This document provides an overview of the Institute of Education Sciences (IES) and its funding opportunities for research grants, with a focus on opportunities for Historically Black Colleges and Universities (HBCUs). IES aims to fund research that identifies best practices to improve education, including the development and testing of new interventions. It encourages HBCUs to apply for grants from its Education Research and Special Education Research programs. Researchers should identify an appropriate topic and goal for their research, such as exploration, development, efficacy/replication, or measurement. Successful applications will require a strong significance section that provides a compelling rationale and justification for the proposed work.