Gennaro D'Urso: PharmaDAO - The future of Medicine DAO Camp 2022 Website: https://daocamp.org Youtube: https://www.youtube.com/channel/UCeHtPZ_ZLZ-nHFMUCXY81RQ FB: https://www.facebook.com/DAO-Camp-102442798988862/

1. Drug Repurposing to Save Humanity
February, 2022
www.geneticnetworks.com
Unlocking the hidden potential of existing drugs

2. Devastating Cost of Being Unprepared
> Infections (confirmed cases) : 428,000,000+
> Hospitalization Rate : ~15%
> Deaths : 5,910,000+
> Decline in Global GDP : ~$3,000,000,000,000
2
The world was tragically unprepared for COVID-19 and the consequences have been devastating

3. 1. Vaccine availability is insufficient in underdeveloped countries
2. Virus is mutating and variants are eroding protection as evidenced
by a rise in breakthrough cases
3. Vaccine resistance is pervasive among many around the globe
Vaccines Alone are Not Enough
3
The industry developed effective vaccines in record time, but we need to do more
Only 2.2% of people in low
income countries have
received at least one dose
WHO recognizes 5 SARS-
CoV-2 variants “of concern”
and 2 variants “of interest”
We need to add effective therapeutics to our arsenal to protect humanity!

4. > Population growth, deforestation, wildlife extinction, and global travel are all contributing to a
significant increase in the number and severity of disease outbreaks.
> We must protect the global population from the ongoing threat of COVID-19 AND all future
pandemics that we know to expect.
Infectious Disease Outbreaks on the Rise
4
Coronavirus isn't an outlier, it's part of our interconnected viral age

5. Drug Discovery & Development is MUCH too slow
5
1. Dickson M., Gagnon JP., 2004.The cost of new drug discovery and development. Discovery Medicine 4, 172-179
2. J.A. DiMasi et al., 2016. Journal of Health Economics 47, 20–30
Discovering and developing new drugs is costly, time consuming and risky
> Time : 9 to 12 years
> Cost : $2,000,000,000 +
> Failure Rate : ~90%
The world needs a MUCH FASTER and more accurate way of developing therapeutics in
order to protect humanity from future outbreaks.

6. What if the solution already exists?
Proprietary & Confidential 6
Many existing, safe drugs have been found to have valuable applications not originally intended by Pharma
> For a general solution to human biological problems there would ideally
be an inhibitor for every enzyme and protein in the cell.
> The Biopharma industry has already spent thousands of billions of
dollars to develop over 10,000 human-ready drugs.
> These drugs were designed to inhibit a single target, and yet most of
them unknowingly impact many other enzymes and proteins.
> Unfortunately, the industry does not have a way to objectively measure
and identify this hidden potential, and there is no financial incentive for
drug companies to repurpose drugs that have outlived their patent
protection.
The ultimate defense against future pandemics and disease is a platform that objectively measures and
maps all targets impacted by every existing safe drug in the world.
Metabolism & amino
acid biosynthesis
Secretion & vesicle
transport
Protein folding &
glycosylation
Cell wall biosynthesis
Cell polarity &
morphogenesis
DNA replication & repair
Mitosis & chromosomal
segregation
Nuclear migration &
protein degredation
Nuclear-cytoplasmic
transport
Chromatin &
transcription
RNA
processing
Ribosome &
translation
Mitochondria
Functional Gene Network Map

7. > Genetic Networks’ scientists invented a fascinating and unique platform called GeneScape.
> GeneScape combines cutting edge biology, genomics, and computer science to quickly and reliably
identify and measure repurposing opportunities for any existing drug.
> Based on a single, wet lab screen the platform measures the impact of a given chemical compound
across 6,000 genes, instantly creating a 2-dimensional barcode that operates like a functional
signature for the drug.
GeneScape!
Proprietary & Confidential 7
Unlocking the hidden potential using the GeneScape platform

8. Gene Level Analysis
Proprietary & Confidential 8
GeneScape explores functional interactions between genes to reveal new therapeutic modalities and novel MoAs

9. > In the early phase of the COVID-19 pandemic, Genetic Networks used GeneScape and the existing
dataset to quickly identify 7 FDA approved drugs, that are likely to be effective in treating COVID-19.
GeneScape in Action
Proprietary & Confidential 9
Genetic Networks used GeneScape to identify 7 possible COVID-19 therapeutics
Retrospective Studies uncovered 2 drugs with
potential against SARS-CoV-2
2 Potential drugs
Lipid Module
7 Drugs
6
Drugs in ClinicalTrials
GeneScape Analytics Identified Lipid Module
GeneScape identified 7, FDA approved drugs
its database that have greatest potential
6 of 7 drugs are now in clinical trials
1
2
3
4
Less
than
30
days
12+
months

10. Expanding GeneScape to protect against the current & future pandemics
> Genetic Networks proposes to collaborate with the U.S. Government and establish a
Global Pandemic Preparedness & Rapid Response Registry
> We would screen every single human approved drug in the world (~8,000), and create a
registry of unbiased evidence that would tell us exactly which drugs are hitting which
genetic targets.
> We could query the resulting dataset and instantly identify existing drugs that can be used
to treat novel viruses as soon as they are discovered.
> The registry would allow us to bypass the slow and expensive process of drug discovery,
fast track to a phase 2b clinical trial with existing, safe drugs, while empowering physicians
to conduct observational studies and leverage off label prescriptions to protect humanity in
a timely manner
Global Pandemic Preparedness & Response Registry
Proprietary & Confidential 10

11. Expanding GeneScape to protect against the current & future pandemics
> The registry will provide the ultimate defense against any future pandemic or biothreat,
including variants of known pathogens and completely novel pathogens. It will enable:
1. Rapid evaluation and screening of any future biothreat
2. Instant identification of all existing safe drugs that can be repurposed to target the
biothreat
3. Rapid iteration to converge on the single most potent and effective drug
Global Pandemic Preparedness & Response Registry
Proprietary & Confidential 11

12. 12
Genetic Networks Team
Gene Response Matrix and
Modular Biology
Dr. Gennaro D’Urso Dr. Leland Hartwell Dr. Corey Nislow Dr. Guri Giaever
Drug Response Matrix and
Chemogenomic Profiling
Founding Management & Science Leadership

13. February, 2022
www.geneticnetworks.com