This document summarizes a mixed methods study conducted in KwaZulu-Natal, South Africa to design and evaluate an intervention program aimed at improving the health, economic, and social capabilities of adolescents at high risk for HIV/AIDS, teenage pregnancy, and other issues. The intervention incorporated life skills education into the school day and was evaluated using longitudinal surveys, focus groups, and interviews with participants, guardians, and facilitators. The mixed methods approach allowed for iterative improvement of the program and instruments as well as triangulation across data sources. Preliminary results were promising and the Department of Education was interested in scaling up the program.