HCG and HPL are protein hormones produced by the placenta. HCG is produced by the syncytiotrophoblast following implantation and promotes maintenance of the corpus luteum during early pregnancy. It can also be used clinically to induce ovulation and testosterone production. HPL, also called HCS, has a similar structure and function to human growth hormone. It decreases maternal insulin sensitivity and glucose utilization to ensure adequate fetal nutrition.

1. PLACENTAL HORMONES
HCG AND HPL
@copyright and owner
POKHREL,BHARAT
DOCTOR OF MEDICINE

2. PLACENTA
l FOETAL ORIGIN → CHORION FRONDOSUM
l MATERNAL ORIGIN → DECIDUA BASALIS

3. HORMONES
PROTEIN HORMONES STEROID HORMONES
l hCG
l hPL
l hCT
l Hypothalamic and
pituitary like hormones
l Others like inhibin, relaxin
and beta endorphins
l Esrogens
l Progestin

4. HCG (Human chorionic
gonadotropin)
HPL (Human placental lactogen)
1)It is a hormone produced by the
syncytiotrophoblast, a portion of
the placenta following
implantation
2)The pituitary analog of hCG,
known as luteinizing hormone
3)promotes the maintenance of the
corpus luteum during the
beginning of pregnancy
4) hCG can also be used clinically
to induce ovulation in the ovaries
as well as testosterone production
in the testes.
1)Also called human chorionic
somatomammotropin (HCS), is a
polypeptide placental hormone.
2)Its structure and function is
similar to that of human growth
hormone
3)↓ maternal insulin sensitivity
leading to an increase in maternal
blood glucose levels.
4)↓ maternal glucose utilization,
which helps ensure adequate fetal
nutrition (the mother responds by
increasing beta cells). Chronic
hypoglycemia leads to a rise in
hPL.

5. Picture taken from : http://www.slideshare.net/NadaGYoussef/lecture-4-development-inheritance

6. PRODUCTION OF HCG