This document discusses a study on e-portfolio implementations at institutions of higher education. It identifies five "threshold concepts" that are troublesome for e-portfolio adoption: the role of purpose, learning activity design, processes involved, issues of ownership, and the disruptive nature of e-portfolios. Overcoming preconceptions related to these concepts is key to successful large-scale implementation. The study analyzes case studies of institutions that have achieved different levels of maturity in e-portfolio adoption based on an "ePI framework." The goal is to develop guidance for practitioners and administrators to help more institutions journey from localized to institutional e-portfolio implementations.