This document provides an update on polio eradication efforts in Afghanistan. It notes that 5 provinces and 47 districts are at high risk for polio, with districts categorized from fully accessible to inaccessible. In 2016, all confirmed polio cases were reported from access-compromised areas. To strengthen polio eradication, the approach focuses on gaining access, implementing alternative strategies, engaging communities, and enhancing monitoring. Lessons from 2015-2016 highlight the importance of strong coordination, maintaining neutrality, and improving quality in accessible but limited areas. Opportunities include political support and neutrality, while challenges include inaccessibility, knowledge gaps, and possible funding issues.