HIPEC, or hyperthermic intraperitoneal chemotherapy, is a treatment for advanced cancers that have spread to the peritoneum. It involves delivering heated chemotherapy directly into the peritoneal cavity during cytoreductive surgery to remove any visible tumors. HIPEC aims to treat any remaining microscopic disease. Heating the chemotherapy to 41-42°C allows it to penetrate deeper tissues and more effectively kill cancer cells compared to normal intraperitoneal or intravenous chemotherapy alone. While HIPEC is effective, it is also associated with increased risks of complications due to the combined effects of surgery, chemotherapy, and localized hyperthermia.