This document provides a simplified diagram of the glycolysis and tricarboxylic acid (TCA) cycle pathways, showing their interconnection and major products. Glycolysis breaks down glucose to produce pyruvate, ATP and NADH. Pyruvate then feeds into the TCA cycle in the mitochondria to further oxidize acetyl-CoA, producing more ATP, NADH, FADH2 and feeding electrons into the electron transport chain. Overall, the complete oxidation of glucose via these pathways generates numerous ATP, NADH, FADH2 and other products to fuel cellular metabolism.

1. GLYCOLYSIS & TCA CYCLE-
COMPARTMENTATION
Simplified version showing major products
Designed by Donald Nicholson c 2003 IUBMB
Citrate
Isocitrate
Succinyl-CoA
PYRUVATE
Glucose-6-P
Fructose-6-P
Fructose-1,6-bis-P
3-P-Glyceraldehyde
1,3-bis-P-Glycerate
3-P-Glycerate
2-P-Glycerate
ATP
ATP
NADH+2H
+
2ATP
Di-OH-acetone-
P
P-enolpyruvate
PYRUVATE
Oxaloacetate
Malate
GLUCOSE
2
ATP2
ACETYL-CoA 2NADH+2H+
2NADH+2H+
2NADH+2H+
2NADH+2H+
2GTP
G
L
Y
C
O
L
Y
S
I
S
T
C
A
C
Y
C
L
E
PYRUVATE
DEHYDROGENASE
Fumarate
Succinate
-OOCCH2CH2COO-
2-Oxoglutarate
2UQH2
Glucose 10NADH + 10H+ + 2UQH2 + 2ATP + 2GTP