HPV inefection , HPV disease prevention, Cervical cancer prevention , Cervical cancer treatment, Female cancer , Female cancer prevention , Uterine cancer , Cancer in india
UPDATE HPV Vaccination IN Cervical Cancer Prevention Dr Sharda Jain Lifecare Centre
Cervical Cancer In India: A Preventable Tragedy That Requires Urgent Attention
It is estimated that in India, about 160 million women aged 30-59 years are at risk of developing cervical cancer, with fatality rate of 50 per cent
HPV Vaccination, Cerviocal Cancer : Do we need it
for Prevention of cervical cancer &
other HPV related diseasesm,
Presentation Outlines
Cervical cancer disease burden
Prevention with HPV vaccination
Vaccination of sexually active women
Opportunity of Postpartum HPV vaccination
Importance of genital warts prevention
Real world effectiveness data
Safety of HPV vaccine
On 4 March 2022, International Human Papilloma Virus (HPV) Day, the Cancer Association of South Africa (CANSA) supports the International Papillomavirus Society’s (IPVS) #OneLessWorry campaign, that aims to raise awareness of the virus, and the tools to overcome it, such as screening and vaccination programmes. HPV can cause cancer and is responsible for almost half a million deaths globally each year.
#OneLessWorry #HPV #EliminateCervicalCancer #CANSACervicalCancerAwareness
Find out more:
https://cansa.org.za/cervical-cancer/
Current knowledge and state of the art about management of abnormal cervical Cancer screening tests and cancer precursors for health providers in low-income settings is presented.
Welcoming remarks by Dr Osborne E Nyandiva on Symposium: Cervical cancer and its prevention
Co-Presenter Dr Giama. We are happy to present to you this very crucial discussion on Cancer.
Cervical cancer is a type of cancer that develops in a woman's cervix (the entrance to the womb from the vagina).
Cancer of the cervix often has no symptoms in its early stages. If you do have symptoms, the most common is unusual vaginal bleeding, which can occur after sex, in between periods or after the menopause.
Say no to cervical cancer-PUBLIC Awareness-Life Care Centre_Dr.Sharda JainLifecare Centre
Cervical Cancer in INDIA
Say no to cervical cancer
Dr.Sharda Jain
Life Care Centre
PUBLIC Awareness_Dr.Sharda Jain
HPV Infection
HPV Vaccination
Cervical Screening
SEE & TREAT Programme tp Prevent Cervical Cancer
Cervical Cancer is common worldwide , ranking 3rd among all malignancies for women.
Second leading cause of cancer death.
Most of these cancers stem from infection with the Human Pappiloma Virus (HPV).
UPDATE HPV Vaccination IN Cervical Cancer Prevention Dr Sharda Jain Lifecare Centre
Cervical Cancer In India: A Preventable Tragedy That Requires Urgent Attention
It is estimated that in India, about 160 million women aged 30-59 years are at risk of developing cervical cancer, with fatality rate of 50 per cent
HPV Vaccination, Cerviocal Cancer : Do we need it
for Prevention of cervical cancer &
other HPV related diseasesm,
Presentation Outlines
Cervical cancer disease burden
Prevention with HPV vaccination
Vaccination of sexually active women
Opportunity of Postpartum HPV vaccination
Importance of genital warts prevention
Real world effectiveness data
Safety of HPV vaccine
On 4 March 2022, International Human Papilloma Virus (HPV) Day, the Cancer Association of South Africa (CANSA) supports the International Papillomavirus Society’s (IPVS) #OneLessWorry campaign, that aims to raise awareness of the virus, and the tools to overcome it, such as screening and vaccination programmes. HPV can cause cancer and is responsible for almost half a million deaths globally each year.
#OneLessWorry #HPV #EliminateCervicalCancer #CANSACervicalCancerAwareness
Find out more:
https://cansa.org.za/cervical-cancer/
Current knowledge and state of the art about management of abnormal cervical Cancer screening tests and cancer precursors for health providers in low-income settings is presented.
Welcoming remarks by Dr Osborne E Nyandiva on Symposium: Cervical cancer and its prevention
Co-Presenter Dr Giama. We are happy to present to you this very crucial discussion on Cancer.
Cervical cancer is a type of cancer that develops in a woman's cervix (the entrance to the womb from the vagina).
Cancer of the cervix often has no symptoms in its early stages. If you do have symptoms, the most common is unusual vaginal bleeding, which can occur after sex, in between periods or after the menopause.
Say no to cervical cancer-PUBLIC Awareness-Life Care Centre_Dr.Sharda JainLifecare Centre
Cervical Cancer in INDIA
Say no to cervical cancer
Dr.Sharda Jain
Life Care Centre
PUBLIC Awareness_Dr.Sharda Jain
HPV Infection
HPV Vaccination
Cervical Screening
SEE & TREAT Programme tp Prevent Cervical Cancer
Cervical Cancer is common worldwide , ranking 3rd among all malignancies for women.
Second leading cause of cancer death.
Most of these cancers stem from infection with the Human Pappiloma Virus (HPV).
Polycythemia is a rare bone marrow disorder, which causes the increase in the production of cells in the blood, mainly red blood cells. The primary function of the red blood cells is to carry oxygen to the different parts of the body.
Using Mobile Phones for Cervical Cancer ScreeningClickMedix
ClickMedix founder partnered with University of Pennsylvania and Botswana-UPenn Partnership program to pioneer cervical cancer screening using mobile camera phones.
*Note: This presentation contains medical images which may be unsuitable for those not accustomed.
HPV Diseases More Than Cervical Cancer, Dr. Sharda Jain Lifecare Centre
HPV Disease . Cervical cancer , prevention cervical cancer , HPV prevention , cancer prevention , Human Papillomavirus (HPV), cervical cancer prevention
Cervical cancer global burden and where do we stand todayNiranjan Chavan
Cervical cancer is the 4th most common cancer in women worldwide but most common cause of cancer related death in India.
All over the world, including India, there is decreasing trend of cervical cancer.
Ca cervix epidemiology,screening and preventionDrAnkitaPatel
CA CERVIX IS PREVENTABLE AND CURABLE IF DETECTED AT EARLY STAGE .VACCINATION, PAP SMEAR AND HPV VACCINATION ARE KEY COMPONENTS FOR PREVENTION AND EARLY DETECTION.
Epidemiology and carcinogenesis of premalignant lesions of cervixManinder Ahuja
Cervicall cancer is number one cancer in India and mortality is every seven minute one woman is dyign of cervical cancer. And we still have to make a desicsion that these women's lives are worth saving by doing simple screening tests like VIA. Cytology by PAP Or LBC and HPV DNA ,
Standard Treatment Guidelines
serve as an important vehicle in assisting the doctor in decision making & providing the best treatment options for her patients.
The Newer Concepts In Endometriosis Management : Dr Sharda JainLifecare Centre
The Newer Concepts In
Endometriosis Management
ENDOMETRIOSIS IS ENIGMA
DIAGNOSTIC DELEMMA
DEBILITATING DISEASE QOL
PROGRESSIVE DISEASE
RECURRENCE IS BIG PROBLEM
NO FINAL VERDICT ON CAUSE
NO PERMANENT CURE
The exact prevalence of endometriosis is unknown, but estimates 10% in the general female population in India but up to 50% in infertile women
The Newer Concepts forReduced Surgery to preserve fertility in Endometrios...Lifecare Centre
The Newer Concepts forReduced Surgery to preserve fertility in Endometriosis
ENDOMETRIOSIS IS ENIGMA
DIAGNOSTIC DILEMMA
DEBILITATING DISEASE QOL
PROGRESSIVE DISEASE
RECURRENCE IS BIG PROBLEM
NO FINAL VERDICT ON CAUSE
NO PERMANENT CURE
The exact prevalence of endometriosis is unknown, but estimates 10% in the general female population in India but up to 50% in infertile women
Anemia Free India Gynaecologist to focuss on *12gm Haemoglobin at Delivery I...Lifecare Centre
Important Highlights
Prophylactic Iron and Folic Acid Supplementation in all six target age groups.
Intensified year-round Behaviour Change Communication (BCC) Campaign for:(a) improving compliance to IFA and deworming, (b) enhancing appropriate infant and young child feeding practices, (c) encouraging increase in intake of iron-rich food through diet and/or fortified foods (d) ensuring delayed cord clamping .
Testing and treatment of anaemia, using digital methods and point of care treatment, with special focus on pregnant women and school-going adolescents.
Addressing non-nutritional causes of anaemia
in endemic pockets with special focus on malaria, hemoglobinopathies and fluorosis
Strategies for Improving Success Rates in ART PARTLifecare Centre
Strategies for Improving Success Rates in ART
Part - 2
Strategies for Improving Success Rates in ART
Tailoring Controlled Ovarian Stimulation
Strategies for Luteal Phase in ART cycles
Endometrial Receptivity Array
How to optimize success rates in ART? : Dr Sharda JainLifecare Centre
How to optimize success rates in ART? : Dr Sharda Jain
How to improve success rates in ART?
The big debate कार्य में आनंद
Evolution of In-vitro Fertilization (IVF)
Factors Influencing IVF Success Ist Part
Strategies for Improving Success Rates in ART Second Part
Innovations & Breakthroughs in IVF Part Three
OPEN DEBATE
SOCIALEGG FREEZING : Dr Poorva Bhargav and Dr Sharda JainLifecare Centre
SOCIALEGG FREEZING : Dr Poorva Bhargav and Dr Sharda Jain
Introduction
Social egg freezing (oocyte cryopreservation for non-medical reasons) has evolved as a proactive option for women looking to extend their reproductive possibilities past their peak childbearing years
It is the process of saving or protecting eggs, or reproductive tissues so that a person can use them to have biological children in future
5. Human Papillomavirus
• Papillomaviridae family, ds-DNA genome, non-
enveloped, icosahedral capsid with major (L1) and
minor (L2) structural proteins
• Persistent infection by oncogenic HPV types is a
prerequisite for the development of cervical cancer
• >190 types of HPV, 12 high-risk type for human
cancers, type 16 and 18 responsible for ~70% of all
cervical cancers in women globally
• Natural infection does not offer full protection
against new HPV infection
L1 protein pentamer
L2 supporting protein
Circular DNA
55 nm
7. Acquisition of HPV Infection
• HPV infections can be acquired at any age.1-2,5 The risk starts from
sexual debut and continues throughout life.3
• Although new infections decrease with age, risk of persistence
(necessary condition for cervical cancer) increases.4 It puts adults
at risk.
• Penetrative intercourse is not necessary to become infected.6-7
HPV may be acquired by genital skin-to-skin contact.6
• Condoms do not fully protect against HPV transmission but
reduce the risk of infection.6-9
1. Gravitt PE et al. Infect Dis Clin North Am 2005; 19: 439–58; 2. Bosch FX et al. J Clin Pathol 2002; 55: 244–65; 3. Burk RD. Hosp Pract (Off Ed)
1999; 34: 103–11; 4. Castle PE et al. JID 2005;191:1806-16; 5. Franco EL et al. Vaccine 2005; 23:2388–94; ; 6. McIntosh N. Human
papillomavirus and cervical cancer. JHPIEGO 2000; 7. Partridge JM et al. Lancet Infectious Diseases 2006; 6: 21–31; 8. Winer RL et al. NEJM
2006; 354:2645-54; 9. Grainge MJ et al. Emerg Infect Dis. 2005; 11:1680-5.
8. Global total HPV-attributable cancers in females, 2002
Site
Total
cancers
Attributable to
HPV
% all
HPV
cancer
in
females
Attributable to HPV
16/18
% Cases % Cases
Cervix 492,800 ~100 492,800 93.5 70+ 344,900
Anus 15,900 90 14,300 2.7 92 13,100
Oropharynx 9,600 12 1,100 0.2 91 1,000
Mouth 98,400 3 2,900 0.6 97 2,800
Vulva, vagina 40,000 40 16,000 3.0 80 12,800
Total 527,100 374,600
HPV is a Necessary Cause for Cervical Cancer as virtually all cervical cancers
are caused by HPV.
HPV and Cervical Cancer
Adapted from Parkin DM & Bray F. Vaccine 2006; 24:S11–S25; Walboomers JMM, et al. J Pathol 1999; 189:12–19.
9. CIN3 is the immediate precursor of invasive cancer- Used as a better proxy
indicator for HPV vaccine efficacy .
Invasive
carcinoma
Normal
epithelium
HPV infection
koilocytosis
CIN1
3m
CIN2
6m
CIN3
12-24m
YearsMonths
PROGRESSION*
LSIL/ASCUS HSIL
REGRESSION ( ~1-2 Yrs)
HPV Infection to Cervical Cancer
57% 43% 32%
Burd. Clin Microbiol Rev 2003;16:1–17; Solomon et al. JAMA 2002;287:2114–2119
10. Burden of cervical HPV infection
HPV prevalence (%) in the general population (among
women with normal cytology)
7.9
Prevalence (%) of HPV 16 and/or HPV 18 among women with:
Normal Cytology 6
Low-grade cervical lesions (LSIL/CIN-1) 28.2
High-grade cervical lesions (HSIL//CIN-2/CIN-3/CIS) 56..5
Cervical cancer 84.1
Data sources: Bhatla N, Int J Gynecol Pathol 2006;25:398; Franceschi S, Int J Cancer 2003;107:127; Gheit T, Vaccine
2009;27:636; Munirajan AK, Gynecol Oncol 1998;69:205; Nagpal JK, Eur J Clin Invest 2002;32:943; Peedicayil A, Int
J Gynecol Cancer 2006;16:1591; Sowjanya AP, MBC Infect Dis 2005;5:116.
http://apps.who.int/hpvcentre/statistics/dynamic/ico/country_pdf/IND, p 28. Accessed on Nov 30, 2014
Burden of HPV Infection in India-
CIN, cervical intraepithelial neoplasia; LSIL, low-grade squamous intraepithelial lesion; HSIL, high-grade squamous intraepithelial lesion;
CIS, changes in situ
1
11. Burden of HPV Infection in India-
Adapted from Bruni L et al. Summary Report 2014-12-18 p.39. Available at:
http://www.hpvcentre.net/statistics/reports/IND.pdf (Accessed on Feb 08, 2015).
Site Study Prevalence (%)
New Delhi Gupta 2009, Bhatla 2008, Arora 2005 16.6, 7.6, 10.0
North India Singh 2009 10.1
Chandigarh Aggarwal 2006 36.9
Lucknow Pandey 2012 (d) 11.7
Varanasi Srivastava 2012 (d) 9.7
Kolkata Mittal 2014 (d), Sankaranarayanan 2004 4.6, 7.8
WB Basu 2013 (d), Sarkar 2011 (e), Laikangbam 2007 5.8, 9.7, 11.6
Mumbai Kerkar 2011, Sankaranarayanan 2004 8.1, 6.3
TN Vinodhini 2012, Franceschi 2015 30.4, 14.0
East India Dutta 2012 9.2
Sikkim Laikangbam 2007 11.1
Manipur Laikangbam 2007 6.7
Prevalence of HPV among women with normal cytology in India, by study
d=Women from the general population, including some with cytological cervical abnormalities. e=Few HPV types tested: 16, 18 only.
2
12. An Airbus-320 full of WOMEN crashing every day in India
Deaths Due to CaCx - Just Think !
13. Burden of Cervical Cancer- in India
0
10CervicalCancerMortalityper100,000
20
30
50
15-19
Age Group in Years
20-24
25-29
30-34
35-39
40-44
45-49
50-54
55-59
60-64
65-69
70-74
=>75
India
South Asia
World
Estimated age-specific mortality of
cervical cancer in India, 2012
40
• Globally 528,000 cases of cervical
cancers (CaCx). It kills 266,000
women each year
• In India, every year 122,844 cases
and 67,477 deaths
• 334 cases per day and 185 deaths
everyday
• HPV 16 and/or 18 is responsible
for 83%
• It ranks as 2ND most common
cancer in women aged 15 to 44
years in India
1
Bruni L et al. Summary Report 2014-12-18. Available at:
http://www.hpvcentre.net/statistics/reports/IND.pdf (Accessed on Feb 08, 2015).
14. Burden of Cervical Cancer- in India
Incidence of cervical cancer compared to other cancers in women of all ages in India
2
Bruni L et al. Summary Report 2014-12-18. Available at:
http://www.hpvcentre.net/statistics/reports/IND.pdf (Accessed on Feb 08, 2015).
15. Burden of CaCx from Cancer Registry
Bruni L et al. Summary Report 2014-12-18 (p6-7). Available at:
http://www.hpvcentre.net/statistics/reports/IND.pdf (Accessed on Feb 08, 2015).
16. Burden of CaCx: Latest Publication, 2015
Sreedevi A et al. Int J Womens Health 2015;7:405-14
Age adjusted incidence rates of CaCx in female (rate per 100,000)
17. Appeal to Govt. Of India
CaCx: The Forgotten Killer in India
Annual Deaths
Mortality Trend
Priority in MDG
Current Investment in
Developing World
Maternal Mortality* Cervical Cancer **
50,000 Annually 67,000 Annually
- 38%, 1990-2008 + 50%, 1990-2008
YES, MDG-5 NO
USD 12 Billion,
Globally
???
MDG, Millennium Development Goal.
*Trends in maternal mortality: 1990 to 2013Estimates by WHO, UNICEF, UNFPA,
The World Bank and the United Nations Population Division