SlideShare a Scribd company logo
Global health, neglected diseases,  and drug development –  a newcomer’s perspective Gregory J. Crowther, Ph.D. Department of Medicine University of Washington http://faculty.washington.edu/crowther/ early-stage research preclinical studies clinical trials (I) clinical trials (II) clinical trials (III) FDA review & approval market
What does that title mean? ,[object Object],[object Object],[object Object],about health disparities between rich & poor malaria, tuberculosis, dengue, filariasis, etc. early-stage research preclinical studies clinical trials (I) clinical trials (II) clinical trials (III) FDA review & approval market
“A shot at adulthood” video http://zooppa.com/ads/uw-pocket-media-film-festival/videos/a-shot-at-adulthood
Drug development for neglected diseases: Why is it so hard? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Image: tulane.edu/~wiser/
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Drug development for neglected diseases: Are there reasons for optimism?
What would a perfect drug be like? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
What would a perfect drug be like? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
What would a perfect drug be like? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Image: alphahelix.co.uk
What would a perfect drug be like? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Structure-based drug design Nelfinavir in the active site of HIV-1 protease. Image from C.M. Henry,  C&EN   79 : 69, 2001.
Recent advances in malaria research: cool example #1 ,[object Object],[object Object],[object Object],[object Object],[object Object],Reference:  F.J. Gamo et al.,  Nature   465 : 305, 2010
Recent advances in malaria drug research: cool example #2 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Reference:  M. Rottmann et al.,  Science   329 : 1175, 2010
Conclusion ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
T I M E S ’ U P
The malaria song ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],to the tune of “Maria”  ( West Side Story )  music by  Leonard Bernstein lyrics by  Wes Van Voorhis, MD, PhD
Recent advances in malaria research: bonus example ,[object Object],[object Object],[object Object],[object Object],Reference: R. Gujjar et al.,  Journal of Medicinal Chemistry  52 : 1864, 2009.
Research frontier: the challenge of drug resistance and “polypharmacology” ,[object Object],[object Object],[object Object],[object Object],[object Object],Image from  Chemical & Engineering News  after M.J. Keiser et al.,  Nature  2009

More Related Content

Viewers also liked

An analysis of metabolic fluxes in contracting human muscle
An analysis of metabolic fluxes in contracting human muscleAn analysis of metabolic fluxes in contracting human muscle
An analysis of metabolic fluxes in contracting human muscle
Greg Crowther
 
Is Brugia malayi’s cofactor-independent phosphoglycerate mutase (iPGM) drugga...
Is Brugia malayi’s cofactor-independent phosphoglycerate mutase (iPGM) drugga...Is Brugia malayi’s cofactor-independent phosphoglycerate mutase (iPGM) drugga...
Is Brugia malayi’s cofactor-independent phosphoglycerate mutase (iPGM) drugga...
Greg Crowther
 
The Do-Re-Mi's of A&P: teaching interactively with content-rich jingles
The Do-Re-Mi's of A&P: teaching interactively with content-rich jinglesThe Do-Re-Mi's of A&P: teaching interactively with content-rich jingles
The Do-Re-Mi's of A&P: teaching interactively with content-rich jingles
Greg Crowther
 
New insights into the metabolic network of Methylobacterium extorquens AM1
New insights into the metabolic network of Methylobacterium extorquens AM1New insights into the metabolic network of Methylobacterium extorquens AM1
New insights into the metabolic network of Methylobacterium extorquens AM1
Greg Crowther
 
TDRtargets.org: an open-access resource for prioritizing possible drug target...
TDRtargets.org: an open-access resource for prioritizing possible drug target...TDRtargets.org: an open-access resource for prioritizing possible drug target...
TDRtargets.org: an open-access resource for prioritizing possible drug target...
Greg Crowther
 
Learning from the primary literature: selected approaches
Learning from the primary literature: selected approachesLearning from the primary literature: selected approaches
Learning from the primary literature: selected approaches
Greg Crowther
 
Learning from the primary literature: selected approaches
Learning from the primary literature: selected approachesLearning from the primary literature: selected approaches
Learning from the primary literature: selected approaches
Greg Crowther
 

Viewers also liked (7)

An analysis of metabolic fluxes in contracting human muscle
An analysis of metabolic fluxes in contracting human muscleAn analysis of metabolic fluxes in contracting human muscle
An analysis of metabolic fluxes in contracting human muscle
 
Is Brugia malayi’s cofactor-independent phosphoglycerate mutase (iPGM) drugga...
Is Brugia malayi’s cofactor-independent phosphoglycerate mutase (iPGM) drugga...Is Brugia malayi’s cofactor-independent phosphoglycerate mutase (iPGM) drugga...
Is Brugia malayi’s cofactor-independent phosphoglycerate mutase (iPGM) drugga...
 
The Do-Re-Mi's of A&P: teaching interactively with content-rich jingles
The Do-Re-Mi's of A&P: teaching interactively with content-rich jinglesThe Do-Re-Mi's of A&P: teaching interactively with content-rich jingles
The Do-Re-Mi's of A&P: teaching interactively with content-rich jingles
 
New insights into the metabolic network of Methylobacterium extorquens AM1
New insights into the metabolic network of Methylobacterium extorquens AM1New insights into the metabolic network of Methylobacterium extorquens AM1
New insights into the metabolic network of Methylobacterium extorquens AM1
 
TDRtargets.org: an open-access resource for prioritizing possible drug target...
TDRtargets.org: an open-access resource for prioritizing possible drug target...TDRtargets.org: an open-access resource for prioritizing possible drug target...
TDRtargets.org: an open-access resource for prioritizing possible drug target...
 
Learning from the primary literature: selected approaches
Learning from the primary literature: selected approachesLearning from the primary literature: selected approaches
Learning from the primary literature: selected approaches
 
Learning from the primary literature: selected approaches
Learning from the primary literature: selected approachesLearning from the primary literature: selected approaches
Learning from the primary literature: selected approaches
 

Similar to Global health, neglected diseases, and drug development -- a newcomer's perspective

Open Source Pharma Foundation
Open Source Pharma FoundationOpen Source Pharma Foundation
Open Source Pharma Foundation
PrateekGarg76472
 
Lean launch pad for Life Sciences and Health Care
Lean launch pad for Life Sciences and Health CareLean launch pad for Life Sciences and Health Care
Lean launch pad for Life Sciences and Health Care
Stanford University
 
Human Genome Project
Human Genome ProjectHuman Genome Project
Human Genome Project
MuhammadIslam136
 
Vaccines
VaccinesVaccines
Vaccines
Bill Vanderbilt
 
Visual arguement
Visual arguementVisual arguement
Visual arguement
ashearer2012
 
PA 513 Lisa Lasker Policy and Evaluation Final
PA 513 Lisa Lasker Policy and Evaluation FinalPA 513 Lisa Lasker Policy and Evaluation Final
PA 513 Lisa Lasker Policy and Evaluation Final
Lisa Lasker
 
Exposure to environmental and Occupational toxins and Human Health-Genotoxici...
Exposure to environmental and Occupational toxins and Human Health-Genotoxici...Exposure to environmental and Occupational toxins and Human Health-Genotoxici...
Exposure to environmental and Occupational toxins and Human Health-Genotoxici...
Vikas Dighe
 
Gennaro D'Urso: PharmaDAO - The future of Medicine
Gennaro D'Urso: PharmaDAO - The future of MedicineGennaro D'Urso: PharmaDAO - The future of Medicine
Gennaro D'Urso: PharmaDAO - The future of Medicine
Edunomica
 
Phage Therapy_ Past, Present and Future.pdf
Phage Therapy_ Past, Present and Future.pdfPhage Therapy_ Past, Present and Future.pdf
Phage Therapy_ Past, Present and Future.pdf
Subburamu Karthikeyan
 
Faster Cures For All
Faster Cures For AllFaster Cures For All
Faster Cures For All
Geoffrey Siwo
 
Personalized Medicine: Balancing the Promise and Peril of ... Personalized ...
Personalized Medicine: Balancing the Promise and Peril of ... 	 Personalized ...Personalized Medicine: Balancing the Promise and Peril of ... 	 Personalized ...
Personalized Medicine: Balancing the Promise and Peril of ... Personalized ...
MedicineAndHealth
 
America's Chemical Brain Drain & Autism - Looking for the Environmental Culpr...
America's Chemical Brain Drain & Autism - Looking for the Environmental Culpr...America's Chemical Brain Drain & Autism - Looking for the Environmental Culpr...
America's Chemical Brain Drain & Autism - Looking for the Environmental Culpr...
v2zq
 
Organs on chip ppt
Organs on chip pptOrgans on chip ppt
Organs on chip ppt
kavya rao
 
Organs on chip ppt
Organs on chip pptOrgans on chip ppt
Organs on chip ppt
kavya rao
 
Drug repurposing
Drug repurposingDrug repurposing
Slides for rare disorders meeting
Slides for rare disorders meetingSlides for rare disorders meeting
Slides for rare disorders meeting
Sean Ekins
 
Gene therapy
Gene therapyGene therapy
Gene therapy
Michael John Pendon
 
Non animal technology the future is amazing, and animal-free. #vivisection ...
Non animal technology   the future is amazing, and animal-free. #vivisection ...Non animal technology   the future is amazing, and animal-free. #vivisection ...
Non animal technology the future is amazing, and animal-free. #vivisection ...
All Animal Rights
 
Drug development process
Drug development processDrug development process
Drug development process
nasim arshadi
 
Genomics in Public Health
Genomics in Public HealthGenomics in Public Health
Genomics in Public Health
Jennifer Gardy
 

Similar to Global health, neglected diseases, and drug development -- a newcomer's perspective (20)

Open Source Pharma Foundation
Open Source Pharma FoundationOpen Source Pharma Foundation
Open Source Pharma Foundation
 
Lean launch pad for Life Sciences and Health Care
Lean launch pad for Life Sciences and Health CareLean launch pad for Life Sciences and Health Care
Lean launch pad for Life Sciences and Health Care
 
Human Genome Project
Human Genome ProjectHuman Genome Project
Human Genome Project
 
Vaccines
VaccinesVaccines
Vaccines
 
Visual arguement
Visual arguementVisual arguement
Visual arguement
 
PA 513 Lisa Lasker Policy and Evaluation Final
PA 513 Lisa Lasker Policy and Evaluation FinalPA 513 Lisa Lasker Policy and Evaluation Final
PA 513 Lisa Lasker Policy and Evaluation Final
 
Exposure to environmental and Occupational toxins and Human Health-Genotoxici...
Exposure to environmental and Occupational toxins and Human Health-Genotoxici...Exposure to environmental and Occupational toxins and Human Health-Genotoxici...
Exposure to environmental and Occupational toxins and Human Health-Genotoxici...
 
Gennaro D'Urso: PharmaDAO - The future of Medicine
Gennaro D'Urso: PharmaDAO - The future of MedicineGennaro D'Urso: PharmaDAO - The future of Medicine
Gennaro D'Urso: PharmaDAO - The future of Medicine
 
Phage Therapy_ Past, Present and Future.pdf
Phage Therapy_ Past, Present and Future.pdfPhage Therapy_ Past, Present and Future.pdf
Phage Therapy_ Past, Present and Future.pdf
 
Faster Cures For All
Faster Cures For AllFaster Cures For All
Faster Cures For All
 
Personalized Medicine: Balancing the Promise and Peril of ... Personalized ...
Personalized Medicine: Balancing the Promise and Peril of ... 	 Personalized ...Personalized Medicine: Balancing the Promise and Peril of ... 	 Personalized ...
Personalized Medicine: Balancing the Promise and Peril of ... Personalized ...
 
America's Chemical Brain Drain & Autism - Looking for the Environmental Culpr...
America's Chemical Brain Drain & Autism - Looking for the Environmental Culpr...America's Chemical Brain Drain & Autism - Looking for the Environmental Culpr...
America's Chemical Brain Drain & Autism - Looking for the Environmental Culpr...
 
Organs on chip ppt
Organs on chip pptOrgans on chip ppt
Organs on chip ppt
 
Organs on chip ppt
Organs on chip pptOrgans on chip ppt
Organs on chip ppt
 
Drug repurposing
Drug repurposingDrug repurposing
Drug repurposing
 
Slides for rare disorders meeting
Slides for rare disorders meetingSlides for rare disorders meeting
Slides for rare disorders meeting
 
Gene therapy
Gene therapyGene therapy
Gene therapy
 
Non animal technology the future is amazing, and animal-free. #vivisection ...
Non animal technology   the future is amazing, and animal-free. #vivisection ...Non animal technology   the future is amazing, and animal-free. #vivisection ...
Non animal technology the future is amazing, and animal-free. #vivisection ...
 
Drug development process
Drug development processDrug development process
Drug development process
 
Genomics in Public Health
Genomics in Public HealthGenomics in Public Health
Genomics in Public Health
 

More from Greg Crowther

Teaching science with music: so many models, so little data
Teaching science with music: so many models, so little dataTeaching science with music: so many models, so little data
Teaching science with music: so many models, so little data
Greg Crowther
 
Genetically engineered bacteria: chemical factories of the future?
Genetically engineered bacteria: chemical factories of the future?Genetically engineered bacteria: chemical factories of the future?
Genetically engineered bacteria: chemical factories of the future?
Greg Crowther
 
Methylobacterium extorquens: Metabolic superstar
Methylobacterium extorquens: Metabolic superstarMethylobacterium extorquens: Metabolic superstar
Methylobacterium extorquens: Metabolic superstar
Greg Crowther
 
Biochemical and bioinformatic investigations of potential drug targets in Pla...
Biochemical and bioinformatic investigations of potential drug targets in Pla...Biochemical and bioinformatic investigations of potential drug targets in Pla...
Biochemical and bioinformatic investigations of potential drug targets in Pla...
Greg Crowther
 
Alcohol consumption as a way of life: the metabolism of methylotrophic bacteria
Alcohol consumption as a way of life: the metabolism of methylotrophic bacteriaAlcohol consumption as a way of life: the metabolism of methylotrophic bacteria
Alcohol consumption as a way of life: the metabolism of methylotrophic bacteria
Greg Crowther
 
If You Give Phil A Cookie
If You Give Phil A CookieIf You Give Phil A Cookie
If You Give Phil A Cookie
Greg Crowther
 
The Wheels On The Bike
The Wheels On The BikeThe Wheels On The Bike
The Wheels On The Bike
Greg Crowther
 

More from Greg Crowther (7)

Teaching science with music: so many models, so little data
Teaching science with music: so many models, so little dataTeaching science with music: so many models, so little data
Teaching science with music: so many models, so little data
 
Genetically engineered bacteria: chemical factories of the future?
Genetically engineered bacteria: chemical factories of the future?Genetically engineered bacteria: chemical factories of the future?
Genetically engineered bacteria: chemical factories of the future?
 
Methylobacterium extorquens: Metabolic superstar
Methylobacterium extorquens: Metabolic superstarMethylobacterium extorquens: Metabolic superstar
Methylobacterium extorquens: Metabolic superstar
 
Biochemical and bioinformatic investigations of potential drug targets in Pla...
Biochemical and bioinformatic investigations of potential drug targets in Pla...Biochemical and bioinformatic investigations of potential drug targets in Pla...
Biochemical and bioinformatic investigations of potential drug targets in Pla...
 
Alcohol consumption as a way of life: the metabolism of methylotrophic bacteria
Alcohol consumption as a way of life: the metabolism of methylotrophic bacteriaAlcohol consumption as a way of life: the metabolism of methylotrophic bacteria
Alcohol consumption as a way of life: the metabolism of methylotrophic bacteria
 
If You Give Phil A Cookie
If You Give Phil A CookieIf You Give Phil A Cookie
If You Give Phil A Cookie
 
The Wheels On The Bike
The Wheels On The BikeThe Wheels On The Bike
The Wheels On The Bike
 

Recently uploaded

Histololgy of Female Reproductive System.pptx
Histololgy of Female Reproductive System.pptxHistololgy of Female Reproductive System.pptx
Histololgy of Female Reproductive System.pptx
AyeshaZaid1
 
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotes
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPromoting Wellbeing - Applied Social Psychology - Psychology SuperNotes
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotes
PsychoTech Services
 
Cell Therapy Expansion and Challenges in Autoimmune Disease
Cell Therapy Expansion and Challenges in Autoimmune DiseaseCell Therapy Expansion and Challenges in Autoimmune Disease
Cell Therapy Expansion and Challenges in Autoimmune Disease
Health Advances
 
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.GawadHemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
NephroTube - Dr.Gawad
 
Top Travel Vaccinations in Manchester
Top Travel Vaccinations in ManchesterTop Travel Vaccinations in Manchester
Top Travel Vaccinations in Manchester
NX Healthcare
 
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
Holistified Wellness
 
share - Lions, tigers, AI and health misinformation, oh my!.pptx
share - Lions, tigers, AI and health misinformation, oh my!.pptxshare - Lions, tigers, AI and health misinformation, oh my!.pptx
share - Lions, tigers, AI and health misinformation, oh my!.pptx
Tina Purnat
 
Artificial Intelligence Symposium (THAIS)
Artificial Intelligence Symposium (THAIS)Artificial Intelligence Symposium (THAIS)
Artificial Intelligence Symposium (THAIS)
Josep Vidal-Alaball
 
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdfCHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
rishi2789
 
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxDoes Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
walterHu5
 
Demystifying Fallopian Tube Blockage- Grading the Differences and Implication...
Demystifying Fallopian Tube Blockage- Grading the Differences and Implication...Demystifying Fallopian Tube Blockage- Grading the Differences and Implication...
Demystifying Fallopian Tube Blockage- Grading the Differences and Implication...
FFragrant
 
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa CentralClinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
19various
 
June 2024 Oncology Cartoons By Dr Kanhu Charan Patro
June 2024 Oncology Cartoons By Dr Kanhu Charan PatroJune 2024 Oncology Cartoons By Dr Kanhu Charan Patro
June 2024 Oncology Cartoons By Dr Kanhu Charan Patro
Kanhu Charan
 
Outbreak management including quarantine, isolation, contact.pptx
Outbreak management including quarantine, isolation, contact.pptxOutbreak management including quarantine, isolation, contact.pptx
Outbreak management including quarantine, isolation, contact.pptx
Pratik328635
 
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptxEar and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Dr. Rabia Inam Gandapore
 
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấuK CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
HongBiThi1
 
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdfCHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
rishi2789
 
10 Benefits an EPCR Software should Bring to EMS Organizations
10 Benefits an EPCR Software should Bring to EMS Organizations   10 Benefits an EPCR Software should Bring to EMS Organizations
10 Benefits an EPCR Software should Bring to EMS Organizations
Traumasoft LLC
 
Chapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptxChapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptx
Earlene McNair
 
Complementary feeding in infant IAP PROTOCOLS
Complementary feeding in infant IAP PROTOCOLSComplementary feeding in infant IAP PROTOCOLS
Complementary feeding in infant IAP PROTOCOLS
chiranthgowda16
 

Recently uploaded (20)

Histololgy of Female Reproductive System.pptx
Histololgy of Female Reproductive System.pptxHistololgy of Female Reproductive System.pptx
Histololgy of Female Reproductive System.pptx
 
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotes
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPromoting Wellbeing - Applied Social Psychology - Psychology SuperNotes
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotes
 
Cell Therapy Expansion and Challenges in Autoimmune Disease
Cell Therapy Expansion and Challenges in Autoimmune DiseaseCell Therapy Expansion and Challenges in Autoimmune Disease
Cell Therapy Expansion and Challenges in Autoimmune Disease
 
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.GawadHemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
 
Top Travel Vaccinations in Manchester
Top Travel Vaccinations in ManchesterTop Travel Vaccinations in Manchester
Top Travel Vaccinations in Manchester
 
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
 
share - Lions, tigers, AI and health misinformation, oh my!.pptx
share - Lions, tigers, AI and health misinformation, oh my!.pptxshare - Lions, tigers, AI and health misinformation, oh my!.pptx
share - Lions, tigers, AI and health misinformation, oh my!.pptx
 
Artificial Intelligence Symposium (THAIS)
Artificial Intelligence Symposium (THAIS)Artificial Intelligence Symposium (THAIS)
Artificial Intelligence Symposium (THAIS)
 
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdfCHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
 
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxDoes Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
 
Demystifying Fallopian Tube Blockage- Grading the Differences and Implication...
Demystifying Fallopian Tube Blockage- Grading the Differences and Implication...Demystifying Fallopian Tube Blockage- Grading the Differences and Implication...
Demystifying Fallopian Tube Blockage- Grading the Differences and Implication...
 
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa CentralClinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
 
June 2024 Oncology Cartoons By Dr Kanhu Charan Patro
June 2024 Oncology Cartoons By Dr Kanhu Charan PatroJune 2024 Oncology Cartoons By Dr Kanhu Charan Patro
June 2024 Oncology Cartoons By Dr Kanhu Charan Patro
 
Outbreak management including quarantine, isolation, contact.pptx
Outbreak management including quarantine, isolation, contact.pptxOutbreak management including quarantine, isolation, contact.pptx
Outbreak management including quarantine, isolation, contact.pptx
 
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptxEar and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
 
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấuK CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
 
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdfCHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
 
10 Benefits an EPCR Software should Bring to EMS Organizations
10 Benefits an EPCR Software should Bring to EMS Organizations   10 Benefits an EPCR Software should Bring to EMS Organizations
10 Benefits an EPCR Software should Bring to EMS Organizations
 
Chapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptxChapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptx
 
Complementary feeding in infant IAP PROTOCOLS
Complementary feeding in infant IAP PROTOCOLSComplementary feeding in infant IAP PROTOCOLS
Complementary feeding in infant IAP PROTOCOLS
 

Global health, neglected diseases, and drug development -- a newcomer's perspective

  • 1. Global health, neglected diseases, and drug development – a newcomer’s perspective Gregory J. Crowther, Ph.D. Department of Medicine University of Washington http://faculty.washington.edu/crowther/ early-stage research preclinical studies clinical trials (I) clinical trials (II) clinical trials (III) FDA review & approval market
  • 2.
  • 3. “A shot at adulthood” video http://zooppa.com/ads/uw-pocket-media-film-festival/videos/a-shot-at-adulthood
  • 4.
  • 5.
  • 6.
  • 7.
  • 8.
  • 9.
  • 10.
  • 11.
  • 12.
  • 13. T I M E S ’ U P
  • 14.
  • 15.
  • 16.