This document discusses hemostatic abnormalities, which are caused by platelet defects, coagulation defects, or both. Coagulation defects can be intrinsic or extrinsic. Hemostatic abnormalities are classified into coagulation disorders, platelet disorders, and blood vessel disorders. Specific disorders discussed include von Willebrand disease, disseminated intravascular coagulation, idiopathic thrombocytopenic purpura, thrombocytopenic purpura, and Henoch-Schonlein purpura. Causes, symptoms, and characteristics of each are described.

1. Hemostatic abnormalities
Prepared by:
Amin khalid

2. Overview
• They are caused either by platelets defects or
coagulation defects or both.
• Coagulation defects may be either intrinsic or
extrinsic defects.
• Hemostatic abnormalities can be classified into:
1- coagulation disorders
2-platels disorders
3-blood vessels disorders

3. (1)-coagulation abnormalities:
• Most common autosomal dominant C. disorder
caused by qualitative or quantitative defect in vWF .
• Pt present with spontaneous bleeding from mucus
membrane & excssive bleeding from the nose and
menorragia
• It has 3 types with various levles
A- Von willebrand disease

4. B- Disseminated intravascular coagulation
• a serious disorder in which the proteins that control
blood clotting become overactive due to the processes of
coagulation and fibrinolysis are dysregulated
• Result in blood in urin and stool or bleeding into the skin
• Can be Caused by: blood cancer, liver disease, sepsis and
hemolytic uremic syndrom
Cont.

5. (2)-Platelet abnormality:
• IS a relatively common disorder and is the
most common frequent cause of an isolated
thrombocytopenia without anemia.
• More common in women aged 15-50
• Can occur in children following viral infection
A- Idiopathic thrombocytopenic purpura

6. Cont.B- Thrombocytopenic Purpura
• Decreased platelet production due to bone marrow failure, viral infections,
drugs inhibiting thrombopoiesis or Increased platelet destruction
• Signs and symptoms include
1 .Petechiae, purpura, sometimes mucosal bleeding
2. Major internal/intracranial bleeding rare
3. Mortality rate < 5%
4. Absence of constitutional symptoms or splenomegaly

7. (3)-Blood vessel defects:
• It is hypersensitivity of small blood vessel of
skin, joint, gut and kidney .
• It can occur at any age but more common in
children .
• The pt presented with skin rash and arthritis
Henicho - scolion purpura (vacuities)