Global factors are increasingly influencing national policymaking. Globalization has led to greater interconnectedness between countries through increased cross-border movement, trade, and cultural harmonization. Health issues are now global concerns addressed through various global actors and mechanisms beyond traditional inter-state cooperation. These include global civil society, public-private partnerships, and influence from international organizations, transnational groups, and domestic and foreign bureaucrats. Effective health policymaking now requires engagement with this complex global context and array of global actors.