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The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive function. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms.
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Prototyping for Early Validation - Michael Hawley, 2009
Prototyping for Early Validation - Michael Hawley, 2009
Improving Care Experiences Through Human Centered Design - HXR 2016 - Jonatha...
Improving Care Experiences Through Human Centered Design - HXR 2016 - Jonatha...
How do we talk about healthcare - HXR 2016 - Marli Mesibov & Dana Ortegon
How do we talk about healthcare - HXR 2016 - Marli Mesibov & Dana Ortegon
Structured Data and User Experience - Paul Kahn, 2012
Structured Data and User Experience - Paul Kahn, 2012
Organizational Parkour, the Negotiation Game - Seattle Infocamp 2013 - Joan V...
Organizational Parkour, the Negotiation Game - Seattle Infocamp 2013 - Joan V...
Naratives in Healthcare, Stories as Drivers of Change - HXR 2016 - Samantha D...
Naratives in Healthcare, Stories as Drivers of Change - HXR 2016 - Samantha D...
SearchLove San Diego 2015 | Marli Mesibov, 'Make Magic with Anticipatory Design
SearchLove San Diego 2015 | Marli Mesibov, 'Make Magic with Anticipatory Design
Search & Filter Interface Round Up - Usability Marathon - Cueva
Search & Filter Interface Round Up - Usability Marathon - Cueva
Brains, Games, and Behavior Change - Dustin Ditommaso, 2015
Brains, Games, and Behavior Change - Dustin Ditommaso, 2015
HXR: Behavior Change Design - Samantha Dempsey & Ciara Taylor, Mad*Pow
HXR: Behavior Change Design - Samantha Dempsey & Ciara Taylor, Mad*Pow
Organizational Parkour for Seattle Infocamp, 10/2013
Organizational Parkour for Seattle Infocamp, 10/2013
HXR 2016: Improving Care Experiences through Human-Centered Design - Jonathan...
HXR 2016: Improving Care Experiences through Human-Centered Design - Jonathan...
Prototyping For Early Validation by Michael Hawley, Mad*Pow
Prototyping For Early Validation by Michael Hawley, Mad*Pow
Search&Filter Interface Round Up by Amy Cueva, Mad Pow
Search&Filter Interface Round Up by Amy Cueva, Mad Pow
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How to design, build, and host low-carbon websites
Learn behavior change techniques that can help consumers make greener choices online
Attitudes and beliefs: design for audiences with diverse world-views (including those who disagree about climate change)
HXR 2016: Designing for Addiction and Recovery -Mary Beth Schoening, Behavior...
This panel is comprised of parents who’ve lost their children to addiction, a parent whose son is in recovery, and individuals themselves in long-term recovery. We will hear directly from them about their struggles, the impact on individuals and families dealing with addiction, as well as their opinions on where the system could benefit from solutions. The addiction issue is complex and would benefit from solutions in many areas. We invite you to join us to hear first hand.
HXR 2016: Addressing the Opioid Crisis
David W Casavant and Stephen Carson present on the Online Pediatric Pain and Opioid Education Program. The presentation discusses treating non-cancer pain with minimal risk of addiction or abuse, focusing on physician compensation and patient satisfaction. Resources are provided from the Substance Abuse and Mental Health Services Administration on the 2013 National Survey on Drug Use and Health.
HXR 2016: New Models for Care Delivery -Andrew Schutzbank, Iora Health
Andrew’s passion for revolutionizing health care began as a medical student at Tulane in pre- and post-Katrina New Orleans, continuing during his Internal Medicine & Primary Care residency at the Beth Israel Deaconess Medical Center. Andrew has worked across Iora Health since its founding: building the collaborative care platform, advancing a dynamic model of primary care.
HXR 2016: New Models for Care Delivery -Ethan Berke, Dartmouth-Hitchcock
ImagineCare is a digital health platform developed by Dartmouth-Hitchcock Health System to help people better manage chronic diseases. The platform was designed using principles of behavior change and focuses on making services easy to use, continuously valuable, and aimed at behavior modification. It incorporates consumer health wearables, evidence-based care pathways, and secure cloud technologies. The goal of ImagineCare is to empower individuals to live healthier lives and better self-manage chronic conditions through a mobile app that enables 24/7 access to personalized care plans, remote patient monitoring, and proactive support.
HXR 2016: Human Focused Innovation in a Clinical Setting -Lesley Solomon, Bri...
The Brigham and Women's Hospital Innovation Hub (iHub) was created to foster innovation among clinicians and staff and help move ideas from concept to implementation. The iHub provides programs like innovation accelerators and advisory services to help innovators overcome common barriers to innovation such as lack of funding, time, and clarity on next steps. Notable innovations supported include reducing MRI analysis time from 3 days to 3 seconds. Innovators report that the iHub helped connect them to resources and partners to further develop their ideas.
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HXR 2017: Denise Gosnell, Pokitdok: Blockchain: The Now and The Future:
HXR 2017: Denise Gosnell, Pokitdok: Blockchain: The Now and The Future:
HXR 2017: Susan Hunt Stevens, WeSpire: Holistic Wellbeing
HXR 2017: Susan Hunt Stevens, WeSpire: Holistic Wellbeing
HXR 2017: John Weiss, Human Design: Building a Culture of Health
HXR 2017: John Weiss, Human Design: Building a Culture of Health
HXR 2017: Heather Patrick, Carrot Sense: Motivation and Health Behavior Change
HXR 2017: Heather Patrick, Carrot Sense: Motivation and Health Behavior Change
HXR 2017: Bakul Patel: How the FDA Is Promoting Innovation and Protecting the...
HXR 2017: Bakul Patel: How the FDA Is Promoting Innovation and Protecting the...
HXR 2017: Jay Gupta, RxRelax: RxRelax to Reverse Polypharmacy Trends
HXR 2017: Jay Gupta, RxRelax: RxRelax to Reverse Polypharmacy Trends
HXR 2017: Kathleen Howland, Berklee College of Music: Music Therapy in Health...
HXR 2017: Kathleen Howland, Berklee College of Music: Music Therapy in Health...
HXR 2017: Center for Health Experience Design Announcement
HXR 2017: Center for Health Experience Design Announcement
HXR 2017: Paul Kahn, Mad*Pow: Lessons Learned from a Bill you can understand
HXR 2017: Paul Kahn, Mad*Pow: Lessons Learned from a Bill you can understand
HXR 2017: Aneesh Chopra, NavHealth: Call to Action: All Hands on Deck to Brin...
HXR 2017: Aneesh Chopra, NavHealth: Call to Action: All Hands on Deck to Brin...
HXR 2017: Amy Cueva, Mad*Pow: Purpose Driven Design
HXR 2017: Amy Cueva, Mad*Pow: Purpose Driven Design
HXR 2016: Sustainable Design -Jen Briselli, James Christie, Mad*Pow
HXR 2016: Sustainable Design -Jen Briselli, James Christie, Mad*Pow
HXR 2016: Designing for Addiction and Recovery -Mary Beth Schoening, Behavior...
HXR 2016: Designing for Addiction and Recovery -Mary Beth Schoening, Behavior...
HXR 2016: New Models for Care Delivery -Andrew Schutzbank, Iora Health
HXR 2016: New Models for Care Delivery -Andrew Schutzbank, Iora Health
HXR 2016: New Models for Care Delivery -Ethan Berke, Dartmouth-Hitchcock
HXR 2016: New Models for Care Delivery -Ethan Berke, Dartmouth-Hitchcock
HXR 2016: Human Focused Innovation in a Clinical Setting -Lesley Solomon, Bri...
HXR 2016: Human Focused Innovation in a Clinical Setting -Lesley Solomon, Bri...
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There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
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It includes regulation of combination products and medical devices. FDA and industry liaisons.
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The Electrocardiogram - Physiologic Principles
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Adhd Medication Shortage Uk - trinexpharmacy.com
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Hemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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