GROUP 1: Case 967-- A Teenage Female with an Ovarian Mass
CLINICAL HISTORY
A teenage female presented with secondary amenorrhea (https://www.healthline.com/health/secondary-amenorrhea#causes). The patient had 1 menstrual cycle 3 years ago and has had no menses since. Laboratory work-up was negative for pregnancy test, mildly increased calcium level (11.7 mg/dL, normal range: 8.5-10.2 mg/dL) and CA 125 (43 Units/ml, normal range: 0-20 Units/ml). Prolactin, TSH, AFP, Inhibin A, Inhibin B and CEA were normal. Imaging revealed a 13 x 11.8 x 8.6 cm, predominately cystic left pelvis mass, with multiple internal septations. Her past medical history was not contributory. Patient underwent left salpingo-oophorectomy (https://www.healthline.com/health/salpingo-oophorectomy), omentectomy (https://moffitt.org/cancers/ovarian-cancer/omentectomy/) and tumor debulking (https://en.wikipedia.org/wiki/Debulking) with intraoperative frozen section consultation.
GROSS EXAMINATION
The 930.9 g tubo-ovarian complex consisted of a 20.0 x 16.0 x 8.0 cm large mass, with no recognizable normal ovarian parenchyma grossly and an unremarkable fallopian tube. The cut surface was gray, "fish-flesh", soft with foci of hemorrhage and necrosis.
MICROSCOPIC EXAMINATION
Microscopically, the majority of main tumor was growing in large nests, sheets and cords with focal follicle-like structures and geographic areas of necrosis. It was predominantly composed of small cells with hyperchromatic nuclei, round to oval nucleus with irregular nuclear contour, inconspicuous to occasional conspicuous nucleoli and minimal cytoplasm. This component was variably admixed with a population of larger cells, which as the name implies composed of cells with abundant eosinophilic cytoplasm, with central or eccentric round to oval nuclei, pale chromatin and prominent nuclei. Both, the small and large cell components demonstrated brisk mitotic activity. All staging biopsies and omentectomy were composed of large cell component.
An extensive panel of immunohistochemical stains was performed. Overall, the staining pattern was strong and diffuse in small cell component compared to patchy weak staining pattern in the large cell component.
FINAL DIAGNOSIS
Small cell carcinoma (https://en.wikipedia.org/wiki/Small-cell_carcinoma) of the ovary, hypercalcemic type (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939673/)
DISCUSSION
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is an aggressive and highly malignant tumor affecting the women under 40. It was first described as a distinct entity by Dickersin et al in 1982 (1). Fewer than 500 cases have been described in the literature and it accounts for less than 1% of all ovarian cancer diagnoses. Due to the initial consideration of epithelial origin, the term of SCCOHT has been used to distinguish this entity from its mimicker, the neuroendocrine or pulmonary type (2). In fact epithelial origin of SCCOHT was recently challenged as new imm.
A seminar I gave as a PhD student reviewing the role of stem cells in the development of various different kinds of cancers, as well as emerging treatment options.
EXPRESSION OF CK5 BASAL CYTOKERATIN DURING METASTATIC DEVELOPMENT OF BREAST C...ANCA MARIA CIMPEAN
Objective. Breast cancer is a one of the most common cancers in females worldwide. Basal cytokeratin CK5 represent the marker of progenitors for glandular and myoepithelial lineages of mammary epithelium. During epithelial differentiation there is a gradual decrease of CK5 expression. The purpose of this study was to compare the expression of basal cytokeratin CK5 vs hormone receptors, HER2, Ki67 and molecular subtypes immunohistochemically defined in the primary breast carcinoma of NST type and axillar lymph node metastasis. Material and Methods. We processed immunohistochemically 91 invasive breast carcinomas of NST type and their ipsilateral axillar lymph node metastasis (LNM). Results. The majority of primary tumors were evaluated as CK5 negative (78 cases/85.7%). The majority of cases were evaluated as Luminal B (50 cases/54.9%) and Luminal A (28 cases/30.8%) tumors. The HER2 subtype was confirmed in 8 cases/8.8%, 5NP in 3 cases/3.3% and Basal-like in 2 cases/2.2%. The parallel comparison of CK5 expression at both sites, primary and metastatic, revealed that this marker is not stable during metastatic progression. The molecular subtypes were not stable during metastatic process in 21 cases/23.1%. Conclusions. The majority of NST invasive ductal breast carcinomas are CK5 negative. The molecular subtypes and CK5 are not stable during metastatic process. Cancerous cells prefer to lose this marker in the lymph node environment. The presence of cases with simultaneous expression of CK5 and hormone receptors is an open field to debate the existence of other, transient molecular subtypes. We expect a further confirmation in larger study groups.
Key Words: molecular subtypes, invasive carcinoma NST type, basal cytokeratin.
Thyroid Papillary Carcinoma and Noninvasive Follicular Thyroid Neoplasm with ...CrimsonPublishersGJEM
Papillary thyroid carcinomas (PTC) are well differentiated malignante pithelial tumors with characteristic nuclear features and they originate from epithelial cells of thyroid follicle. Papillary thyroid carcinoma is the most common type of thyroid cancers, which composes 85-90% of all thyroid carcinomas. Number of patients diagnosed with thyroid cancer has significantly increased during the last two decades due to increased awareness of nodular thyroid diseases, developments in diagnostic methods, wide applicability of thyroid fine needle aspiration, new descriptions of histopathology criteria and increased radiation exposure. It is more common in males than females with some ethnic variations. Although it is very rare during early childhood, it is the most common thyroid cancer of this age group. The mean age is 46 years at the time of diagnosis. Tumor has some histologic variants, the most common ones are being classical and follicular variants
https://crimsonpublishers.com/gjem/fulltext/GJEM.000505.php
For more open access journals in Crimson Publishers
Please click on link: https://crimsonpublishers.com
For More Articles on Medical research
Please click on: https://crimsonpublishers.com/gjem/
A seminar I gave as a PhD student reviewing the role of stem cells in the development of various different kinds of cancers, as well as emerging treatment options.
EXPRESSION OF CK5 BASAL CYTOKERATIN DURING METASTATIC DEVELOPMENT OF BREAST C...ANCA MARIA CIMPEAN
Objective. Breast cancer is a one of the most common cancers in females worldwide. Basal cytokeratin CK5 represent the marker of progenitors for glandular and myoepithelial lineages of mammary epithelium. During epithelial differentiation there is a gradual decrease of CK5 expression. The purpose of this study was to compare the expression of basal cytokeratin CK5 vs hormone receptors, HER2, Ki67 and molecular subtypes immunohistochemically defined in the primary breast carcinoma of NST type and axillar lymph node metastasis. Material and Methods. We processed immunohistochemically 91 invasive breast carcinomas of NST type and their ipsilateral axillar lymph node metastasis (LNM). Results. The majority of primary tumors were evaluated as CK5 negative (78 cases/85.7%). The majority of cases were evaluated as Luminal B (50 cases/54.9%) and Luminal A (28 cases/30.8%) tumors. The HER2 subtype was confirmed in 8 cases/8.8%, 5NP in 3 cases/3.3% and Basal-like in 2 cases/2.2%. The parallel comparison of CK5 expression at both sites, primary and metastatic, revealed that this marker is not stable during metastatic progression. The molecular subtypes were not stable during metastatic process in 21 cases/23.1%. Conclusions. The majority of NST invasive ductal breast carcinomas are CK5 negative. The molecular subtypes and CK5 are not stable during metastatic process. Cancerous cells prefer to lose this marker in the lymph node environment. The presence of cases with simultaneous expression of CK5 and hormone receptors is an open field to debate the existence of other, transient molecular subtypes. We expect a further confirmation in larger study groups.
Key Words: molecular subtypes, invasive carcinoma NST type, basal cytokeratin.
Thyroid Papillary Carcinoma and Noninvasive Follicular Thyroid Neoplasm with ...CrimsonPublishersGJEM
Papillary thyroid carcinomas (PTC) are well differentiated malignante pithelial tumors with characteristic nuclear features and they originate from epithelial cells of thyroid follicle. Papillary thyroid carcinoma is the most common type of thyroid cancers, which composes 85-90% of all thyroid carcinomas. Number of patients diagnosed with thyroid cancer has significantly increased during the last two decades due to increased awareness of nodular thyroid diseases, developments in diagnostic methods, wide applicability of thyroid fine needle aspiration, new descriptions of histopathology criteria and increased radiation exposure. It is more common in males than females with some ethnic variations. Although it is very rare during early childhood, it is the most common thyroid cancer of this age group. The mean age is 46 years at the time of diagnosis. Tumor has some histologic variants, the most common ones are being classical and follicular variants
https://crimsonpublishers.com/gjem/fulltext/GJEM.000505.php
For more open access journals in Crimson Publishers
Please click on link: https://crimsonpublishers.com
For More Articles on Medical research
Please click on: https://crimsonpublishers.com/gjem/
a nice presentation about the Ovarian Cancer its include an introduction with brief notes about the epidemiology and risk factors then shift to pathology and pathogenesis and diagnosis with signs , symptoms and lab tests with imaging modules , screening , management
This is a presentation on most common applications of immunohistochemistry in breast lesions. Prepared by Dr Ashish Jawarkar, Assistant professor in pathology, Parul Institute of Medical sciences and research Vadodara
Group Presentation Once during the quarter, each student will.docxgilbertkpeters11344
Group Presentation
: Once during the quarter, each student will prepare a brief presentation on a specific neighborhood, a racial or cultural group, or a historical event, migration or shift in the urban landscape,
related to the themes for that week
. Students will select preferred weeks in advance and be scheduled by Week 2 as best as your professor can allow. The presentation is open in form and format but should be 20 minutes in duration, consist mostly of your own original words and discussion, but involve some form of visual, quotes, or data, and represent some amount of additional research beyond the readings for that week, and include 5 or more questions for discussion to be presented to the class. Your group grade will reflect an average of 4 grades in content, delivery, relevance and engagement with the class in discussion.
.
Group Presentation Outline
•
Slide 1: Title slide
•
This contains your topic title, your names, and the course.
•
Slide 2: Introduction slide
•
Remember that you are presenting this information to others. Acknowledge the audience, and mention the purpose of the
presentation.
•
This slide should contain at least 50–100 words of speaker notes.
•
Slides 3–10 (or more): Content slides
•
Describe the topic and structure
•
Outline and discuss the issues/components each separately
•
Discuss theories, laws, policies, and other labor relations related topics
•
Provide support for your perspective and analysis
•
Lessons learned documented, what you have learned
•
Conclusion
•
The slides should each contain at least
50–100 words of speaker notes.
•
Final slide(s): Reference slide(s)
•
List your references according to the APA sty
.
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a nice presentation about the Ovarian Cancer its include an introduction with brief notes about the epidemiology and risk factors then shift to pathology and pathogenesis and diagnosis with signs , symptoms and lab tests with imaging modules , screening , management
This is a presentation on most common applications of immunohistochemistry in breast lesions. Prepared by Dr Ashish Jawarkar, Assistant professor in pathology, Parul Institute of Medical sciences and research Vadodara
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: Once during the quarter, each student will prepare a brief presentation on a specific neighborhood, a racial or cultural group, or a historical event, migration or shift in the urban landscape,
related to the themes for that week
. Students will select preferred weeks in advance and be scheduled by Week 2 as best as your professor can allow. The presentation is open in form and format but should be 20 minutes in duration, consist mostly of your own original words and discussion, but involve some form of visual, quotes, or data, and represent some amount of additional research beyond the readings for that week, and include 5 or more questions for discussion to be presented to the class. Your group grade will reflect an average of 4 grades in content, delivery, relevance and engagement with the class in discussion.
.
Group Presentation Outline
•
Slide 1: Title slide
•
This contains your topic title, your names, and the course.
•
Slide 2: Introduction slide
•
Remember that you are presenting this information to others. Acknowledge the audience, and mention the purpose of the
presentation.
•
This slide should contain at least 50–100 words of speaker notes.
•
Slides 3–10 (or more): Content slides
•
Describe the topic and structure
•
Outline and discuss the issues/components each separately
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Discuss theories, laws, policies, and other labor relations related topics
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Provide support for your perspective and analysis
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Lessons learned documented, what you have learned
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Conclusion
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The slides should each contain at least
50–100 words of speaker notes.
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Final slide(s): Reference slide(s)
•
List your references according to the APA sty
.
Group PortionAs a group, discuss and develop a paper of 10 p.docxgilbertkpeters11344
Group Portion
As a group, discuss and develop a paper of 10 pages that addresses the following questions. Work together to determine who will complete each section:
Who will comprise your planning committee? Explain.
Identify public- and private-sector partner agencies and elected officials (if any) that should serve on the planning committee.
What are the component parts of the plan (be specific and detailed)? Explain.
What participating agencies may be more or less involved in which parts of the plan development? Explain.
Are there subject matter experts (SMEs) or other entities that should be involved in any one specific area of the plan development? Explain.
Based upon the emergency management concept of incident management that includes the phases of preparedness and mitigation, response, and recovery, identify the actions that will need to be taken in each phase as they relate to the hazard you have selected.
Identify the major challenges that the community and responders will encounter when responding to the hazard.
What solutions exist (e.g., mutual aid, contract services) to overcome those challenges? Explain in detail.
What should be the short- and long-term recovery goals of the community following this event’s occurrence?
Be sure to reference all sources using APA style.
Please add your file.
Individual Portion
Develop a PowerPoint presentation of 6–7 slides that provides details about your plan.
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Group Behavior in OrganizationsAt an organizational level,.docxgilbertkpeters11344
Group Behavior in Organizations
At an organizational level, group behavior is necessary for continued functioning of the
organization. Within an organization, there are established rules, procedures, and processes
developed that define how an organization operates. In addition, there are systems in place
to reward behaviors of those who effectively participate in the organization's operations.
Besides, there are also systems that define consequences that can take place in case
individuals behave outside the accepted practices of the organization. What develops out of
this is an employee's attachment to the organization based on common beliefs, values, and
traditions. The shared attachment and even the commitment to common beliefs, values, and
traditions make up an organization's culture (Helms & Stern, 2001; Lok & Crawford, 2001).
What Is Organization Culture?
Sheard and Kakabadse (2002) explained organizational culture in terms of solidarity and
sociability. Solidarity, in this case, referred to a group's willingness to pursue and maintain
conformity in shared objectives, processes, and systems. Sociability referred to a group's
sense of belongingness by its members and level of camaraderie.
They also mentioned there might be differences between hierarchies or levels within an
organization's culture. Based on the solidarity and sociability of each, upper management
might differ from the decisions made by middle management and line staff. These differences
might also occur between functional departments and, in larger organizations, between
geographically distinct sections of the organization.
What Sheard and Kakabadse wanted to emphasize through this discussion was there might
be distinct subcultures within an organization's culture.
According to De Long and Fahey (2000), "Subcultures consist of distinct sets of values,
norms, and practices exhibited by specific groups or units in an organization." Subcultures
may be readily observed in larger, more bureaucratic organizations or organizations having
well-established departments with employees that have highly specialized or possessing
unique skills.
De Long, D., & Fahey, L. (2000). Diagnosing cultural barriers to knowledge management. The
Academy of Management Executive, 14(4), 113–127.
Helms, M., & Stern, R. (2001). Exploring the factors that influence employees 'perceptions of
their organization's culture. Journal of Management in Medicine, 15(6), 415–429.
Lok, P., & Crawford, J. (2001). Antecedents of organizational commitment and the mediating
role of job satisfaction. Journal of Managerial Psychology, 16(8), 594–613.
Sheard, A., & Kakabadse, A. (2002). Key roles of the leadership landscape. Journal of
Managerial Psychology, 17(1/2), 129–144.
3-17 Kenneth Brown is the principal owner of Brown Oil, Inc. After quitting his university teaching job,
Ken has been able to increase his annual salary by a factor of over 100. At the present time, Ken is
f.
Group assignment Only responsible for writing 275 words on the foll.docxgilbertkpeters11344
Group assignment: Only responsible for writing 275 words on the following
Explain immigration and how that is connected.
Identify current and future issues in serving diverse clients and legally protected classes.
GroupgrAssignment content:
Access
the
Prison Rape Elimination Act
website.
Write
a 1,000- to 1,400-word report for an audience of potential new employees in human services in a correctional setting in which you:
Summarize current and future civil rights issues that affect the criminal justice system.
Identify why PREA affects the future of corrections.
Explain immigration and how that is connected.
Identify current and future issues in serving diverse clients and legally protected classes.
Explain options for advocacy.
Identify
boundaries in advocacy for human service workers.
Format
your resources consistent with APA guidelines.
.
Group 2 WG is a 41-year-old female brought herself into the ER la.docxgilbertkpeters11344
Group 2: WG is a 41-year-old female brought herself into the ER last night asking to "detox from vodka." She tells you she has a long-standing history of alcohol dependence with multiple relapses. She also reports that she has experienced alcohol withdrawal seizures before. Current CIWA-Ar is 17. She denies any past medical history but lab work indicates hepatic insufficiency (LFTs x3 ULN). All other lab work is normal. She denies taking any medications.
How will you manage this patient’s withdrawal syndrome?
Responses must be a minimum of 200 words, scholarly written, APA7 formatted, and referenced. A minimum of 2 references are required (other than your text). Plagiarism and grammatical errors free.
.
Group 2 Discuss the limitations of treatment for borderline and.docxgilbertkpeters11344
Group 2: Discuss the limitations of treatment for borderline and histrionic PD and what can be done from a psychopharmacological perspective.
Post must be a minimum of 200 words, scholarly written, APA formatted, and referenced. A minimum of 2
scholarly
references are required
(other than your text
).
.
Group 3 Discuss the limitations of treatment for antisocial and.docxgilbertkpeters11344
Group 3: Discuss the limitations of treatment for antisocial and narcissistic PD and what can be done from a psychopharmacological perspective.
Post your initial response by Wednesday at midnight. Respond to at least one student
with a different assigned DB question
by Sunday at midnight. Both responses must be a minimum of 200 words, scholarly written, APA formatted, and referenced. A minimum of 2
scholarly
references are required
(other than your text
). attached lecture for the theme.
.
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Group 1: Describe the differences between Naloxone, Naltrexone, and Buprenorphine/Naloxone. Include the properties of each, their classification, mechanism of actions, onset, half-life, and formulations (routes of delivery). Please discuss the implications of differences in the clinical setting (including pre-hospital)
Responses must be a minimum of 200 words, scholarly written, APA7 formatted, and referenced. A minimum of 2 references is required (other than your text). Plagiarism and grammatical errors free.
.
Grotius, HobbesDevelopment of INR – Week 3HobbesRelati.docxgilbertkpeters11344
Grotius, Hobbes
Development of INR – Week 3
Hobbes
Relationship between Natural Law and Law of Nations?
Mediated by the idea of the state of nature as the predicament of insecurity:
Natural right: self-preservation.
Natural law: the observation of promises and contracts.
For states: minimum observation of natural law in the form of consenting to agreements.
Written agreement: treaty-making
Unwritten agreements: customary law
Hobbes
State of Nature: the condition in which individuals find themselves in a perpetual condition of war.
Natural right to self-preservation:
We each have the right to judge what is in our interest for self-preservation.
Conflict occurs because of:
Competition
Diffidence
Glory
Different meanings for words in the State of Nature; no ability in the State of Nature to determine whose judgment is valid (Wolin).
Life in the state of nature: “Solitary, poor, nasty, brutish, and short”
Commonwealth
Commonwealth by institution:
Social contract: it is the collective agreement among all individuals in the state of nature to establish:
Sovereign power
Able to speak and act for a multiplicity of people (which becomes a unified group).
State
The unity of sovereign power and the unified people.
Sovereign is the man or assembly that carries the person of the State.
State is the Leviathan: the mortal God on earth.
Sovereigns come and go but the State remains.
Consequences
The implication: fear is displaced from the condition of the state of nature to the relation between individual and state.
What continues to bind the state is fear of a return to the State of Nature:
the relation between individual and state is one of protection in exchange for obedience.
Private vs. public conscious: does one need to truly believe (i.e. like a Christian) or does the appearance of belief suffice?
“belief and unbelief never follow men’s commands.”
Loyalty only to those that are in power?
Historical context: The Norman Yoke and the English Civil Wars
Stability should not sacrificed as a result of ‘injustice’.
The rise of the ‘mechanical’ centralized administrative state.
Grotius
Dutch legal theorist 16th century;
Along with Vitoria and Gentili laid the foundation for the Law of Nations (Public European Law) on Natural Law.
Moves away from a theological conceptualization of Natural Law to a secular one.
Develops the notion of Natural Rights which becomes key for understanding human morality and law.
Notion of natural right emerged out of the massacre of St. Bartholomew (25 August 1572).
Attempted to establish limitation on the Sovereign’s power:
notion of individual right that the state cannot transgress.
Grotius: “a RIGHT is a moral quality annexed to the person, justly entitling him to possess some privilege, or to perform some particular act”
Four Fundamental Rights
1) the right for others not to take my possessions.
2) the right of restoration of property in case of injury.
3) honoring promises.
4) punish wrongdoing.
Natural.
Greek Drama Further Readings and Short Report GuidelinesOur s.docxgilbertkpeters11344
Greek Drama: Further Readings and Short Report Guidelines
Our study of Greek drama will begin with an overview of Greek theater in general and focus on Aeschylus’ Agamemnon (Norton rental text, Vol. A). You will be completing a quiz/worksheet on Agamemnon (open book) and that play will be the focus of our class from March 26 through April 2. After that, each of you will have the opportunity to focus more intensively on one of three other Greek plays, Sophocles’ Philoctetes, Euripides’ Medea, or Aristophanes’ Lysistrata.
I will be asking you to submit a short report that focuses primarily on the play you chose to study in more depth. Your first task, though, is to choose which of the three plays you want to work on. Here are brief overviews of the three plays.
Sophocles’ Philoctetes(available in the Sophocles II purchase text). Philoctetes, an outstanding Greek warrior, was abandoned by Odysseus, Agamemnon and Menelaos on the way to fight in Troy because they could not bear the agonies of his suffering from a poisonous snake bite. The hero, an exceptional archer who wields the bow of Heracles, has been living in isolation on the wild island of Lemnos for nine years. Now the Greek forces have received a prophecy that they cannot conquer Troy without Philoctetes’ help. Odysseus, whom Philoctetes hates, and Neoptolemus, the son of Achilles, are sent to lure Philoctetes back to the war, by persuasion, treachery or force.
Euripides’ Medea (available in Norton rental text, Vol. A. Medea, the sorceress who helped the hero Jason find the Golden Fleece and also helped save his life, is living with Jason in exile from her homeland with their two children. She has learned that, in order to advance his fortune and social standing, Jason wants to jilt Medea and marry a younger woman. Out of despair and rage, Medea contrives to take revenge against Jason in the most horrific way she can.
Aristophanes’ Lysistrata (available in Norton rental text, Vol. A). Fed up with the emotional and economic hardships caused by the Peloponnesian War (431-404 BC), the Athenian and Spartan women, under the leadership of Lysistrata, unite to undertake two group actions: first, to refuse to have sex with their men until the men agree to stop fighting and, second, to cut off funding for the war by occupying the Athenian treasury. Aristophanes’ comedy still raises questions today about who should wield political power and why, as well as about how much humans really value peace.
NOTE: While I am requiring you to focus on only one of the three plays, I strongly encourage you to read all three. I will be saying something about each of the three plays before the short report is due, after we spend some time with Aeschylus’ Agamemnon.
Guidelines for Short Report on Greek Drama
For the short report on Greek drama, please write complete, incisiveresponses to each of the following five topics or questions concerning the play—Philoctetes,Medea or Lysistrata—that you h.
Graph 4 (You must select a different graph than one that you hav.docxgilbertkpeters11344
Graph 4 (You must select a different graph than one that you have previously discussed)
Select a data presentation from chapter 6 of the text (Grey Section).
Answer the following:
What is the visual that you selected?
What is the purpose of the visual?
What kind of data should be compiled in the selected visual?
What kinds of data should not be compiled in the selected visual?
How can you avoid making the visual misleading?
.
Graphs (Help! Really challenging assignment. Would appreciate any bi.docxgilbertkpeters11344
Graphs (Help! Really challenging assignment. Would appreciate any bit of help!)
Family tree's and genealogy software has become more and more prevalent in recent years. From the name you might expect that a family tree would be easily represented by a tree structure, but that is not the case! A more appropriate data structure to represent a family tree would be a type of graph. Using the description of the family that accompanies this assignment, you must represent this family using a graph structure. The graph needs to be a weighted graph. The weights will constitute the types of relationships, I recommend using some kind mapping between numbers and strings to represent the relationships. When adding family members to the graph, this can be done programmatically for the provided family members within the description file. Additionally, I also want there to be an interface in which a user can create a new family member and add them to the tree. This can be a simple CLI where the user provides a name, gender, and age to create a person. Then another simple CLI where they select which member of the family they want the original relationship to be with and what kind of relationship it should be. Finally, they can edit the family member using another CLI and selecting the family member they wish to edit, the operation they wish to perform (edit name, edit age, edit relationship), and then add new relationship between family members which can call a function that you create in order to add the original relationship. Remember the DRY philosophy, where code can be modularized or made into a function, it should be if you plan on using the logic again.
Finally, I want you to make data assertions within the
FamilyTree
class that enforce certain "rules" that exist in a typical human family. An example would be a person should not have any kind of relationship to itself (a person can not marry themselves, a person can not be their own brother, sister, father, mother, etc.). There should be at least 3 data assertions. These should exists as part of the family tree, not as part of the graph.
As a hint, for a successful design: I would recommend using layers of abstraction. Your graph class is the backing structure to the family tree class. Your family tree should implement methods that interface with the graph class, i.e. add_family_member() should call the constructor to create a node and then call a function within the graph class to add a node to the graph. Then using the relationships function parameter, you can add edges to the graph between the new nodes and the existing nodes. The family tree should be what enforces what relationships can exist through the data assertions, the graph does not care about what relationships are made between family members. Your functions that the user would interface with would be greatly reduced compared to the total number of methods within the classes themselves. The user should be able to add, remove, and modi.
Grandparenting can be highly rewarding. Many grandparents, though, u.docxgilbertkpeters11344
Grandparenting can be highly rewarding. Many grandparents, though, unexpectedly become guardians and raise small children. How might this responsibility affect their normal course of adult development? What components might require transitions? How would a professional counselor encourage these older guardians in their new roles? Just need 135 words (ASAP)!
.
Great Marketing Moves The evolving art of getting noticed Ov.docxgilbertkpeters11344
Great Marketing Moves The evolving art of getting noticed
Over three decades,
Inc.
has seen entrepreneurs, often with little cash but lots of creativity)', produce clever marketing campaigns time and again. Here are 3U classic examples from the archives. —
Kelly Fairdoth
Make a article summary from 2-3 paragraphs.
.
“GREAT MIGRATION”
Dr. G. J. Giddings
Characteristics
Human
Propelled – push-pull (E. Lee, 1966)
Impactful – consequential … cause/effect
Dynamic – leaderless …democratic …
Demographics
Demographics
1.2 million, 1915-’30
6.4 million, 1980
(Caribbean:
140,000,1899-1937)
Precursors
Post-Reconstruction, 1877-1914
Rural - Urban
Westward – “Black Exodus”
Henry Adams (LA)
89,000 migrants/interest
Benjamin “Pap” Singleton (TN)
“Advantage of Living in a Free State”
Thousands migrated
Emigration
Bishop Henry M. Turner,
Mary Ann Shadd Cary
Precursors …
U.S. Empire
Berlin Conf.,1884
Philippines, 1898
Puerto Rico, Guam
Hawaii,
(Cuba)
Haiti, (1915-’34)
U.S. Virgin Isl.,1916
Guyana, 1941
Atkinson Airstrip
6
Great Migration
Caribbean
140,000,1899-1937
M. M. Garvey
C. Powel
DJ Kool Herc
S. Chisholm
G. J. Giddings
Great Migration
“PUSH”
-Boll weevil, 1915/6
-Mississippi flood, 1927
-Racist Terroism
-Racist laws: Jim Crow
Great Migration
“PULL”
E. World War I, 1914-1919
(367,000 AAs served)
European immigration desisted
Chicago Defender
“To die from the bite of frost is more glorious than by the hands of a lynch mob”
“Every Black man for the sake of his wife and daughter should lave even at a financial sacrifice every spot in the south where his worth is not appreciated enough to give him the standing of a man and a citizen in the community.”
Great Migration
IMPACT
Detroit, MI
611 % increase
Urban League, 1911
National League of Urban Conditions among Negroes, NY
Rep. Oscar DePriest (R)
Chicago Alderman, 1915; U.S. Rep, 1929-’35
1970s: Chicago had more Blacks than Mississippi!
Harlem Renaissance, 1919-1932
L. Hughes, “Negro Artist …”
Some pastors followed migrants.
Return Migration/RE-PATRIATION
Post-Industrial
“Reverse migration”
1980-present
Service economy
“Sun Belt” industrial service areas
Destinations
Atlanta, GA; Charlotte, NC, Houston, TX, …
(F&H, chap. 23)
GREAT MIGRATION
Franklin & Higginbotham (F&H)
1, (12),13, 14, 15, 16, 17, 19, 23 …
Great Migration
The Warmth of Other Suns, 2010
Isabel Wilkerson, Pulitzer laureate
National Book Critics Circle award
“best non-fiction ...” NY Times
1,200 interviews
I.M. Gladney
G. Starling
R. P. Foster
Wilkerson …
Ida Mae Gladney
1934
MS – Chicago, IL
Wilkerson …
George Starling
1945
Florida–New York
(.
Grand theory and Middle-range theoryHow are Nursing Theories c.docxgilbertkpeters11344
Grand theory and Middle-range theory
How are Nursing Theories classified?
What are the differences between grand theory and middle-range Theory?
Examples of grand Theory and Middle range Theory?
Write an Essay.
Use the APA style 7
Avoid plagiarism by submitting your work to SafeAssign.
.
Grand Rounds Hi, and thanks for attending this case presen.docxgilbertkpeters11344
Grand Rounds
Hi, and thanks for attending this case presentation. My name is Dr. Stephen Brewer and I am a licensed
clinical psychologist in San Diego, California and Assistant Professor of Psychology and Applied
Behavioral Sciences at Ashford University. Today, I will be sharing with you the story of Bob.
Presenting problem
Bob Smith is a 36-year-old man who came to me approximately six months ago with concerns about his
career choice and life direction. He did not have any significant psychiatric symptoms, besides some
understandable existential anxiety regarding his future. Bob was cooperative, friendly, open, and
knowledgeable about psychology during our first few sessions together. I noticed that he seemed
guarded only when talking about his family and childhood experiences. To confirm his identity, I checked
his driver’s license to ensure his name was indeed Bob Smith and that he lived close by in a mobile home
in Spring Valley. Given his relatively mild symptoms, we decided to meet once a week for supportive
psychotherapy so he could work through his anxieties. I gave him a diagnosis of adjustment disorder
with anxiety.
History
Here’s some background on Bob to give you a sense of who he is.
Family
Bob grew up as an only child in Edmonton, Canada, in a low-income, conservative, and very religious
household.
He shared that his father was largely absent during his childhood, as he spent most of the week residing
north of Edmonton, where he worked as a mechanic in the oil fields near Fort McMurray. On weekends,
Bob’s father would return home and spend as much time as possible with his family. Bob described his
father as warm, caring, and a hard worker. His father reportedly died one year ago.
Bob’s mother was described as a strict, rule-based woman who had a short temper and was prone to
furious outbursts over trivial matters. She worked in Bob’s junior high as a janitor, which meant that Bob
often crossed paths with his mother at school, where she would often check up on him. During Bob’s
high school years, Bob’s mother got a new job as a high school librarian.
At 18, Bob moved to San Diego to study psychology at San Diego State University. He lived in the dorms
for his first few years, where he easily made friends and joined a fraternity. Bob maintained contact with
his parents, but ceased all contact when his mother suggested she would move to San Diego to be closer
to him. He graduated with a 3.2 GPA and began working for the county as a psychiatric technician. He
worked as a psych tech for 14 years and described it as “fun at first, but it got boring and predictable
after a while.”
Treatment
Bob shared that he has a medical doctor that he visits once every few years for his routine physical. He
denied having any significant medical problems. Additionally, he denied using any illicit substances and
reported drinking only on occasion with friends from his fratern.
Graduate Level Writing Required.DUEFriday, February 1.docxgilbertkpeters11344
Graduate Level Writing Required.
DUE:
Friday, February 14, 2020 by 5pm Eastern Standard Time.
Resources: U.S. Department of Labor, Bureau of Labor Statistics, U.S. Department of Labor Wages, U.S. Department of Education, U.S. Census Bureau
Based
on
Dallas, Texas
Write a 900- to 1,050-word paper in which you analyze the criminal profile of Dallas, Texas.
Include the following information in your analysis:
-Characterization of the city in terms of social and intellectual context
-Identity of social factors that contribute to crime
-Linking of events or attitudes to a description of beliefs people living there would accept for explaining criminal behavior
-Consideration of changes in land use, property values, transportation, and retail as one moves away from the city center
-If there are changes, what distance do you estimate exist between these areas?
-How noticeable are the changes?
-Discussion of whether or not zones of transition apply to this city
-Identification of criminal hot spots
-Relevant data to support answers
-How your findings relate to the role of socioeconomic status and values in criminological theory
-Identification and rationale for the choice of one sociologic theory that best explains the crime in your chosen city
-Format your paper consistent with APA guidelines
.
-Provide at least 4 Academic / Scholarly references
.
-100% Original Work. ZERO Plagiarism.
-Must Be Graduate Level Writing.
.
Graduate Level Writing Required.DUEWednesday, February .docxgilbertkpeters11344
Graduate Level Writing Required.
DUE:
Wednesday, February 12, 2020 by 5pm Eastern Standard Time.
Provide a 200-250 word response answering the following questions:
Are there everyday behaviors that might be useful or functional in lower classes, but would not serve the same purpose for those of higher socioeconomic standing?
What about interactions with peers, teachers, or other authorities?
-Provide at least 1 Academic / Scholarly reference
.
-100% Original Work. ZERO PLAGARISM
-Must Be Graduate Level Writing.
.
The Art Pastor's Guide to Sabbath | Steve ThomasonSteve Thomason
What is the purpose of the Sabbath Law in the Torah. It is interesting to compare how the context of the law shifts from Exodus to Deuteronomy. Who gets to rest, and why?
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
How to Split Bills in the Odoo 17 POS ModuleCeline George
Bills have a main role in point of sale procedure. It will help to track sales, handling payments and giving receipts to customers. Bill splitting also has an important role in POS. For example, If some friends come together for dinner and if they want to divide the bill then it is possible by POS bill splitting. This slide will show how to split bills in odoo 17 POS.
We all have good and bad thoughts from time to time and situation to situation. We are bombarded daily with spiraling thoughts(both negative and positive) creating all-consuming feel , making us difficult to manage with associated suffering. Good thoughts are like our Mob Signal (Positive thought) amidst noise(negative thought) in the atmosphere. Negative thoughts like noise outweigh positive thoughts. These thoughts often create unwanted confusion, trouble, stress and frustration in our mind as well as chaos in our physical world. Negative thoughts are also known as “distorted thinking”.
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
How to Create Map Views in the Odoo 17 ERPCeline George
The map views are useful for providing a geographical representation of data. They allow users to visualize and analyze the data in a more intuitive manner.
This is a presentation by Dada Robert in a Your Skill Boost masterclass organised by the Excellence Foundation for South Sudan (EFSS) on Saturday, the 25th and Sunday, the 26th of May 2024.
He discussed the concept of quality improvement, emphasizing its applicability to various aspects of life, including personal, project, and program improvements. He defined quality as doing the right thing at the right time in the right way to achieve the best possible results and discussed the concept of the "gap" between what we know and what we do, and how this gap represents the areas we need to improve. He explained the scientific approach to quality improvement, which involves systematic performance analysis, testing and learning, and implementing change ideas. He also highlighted the importance of client focus and a team approach to quality improvement.
GROUP 1 Case 967-- A Teenage Female with an Ovarian MassCLI.docx
1. GROUP 1: Case 967-- A Teenage Female with an Ovarian Mass
CLINICAL HISTORY
A teenage female presented with secondary amenorrhea
(https://www.healthline.com/health/secondary-
amenorrhea#causes). The patient had 1 menstrual cycle 3 years
ago and has had no menses since. Laboratory work-up was
negative for pregnancy test, mildly increased calcium level
(11.7 mg/dL, normal range: 8.5-10.2 mg/dL) and CA 125 (43
Units/ml, normal range: 0-20 Units/ml). Prolactin, TSH, AFP,
Inhibin A, Inhibin B and CEA were normal. Imaging revealed a
13 x 11.8 x 8.6 cm, predominately cystic left pelvis mass, with
multiple internal septations. Her past medical history was not
contributory. Patient underwent left salpingo-oophorectomy
(https://www.healthline.com/health/salpingo-oophorectomy),
omentectomy (https://moffitt.org/cancers/ovarian-
cancer/omentectomy/) and tumor debulking
(https://en.wikipedia.org/wiki/Debulking) with intraoperative
frozen section consultation.
GROSS EXAMINATION
The 930.9 g tubo-ovarian complex consisted of a 20.0 x 16.0 x
8.0 cm large mass, with no recognizable normal ovarian
parenchyma grossly and an unremarkable fallopian tube. The
cut surface was gray, "fish-flesh", soft with foci of hemorrhage
and necrosis.
MICROSCOPIC EXAMINATION
Microscopically, the majority of main tumor was growing in
large nests, sheets and cords with focal follicle-like structures
and geographic areas of necrosis. It was predominantly
composed of small cells with hyperchromatic nuclei, round to
oval nucleus with irregular nuclear contour, inconspicuous to
occasional conspicuous nucleoli and minimal cytoplasm. This
component was variably admixed with a population of larger
2. cells, which as the name implies composed of cells with
abundant eosinophilic cytoplasm, with central or eccentric
round to oval nuclei, pale chromatin and prominent nuclei.
Both, the small and large cell components demonstrated brisk
mitotic activity. All staging biopsies and omentectomy were
composed of large cell component.
An extensive panel of immunohistochemical stains was
performed. Overall, the staining pattern was strong and diffuse
in small cell component compared to patchy weak staining
pattern in the large cell component.
FINAL DIAGNOSIS
Small cell carcinoma (https://en.wikipedia.org/wiki/Small-
cell_carcinoma) of the ovary, hypercalcemic type
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939673/)
DISCUSSION
Small cell carcinoma of the ovary, hypercalcemic type
(SCCOHT) is an aggressive and highly malignant tumor
affecting the women under 40. It was first described as a
distinct entity by Dickersin et al in 1982 (1). Fewer than 500
cases have been described in the literature and it accounts for
less than 1% of all ovarian cancer diagnoses. Due to the initial
consideration of epithelial origin, the term of SCCOHT has been
used to distinguish this entity from its mimicker, the
neuroendocrine or pulmonary type (2). In fact epithelial origin
of SCCOHT was recently challenged as new immunostains and
molecular studies become available. Sex cord, germ cell or
neuroendocrine origin has been suggested and SCCOHT is
currently listed within the category of miscellaneous ovarian
neoplasms in 2014 World Health Organization (WHO)
classification (3).
Clinically, SCCOHT are generally diagnosed in second or third
decades of life (peak at 18-30 years). Rare familial cases have
also been reported (4). The symptom is non-specific and is
3. those related to an abdominal or pelvic mass. Approximately
two-thirds patients have hypercalcemia and one-third of patients
presents with signs of hypercalcemia
(https://www.mayoclinic.org/diseases-
conditions/hypercalcemia/symptoms-causes/syc-20355523).
SCCOHT is predominately unilateral, although familial cases
can be bilateral. Macroscopically, the tumor is usually large
predominately solid, tan, or cream-colored with foci of cystic
degeneration. Areas of hemorrhage or necrosis are commonly
seen. Microscopically, the tumor is often composed of diffuse
growth of closely packed neoplastic cells with round to oval
hyperchromatic nuclei and minimal cytoplasm resembling in a
"small round blue cell" appearance. Other growth patterns such
as nests, cords, clusters or single cells can be present. Follicle-
like structures containing eosinophilic, or rarely basophilic,
fluid are seen in ~ 80% of cases. In up to 50% of cases, a
component of large cells with abundant eosinophilic cytoplasm,
eccentric pale nuclei with prominent nucleoli can be present
focally, predominately or exclusively, resulting in a rhabdoid
appearance. In those cases with large cell component, SCCOHT
shows striking morphologic similarity to malignant atypical
teratoid/rhabdoid tumor (AT/RT) of the central nervous system
(CNS) and malignant renal rhabdoid tumor (MRT).
Immunohistochemical studies have described a rather non-
specific profile of variably positive staining for EMA, pan-
keratin, WT1, calretinin, P53 and CD10 and negativity for
desmin, S100, ?-inhibin and TTF-1. Variable
immunohistochemical staining for neuroendocrine markers has
been reported. In 2014, 3 separate groups discovered that
SCCOHT is characterized by deleterious mutation of
SMARCA4, which encodes the BRG1 protein (5-7). Loss of
expression of SMARCA4 (BRG1) on immunohistochemistry is
considered highly sensitive and specific for the diagnosis of
SCCOHT (8,9). Interestingly, genetic alteration of SMARCA4
are also frequent present in malignant rhabdoid tumors. Given
the morphologic and genetic similarity, some authors propose to
4. rename SCCOHT as 'malignant rhabdoid tumor of the ovary'
(10).
The differential diagnosis of SCCOHT includes numerous other
tumors that occurs in young women including juvenile and adult
granulosa cell tumor, poorly-differentiated or unclassified
Steroli-Leydig cell tumor, desmoplastic small round cell tumor,
Ewing family of tumors, lymphoma, ovarian small cell
carcinoma of pulmonary type, metastatic melanoma, etc.
SCCOHT is usually distinguished from these mimickers by its
unique clinical presentation, histological appearance,
immunophenotype and cytogenetic characteristics, especially
the loss of nuclear expression of BRG1.
SCCOHT has a very poor prognosis, with a 33% survival rate
when diagnosed at an early stage and a much more dismal
prognosis with advanced stage at diagnosis. The traditional
management includes surgical resection, followed by multiple
adjuvant chemotherapy. The favorable prognostic parameters
include increased age at diagnosis, normal serum calcium at
presentation, no large cell component and small tumor size (<10
cm) (10).
What is the theme here? Ovarian cancer.
REFERENCES
1. Dickersin GR, Kline IW, Scully RE. Small cell carcinoma of
the ovary with hypercalcemia: a report of eleven cases. Cancer.
1982;49(1):188-97.
2. Young RH, Oliva E, Scully RE. Small cell carcinoma of the
ovary, hypercalcemic type. A clinicopathological analysis of
150 cases. Am J Surg Pathol. 1994;18(11):1102-16.
3. Kurman RJ, Carcangiu ML, Herrington CS, Young RH. WHO
Classification of Tumours of Female Reproductive Organs.
Fourth Edition. 2014
4. Witkowski L, Donini N, Byler-Dann R, et al. The hereditary
nature of small cell carcinoma of the ovary, hypercalcemic type:
two new familial cases. Fam Cancer. 2017;16(3):395-399.
5. 5. Jelinic P, Mueller JJ, Olvera N, et al. Recurrent SMARCA4
mutations in small cell carcinoma of the ovary. Nat Genet.
2014;46(5):424-6.
6. Witkowski L, Carrot-Zhang J, Albrecht S, et al. Germline and
somatic SMARCA4 mutations characterize small cell carcinoma
of the ovary, hypercalcemic type. Nat Genet. 2014;46(5):438-
43.
7. Ramos P, Karnezis AN, Craig DW, et al. Small cell
carcinoma of the ovary, hypercalcemic type, displays frequent
inactivating germline and somatic mutations in SMARCA4. Nat
Genet. 2014;46(5):427-9.
8. Conlon N, Silva A, Guerra E, et al. Loss of SMARCA4
Expression Is Both Sensitive and Specific for the Diagnosis of
Small Cell Carcinoma of Ovary, Hypercalcemic Type. Am J
Surg Pathol. 2016;40(3):395-403.
9. Karanian-Philippe M, Velasco V, Longy M, et al. SMARCA4
(BRG1) loss of expression is a useful marker for the diagnosis
of ovarian small cell carcinoma of the hypercalcemic type
(ovarian rhabdoid tumor): a comprehensive analysis of 116 rare
gynecologic tumors, 9 soft tissue tumors, and 9 melanomas. Am
J Surg Pathol. 2015;39(9):1197-205.
10. Witkowski L, Goudie C, Foulkes WD, et al. Small-Cell
Carcinoma of the Ovary of Hypercalcemic Type (Malignant
Rhabdoid Tumor of the Ovary): A Review with Recent
Developments on Pathogenesis. Surg Pathol Clin.
2016;9(2):215-26. .
1
MD PROGRAMME
6. Year: Year 2 (Academic Year 2019-2020)
Semester: Semester 4 (Spring 2020)
Course: MED 207 Histology II
Assessment: Case report preparation
Submission:
Assignments:
1. Group 1 assignment:
https://path.upmc.edu/cases/case967/dx.html
2. Group 2 assignment:
https://path.upmc.edu/cases/case759/dx.html
3. Group 3 assignment:
https://path.upmc.edu/cases/case291/dx.html
4. Group 4 assignment:
https://path.upmc.edu/cases/case421.html
5. Group 5 assignment: https://path.upmc.edu/cases/case44.html
https://path.upmc.edu/cases/case967/dx.html
https://path.upmc.edu/cases/case759/dx.html
7. https://path.upmc.edu/cases/case291/dx.html
https://path.upmc.edu/cases/case421.html
https://path.upmc.edu/cases/case44.html
2
Guidelines for writing the case report
You are required to write a case report based on the case
allocated to you. The case describes the
histopathological findings of diagnostic laboratory for the
referred case. You must pretend that you
are the histopathology lab head and you are writing the
scientific report for publication. In writing
the report, follow the following general guidelines:
1. Length of report required 1,800 to 2,000 words, excluding
title, references list, but including any
text boxes, tables and figures.
2. Report needs to be accessible by a general professional
audience.
3. The writing should demonstrate coherence and structure.
Each section should be concise and self-
contained, leading into the next section.
4. Use straightforward language that facilitates understanding.
Avoid complex jargon.
5. The main body of report text should be in a font accessible to
examiners (guidance currently
8. recommends Arial font size 12.)
Required Sections
Name of the Student:
1. Title
The title should be deduced from the case report assigned and
should best describe the case.
2. Introduction
In this section, you should introduce the disease that the patient
suffers from. Refer to the clinical
and histological manifestations. Mention any related diseases or
group of diseases that are similar to
the one under investigation and talk about the prevalence, if
applicable. Use literature sources from
the internet to familiarise yourself with the disease and use
scientific papers to acquire a better
knowledge of the scientific basis of the disease. This section
should not be more than 400-500 words
in length.
3. Materials and Methods
Present the materials and methods used to produce the
histological pictures that appear in
9. the report. Although you did not do the work and no details of
the methods used are given, just by
looking at the pictures (which have short legends) you can
deduce what technique (s) were used to
produce the images. Put yourself in the shoes of the
histopathologist and describe, briefly, the
methodology used to generate the slides. There are cases were
immunohistochemistry was used but
the report does NOT actually say this. You should work out if
an antibody was used and try to find
3
out (if possible from the picture legends) against which antigen
an antibody was used to come to a
diagnosis. This section should not exceed 300 words
4. Results
Present the findings descriptively by referring to the pictures
shown in the report. Each
picture or (group of pictures) must be organised in Figures.
Figures may contain more than one
image of the case. This is preferred in cases that several images
may refer to the same pathological
10. finding. Each figure must contain a short title and a figure
legend. The legend must describe what
the picture shows and use annotation (arrows etc) if necessary
to point to important histological
findings if necessary. The case report you have been assigned
describes the findings, but there is no
direct reference to each picture in the report. You should work
out, by looking at the pictures and by
reading the text of the report, where the abnormality actually
lies and describe it in the figure
legend. Each figure legend must not exceed 40-50 words. You
are not expected to produce more
than 2-3 figures.
5. Discussion
Discuss the findings of this case and the final diagnosis. You
should also relate the findings for
this patient to what is known about the disease. You should talk
about disease management and refer
to any prospects for developing new therapies for this disease.
This section should be around 700-
1000 words.
6. References: You should cite references in the Harvard style.
The number of references should be
11. between 10-15 and be presented in the Harvard style
(https://infolib.blog.jbs.cam.ac.uk/wp-
content/uploads/2013/10/HarvardReferencingStyle-2013.pdf).
https://infolib.blog.jbs.cam.ac.uk/wp-
content/uploads/2013/10/HarvardReferencingStyle-2013.pdf
https://infolib.blog.jbs.cam.ac.uk/wp-
content/uploads/2013/10/HarvardReferencingStyle-2013.pdf
4
Guidance when marking (for the examiner)
Assessment of the written report is based on content and
delivery:
Content: Exploration of topic, breadth/depth of reading, level of
critical thinking.
Delivery: Appearance and structure, organisation and
coherence, clarity of expression.
The following should be used as guidance, along with the
grades for the individual
criteria, when assigning an overall grade for the written report.
The individual criteria
do not carry equal weight, and their relevance will no doubt
vary between students.
12. CONTENT
ORGANISATION
- Full title describing the focus of the report
- Traditional organisation for case report:
- Introduction, Methods, Results, Discussion.
- Kept to a reasonable word count.
15%
CRITICAL REVIEW
- Understood well the importance of the case
- The introduction delivered the context of the case.
- The importance of the case was understood well and delivered
adequately in the discussion.
50%
Understanding of techniques used
- Clear description of the techniques used.
- Logical presentation of the case in the materials and methods
section.
- Clear presentation of the case in the results section.
15%
13. STYLE
- Clear use of English
- Aim for standard for publication
- All abbreviations qualified on first use in the text
- Harvard referencing style, correctly applied in text and
reference list.
- Figures appropriately labelled and presented.
20%