦ In Adipose tissue
◦ Decreased glucose uptake
◦ Increased lipolysis; hence decreased adiposity
58. In Muscle
Decreased glucose uptake
Increased amino acid uptake
Increased protein synthesis
Anti insulin effect in muscle
Increased lean body mass
Increased calcium absorption in
Gastrointestinal tract and decreased
sodium and potassium excretion in
kidney
59. Somatomedins
Polypeptide growth factors secreted
by liver and other tissues
Principal circulating somatomedins are
- IGF I (somatomedin C)
- IGF II
They are closely related to insulin but
C chains are not separated
60. Somatomedins (cont.)
There are 6 binding proteins
IGF I is mainly bound to IGFBP 3
(95%).
GH increases synthesis of this protein
The protein directs IGF to their
specific receptors
IGF receptor is similar to that of insulin
IGFs are essential for embyronic
development
61. Effects of Somatomedins
Increase protein sythesis
Increase RNA synthesis
Increase DNA synthesis
Increase cell size and number
This leads to increased organ size and
function
62. Effects on chrondrocytes
Increased amino acid uptake
Increase protein synthesis
Increase RNA synthesis
Increase DNA synthesis
Increase collagen
Increase chrondoiton sulfate
Increase cell size and number
This increases linear growth
64. Control of GH release
Stimulation
◦ Glucose and free fatty acid decrease
◦ Increase in amino acids
◦ Fasting and prolonged caloric deprivation
◦ Deep sleep
◦ Exercise
65. Cntd
Estrogens and androgens
Dopamine and serotonin
Alpha adrenergic agonists
Enkephalins
Stress (due to pain, surgery,
psychogenic)
68. Physiology of growth
Growth is a complex process
It is also affected by thyroid hormones,
insulin, glucocorticoids, nutrition and
genetic factors
69. Role of nutrition
Food supply is the most important
extrinsic factor affecting growth
A diet should be adequate in proteins,
vitamins and calories
Fasting and protein deprivation
decreases IGF secretion
Age at which deficiency occurs is of
importance
70. Growth Periods
In humans there are two periods of rapid
growth which are
i) Infancy and
ii) Late puberty before growth stops
The 2nd growth spurt is due to GH, sex
hormones, and cessation of growth due to
closure of epiphyses
Sex hormones increase spikes of IGF I
release
71. In infants there is episodic growth
Thyroid hormones are critical during
this period
Thyroid hormones potentiate the
action of IGF I and are permissive to
the effects of GH.
They are necessary for normal GH
secretion
72. Insulin is also important for growth.
When deficient, IGF I secretion is
decreased
Adrenocortical hormones other than
androgens have a permissive effect
on growth
However, Glucocorticoid treatment
can slow or stop growth in children
73. Catch Up Growth
In periods of severe stress like
illnesses children do not grow
They will be below the expected
averages compared to peers of the
same age
They will, after they recover,
experience a period of growth which is
greater than average to catch up with
their peers – catch up growth
74. Short Stature
Short stature can be due to
i) GHRH deficiency
ii) GH deficiency
iii) Deficient secretion of IGF I
iv) Other causes
Isolated GH deficiency is usually due
to deficient GHRH
75. Laron Dwarfs
Is due to GH insensitivity due to loss
of function mutation in the receptor
The plasma IGF I and IGFBP 3 are
decreased, while the concentration of
GH is either normal or increased
76. African Pygmies
They have a normal GH level and a modest
decrease in plasma level of GHBP
Plasma [IGF I] fails to increase at the time
of puberty
However, they experience less growth than
non pygmy controls throughout the pre
pubertal period
Explanation for short stature is still
unsettled
77. Other Causes of short stature
Cretinism
Precocious Puberty
Gonadal dysgenesis (Turner’s
Syndrome)
Chronic abuse and neglect can cause
dwarfism (Psychosocial dwarfism –
Kasper Hauser Syndrome)
Achondroplasia
78. Achondroplasia
It is the most common form of
dwarfism in humans
It is characterised by short limbs and a
normal trunk
It is inherited Autosomal Dominant
with complete penetrance
It is due to a mutation that codes for
fibroblast growth factor receptor 3
(FGFR3)
81. Prolactin
Is a hormone principally concerned
with stimulating breast development
and milk production
It is secreted by acidophils and it has
receptors which resemble those for
GH
It is unique in that it is under
predominant inhibition from the
hypothalamus by dopamine
82. Control of Secretion
Secretion is stimulated by
◦ Sleep
◦ Nursing
◦ Breast stimulation in non lactating women
◦ Stress
◦ Hypoglycemia
◦ Exercise
83. cntd
Pregnancy
TRH (hypothyroidism)
Estrogens
Sexual intercourse in women
Histamine antagonists (H2) eg
cimetidine
-Dopamine antagonists
84. Factors decreasing secretion
Dopamine
L Dopa
Apomorphine
Bromocriptine and related ergot
derivatives
Prolactin
85. Effects of Prolactin
Stimulating breast development (done
in concert with other hormones like
estrogens, progesterone, cortisol, GH)
Causes milk production secretion from
breast after estrogen and
progesterone priming (increases
synthesis of casein and lactalbumin)
Inhibits action of gonadotropins
86. Effects of prolactin
dysfunction
In women prolactin deficiency
produces an inability to lactate
Hypersecretion of prolactin causes
hyperprolactenemia
87. Hyperprolactinemia
Is caused by chromophobe adenoma,
damage to pituitary stalk and tumors
secreting prolactin
It is characterised by
◦ Loss of menses, decreased libido
◦ Anovulation
◦ Infertility and less often
◦ Galactorrhea (lactation unassociated with
pregnancy).
◦ Gynecomastia is uncommon
88. Excessive production of GH
Leads to either gigantism or
acromegaly
Gigantism occurs when there is an
excessive secretion before epiphyses
close and acromegaly occurs after
epiphyseal closure
Is usually due to microadenomas of
the GH secreting cells in the pituitary
89. Acromegaly-features
Enlarged hands and feet (spade like
hands)
Prognathism,coarse facial features,
bulbous nose, prominent bony ridges
Hirsutism
-Gynecomastia and lactation
Osteoarthritic vertebral changes
92. B MSH, B Lipotropin
Function of B lipotrophin is unsettled
but it may be for mobilisation of fats
MSH is important for skin
pigmentation
It increases synthesis of melanin
It is under the control of hypothalamus
via MIF
ACTH can also cause skin
pigmentation
94. Pituitary Insufficiency
It is usually caused by tumors of
anterior pituitary and suprasellar cysts
Pituitary infarction can also lead to
pituitary insufficiency (Sheehan’s
syndrome, hemorrhagic fevers)
95. Clinical Features
It is characterised by
◦ Growth inhibition
◦ Hypothyroidism
◦ Hypogonadism
◦ Inability to cope with stress
◦ Pallor
96. Other Anterior Pituitary
Hormones
Regulate the function of peripheral
glands
i) TSH – thyroid gland
ii) ACTH – adrenal cortex
iii) Gonadotropins – Gonads
These will be covered in subsequent
lectures
Hypothalamus:portion of the brain that contains a number of small nuclei with a variety of functions, secretes hormones n chemicals
Dorsal: Relating to the back or posterior of a structure
hypophyseal portal system:system of blood vessels in the brain that connects the hypothalamus with the anterior pituitary.
A plexus is a branching network of vessels or nerves
-Thalamus: large mass of gray matter in the brain, relay motor and sensory signals to the cerebral cortex
-limbic system are involved in motivation, emotion, learning, and memory.
reticular formation plays a central role in states of consciousness ie alertness and sleep higher-order brain functions ie cognition,
-neocortex-a part of the cerebral cortex concerned with sight and hearing, regarded as the most recently evolved part of the cortex.
The third ventricle is one of four connected fluid-filled cavities comprising the ventricular system within the mammalian brain
Diencephalon:region of the embryonic vertebrate neural tube that gives rise to anteriorforebrain structures including the thalamus, hypothalamus, posterior portion of the pituitary gland, and pineal gland.
Apposed, side by side
-The sphenoid bone is one of the eight bones that make up the cranium (braincase) – superior (above) aspect of the skull
Sella turcica: saddle-shaped depression in the body of the sphenoid bone of the human skull
-median eminence: part of the hypothalamus from which regulatory hormones are released, connects hypothal & pitu.
The hypophyseal portal system is a system of blood vessels in the microcirculation at the base of the brain, connecting the hypothalamus with the anterior pituitary.
A chromophobe is a histological structure that does not stain readily, and thus appears relatively pale under the microscope
acidophil- (of a cell or its contents) readily stained with acid dyes.
Basophil- ((of a cell or its contents) readily stained with basic dyes.) eg haematoxylin
TRH-Thyrotropin Rele
ACTH=adrenocorticotropin rel
The glial cells surround neurons and provide support for and insulation between them.
Histology-SON- supraopti nuclei, PVN- paraventricular nerve
Astrocytes-type of glial cell
The pituitary regions: pars distalis (anterior lobe), pars intermedia (interm lobe), pars nervosa (neural lobe or neurohypophysis).
Dopamine is an amine derived frm tyrosine (not peptide)
GnRH responsible 4 LH & FSH eg
TSH-Thyroid stimulating hormone
HPA –Hypothalamic Pituitary axis
Feedback systems
Cysteine is a signal peptide
PVN-paraventricular nuclei….SON-Supraoptic nuclei
Imagine u take overdose of vasopressin, or u have a tumor secreting & u’re preg??
Too much oxyto will as well overlap into vasopressin activities (oedema)
Diff in Arg #8 aa names vasopressin as such
Not expected to knw the a.a seq neh
Initial transient diabetes insipidus (loss of water) since therz decrease in ADH 1st from the damaged pituitary stalk then they pick up again, coz nw from hypothala they will be released straight into the system
Vee 1, 2 and 3 receptors
TAL-Thin ascending limb
A diuretic promotes diuresis, that is, the increased production of urine. So ADH limits dilute urine loss (retains water)
V1- PIP &DAG V2- cAMP
Water balance & blood volume/pressure
-AVP (vasoconstriction. It binds 2 V1 receptors on vascular smooth muscle to cause vasoconstriction through the IP3 signal transduction
Acts on glycogenolysis thru V1 receptors, ca 2 influx
-Hypovolemia, as occurs during hemorrhage and dehydration, results in a decrease in atrial pressure so ADH helps restore vWF)
-Lower plasma osmotic pressure induces intracellular edema, so increased leads to deficiency in water n ADH comes into play
-Angiotensin is a peptide hormone that causes vasoconstriction and an increase in blood pressure.(blood vol reg)
-The adrenergic receptors are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine (noradrenaline) and epinephrine (adrenaline).fight-or-flight response, which includes dilating the pupil, increasing heart rate
-antidepressants, & other inhibitors, nicotine,, carbamazepine increase ADH by stimulation of V1 and V2 receptors, V1 mainly responsible for vasoconstriction, V2 for the antidiuretic effect.
Osmolarity is the solute concentration in the blood (blood cells, minerals eg sodium etc), so when concentrated they have to be absorbed into the cells
Fibrous neurons in the heart send signal for decreased blood vol
Treats physhosis, motion, disruptive behaviours, -interfers with ADH like alcohol, increase loss of water
the rest and digest system, the parasympathetic system conserves energy as it slows the heart rate, increases intestinal and gland activity, and relaxes sphincter muscles in the gastrointestinal tract.(depresses cardiovascular centres)
Very low Na concn
Vasopressin escape is characterized by a sudden increase in urine volume with a decrease in urine osmolality independent of circulating vasopressin levels
With low solutes, ADH is not released, thus causing water loss from the body
Neurogenic is due to lack of ADH prodn in the SON Supra optic nuclei hypothala causing polyuria
Receptor problem
They cause contraction of ECF hence stimulate fluid retention mech n try 2 restore Na n total body water
ADH absorbs water. In nephrogenic diabetes insipidus, the kidney is unresponsive to ADH.What do you then?You use a drug called thiazide.Thiazide diuretics inhibit the NaCl co-transporter in the renal distal convoluted tubule (DCT).The DCT is water impermeable.. So the DCT action is NOT how thiazides preserve water.Then what is preserving water?The antidiuretic action of thiazides is secondary to increased renal sodium excretion. The renal sodium loss causes extracellular volume contraction leading to lowered GFR and increased proximal tubular sodium and water reabsorption. Hence, less water and solutes are delivered to the distal tubule and collecting duct and are lost as urine.
PLC=phospholipase C
Luteolysis=luteal regression (corpus L degradation)
In pharmacological doses can cause transient vasodilation
MSH=Melanostimulating hormone
Somatomedins= prtns that are involved in growth promotion & division in response to GH
EC domain=extracellular
any of a group of peptides found in the liver and in other tissues which mediate the effect of growth hormone (somatotropin)
Arginine, glutamate circulating a.as that is
class of sympathomimetic agents that selectively stimulates alpha adrenergic receptors.
Enkephalins-enkephalin: Naturally occurring peptide that has potent painkilling effects and is released by neurons in the central nervous system and by cells in the adrenal
-GH cld reduces obesity through its actions on two enzymes which control fat accumulation and the breakdown of stored triglycerides into free fatty acids bt nw GH is inhibited in obesity
GH secretion is inhibited by the excess leptin levels in obesity
-obesity disrupts the physiological and pathological factors that regulate, suppress or stimulate GH release
-Several hypotheses have been put forth regarding how obesity-associated hyperinsulinemia may suppress GH production
?
GH receptor mutation, or grwth hormone insensitivity
A pygmy is a member of an ethnic group whose average height is unusually short; anthropologists define pygmy as a member of any group where adult men are on average less than 150 cm. Pple from Central Africa
Cretinism-severely stunted physical and mental growth owing to untreated congenital deficiency of thyroid hormone (congenital hypothyroidism)
Kasper Hauser syndr- German guy who grew up in isolation in a dark cell. Deficient Statural, Intellectual, and Social Growth Induced by Child Abuse
Normal trunk??
homophilic
L-Dopa- L-DOPA is a direct precursor to dopamine, and its supplementation can increase dopamine levels in the body
Apomorphine- dopa agonist
Uncommon=rare
Prognathism is the positional relationship of the mandible or maxilla to the skeletal base where either of the jaws protrudes beyond a predetermined imaginary line in the coronal plane of the skull.
Hirsutism is excessive body hair in men and women on parts of the body where hair is normally absent or minimal, such as on the chin or chest in particular
-visual field impairment frequently leads to binocular vision difficulties
-Proximal myopathy presents as symmetrical weakness of proximal upper and/or lower limbs