Association between the plasma hs-CRP levels and the severity of coronary
stenosis in subjects remains controversial. This cross sectional study was performed in the
Department of Cardiology, Dhaka Medical College during July 2008 to December 2009, to determine whether the concentrations of hs-CRP correlate with the coronary atherosclerotic disease assessed by coronary angiography.
Sample Work of an Meta-Analysis | Hire a Meta-Analysis Expert: Pubrica.comPubrica
Pubrica has a broad experience in all aspects of Scientific Medical Writing, Editing, and Publishing. A global leader in comprehensive manuscript publication support service for academic and scientific journals, We provide a wide range of services that include Scientific medical research writing, Clinical data analysis, Literature review, Meta-analysis, medical Communication and medico-marketing solutions to healthcare/pharmaceutical/food and beverage companies.
Find freelance Meta-Analysis professionals, consultants, freelancers and get your project done - https://bit.ly/30V8QUK
Why Pubrica:
When you order our services, we promise you the following – Plagiarism free, always on Time, outstanding customer support, written to Standard, Unlimited Revisions support and High-quality Subject Matter Experts.
Contact us:
Web: https://pubrica.com/
Blog: https://pubrica.com/academy/
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Prevalence of Chronic Kidney disease in Patients with Metabolic Syndrome in S...asclepiuspdfs
Background and Objective: Chronic kidney disease (CKD) which is an increasingly important clinical and public health issue is associated with cardiovascular disease. Epidemiologic studies have also linked metabolic syndrome (MetS) with an increased risk of incident CKD. Therefore, the present study was designed retrospectively to find the prevalence and potential risk factors of CKD in patients with MetS in Saudi Arabia.
Study of Lipid Profile in Patients of Coronary Artery Disease among Rural Pop...iosrjce
India and other developing countries in South Asia are progressively facing alarming proportions of
morbidity and mortality caused by coronary artery disease. There are a number of studies on dyslipidemia in
coronary artery disease patients in Indian subcontinent, mostly in urban population in different geographical
territories of the country. There was no such community-based study in rural population of Bihar. Hence this
case control study was undertaken to study dyslipidemia among the rural patients admitted to hospital with
coronary artery disease. 100 consecutive cases diagnosed as coronary artery disease aged 30 to 90 years were
compared to 50 ages and sex matched healthy controls. Age, gender, blood pressure, history of smoking and
diabetes mellitus, waist-hip ratio and Body Mass Index were recorded in each subject. Blood samples for
investigations of lipid profile i.e. serum cholesterol (CHO), triglyceride (TG), high density lipoprotein–
cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C) were collected from cases. It was found
that high prevalence of dyslipidemia i.e. elevated serum cholesterol and TG and low HDL cholesterol were
significant in all the age groups above 40 years. Interestingly our study in rural population is not associated
with increased risk of coronary artery disease with LDL levels. In order to implement preventive approach to
CAD, our findings suggest that early detection of abnormal lipid profile and modification of lifestyles are important
Sample Work of an Meta-Analysis | Hire a Meta-Analysis Expert: Pubrica.comPubrica
Pubrica has a broad experience in all aspects of Scientific Medical Writing, Editing, and Publishing. A global leader in comprehensive manuscript publication support service for academic and scientific journals, We provide a wide range of services that include Scientific medical research writing, Clinical data analysis, Literature review, Meta-analysis, medical Communication and medico-marketing solutions to healthcare/pharmaceutical/food and beverage companies.
Find freelance Meta-Analysis professionals, consultants, freelancers and get your project done - https://bit.ly/30V8QUK
Why Pubrica:
When you order our services, we promise you the following – Plagiarism free, always on Time, outstanding customer support, written to Standard, Unlimited Revisions support and High-quality Subject Matter Experts.
Contact us:
Web: https://pubrica.com/
Blog: https://pubrica.com/academy/
Email: sales@pubrica.com
WhatsApp : +91 9884350006
United Kingdom : +44-1143520021
Prevalence of Chronic Kidney disease in Patients with Metabolic Syndrome in S...asclepiuspdfs
Background and Objective: Chronic kidney disease (CKD) which is an increasingly important clinical and public health issue is associated with cardiovascular disease. Epidemiologic studies have also linked metabolic syndrome (MetS) with an increased risk of incident CKD. Therefore, the present study was designed retrospectively to find the prevalence and potential risk factors of CKD in patients with MetS in Saudi Arabia.
Study of Lipid Profile in Patients of Coronary Artery Disease among Rural Pop...iosrjce
India and other developing countries in South Asia are progressively facing alarming proportions of
morbidity and mortality caused by coronary artery disease. There are a number of studies on dyslipidemia in
coronary artery disease patients in Indian subcontinent, mostly in urban population in different geographical
territories of the country. There was no such community-based study in rural population of Bihar. Hence this
case control study was undertaken to study dyslipidemia among the rural patients admitted to hospital with
coronary artery disease. 100 consecutive cases diagnosed as coronary artery disease aged 30 to 90 years were
compared to 50 ages and sex matched healthy controls. Age, gender, blood pressure, history of smoking and
diabetes mellitus, waist-hip ratio and Body Mass Index were recorded in each subject. Blood samples for
investigations of lipid profile i.e. serum cholesterol (CHO), triglyceride (TG), high density lipoprotein–
cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C) were collected from cases. It was found
that high prevalence of dyslipidemia i.e. elevated serum cholesterol and TG and low HDL cholesterol were
significant in all the age groups above 40 years. Interestingly our study in rural population is not associated
with increased risk of coronary artery disease with LDL levels. In order to implement preventive approach to
CAD, our findings suggest that early detection of abnormal lipid profile and modification of lifestyles are important
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
This Journal publishes original research work that contributes significantly to further the scientific knowledge in pharmacy.
Impact of Malnutrition on Lipid Profile in Chronic Kidney Disease Patients in...Neeleshkumar Maurya
The present study was carried out to identify the role of malnutrition and its relationship for the development of cardiovascular disease (CVD) in chronic kidney disease (CKD) patients taking hemodialysis. We conducted an analytical study with 100 patients. It was carried out over one-year period, from February 25, 2017 to March 30, 2018. The inclusion criteria were the patients who have been on hemodialysis for at least past three months period and at least more than 18-year-old. All the patients were divided into two groups: first group of patients have both CVD and CKD and other group of patients have only CKD. Patients were subjected to biochemical and anthropometric parameters. Out of hundred patients, about 60 followed the inclusion and exclusion criteria. Eight women and 52 men with the age range from 18 to 80 years with 49±10.2years as mean age. We found that higher level of cholesterol, triglyceride, low protein intake and low energy conception in CKD alone patients is directly associated with malnutrition. The association between cholesterol levels and CKD would be altered by the presence of malnutrition. Low level of protein and total energy intake also confirms the presence of malnutrition in CKD patient developed the CVD.
Keywords: Malnutrition, hemodialysis patients, chronic kidney disease (CKD), cardiovascular disease (CVD)
Predictors of Ischaemia and Outcomes in Egyptian Patients with Diabetes Mellitus Referred for Perfusion Imaging. Samir Rafla*, Ahmed Abdel-Aaty, Mohamed Ahmed Sadaka, Aly Ahmed Abo Elhoda and Ahmed Mohamed Shams
Implication of preoperative glycosylated hemoglobin level on short term outco...Dr.Debmalya Saha
ABSTRACT
Background: Diabetes mellitus is one of the significant risk factors for adverse outcomes after coronary artery bypass surgery. The glycosylated haemoglobin i.e. HbA1c is a reliable diagnostic test to know the long-term glycemic status. The objective of the study is to investigate the implication of preoperative HbA1c level on short term outcomes after coronary artery bypass grafting (CABG).
Method: Total 218 patients were studied, and the data were collected retrospectively. Patients are distributed into group 1 with HbA1c≤7 (good glycemic control) and group 2 with HbA1c>7 (poor glycemic control). The parameters studied for short term outcomes were revision due to bleeding, duration of mechanical ventilation, cerebrovascular accident (CVA), atrial fibrillation (AF), renal failure requiring dialysis, infective complications like sternal and leg wound infection, mediastinitis, pneumonia, urinary tract infection (UTI), sepsis; length of ICU stay and in-hospital mortality.
Result: In comparison to group 1, patients of group 2 showed statistically significant more morbidity in view of short-term outcomes in this study.
Conclusion: HbA1c>7 is associated with statistically significant adverse short-term outcomes after CABG.
Relative risk of cardiovascular morbidity is increased in Chronic Kidney Disease (CKD). According to current KDIGO guideline
cardiovascular risk can be estimated from Glomerular Filtration Rate (GFR) and proteinuria.
Quantitative Statistical Analysis Work Sample From StatsworkStats Statswork
Quantitative Data Collection perhaps the most widely used method for primary data collection. A variety of different collection methods of research, including mail surveys and face to face interviews.
Copeptin as a Novel Biomarker in the Diagnosis of Acute Myocardial Infarction...Premier Publishers
To evaluate the diagnostic value of Copeptin as a novel biomarker in early diagnosis of Acute Myocardial Infarction. 56 patients with acute Myocardial Infarction (STEMI) and 25 healthy controls who were admitted to the Cardiology and Clinical Pathology Departments, national heart institute (NHI) from October 2015 to April 2016. The kit used a double-antibody sandwich enzyme-linked immune-sorbent assay (ELISA) to assay the level of Human Copeptin in samples. As regard copeptin, the median range of copeptin level was 242.5pg/ml in patient group and 75pg/ml in control group. The comparative study between the two groups shows a significant difference (p < 0.05) Conclusion: Copeptin is a reliable diagnostic tool in patients with AMI (STEMI) with sensitivity 85.7%, specificity 86.7%, PPV 96% and NPV 61.9%.
Association of cardio metabolic risk factors, serum nitric oxide metabolite a...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
This cross sectional study was conducted at Department of Biochemistry, Govt. Medical College Srinagar Kashmir. A total of 120 Kashmiri Type 2 diabetic patients and 30 normal controls were randomly selected. Diabetic dyslipidaemia is characterized by raised triglycerides, low high density lipoprotein and raised low density lipoprotein. Determination of serum lipid levels in people with diabetes is considered a standard of care because detection and treatment of dyslipidaemia is one means of reducing cardiovascular disease risk. The lipid profiles and lipoprotein levels of 120 known diabetic patients were studied. Total cholesterol (TC), Triacylglycerol’s (TG) Low density lipoprotein-cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C) levels were assayed for each group using standard biochemical methods. Dyslipidaemia was defined using the national cholesterol education programme – adult treatment panel III (NCEP-AT III) criteria. BMI and waist and hip circumferences were measured.
The Impact of Lymph Node Dissection on Survival in Intermediate- and High-Ris...semualkaira
Aimed to evaluate the therapeutic effect of pelvic lymph node dissection (PLND) on survival and determine the predictors of lymph node involvement (LNI) in patients with intermediate- or high-risk prostate cancer (PCa) treated with Radical Prostatectomy
The Impact of Lymph Node Dissection on Survival in Intermediate- and High-Ris...semualkaira
Aimed to evaluate the therapeutic effect of pelvic lymph node dissection (PLND) on survival and determine the
predictors of lymph node involvement (LNI) in patients with intermediate- or high-risk prostate cancer (PCa) treated with Radical
Prostatectomy
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
This Journal publishes original research work that contributes significantly to further the scientific knowledge in pharmacy.
Impact of Malnutrition on Lipid Profile in Chronic Kidney Disease Patients in...Neeleshkumar Maurya
The present study was carried out to identify the role of malnutrition and its relationship for the development of cardiovascular disease (CVD) in chronic kidney disease (CKD) patients taking hemodialysis. We conducted an analytical study with 100 patients. It was carried out over one-year period, from February 25, 2017 to March 30, 2018. The inclusion criteria were the patients who have been on hemodialysis for at least past three months period and at least more than 18-year-old. All the patients were divided into two groups: first group of patients have both CVD and CKD and other group of patients have only CKD. Patients were subjected to biochemical and anthropometric parameters. Out of hundred patients, about 60 followed the inclusion and exclusion criteria. Eight women and 52 men with the age range from 18 to 80 years with 49±10.2years as mean age. We found that higher level of cholesterol, triglyceride, low protein intake and low energy conception in CKD alone patients is directly associated with malnutrition. The association between cholesterol levels and CKD would be altered by the presence of malnutrition. Low level of protein and total energy intake also confirms the presence of malnutrition in CKD patient developed the CVD.
Keywords: Malnutrition, hemodialysis patients, chronic kidney disease (CKD), cardiovascular disease (CVD)
Predictors of Ischaemia and Outcomes in Egyptian Patients with Diabetes Mellitus Referred for Perfusion Imaging. Samir Rafla*, Ahmed Abdel-Aaty, Mohamed Ahmed Sadaka, Aly Ahmed Abo Elhoda and Ahmed Mohamed Shams
Implication of preoperative glycosylated hemoglobin level on short term outco...Dr.Debmalya Saha
ABSTRACT
Background: Diabetes mellitus is one of the significant risk factors for adverse outcomes after coronary artery bypass surgery. The glycosylated haemoglobin i.e. HbA1c is a reliable diagnostic test to know the long-term glycemic status. The objective of the study is to investigate the implication of preoperative HbA1c level on short term outcomes after coronary artery bypass grafting (CABG).
Method: Total 218 patients were studied, and the data were collected retrospectively. Patients are distributed into group 1 with HbA1c≤7 (good glycemic control) and group 2 with HbA1c>7 (poor glycemic control). The parameters studied for short term outcomes were revision due to bleeding, duration of mechanical ventilation, cerebrovascular accident (CVA), atrial fibrillation (AF), renal failure requiring dialysis, infective complications like sternal and leg wound infection, mediastinitis, pneumonia, urinary tract infection (UTI), sepsis; length of ICU stay and in-hospital mortality.
Result: In comparison to group 1, patients of group 2 showed statistically significant more morbidity in view of short-term outcomes in this study.
Conclusion: HbA1c>7 is associated with statistically significant adverse short-term outcomes after CABG.
Relative risk of cardiovascular morbidity is increased in Chronic Kidney Disease (CKD). According to current KDIGO guideline
cardiovascular risk can be estimated from Glomerular Filtration Rate (GFR) and proteinuria.
Quantitative Statistical Analysis Work Sample From StatsworkStats Statswork
Quantitative Data Collection perhaps the most widely used method for primary data collection. A variety of different collection methods of research, including mail surveys and face to face interviews.
Copeptin as a Novel Biomarker in the Diagnosis of Acute Myocardial Infarction...Premier Publishers
To evaluate the diagnostic value of Copeptin as a novel biomarker in early diagnosis of Acute Myocardial Infarction. 56 patients with acute Myocardial Infarction (STEMI) and 25 healthy controls who were admitted to the Cardiology and Clinical Pathology Departments, national heart institute (NHI) from October 2015 to April 2016. The kit used a double-antibody sandwich enzyme-linked immune-sorbent assay (ELISA) to assay the level of Human Copeptin in samples. As regard copeptin, the median range of copeptin level was 242.5pg/ml in patient group and 75pg/ml in control group. The comparative study between the two groups shows a significant difference (p < 0.05) Conclusion: Copeptin is a reliable diagnostic tool in patients with AMI (STEMI) with sensitivity 85.7%, specificity 86.7%, PPV 96% and NPV 61.9%.
Association of cardio metabolic risk factors, serum nitric oxide metabolite a...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
This cross sectional study was conducted at Department of Biochemistry, Govt. Medical College Srinagar Kashmir. A total of 120 Kashmiri Type 2 diabetic patients and 30 normal controls were randomly selected. Diabetic dyslipidaemia is characterized by raised triglycerides, low high density lipoprotein and raised low density lipoprotein. Determination of serum lipid levels in people with diabetes is considered a standard of care because detection and treatment of dyslipidaemia is one means of reducing cardiovascular disease risk. The lipid profiles and lipoprotein levels of 120 known diabetic patients were studied. Total cholesterol (TC), Triacylglycerol’s (TG) Low density lipoprotein-cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C) levels were assayed for each group using standard biochemical methods. Dyslipidaemia was defined using the national cholesterol education programme – adult treatment panel III (NCEP-AT III) criteria. BMI and waist and hip circumferences were measured.
The Impact of Lymph Node Dissection on Survival in Intermediate- and High-Ris...semualkaira
Aimed to evaluate the therapeutic effect of pelvic lymph node dissection (PLND) on survival and determine the predictors of lymph node involvement (LNI) in patients with intermediate- or high-risk prostate cancer (PCa) treated with Radical Prostatectomy
The Impact of Lymph Node Dissection on Survival in Intermediate- and High-Ris...semualkaira
Aimed to evaluate the therapeutic effect of pelvic lymph node dissection (PLND) on survival and determine the
predictors of lymph node involvement (LNI) in patients with intermediate- or high-risk prostate cancer (PCa) treated with Radical
Prostatectomy
Association between Galectin-3 and oxidative stress parameters with coronary ...komalicarol
Galectin-3 (Gal-3), as a mediator of inflammation and fibrosis, has been reported to be a biomarker of severity in
coronary artery disease (CAD). The study aimed to assess the relationships between coronary artery disease (CAD) and risk factors,
including parameters of oxidative stress in Tunisian patients CAD.
Association Between Galectin-3 and Oxidative Stress Parameters with Coronary ...semualkaira
Galectin-3 (Gal-3), as a mediator of inflammation and fibrosis, has been reported to be a biomarker of severity in
coronary artery disease (CAD). The study aimed to assess the relationships between coronary artery disease (CAD) and risk factors,
including parameters of oxidative stress in Tunisian patients CAD
Clinical Profile of Acute Coronary Syndrome among Young AdultsPremier Publishers
Acute Coronary Syndrome accounts for 30% of hospital admissions with cardiovascular diseases. The risk of this syndrome is increasing among the younger adults, and a deep insight into the clinical profile among these patients will help in devising a preventive strategy, in order to alleviate the morbidity and mortality due to the syndrome. A cross sectional study was done among 125 subjects admitted to our tertiary care hospital with Acute Coronary Syndrome. Their risk factors were assessed and a 12 Lead electrocardiogram and 2D Echocardiogram were taken. Cardio III panel which consists of Troponin I, CK MB, BNP by COBAS meter machine was also measured. STEMI was present in 73.6% of the patients, while unstable angina was present in 16%. About 90% of STEMI patients were males and 62% of them were hypertensives. LV Ejection Fraction <30% was found in 9% of STEMI patients. This study elucidates the need for a preventive strategy for primordial prevention of cardiovascular events among young adults. The study envisaged the male, urban preponderance towards these events.
Serum Procalcitonin as a marker of infection in chronic kidney disease patien...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Abnormal Sodium and Chlorine Level Is Associated With Prognosis of Lung Cance...JohnJulie1
The imbalance of sodium and chloride ions occurs frequently in patients with lung cancer. However, the correlation between ion concentration change and patients prognosis have not been studied thoroughly. Our research will fill the gap, especially for high ion concentration.
Abnormal Sodium and Chlorine Level Is Associated With Prognosis of Lung Cance...daranisaha
The imbalance of sodium and chloride ions occurs frequently in patients with lung cancer. However, the correlation between ion concentration change and patients prognosis have not been studied thoroughly. Our research will fill the gap, especially for high ion concentration.
Abnormal Sodium and Chlorine Level Is Associated With Prognosis of Lung Cance...semualkaira
The imbalance of sodium and chloride ions occurs frequently in patients with lung cancer. However, the correlation between ion concentration change and patients prognosis have not been studied thoroughly. Our research will fill the gap, especially for high ion concentration.
Abnormal Sodium and Chlorine Level Is Associated With Prognosis of Lung Cance...semualkaira
The imbalance of sodium and chloride ions occurs frequently in patients with lung cancer. However, the correlation between ion concentration change and patients prognosis have not been studied thoroughly. Our research will fill the gap, especially for high ion concentration.
Surgery or Endovascular Treatment, which is the Better Way to Treat Acute and...semualkaira
To investigate the influence of surgical and endovascular treatment on the prognosis of acute and chronic mesenteric ischemia and to further evaluate whether endovascular
treatment can reduce postoperative complications by performing
a meta-analysis.
Surgery or Endovascular Treatment, which is the Better Way to Treat Acute and...semualkaira
To investigate the influence of surgical and endovascular treatment on the prognosis of acute and chronic mesenteric ischemia and to further evaluate whether endovascular
treatment can reduce postoperative complications by performing
a meta-analysis.
Surgery or Endovascular Treatment, which is the Better Way to Treat Acute and...semualkaira
To investigate the influence of surgical and endovascular treatment on the prognosis of acute and chronic mesenteric ischemia and to further evaluate whether endovascular treatment can reduce postoperative complications by performing a meta-analysis.
clinical distribution and molecular profiling on postoperative colorectal can...LucyPi1
Abstract
Background: Traditional Chinese medicine (TCM) syndrome, also named syndrome, are comprehensive and
integral analyses of clinical information which helps to guide different individualized treatment prescriptions.
Methods: Thirty healthy controls and 80 colorectal cancer (CRC) patients (including 33 Spleen Qi Deficiency
syndrome, 23 Dampness Heat syndrome, 17 Blood Stasis syndrome and 7 other syndrome) were enrolled into this
study. Human mRNAs were extracted from peripheral blood mononuclear cells. The gene expression for CRC
patients with different TCM syndrome was determined by microarray and qRT-PCR. Results: Spleen Qi Deficiency,
Dampness Heat and Blood Stasis were the most common syndromes in CRC patients. There is a significant
difference was found in mRNA expression levels (especially for PIK3CA, STAT3, SOX9 and KDM5C) among
Spleen Qi Deficiency, Dampness Heat and Blood Stasis syndrome groups. The higher mRNA levels of JNK1, TP53,
MLH1, MSH6, PMS2, SOCS3, TCF7L2, FAM123B, PSAP, FBXW7, SALL4 and the lower expression of
inflammatory cytokine IL-6 were found in Spleen Qi Deficiency group but not other syndrome types. The higher
mRNA levels of KRAS, MUC16, EGFR, GRASP65, PIK3CA, MAPK7, CD24, STAT3, SLC11A1, Bcl-2, TXNDC17
and some inflammatory cytokines (IL-6, IL-23, TNF-a, CXCR4) were found in Dampness Heat group but not other
syndrome types. Blood Stasis syndrome showed higher expression of SOX9, MLH1, MSH6, KDM5C, PCDH11X,
PSAP and SALL4, and lower mRNA levels of PIK3CA, CD24, STAT3, CXCR4, TXNDC17 and TP53. The CRC
patients with Dampness Heat syndrome might have a poor prognosis than other syndrome types. Conclusion: The
identification of syndrome conditions had different impacts on CRC prognosis, and which might be related with
different mRNA expression levels. Some oncogenes and pro-inflammatory cytokines were highly expressed in
Dampness Heat group but not other syndrome types, suggesting that the CRC patients with Dampness Heat
syndrome might have a poor prognosis. Our results prelimitarily uncovered the molecular basis of syndrome
differences in CRC prognosis, a better understanding for TCM treatment of CRC.
Similar to HIGH SENSITIVE C-REACTIVE PROTEIN (hs-CRP) AND ITS CORRELATION WITH ANGIOGRAPHIC SEVERITY OF PATIENT WITH CORONARY ARTERY DISEASE (CAD) (20)
Regional variation in chronic kidney disease and associated factors in hypert...M A Hasnat
We aimed to determine the prevalence of chronic
kidney disease (CKD) and its cross-country variation among
hypertensive individuals in rural Bangladesh, Pakistan and
Sri Lanka.We also explored the factors associated with CKD in
these populations.
Percutaneous Transvenous Mitral Commissurotomy in 71 Years Old Woman with Mit...M A Hasnat
AAS Majumder, MA Hasnat, AKMM Islam, M Ullah, MZ Rahman, S Zaman, MM Rahman, MH Alamgir.
Department of Cardiology, NICVD, Dhaka.
(Cardiovasc. j. 2013; 6(1): 68-70)
Study of 89 Cases of Peripheral Vascular Disease by CT AngiographyM A Hasnat
The purpose of this study was to observe the morphological pattern by CT angiography
and risk factors for development of peripheral vascular disease in Bangladeshi patient suffering
from peripheral vascular disease using a multidetector scanner in the evaluation of patients with
peripheral vascular disease.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
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5cl-adba precursor (semi finished )
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Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
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We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
HIGH SENSITIVE C-REACTIVE PROTEIN (hs-CRP) AND ITS CORRELATION WITH ANGIOGRAPHIC SEVERITY OF PATIENT WITH CORONARY ARTERY DISEASE (CAD)
1. Vol. 19, No. 2, October 2010 91
Introduction:
Coronary artery disease (CAD) is the end result
of the accumulation of atheromatous plaques
within the walls of the coronary arteries that
supply the myocardium.1
CAD is the largest single cause of death in the
UK and many parts of the world. Each year
there are approximately 60 deaths per 100,000.
Sudden cardiac death is a prominent feature
of CAD. One in every six coronary attacks was
found to present with sudden death as the first,
last, and only symptom.2
In USA, among adults age 20 and older, the total
number of coronary heart disease (CHD) in
2006 was 16,800,000 (about 8,700,000 men and
8,100,000 women). CHD caused about one of
every five deaths in the United States in 2005.
It is the largest single killer of American males
and females.3
National data on incidence and mortality of
coronary heart disease are few in Bangladesh.
The prevalence of coronary heart disease was
estimated as 3.3/1000 in 1976 and 17.2/1000
in 1986 indicating 5 folds in the disease in 10
years.4,5
HIGH SENSITIVE C-REACTIVE PROTEIN (hs-CRP)
AND ITS CORRELATION WITH ANGIOGRAPHIC
SEVERITY OF PATIENT WITH CORONARY ARTERY
DISEASE (CAD)
HASNAT MA1, ISLAM AEMM2, CHOWDHURY AW3, KHAN HILR4, HOSSAIN MZ5
Abstract:
Background: Association between the plasma hs-CRP levels and the severity of coronary
stenosis in subjects remains controversial. This cross sectional study was performed in the
Department of Cardiology, Dhaka Medical College during July 2008 to December 2009, to
determine whether the concentrations of hs-CRP correlate with the coronary atherosclerotic
disease assessed by coronary angiography.
Methods: For this purpose, a total number of 90 consecutive patients having IHD admitted in
the Dhaka Medical College Hospitals were enrolled in this study. Patients were divided into
three groups according to their level of hs-CRP. Out of 90 cases, 22(24.4%) patients were in
group I, in group II 33(36.7%) patients and rest 35(38.9%) were in group III according to their
hs-CRP level.
Severity of CAD was assessed by vessel score, stenosis score and extent score.
Result: Significant positive correlation (r=0.7409; p<0.001 r=0.6648; p<0.001 and r=0.6386;
p<0.001) was found between hs-CRP and vessel score, stenosis score and hs-CRP and extent
score suggesting increasing level of hs-CRP strongly suggestive of extensive coronary artery
disease.
Conclusion: High level of hs-CRP strongly suggestive of extensive coronary artery disease
Key words: hs-CRP, angiogram, coronary artery disease, vessel score, stenosis score and
extent score.
J Dhaka Med Coll. 2010; 19(2) : 91-97.
1. Dr. Mohammad Abul Hasnat, MD-Final Part Student, Dept. of Cardiology, DMCH.
2. Dr. AEM Mazharul Islam, Assistant Professor, Dept. of Cardiology, DMCH.
3. Dr. Abdul Wadud Chowdhury, Associate Professor, Dept. of Cardiology, DMCH.
4. Dr. HI Lutfur Rahman Khan, Professor and Head, Dept. of Cardiology, DMCH.
5. Dr. Mohammad Zaid Hossain, Assistant Professor, Dept. of Medicine, DMCH.
Correspondence: Dr. Mohammad Abul Hasnat, Department of Cardiology, Dhaka Medical College & Hospital
Cell Phone: +8801711229128, Email: drhasnat@hotmail.com
2. Vol. 19, No. 2, October 2010 92
Traditionally there are some conventional risk
factors like age, male sex, positive family
history, hypertension, smoking,
hyperlipidaemia, metabolic syndrome,
diabetes, lack of exercise, obesity, and some
emerging risk factors, like C-Reactive Protein,
Homocysteine, Fibrinogen.6
Less than 50% of the CAD can be ascribed to
traditional risk factors and rests are
unexplained.7 CRP has emerged as the most
exquisitely sensitive systemic marker of
inflammation and a powerful predictive marker
of future cardiovascular risk. Role for
inflammation has become well established over
the past decade or more in theories describing
the atherosclerotic disease process.8
A body of evidence now suggests that
atherosclerosis represents a chronic
inflammatory response to vascular injury
caused by a variety of agents that activate or
injure endothelium and promote lipoprotein
infiltration, retention, and modification,
combined with inflammatory cell entry,
retention and activation.9
So, from a pathological viewpoint, all stages,
i.e., initiation, growth, and complication of the
atherosclerotic plaque might be considered to
be an inflammatory response to injury.10,11 C-
reactive protein (CRP) is one of the acute phase
proteins that increase during systemic
inflammation.12 Several prospective studies
recently showed that plasma high sensitive C-
reactive protein (hs-CRP) levels, a more
sensitive CRP test, are a powerful predictor of
future myocardial infarction and cardiac death
among apparently healthy individuals.13
However, the association between the plasma
hs-CRP levels and the severity of coronary
stenosis in subjects remains controversial.
Some studies previously demonstrated such
associations whereas other could not found
it.14,15
This study was performed to determine
whether the concentrations of hs-CRP
correlate with the coronary atherosclerotic
disease assessed by coronary angiography.
Objectives:
General Objective:
1. To correlate the levels of hs-CRP with
angiographic severity of coronary artery
stenosis in patients with IHD admitted for
CAG in DMCH.
Specific objectives:
1. To correlate the levels of hs-CRP with vessel
score.
2. To correlate the levels of hs-CRP with
stenosis score.
3. To correlate the levels of hs-CRP with extent
score.
Materials and Methods:
This cross sectional study was done in the
department of cardiology, Dhaka Medical
College during July 2008 to, December 2009.
hs-CRP test was done in immunology
department of BSMMU.
CAG was done in the cath-lab of the
Department of Cardiology, Dhaka Medical
College Hospital.
Inclusion criteria
All patients of IHD admitted for CAG in
department of cardiology DMCH.
Exclusion criteria
1. Patient with past CABG
2. Patient with PTCA
3. Patient with valvular heart disease.
4. Patient with hepatic dysfunction.
5. Patient with a major non-cardiovascular
disease.
6. Patient with collagen vascular disease.
7. Any systemic infection.
8. Unwilling to give consent.
Statistical analysis:
For all statistical analyses, SPSS version 16.0
was used. For all statistical tests, p<0.05 was
considered as statistically significant.
Continuous variables were presented as mean
± SD and numerical variables were presented
as proportions. Continuous variables were
compared through the ANOVA test, categorical
variable by chi-square test, and correlation co-
efficient was done where applicable.
High Sensitive C-Reactive Protein (hs-CRP) and its Correlation Hasnat MA et al.
92
3. Vol. 19, No. 2, October 2010 93
Observation and Results:
Table I
hs-CRP distribution of the study patients (n=90).
hs CRP Number of Percentage
patients
Group I: <1.0 mg/L 22 24.4
Group II: 1.0 – 3.0 mg/L 33 36.7
Group III: >3.0 mg/L 35 38.9
Total 90 100.0
Table-I shows distribution of hs- CRP levels
among the study patients. A total of 90 cases
were included in the study the age ranged from
20 to 72 years. Among them 73 patients were
male and rest are female.
Patients were divided into three groups according
to their level of hs-CRP. The level of hs-CRP <1.0
mg/L was consider as group I, 1.0 mg/L to 3.0
mg/L group II and >3.0 mg/L group III. Out of 90
cases 22(24.4%) belong to group I, 33(36.7%) was
group II and rest 35(38.9%) was group III.
Table-II
Major risk factors status of the study patients (n=90)
Smoking Group I (n=22) Group II(n=33) Group III (n=35) Pvalue
n % n % N %
Present 9 40.9 22 66.7 21 60.0 0.157NS
Absent 13 59.1 11 33.3 14 40.0
Hypertension
Present 13 59.1 19 57.6 23 65.7 0.769NS
Absent 9 40.9 14 42.4 12 34.3
DM
Present 3 13.6 13 39.4 12 34.3 0.113NS
Absent 19 86.4 20 60.6 23 65.7
Dyslipidemia
Present 13 59.1 21 63.6 21 60.0 0.930NS
Absent 9 40.9 12 36.4 14 40.0
F/H IHD
Present 6 27.3 7 21.2 11 31.4 0.634NS
Absent 16 72.7 26 78.8 24 68.6
Group I= <1.0 mg/L; Group II= 1.0 – 3.0 mg/L; Group III= >3.0 mg/L; NS= not significant
Table III
Distribution of patients by vessel score (n=90)
Vessel score Group I(n=22) Group II(n=33) Group III (n=35) Pvalue
n % n % n %
0 18 81.8 4 12.1 2 5.7
1 2 9.1 16 48.5 4 11.4
2 1 4.5 10 30.3 6 17.1
3 1 4.5 3 9.1 23 65.7
Mean±SD 0.3 ±0.8 1.4 ±0.8 2.4 ±0.9 0.001S
Range (min-max) (0 -3) (0 -3) (0 -3)
J Dhaka Med Coll. Vol. 19, No. 2 October 2010
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4. Vol. 19, No. 2, October 2010 94
Table-II shows distribution of major risk factors
among study patients. Regarding the smoking
status it was found that 9(40.9%) in group I,
22(66.7%) in group II and 21(60.0%) in group
III were smoker. No significant (p>0.05)
difference was found among three groups in
chi square test.
Hypertension was found in 13(59.1%) in group
I, 19(57.6%) in group II and 23(65.7%) in group
III. No significant (p<0.05) difference was found
among three groups in chi square test. The
results are shown in the table II.
Diabetes mellitus was found 3(13.6%) in group
I, 13(39.4%) in group II and 12(34.3%) in group
III. No significant (p>0.05) difference was found
among three in chi square test. The results
are shown in the table II.
Family history of IHD was found 6(27.3%),
7(21.2%) and 11(31.4%) in group I, group II and
group II respectively. No significant (p>0.05)
difference was found among three groups in
chi square test. The results are shown in the
table II.
Dyslipidemia was found in 13(59.1%) in group
I, 21(63.6%) in group II and 21(60.0%) in group
III. No significant (p>0.05) difference was found
among three groups in chi square test. The
results are shown in the table II.
Table –III shows distribution of patients by
vessel score. More than eighty (81.8%) had
vessel score ‘0’ in group I, in group II majority
(48.5%) had vessel score 1 and in group III most
(65.7%) had vessel score 3. The mean (±SD)
vessel score was 0.3±0.8, 1.4±0.8 and 2.4±0.9
in group I, group II and group III respectively.
The vessel score difference was statistically
significant (p<0.05) among three groups in
ANOVA test.
Table-IV shows Distribution of patients by
stenosis and extent score. The mean (±SD)
Stenosis score was 3.2±7.4, 23.5±18.9 and
38.3±26.5 in group I, group II and group III
respectively. The mean (±SD) extent score was
8.9±18.0 in group I, 36.1±16.9 in group II and
51.2±16.6 in group III. The Stenosis and extent
score difference were statistically significant
(p<0.05) among three groups in ANOVA test.
Correlation between hs CRP with vessel score
(n=90).
Hs CRP was expressed in mg/L and vessel score
ranges from 0 to 3 depending on the number of
vessel involve. Significant positive correlations
were found between hs-CRP and vessel score.
The values of Pearson’s correlation coefficient
was 0.7409 which is highly significant
(p<0.001). Therefore, there was linear positive
correlation between hs-CRP and vessel score
(Fig. 1).
Table IV
Distribution of patients by stenosis and extent score (n=90)
Group I(n=22) Group II(n=33) Group III (n=35) P value
Mean ±SD Mean ±SD Mean ±SD
Stenosis score 3.2 ±7.4 23.5 ±18.9 38.3 ±26.5 0.001S
Range (min-max) (0 -24) (0 -72) (0 -112)
Extent score 8.9 ±18.0 36.1 ±16.9 51.2 ±16.6 0.001S
Range (min-max) (0 -60) (0 -80) (0 -80)
Group I= <1.0 mg/L, Group II= 1.0 – 3.0 mg/L, Group III= >3.0 mg/L, NS= not significant
Fig.-1: The scatter diagram shows significant
relationship (r=0.7409) between hs-CRP and
vessel score.
High Sensitive C-Reactive Protein (hs-CRP) and its Correlation Hasnat MA et al.
94
5. Vol. 19, No. 2, October 2010 95
Correlation between hs CRP with stenosis score
(n=90).
Hs CRP was expressed in mg/L and stenosis
score ranges from 0 to 112. Significant positive
correlations were found between hs-CRP and
stenosis score.
The values of Pearson’s correlation coefficient
was 0.6648 which is highly significant
(p<0.001). Therefore, there was linear positive
correlation between hs-CRP and stenosis score
(Fig. 2).
(p<0.001). Therefore, there was linear positive
correlation between hs-CRP and extent score
(Fig.-3).
Discussion
This cross sectional study was carried out with
an aim to correlate the levels of hs-CRP with
angiographic severity of coronary artery
stenosis in patients with IHD admitted for CAG
in DMCH and to correlate the levels of hs-CRP
with vessel score, stenosis score and extent
score.
A total of 90 patients with IHD age ranging from
20 to 70 years were included in the study, who
were admitted for CAG in the department of
Cardiology, Dhaka Medical College during July
2008 to December 2009.
The patients were divided into three groups
according to their level of hs-CRP, which were
<1.0 mg/L was considered as group I, hs-CRP
range from 1.0 to 3.0 mg/L considered as group
II and >3.0 mg/L considered as group III.
According to hs-CRP level 22(24.4%) cases were
in group I, 33(36.7%) cases group II and rest
35(38.9%) cases group III.
Danesh et al.15 reported that in general, CRP
concentrations increase among smokers with
increased cigarette consumption.16 Regarding
the smoking status it was found in this current
study that 40.9%, 66.7% and 60.0% was smoker
in group I, group II and group III respectively.
Koenig et al.16 have shown in their series 50.0
percent of the patients were hypertensive
which is a little inferior to the present study,
where the current study observed that
hypertensive was 59.1% in group I, 57.6% in
group II and 65.7% in group III. Hypertensive
patients was comparatively higher in group III
but no significant (p>0.05) difference was found
among three group.
In the present study, diabetes mellitus was
higher in group II and group III with compared
to group I, but no significant (p>0.05) difference
was found among three groups. Diabetes
mellitus observed in the present study are in
higher with Koenig et al.
The family history of IHD and dyslipidemia were
almost parallel among three groups, which
were not statistically significant (p>0.05)
Fig.-2: The scatter diagram shows significant
relationship (r=0.6648) between hs-CRP and
stenosis score.
Correlation between hs CRP with extent score
(n=90).
Hs CRP was expressed in mg/L and extent score
ranges from 0 to 80. Significant positive
correlations were found between hs-CRP and
extent score.
The values of Pearson’s correlation coefficient
was 0.6386 which is highly significant
Fig.-3: The scatter diagram shows significant
relationship (r=0.6386) between hs-CRP and
extent score.
J Dhaka Med Coll. Vol. 19, No. 2 October 2010
95
6. Vol. 19, No. 2, October 2010 96
difference among three groups. Nearly one
third of the patient had family history of IHD
and two third had dyslipidemia of the study
patients in the current study.
In this current series it was observed that the
mean (±SD) vessel score was 0.3±0.8 in group
I, 1.4±0.8 in group II and 2.4±0.9 in group III.
More than a eighty (81.8%) had no vessel score
in group I, majority (48.5%) of the patients in
group II patients had vessel score 1 and most
(65.7%) of the patients in group III had vessel
score 3. The mean vessel score difference was
significantly (p<0.05) higher in group III with
compared to others two groups. Similarly, the
mean stenosis score and extent score were
significantly (p<0.05) higher in group III with
compared to others two groups. Where the mean
(±SD) stenosis score was observed in this
current study was 3.2±7.4 in group I patients,
23.5±18.9 in group II patients and 38.3±26.5 in
group III patients. The mean (±SD) extent score
was 8.9±18.0 in group I, 36.1±16.9 in group II
and 51.2±16.6 in group III.
In this present study a significant (p<0.001)
positive correlation coefficient (r=0.7409) was
found between hs-CRP and vessel score, which
indicates that there was linear positive
correlation between hs-CRP and vessel score.
Similarly, significant (p<0.001) positive
correlation coefficient (r=0.6648 and r=0.6386)
were found between hs-CRP with stenosis
score and hs-CRP and extent score. Nyandak
et al.17 who have observed in their studies,
Spearman’s correlation coefficient between
hs-CRP and angiographic stenosis score was
r = 0.316 (p<0.004) and hs-CRP with
angiographic extent score was r= 0.338
(p<0.005).18 Higher hs-CRP levels were
associated with higher stenosis and extent
score in CAD patients, which are consistent
with the present study results.
So, hs-CRP is a single cardiovascular risk factor
and increases CRP concentration within
reference limit are associated with future
cardiovascular events. Elevated level of CRP
can predict the coronary atherosclerotic
disease burden.
Conclusion:
Significant positive correlation was observed
between the extent of coronary artery disease
and hs-CRP levels. Similarly hs-CRP levels were
found to be higher in patients with higher
degree of angiographic stenosis. This shows
that hs-CRP levels have a positive correlation
with the disease burden in CAD patients. hs-
CRP is a single cardiovascular risk factor and
are associated with severity of disease.
Increases CRP concentration within reference
limit are associated with future cardiovascular
events. Elevated level of CRP can predict the
coronary atherosclerotic disease burden.
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