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These clinical practice guidelines were developed by a task force consisting of experts from the American College of Critical Care Medicine, the Society of Critical Care Medicine, the American Society of Health-System Pharmacists, and the American College of Chest Physicians. The guidelines provide recommendations for the sustained use of sedatives and analgesics in critically ill adult patients.
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This document discusses personalized medicine, which aims to provide the right treatment for each individual patient based on their genetic profile. It defines personalized medicine as tailoring medical treatment to each patient's characteristics, needs and preferences. The development of genomic sequencing allows for more precise treatment by understanding how genetic variations impact drug metabolism and response. Pharmacogenomics studies how DNA and RNA variations affect drug effectiveness. Implementing personalized medicine through genetic testing can help reduce disease burden by improving prevention, treatment and healthcare costs while minimizing risks.
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3. While opioids may provide pain relief in the short term for chronic non-cancer pain, studies find limited evidence for their efficacy and safety over the long term. Higher doses are associated with greater risks without clear benefits for pain treatment.
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1. Several studies examined the relationship between adherence to antiretroviral drug regimens and virologic outcomes in HIV/AIDS patients. Simpler once-daily dosing was associated with improved adherence and clinical outcomes compared to more complex twice-daily regimens.
2. Other research showed that once-daily dosing of hypertension and diabetes medications led to better adherence rates and health outcomes over twice-daily administration.
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The document discusses several studies that have been conducted on the relationship between vitamins and prostate cancer. It summarizes the findings of several large studies, including the SELECT trial, ProtecT trial, and PHS II trial, which found that vitamins like selenium, vitamin E, and multivitamins did not effectively treat or prevent prostate cancer. However, it notes that the scientific community remains uncertain and more research is still needed to fully understand the complex relationship between vitamins and prostate cancer.
16. IM Clinic
The document describes the approach taken by one institution, Mayo Clinic, to implement individualized medicine into clinical practice through a standalone Individualized Medicine (IM) Clinic. The IM Clinic was designed to overcome barriers to translating genomic medicine into routine patient care. Initial services offered by the IM Clinic included whole exome sequencing for patients with undiagnosed genetic conditions (diagnostic odyssey) and tumor sequencing for cancer patients who have failed standard therapies. The IM Clinic utilizes a multidisciplinary team approach and coordinates various components including genomic counseling, sample collection, sequencing, data analysis, expert review boards, and communication of results to patients. The goals are to improve patient outcomes by enabling more targeted and personalized care approaches.
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This document contains 23 references related to nausea and vomiting caused by cancer treatment. The references describe research on different antiemetic drugs for preventing chemotherapy-induced nausea and vomiting, including ondansetron, dolasetron, granisetron, metoclopramide, dexamethasone, aprepitant, palonosetron, netupitant, and rolapitant. Many of the references are randomized controlled trials that compare the efficacy of different antiemetic combinations in reducing nausea and vomiting from chemotherapy. The references also include guidelines on managing chemotherapy-induced nausea and vomiting from cancer organizations.
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The power point presentation describes development of Ru(II) complexes for cancer treatment. The presentation is prepared based on three review articles published in Chemical Society Reviews on 2017 and 2018:
(1)Chem. Soc. Rev., 2017,46,5771
(2)Chem. Soc. Rev., 2017,46,7706
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INTRODUCTION
DNA VACCINES
GENE THERAPY
TIME LINE OF DEVELOPING GENE THERAPY
GENE THERAPY STRATEGIES
TECHNOLOGY OF CLASSICAL GENE THERAPY
PRINCIPLES OF GENE TRANSFER
VECTORS
VIRAL VECTORS
NON-VIRAL VECTORS
APPLICATIONS OF GENE THERAPY
ETHICAL IMPLICATIONS
THE FUTURE
CONCLUSION
REFERENCES
HXR 2017: Casey Quinlan: the Price is Right
This document introduces several people involved in health care including a precision medicine research advocate who is a lung cancer survivor, a health and health tech consultant nicknamed Wonder Woman, a writer and policy expert nicknamed Mighty Mouth, and a writer and analyst who is a marathon addict. It also lists several common medical procedures and experiences in the U.S. healthcare system such as mammograms, emergency room stitches, childbirth, and multiple sclerosis treatment, followed by a call to discuss healthcare delivery and patients.
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The document evaluates popular diets for cancer treatment. It discusses a journal article that analyzed cancer patient chat rooms to determine the most popular diets, then analyzed the macrobiotic diet for cancer. The journal article found no sound medical evidence that the macrobiotic diet works to treat cancer. A related website contained an unbiased medical analysis that various diets, including the macrobiotic diet, lacked sound evidence to prove they work for cancer treatment.
CIRRICULUM VITAE
This document is a curriculum vitae for Tricia Brantner. It provides biographical information about her, including her education, current position as a Senior Research Technologist at Mayo Clinic, and a list of original articles and abstracts that she has contributed to, primarily focused on celiac disease epidemiology and outcomes. The CV demonstrates her expertise in celiac disease research through her involvement in numerous peer-reviewed publications on topics like the prevalence and mortality of undiagnosed celiac disease.
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This presentation forms a part of a Virtual Edition on Radiotherapy for bladder cancer
on www.bjui.org.
Cancer
This document discusses new pathways for cancer treatment. It summarizes two recent studies that could revolutionize cancer treatment approaches. The first study identified a DNA-dependent protease involved in repairing DNA-protein crosslinks (DPCs). Inducing DPCs could suppress cellular replication in cancer by blocking DNA replication and stopping tumor growth. The second study found that cyclin D activates the tumor suppressor Rb through mono-phosphorylation, rather than inactivating it as previously thought. This corrects the understanding of cell cycle control and tumor suppression activation involving cyclin D. These advances in understanding cancer at the cellular level provide hope for more effective radical treatments for this disease.
August 2019 - Recurrence: What now?
In this webinar, Dr. Azad discusses colorectal cancer recurrence. She addresses things to do to help reduce the risk of recurrence, in addition to what steps should be taken if colon or rectal cancer returns.
Colo-rectal Cancer poster
This document summarizes information about colorectal cancer, including key statistics, risk factors, stages of progression, screening recommendations, and dietary guidelines. It notes that colorectal cancer is the third most common cancer in the US, with over 95,000 new cases expected in 2016. Risk factors include age over 50, obesity, lack of physical activity, smoking, heavy alcohol use, and family history. Screening is recommended starting at age 50 to detect polyps and early cancers. Diet guidelines focus on increasing fiber and plant foods while limiting red meat and processed foods.
Strategic Planning in Cancer Prevention
This document discusses strategic planning for cancer prevention. It provides information on various dietary and environmental factors that can increase cancer risk such as high glycemic diets, oxidative overload, inflammation, and exposure to toxins like PBDEs and BPA. It summarizes several studies that show relationships between certain foods/supplements and reduced cancer rates, such as broccoli consumption being associated with lower prostate cancer risk and green tea supplementation correlating with fewer prostate cancer cases. The document advocates for lifestyle changes like plant-based diets, exercise, and detoxification to potentially prevent or slow cancer progression.
What Is a Phase I Clinical Trial?
Audio and slides for this presentation are available on YouTube: http://youtu.be/NzJ_fvSxwGk
Sara Tolaney, MD, MPH, a breast oncologist with the Susan F. Smith Center for Women's Cancers at Dana-Farber Cancer Institute, gives an overview of phase I clinical trials and some of the new drugs being tested to treat breast cancer. This talk was originally given at the Metastatic Breast Cancer Forum at Dana-Farber on Oct. 5, 2013.
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Improving Adherence in HIV Treatment with Once-Daily Therapies
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Effectiveness of Vitamins in the treatment of Prostate Cancer v5 - Copy
Effectiveness of Vitamins in the treatment of Prostate Cancer v5 - Copy
Anticancer ruthenium(ii) complexes - Anjali Devi J S
Anticancer ruthenium(ii) complexes - Anjali Devi J S
A multicentre phase II study of hypofractionated conformal radiotherapy with ...
A multicentre phase II study of hypofractionated conformal radiotherapy with ...
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This document describes an economics leadership program that challenges teenagers to step outside their comfort zones through activities like zip lining over 400 feet, being blindfolded and silent for three hours, and trusting others to catch them as they fall 50 feet from a pole. The program aims to teach teenagers leadership skills and help them learn about themselves and others through experiential activities held at historic locations across the U.S.
P5 Simple Machines
This document summarizes several simple machines: levers, wheels and axles, inclined planes, gears, and pulleys. Levers use a fulcrum to multiply force or reduce effort depending on where the effort is applied. Wheels and axles reduce the effort needed to move or overcome a load. Inclined planes also reduce the effort needed to lift a load compared to lifting vertically. Gears can change the speed and direction of rotation or applied force. Pulleys can reduce the effort needed to lift a load by half but do not change the direction of applied force.
Starchman Coyle What is Project Based Learning
Project Based Learning is a student-driven, democratic, hands-on approach to learning that utilizes research, higher-order thinking skills, and technology. It differs from traditional book learning and lecture-based methods that rely on rote memorization by engaging students through multiple modalities in projects suited to their interests and skills.
Digital Multimedia Productions: Incroporating Wikis, the Jing Project and Oth...
The document discusses creating and sharing copyright-free digital stories using various software and web tools. It provides examples of how students can incorporate images, audio, and video from the Creative Commons network to tell stories on topics like technology innovations. Guidelines are given for storyboarding, narrating, and publishing digital stories in a class wiki for others to access.
Mind Reader
The document provides instructions for a mind reading game where the player thinks of a two-digit number, adds the digits together to get a second number, subtracts the second number from the first to get an answer, and matches the answer to a symbol on a provided chart to reveal whether the mind reader correctly guessed the player's number.
Rich & Poor
The father took his wealthy son on a trip to experience how poor people live. They stayed with a poor family on their farm for a few days. When they returned, the father asked the son what he learned. The son said that while they have many luxuries, the poor family had friends and a sense of community to rely on. He thanked his father for teaching him how poor they really are by comparison. Having a new perspective on appreciating what you have is important.
P6 Forces
Forces are pushes or pulls that cannot be seen but can be detected through their effects such as making stationary objects move, changing the speed or direction of moving objects, slowing or stopping moving objects, and changing the shape of objects. There are different types of forces including gravitational, elastic spring, frictional, and magnetic forces. Gravitational force is the force of attraction between objects with mass. Elastic spring force stores energy when compressed or stretched and releases it to return the spring to its original shape. Frictional force slows and stops moving objects when they contact another surface. Magnetic force can be either attractive or repulsive depending on the object and magnet.
P6 Energy
The document discusses different types of energy including light, heat, kinetic, potential, electrical, and sound energy. It explains that the sun is the main source of energy for living things and provides heat and light. It also describes how energy can be converted from one form to another through various processes like chemical and kinetic energy conversions.
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Breast Cancer
VEGF plays an important role in breast cancer development and progression. VEGF overexpression is associated with increased angiogenesis, tumor growth, metastasis, and poorer survival outcomes in breast cancer patients. VEGF expression has been correlated with other breast cancer markers like ER, HER2, and BRCA1. Ongoing research continues to provide insights into VEGF's complex role in breast cancer biology and its potential as a prognostic and predictive factor.
SELECT trial 2009
The SELECT trial investigated whether selenium or vitamin E supplements could prevent prostate cancer. Over 35,000 relatively healthy men in the US, Canada, and Puerto Rico were randomly assigned to take selenium, vitamin E, both supplements, or placebo pills daily for at least 7 years. The trial found that neither selenium nor vitamin E reduced prostate cancer risk overall. Selenium was associated with a small increased risk of more aggressive prostate cancers. This large, long-term clinical trial showed that the supplements did not prevent prostate cancer and selenium may increase risk of some forms of the disease.
Consensus overview on ME/CFS
The document provides an overview of the Canadian Consensus Document on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). It summarizes the development of the consensus document, which was spearheaded by the National ME/FM Action Network of Canada in response to the need for a clinical case definition and guidelines for diagnosis and treatment of ME/CFS. An expert panel of 11 clinicians and researchers with experience treating over 20,000 ME/CFS patients was selected to develop the consensus document. The panel held a funded workshop to reach consensus on a clinical case definition, diagnostic guidelines, and treatment guidelines for medical practitioners dealing with ME/CFS patients.
Singh et al acr ra gl-may 2012 ac&r
These guidelines from the American College of Rheumatology update their 2008 recommendations for treating rheumatoid arthritis with disease-modifying antirheumatic drugs and biologics. The updates provide guidance on indications for treatment, switching between medications, using biologics in high-risk patients, tuberculosis screening, and vaccination. The recommendations were developed by reviewing evidence and forming consensus opinions among experts in rheumatology clinical practice and research.
Asccp guidelines 2012 cx cancer prevention
This document provides updated guidelines from the American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology for screening and early detection of cervical cancer. The guidelines are based on evidence reviews and input from multiple working groups and organizations. The new screening recommendations address age-appropriate screening strategies and the use of cytology and HPV testing.
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Fact Sheet onFact Sheet onFact Sheet onFact Sheet onFact Sheet on
End-of-Life CareEnd-of-Life CareEnd-of-Life CareEnd-of-Life CareEnd-of-Life Care
WHAT ARE OLDER ADULTS’ MENTAL HEALTH NEEDS
NEAR THE END OF LIFE?
The US Supreme Court agreed that Americans should expect palliative care,
which combines active and compassionate therapies to comfort and support
individuals and families nearing the end of life. End of life is defined as that
time period when health care providers would not be surprised if death
occurred within about 6 months. Older Americans with chronic illness think
about how they would prefer their lives to end, and want a “good death”
without burdensome pain, symptoms and technology.
Most deaths (70%) occur in those aged 65 and older. Older adults want better discussions,
information, and a chance to influence decisions about their care—whether to be at home
or in the hospital and to have CPR (cardiopulmonary resuscitation) (Foley, 1995). Most
Americans die in hospitals (63%), and another 17% die in institutional settings such as
long-term care facilities (Foley, 1995; Isaacs & Knickman, 1997). In addition, most
people are referred too late to hospice or palliative care, so they are unable to get the most
benefit possible from these specialized services.
WHAT DO OLDER ADULTS FEAR MOST?
People fear that their pain, symptoms, anxiety, emotional suffering, and family
concerns will be ignored. Many critically ill people who die in hospitals still receive
unwanted distressing treatments and have prolonged pain. Many fear that their
wishes (advance directives) will be disregarded and that they will face death alone
and in misery. Physicians may use confusing or vague medical terms and talk briefly
about treatment options when the patients are too sick to participate. Most people
want to discuss advance directives when they are healthy and often want their
families involved.
Caregivers reported that a third of 1227 elderly individuals were in unnecessary pain
during the 24 hours before their death. Studies show that two thirds of elderly patients have
pain in the last month of life (Foley, 1995). Although palliative/comfort care could relieve
most of this pain and suffering, patients typically spend 8 days in ICU (an intensive care
unit) comatose or on a ventilator and 30% of patients spend at least 10 days in ICU
before they die (Isaacs & Knickman, 1997).
When discussing a good end of life with a patient, physicians in one study talked about 5-6
minutes, spoke for 2/3 of this time, and did not consider the patient’s values or preferences
(Tulsky, Fischer, Rose & Arnold, 1998). If patients were too sick to make decisions, most
wanted their family to be given choices about treatment and only 41% wanted the
physician to make treatment decisions without consulting them. In 91% of cases in which
physicians discussed end of life treatment options, they did so in scenarios in which most
patients would not want to be treated, whereas o ...
Lung cancer, 3rd ed
This document is the third edition of a book on lung cancer edited by Jack A. Roth, James D. Cox, and Waun Ki Hong. It contains chapters written by experts on various topics related to lung cancer, including smoking cessation, lung cancer genetics, detection and diagnosis of preneoplastic lung lesions, surgical and non-surgical treatments, targeted therapies, screening and prevention. The book provides a comprehensive overview of the current state of knowledge across the multidisciplinary field of lung cancer research and clinical management.
Vitamin d3
This randomized controlled trial investigated whether early administration of a single high dose of 540,000 IU of vitamin D3 would reduce 90-day mortality in critically ill patients with vitamin D deficiency. 1360 patients screened vitamin D deficient and underwent randomization to receive either vitamin D3 or placebo within 12 hours of ICU admission. 1078 patients had baseline vitamin D deficiency (<20 ng/mL) confirmed by liquid chromatography-tandem mass spectrometry and comprised the primary analysis population. The trial found no significant difference in 90-day mortality between those receiving vitamin D3 (23.5%) versus placebo (20.6%), and no differences in other clinical or safety outcomes.
RACM 2011 brochure
The University of Virginia Department of Medicine is hosting the 38th Annual Recent Advances in Clinical Medicine Conference from October 26-28, 2011 at the Omni Charlottesville Hotel. The conference will feature lectures on current issues in both outpatient and inpatient care, as well as interdisciplinary sessions on topics such as sleep disorders, joint replacement, and caring for pregnant patients. Attendees will have opportunities to ask questions and discuss cases with speakers. The conference aims to provide practical information that physicians can apply in their practices. It is designed for generalists but also specialists staying updated in their fields.
Concerns and Perceived Barriers Related to Treatment of Opioid Addiction with...
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A Tool to Engage the Patient in Web-based Coordinated Treatment of Opioid Add...
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
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2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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