Breast Cancer and Gene therapy Patent Landscape: Discussion on Myriad Genetics and Indian Ministry Wants To Cancel Patent on Trastuzumab under section 66 of the Indian Patent Act
This document provides an overview of patents related to breast cancer, with a focus on gene therapy patents and legal developments in the US and India. It summarizes Myriad Genetics' patents on the breast cancer genes BRCA1 and BRCA2, the US Supreme Court case that invalidated patents on isolated genomic DNA, and ongoing debates around patenting genes and healthcare costs. The document also reviews India's consideration of revoking patents on the breast cancer drug Trastuzumab to lower treatment costs and increase access.
After Myriad: Where next for gene patents in the US? by Patent Attorney Dr Mi...Jeremy M. Ben-David
Following the recent Supreme Court decision regarding Myriad, Dr. Hammer has sided with those who declare that "the sky has not fallen." He analyses the decision and points to the way forward. Dr. Hammer heads the "US Direct" patent prosecution practice at JMB Davis Ben-David, a US and Israel Intellectual Property Boutique located in the Har-Hotzvim high tech park in Jerusalem, Israel.
In addition to filing and prosecuting patent and trademark applications worldwide for their Israeli clients, JMB Davis Ben-David files and prosecutes patent and trademark applications for clients the world over, both in the Israeli and US Patent and Trademark Offices.
Obtaining patentable claims after Prometheus and MyriadMaryBreenSmith
The Supreme Court cases significantly changed what is patentable subject-matter in the U.S. But how broadly has the scope of patentable subject matter been narrowed by these decisions? Presentation analyzes major claim types in diagnostics and gene-type patents and whether they remain patentable under this new case law.
This esteemed panel of leading patent experts, included members of the European Patent Office, addressed U.S. and European perspectives on patenting stem cells, genes, and medical uses, as well as other ethical and legal issues.
After Myriad: Where next for gene patents in the US? by Patent Attorney Dr Mi...Jeremy M. Ben-David
Following the recent Supreme Court decision regarding Myriad, Dr. Hammer has sided with those who declare that "the sky has not fallen." He analyses the decision and points to the way forward. Dr. Hammer heads the "US Direct" patent prosecution practice at JMB Davis Ben-David, a US and Israel Intellectual Property Boutique located in the Har-Hotzvim high tech park in Jerusalem, Israel.
In addition to filing and prosecuting patent and trademark applications worldwide for their Israeli clients, JMB Davis Ben-David files and prosecutes patent and trademark applications for clients the world over, both in the Israeli and US Patent and Trademark Offices.
Obtaining patentable claims after Prometheus and MyriadMaryBreenSmith
The Supreme Court cases significantly changed what is patentable subject-matter in the U.S. But how broadly has the scope of patentable subject matter been narrowed by these decisions? Presentation analyzes major claim types in diagnostics and gene-type patents and whether they remain patentable under this new case law.
This esteemed panel of leading patent experts, included members of the European Patent Office, addressed U.S. and European perspectives on patenting stem cells, genes, and medical uses, as well as other ethical and legal issues.
A User’s Perspective: ACMG Guidelines for CNVs in VSClinicalGolden Helix
Our last webcast introduced the newest features of VarSeq that will be included in our upcoming release. After a serious developmental effort, we are excited to announce one of these being the integration of ACMG Guidelines for CNVs!
VarSeq is not only the tertiary environment to filter through your imported SNVs and indels from any VCF file, but also includes robust and proven capabilities of CNV detection and clinical variant interpretation. With our upcoming release, users will be able to leverage an automated CNV ACMG classification filter that is paired with the CNV evaluation in the VSClinical interpretation hub. This webcast will expose attendees to literature reinforcing the quality of our CNV caller, as well as showing examples of CNV analysis to demonstrate how this tool can streamline the analysis process. In this webcast, we will cover:
Describing the new CNV guidelines and how Golden Helix tackles their complexity
Assessing CNV impact on Gene and Gene Dosage
Cited literature referencing the accuracy of VarSeq’s CNV calling
Product demonstrations of VSClinical’s CNV interpretation/classification and final report functionalities
Manually traversing the guidelines and classification process is fundamentally complex with multiple criteria considerations, collecting any necessary caveats, and bulk literature review just to name a few. It is our goal to simplify and streamline this process without losing user-control of final results or overlooking any crucial criteria components necessary for final classification. We hope you will join us to see how this is accomplished as we explore the ACMG CNV Guidelines within VSClinical from the user’s perspective!
Merchant & Gould Whitepaper: Association of Molecular Pathology v. Myriad Ge...Gary M. Myles, Ph.D.
This Merchant & Gould whitepaper summarizes the holding of the recent Supreme Court Association of Molecular Pathology v. Myriad Genetics decision, outlines its impact, and provides practice tips to those endeavoring to protect nucleic acids, genes, cDNAs, and other biological molecules, including proteins and antibodies as well as diagnostic methods that relate to laws and products of nature.
A User’s Perspective: ACMG Guidelines for CNVs in VSClinicalGolden Helix
Our last webcast introduced the newest features of VarSeq that will be included in our upcoming release. After a serious developmental effort, we are excited to announce one of these being the integration of ACMG Guidelines for CNVs!
VarSeq is not only the tertiary environment to filter through your imported SNVs and indels from any VCF file, but also includes robust and proven capabilities of CNV detection and clinical variant interpretation. With our upcoming release, users will be able to leverage an automated CNV ACMG classification filter that is paired with the CNV evaluation in the VSClinical interpretation hub. This webcast will expose attendees to literature reinforcing the quality of our CNV caller, as well as showing examples of CNV analysis to demonstrate how this tool can streamline the analysis process. In this webcast, we will cover:
Describing the new CNV guidelines and how Golden Helix tackles their complexity
Assessing CNV impact on Gene and Gene Dosage
Cited literature referencing the accuracy of VarSeq’s CNV calling
Product demonstrations of VSClinical’s CNV interpretation/classification and final report functionalities
Manually traversing the guidelines and classification process is fundamentally complex with multiple criteria considerations, collecting any necessary caveats, and bulk literature review just to name a few. It is our goal to simplify and streamline this process without losing user-control of final results or overlooking any crucial criteria components necessary for final classification. We hope you will join us to see how this is accomplished as we explore the ACMG CNV Guidelines within VSClinical from the user’s perspective!
Genome in a Bottle- reference materials to benchmark challenging variants and...
Similar to Breast Cancer and Gene therapy Patent Landscape: Discussion on Myriad Genetics and Indian Ministry Wants To Cancel Patent on Trastuzumab under section 66 of the Indian Patent Act
Merchant & Gould Whitepaper: Association of Molecular Pathology v. Myriad Ge...Gary M. Myles, Ph.D.
This Merchant & Gould whitepaper summarizes the holding of the recent Supreme Court Association of Molecular Pathology v. Myriad Genetics decision, outlines its impact, and provides practice tips to those endeavoring to protect nucleic acids, genes, cDNAs, and other biological molecules, including proteins and antibodies as well as diagnostic methods that relate to laws and products of nature.
1 (Slip Opinion) OCTOBER TERM, 2012
Syllabus
NOTE: Where it is feasible, a syllabus (headnote) will be released, as is
being done in connection with this case, at the time the opinion is issued.
The syllabus constitutes no part of the opinion of the Court but has been
prepared by the Reporter of Decisions for the convenience of the reader.
See United States v. Detroit Timber & Lumber Co., 200 U. S. 321, 337.
SUPREME COURT OF THE UNITED STATES
Syllabus
ASSOCIATION FOR MOLECULAR PATHOLOGY ET AL.
v. MYRIAD GENETICS, INC., ET AL.
CERTIORARI TO THE UNITED STATES COURT OF APPEALS FOR
THE FEDERAL CIRCUIT
No. 12–398. Argued April 15, 2013—Decided June 13, 2013
Each human gene is encoded as deoxyribonucleic acid (DNA), which
takes the shape of a “double helix.” Each “cross-bar” in that helix
consists of two chemically joined nucleotides. Sequences of DNA nu-
cleotides contain the information necessary to create strings of amino
acids used to build proteins in the body. The nucleotides that code
for amino acids are “exons,” and those that do not are “introns.” Sci-
entists can extract DNA from cells to isolate specific segments for
study. They can also synthetically create exons-only strands of nu-
cleotides known as complementary DNA (cDNA). cDNA contains only the
exons that occur in DNA, omitting the intervening introns.
Respondent Myriad Genetics, Inc. (Myriad), obtained several pa-
tents after discovering the precise location and sequence of the
BRCA1 and BRCA2 genes, mutations of which can dramatically in-
crease the risk of breast and ovarian cancer. This knowledge allowed
Myriad to determine the genes’ typical nucleotide sequence, which, in
turn, enabled it to develop medical tests useful for detecting muta-
tions in these genes in a particular patient to assess the patient’s
cancer risk. If valid, Myriad’s patents would give it the exclusive
right to isolate an individual’s BRCA1 and BRCA2 genes, and would
give Myriad the exclusive right to synthetically create BRCA cDNA.
Petitioners filed suit, seeking a declaration that Myriad’s patents are
invalid under 35 U. S. C. §101. As relevant here, the District Court
granted summary judgment to petitioners, concluding that Myriad’s
claims were invalid because they covered products of nature. The
Federal Circuit initially reversed, but on remand in light of Mayo
Collaborative Services v. Prometheus Laboratories, Inc., 566 U. S. ___,
the Circuit found both isolated DNA and cDNA patent eligible.
2 ASSOCIATION FOR MOLECULAR PATHOLOGY v.
MYRIAD GENETICS, INC.
Syllabus
Held: A naturally occurring DNA segment is a product of nature and
not patent eligible merely because it has been isolated, but cDNA is
patent eligible because it is not naturally occurring. Pp. 10–18.
(a) The Patent Act permits patents to be issued to “[w]hoever in-
vents or discovers any new and useful . . . composition of matter,”
§101, but “laws of nature ...
Ethics and the Law: The Case of Myriad Genetics, Ethics in Patenting and Eth...Kirby Drake
This presentation provides an overview of gene patents and discusses the case of Myriad Genetics and ethics in patenting and licensing and commercializing innovations.
This presentation discusses the historical context for the recent court decisions that affect the patent eligibility of biotechnology inventions, including those directed to genes, cDNAs, proteins, antibodies, and diagnostic methods. Discussed are the early Funk Brothers and Chakrabarty decisions as well as the Lab Corp, Bilski, Prometheus, Classen, and Myriad court opinions. The impact of the court holdings on the future development of biotechnology inventions, in particular personalized medicine inventions, is analyzed as is the erosion of the requisite incentives of innovative companies to invent and commercialize in areas where patent protection is less certain.
THE FRONTIERS OF MONOPOLIZATION OF HUMAN GENESSaravanan A
This research work critically examines the current trends and future feasibility of gene patents with the help of most celebrated Myriad Genetics Gene Patent Case.
Report’s Key Features
• PDF with > 160 slides
• Excel file > 5,500 patents
• IP trends, including time-evolution of published patents, and countries of patent filings
• Patents’ legal status
• Ranking of main patent assignees
• Key players’ IP position and relative strength of their patent portfolios
• Summary of the IP related to the physical isolation: size, deformability, electrical charges or density.
• Summary of the IP related to the biological isolation: positive or negative enrichment.
• Summary of the IP related to the CTC detection: nucleic acid, protein or functional assay.
• Analysis of patent litigations and review of key patents.
• Excel database containing all patents analyzed in the report, including biological and physical isolation and detection segmentations
Discusses the available scope of patent protection for advances in diagnostics as well as the types of claims available in different jurisdictions. Additionally covers "support", i.e. the enabling teaching that is the trade-off for the patent monopoly, in the context of diagnostic patent applications. Finally, considers the enforcement and exploitation of patents directed to diagnostics.
Presenters: Anna Wilkinson and Cynthia Tape, Ogilvy Renault
Similar to Breast Cancer and Gene therapy Patent Landscape: Discussion on Myriad Genetics and Indian Ministry Wants To Cancel Patent on Trastuzumab under section 66 of the Indian Patent Act (20)
https://www.blockchainailawyer.com/iprs Oracle Database is a trademark of Oracle Corporation, which is a leading provider of database software and cloud services. Oracle Database trademark applications are the legal documents that seek to register and protect the Oracle Database brand name and logo in various jurisdictions around the world.
Migrating Oracle Database trademark applications to cloud infrastructure means moving the data and processes related to these applications from on-premises servers or other cloud platforms to Oracle Cloud Infrastructure (OCI), which is Oracle’s next-generation cloud platform that offers high performance, security, scalability, and cost-efficiency for various workloads.
There are several advantages of migrating Oracle Database trademark applications to cloud infrastructure, such as:
Reducing the operational and maintenance costs of managing on-premises servers or other cloud platforms
Leveraging the advanced features and services of OCI, such as autonomous database, data management, analytics, integration, security, and identity
Enhancing the availability, reliability, and performance of the trademark applications and data
Simplifying the compliance and governance of the trademark applications and data across different regions and jurisdictions
Accelerating the innovation and development of new trademark applications and services
There are different methods and tools for migrating Oracle Database trademark applications to cloud infrastructure, depending on the source and target environments, the size and complexity of the data, and the migration objectives and requirements. Some of the common methods and tools are:
Oracle Data Pump: A utility that enables the export and import of data and metadata between Oracle databases, either on-premises or on OCI
Oracle GoldenGate: A software solution that enables the replication and synchronization of data and transactions across heterogeneous databases, either on-premises or on OCI
Oracle Zero Downtime Migration: A tool that automates the migration of Oracle databases from on-premises or other cloud platforms to OCI, with minimal or no downtime
Oracle Cloud Infrastructure Database Migration: A fully-managed service that provides a high-performing, self-service experience for migrating Oracle databases from on-premises, Oracle Cloud, or Amazon RDS to OCI
For more information about migrating Oracle Database trademark applications to cloud infrastructure, you can refer to the following resources:
Overview of Oracle Cloud Infrastructure Database Migration
About the Advantages of Migrating Custom Applications to Oracle Cloud
Learn about migrating Oracle Database Appliance workloads to the cloud
Learn About Migrating Application Data to the Cloud
METHOD AND SYSTEM FOR PREDICTING OPTIMAL LOAD FOR WHICH THE YIELD IS
MAXIMUM BY USING MULTIPLE INPUT ELECTROLYZER PARAMETERS filed by RIPIK TECHNOLOGY PRIVATE LIMITED
This patent describes a system to optimize operations in manufacturing facilities that use electrolyzers. Electrolyzers split water into hydrogen and oxygen using electricity. Their electrical load levels impact costs and efficiency.
The present invention uses AI and machine learning to predict the best way to allocate load across multiple electrolyzers. This maximizes total yield for the manufacturing plant while minimizing electricity costs.
It takes into account equipment factors like the capacity of each electrolyzer. It also considers constraints like raw material supply and product storage limits. The system models chlorine evacuation too since that can hinder caustic soda output.
The algorithms are capable of processing the many complex variables at play. No easy spreadsheet could accomplish this modeling. A type of mathematical optimization called "swarm optimization" is applied. Examples are genetic algorithms and particle swarm optimization.
The AI system keeps adapting its load recommendations based on data coming into its monitoring dashboard. Operators can customize certain parameters but the software is configuring most of the decision logic automatically.
The inventors claim results show their AI optimizer significantly cutting power consumption and costs versus alternatives. Smart coordination of multiple electrolyzers is complex. This technology handles the data analysis to efficiently divide load distribution.
In essence, the patent discloses an intelligent electrolyzer load prediction platform. It leverages AI to boost manufacturing performance while reducing electricity usage. Company managers can see optimized operations guidance on easy dashboard interfaces. It aims to save power, costs and effort through algorithmic process coordination.
The U.S. Food and Drug Administration (USFDA) regulates the use of food additives in the United States. Specifically, food additives are subject to regulation under the Federal Food, Drug, and Cosmetic Act (FD&C Act) and the regulations in Title 21 of the Code of Federal Regulations (21 CFR). These regulations define the conditions under which food additives, including acidity regulators like Orthophosphoric acid (Phosphoric Acid), can be used in food and beverages.
The specific regulations and allowable levels of Orthophosphoric acid in food and beverages, including gold drinks, can be found in the Code of Federal Regulations (21 CFR) Title 21, Part 182, which deals with substances generally recognized as safe (GRAS) for use in food. Orthophosphoric acid is covered in the section "21 CFR 182.1073 - Phosphoric acid" and its use in various food categories is outlined in this regulation.
For precise information on the allowable levels of Orthophosphoric acid in gold drinks or any other food and beverage products in the United States, it is advisable to refer to the specific regulations provided in 21 CFR 182.1073 and consult with the U.S. Food and Drug Administration (USFDA) or their official resources to ensure compliance with the most up-to-date regulations.
https://sciwri.club/archives/4288
Prity Khastgir is a techno-savvy patent attorney in India with 12 yrs of experience working with clients across the globe. Her areas of expertise are IP portfolio research, cross-border technology transactions, licensing agreements, product clearance, freedom-to-operate, patent infringement & invalidity analysis, research & opinions. Currently, she helps startups to raise funds, assists foreign companies to find right business partners in India. She also assists enterprises to enter and find the right angels, and VCs in Malaysia, Singapore, US, UK, Japan and India. Here, she answers questions about IP career prospects in India, in her Face-to-face interaction with Reetu Mehta.
Is Intellectual Property Rights (IPR) a good career option in India?
Before answering this question, I ask myself why I do what I do every morning. Am I passionate about my day? IPR is a fascinating field and apt for people who wants answers to questions related to what, why, when and how. IPR is a field of law protecting creations of mind in form of ideas, inventions, brands, trademarks, copyrights, software codes, industrial design registration and trade secrets. However, if research is not your cup of tea then please do not enter this field. You have to passionate about innovations. Many people enter this field because it is a high paying job in the long run compared to normal 9-5 jobs in India. However, not everyone will be able to sustain in this field in the long run. Therefore, be wise before entering this field. You should be fascinated by technologies around you, have a problem solving approach, and be compassionate towards your peers.
How can a life science PhD begin with career in IPR?
Life science is study of life processes. The scope of PhD in IPR is better as the person is familiar with research. The best way to move forward is to do online IPR courses and get an overview of IPR. One should have interest and passion to solve the queries related to the intellectual creations of mind. One should have problem solving approach as client is looking for solutions.
What are the required skill sets?
First and foremost, the person should have technology and legal acumen to understand innovations and have a research capability to work at least for 10-12 hours. Thinking out of the box to solve a research project is the key to assisting inventors to protect their inventions.
How does a career in IP evolve/grow in India?
The individuals I have come across are passionate about protecting innovations. To evolve in this field you have to be technology savvy. The Intellectual Property law has evolved a lot in last 10 years. Now a trademark can be registered in less than one month in India with proper documentation. The Indian government is giving a number of grants to startups in India to grow by leap and bounds.
What is the kind of work one is expected to do and what are the skill sets one can acquire over the course?
Trade Secret as Intellectual Property Strategic
Tool in Industry 4.0
Prity Khastgir
TCIS India, Level-5, Caddie Commercial Tower, Novotel Hotel, Hospitality District Aerocity,
IGI Airport, New Delhi 110037 India
khasip@khastgir.com
Abstract -- In covid situation, most businesses have reviewed
their existing contracts to understand scope of parties involved
and thereby Intellectual Property clauses and sub-clauses of any
contract or agreement become very important. Private blockchain
implementation in the current scenario is key to the maze to
protect trade secrets in a confidential manner.
Progressive IP strategy and partnering with right partners to
create and maintain sustainable development positions in the
market to serve customers and catering to their needs is the need
of the hour. Proactive strategic signed contracts and agreements
should be mandatory for smooth functioning of any start-up or
enterprise. Negotiation, Mediation and Arbitration are like trinity
in law to resolve any arising conflict.
Keywords: Intellectual Property, Trade secrets protection, Blockchain
implementation, Industry 4.0, Public domain
I. INTRODUCTION
EVERY technology launch contributes to macroeconomic
growth of the country. Contracts and agreements drafted around
technology licensing or assignments play a pivotal role as to
how developed innovation would be deployed in different
verticals. Over the last one decade, we have witnessed a very
strong nonlinear curve and especially with what forms part of
terms and conditions to exert control over under applicable
contract law while collaborating with different parties to
manage successful ventures in Industry 4.0 operating in
multiple jurisdictions and protecting trade secrets.
Primarily, contracts and proper agreements in place sets the
ambit right to protect trade secrets of technology driven startup ventures. Understanding Intellectual property landscape and
conducting IP due-diligence is very important and is essentially
a first step to understand short-term and long-term goals to
prepare rock solid IP strategy with a holistic viewpoint.
Intellect is the creation of the mind and protecting intellectual
capacity by utilizing different IPRs is key to deliver market cap
results. In covid situation, most businesses have reviewed their
existing contracts to understand scope of parties involved and
thereby Intellectual Property clauses and sub-clauses of any
t's quite unfair because laundering is taking place either domestic investors we can even take place by foreign investors. What kind of modification we could have done? Now you case capital investors of foreign investors what they have. Some of you are still asking me how do you calculate here. Fair market value for calculation is by a book value method or discounted cash flow method. In order to see examples of beginning for examination, basically calculate the fair market value. So you can see new budget proposal is applicable to capital raise from both as well as foreign. Taxi. Number 21. Venture capitalists and Angel investors are both safe. Companies considered startups were approved. Five years annual turnover? Not usually. The Startup India scheme is implemented by Ministry of Commerce and Industry. There is indeed implemented by Minister. No. The Angel Tax has been introduced for the first time in amendment to Income Tax Act. For the first time, Angel Tax is applicable to both Mr. and Mr. Companies. And the Angel facts made applicable to capital raised for more domestic and foreign investors kits. And there's investors now it is for both. This quarter. This tax is imposed only when the startup company is issuing shares at a price on the fair market price. It's a startup companies raising capital at a fair market value added taxes. The tax on long term debt. So recently the government has made certain changes to the spec long term capital gains tax on debt. Take this on long term capital gains tax on deposits. Let's look at this more capital gains. What is capital gains? Capital gains tax is the tax which people pay on profits which they make by selling. And whenever I sell an asset begin profit a part of that profit paid to commit tax capital gains, for example. I want to share at least in the year 15. I have shared and made a mistake to comment says if you have made pocket. Is capital gains tax will come into play if you make a loss? Your losses. Understand this concept of what is long term comes against that. Which takes money from investors and after taking money from investors, that money is invested in different different financial shares. So here we have predominantly more types of. Mutual funds are those funds. There mutual funds are investing more than 65% money in checks that mutual funds are. More than 65% of money is invested in bonds, which means it pretty much the funds can make investment in shares. Bonds. But where is the priority investment shares? They can make investment in both shares and bonds. Investment. On the equity mutual funds, we have short term capital gains tax and long term capital gains. Short term capital gains tax comes into play if I buy and sell. Long term capital gains tax will come into play if I buy and sell after. Play. March 2023, just in one year. And sending. You can. And. What is long term Complications? They're 2023. I bought it in March 2024. After more than one year. How much is it? Capital
xtell. Why September the 26th, I don't have a good picture, but I know for the first half the intelligence was saying it's gonna be a long war. He decided then to do it, and he had set it up so he could just say yes and a day later would blow away. You said it and say work by sonars. Frequency, you can blow them up, you can do it. So tough thing to do. And so why at that point, whether he was deciding is this is going to be a long war, it's going to cost a lot of money. I'm going to go all the way. He's now moving a lot of American troops and equipment into Poland. I don't know if he's going to commit native to it. I don't know if NATO wants to go, but he basically gave Chancellor Schultz, took away the option of Schultz to say I'm going to stop giving them arms. Winter's coming. I want that pipeline. I want to keep my people warm and wealthy. So he blew it up. So there's been a lot of news reporting, a lot of interest on this very simple question. Who blew up the North Stream pipelines? Remember in September of last year, the North Stream One and N Stream Two, which are two parallelly running pipelines carrying natural gas from Russia to Germany, were blown up. There were massive explosions which happened 250 feet are below the sea. Now the first report that came out, which was last month by a famous American journalist, which seemed to suggest that this was an inside job, it was carried out by the United States using state actors. now just this past week there's been some follow up reporting
September the 26th last year and. I there was no way. Common sense. You have to deal with common sense. Well, let's see. I knew that no Russia would have done it because of Putin already had responded. There's two major pipelines, N Stream one, which has been alive for since 2011, and Nord Stream two, which is. These are huge. They moved millions of whatever the measurement is of natural gas. There is a different measurement and it's not cubic feet, it's they they they move in, they mouth stream one turn Germany because they supplied cheap natural gas. That was very clear. Then they needed it anyway. I'm just giving you all this because I'm not here. I can answer your question, but I be coming from the blue one. I don't want to come from the blue. I want people to understand I've done this a long time. So the White House, Mr. Hush, they have rejected your story outright. They've called it a figment of your imagination. More fiction than fact is the wording that they used. Germany has also taken a very cautious mind on your story. You referred before in your first answer to Western media like the New York Times, The Washington Post. Had you taken your story to the editors there, would they have published such a consequential story basis, Just one single, unnamed anonymous source? How would you react to that? This source? Would I the way described the story and the intent of how I sourced it? Was to be as as vague as possible. It would have
Play with Data aka Magic
tell. Why September the 26th, I don't have a good picture, but I know for the first half the intelligence was saying it's gonna be a long war. He decided then to do it, and he had set it up so he could just say yes and a day later would blow away. You said it and say work by sonars. Frequency, you can blow them up, you can do it. So tough thing to do. And so why at that point, whether he was deciding is this is going to be a long war, it's going to cost a lot of money. I'm going to go all the way. He's now moving a lot of American troops and equipment into Poland. I don't know if he's going to commit native to it. I don't know if NATO wants to go, but he basically gave Chancellor Schultz, took away the option of Schultz to say I'm going to stop giving them arms. Winter's coming. I want that pipeline. I want to keep my people warm and wealthy. So he blew it up. So there's been a lot of news reporting, a lot of interest on this very simple question. Who blew up the North Stream pipelines? Remember in September of last year, the North Stream One and N Stream Two, which are two parallelly running pipelines carrying natural gas from Russia to Germany, were blown up. There were massive explosions which happened 250 feet are below the sea. Now the first report that came out, which was last month by a famous American journalist, which seemed to suggest that this was an inside job, it was carried out by the United States using state actors. now just this past week there's been some follow up reporting
September the 26th last year and. I there was no way. Common sense. You have to deal with common sense. Well, let's see. I knew that no Russia would have done it because of Putin already had responded. There's two major pipelines, N Stream one, which has been alive for since 2011, and Nord Stream two, which is. These are huge. They moved millions of whatever the measurement is of natural gas. There is a different measurement and it's not cubic feet, it's they they they move in, they mouth stream one turn Germany because they supplied cheap natural gas. That was very clear. Then they needed it anyway. I'm just giving you all this because I'm not here. I can answer your question, but I be coming from the blue one. I don't want to come from the blue. I want people to understand I've done this a long time. So the White House, Mr. Hush, they have rejected your story outright. They've called it a figment of your imagination. More fiction than fact is the wording that they used. Germany has also taken a very cautious mind on your story. You referred before in your first answer to Western media like the New York Times, The Washington Post. Had you taken your story to the editors there, would they have published such a consequential story basis, Just one single, unnamed anonymous source? How would you react to that? This source? Would I the way described the story and the intent of how I sourced it? Was to be as as vague as possible.
I know which you know. What is left? So I can close my eyes and enter into this and reach my office. So on a more serious note, I think. You cannot classify it as a treatment team or a team or you know, limited over 50. See Virat Kohli is good in 20, is good in limited over 20 Cricket is also good in Test cricket. So the RBI has to function and perform those fifty over match as well as in our effort. On effort and endeavor is always to optimize our for us to the best thing to extend that we can we put our best foot forward. Thank you very much. Thank you very much for accepting our condition. Great pleasure talking to you. Thank you very much and thank you very much for your patience. For short the time primarily for my longest answers. I can see your colleagues are very very efficient. But thank you once again. Thank you very much for your time. Thank you so much, Governor, and thank you again. Right for our next session. Welcome everyone And there's been talk about. Exciting transformations over the next several years will be the advent of Fight Jail India and this whole idea that India had. Physical. And it is an absolute delight to welcome for this fireside conversation to the Business Today India 100 Country Summit, one of the legendary. This generation. Quality and it's still standing fighting scale this in this fight can they have a popular as he walked through this Business Today and they have. Thank you so much. i want to start by asking you about the hearing which is about 5G everyone watching want We start at what does this mean? Everyone was listening to this. Fighting. And if you really look at the world fighting at most time to take roots, you know most of the Western world, Southeast Asian countries, Singapore and starts right as well I think we are some people think. Check this the perfect time some use cases. You can see devices coming through Priceline devices trying to find one perfectly from the country they can do so. I think we are ready. Thankfully this time the government put up a lot of spectrum because 5G requires made large chunks of spectrum to be effective. Otherwise they don't really get the joy of our friendship and not only the mid band which the seed bank claims. They're All in all, I think India is now ready from the spectrum point of view, but it's now standard and available. We have been building from this day for the last 24 months and predicted that we would want sometimes some of the preparedness felt that would probably come in 2021. But I think they're just takes time to develop the ecosystem. So we are ready. Expect launches October Believe will be from very early in October. Sometime in October you can start to see on your phones if there are any. We'll start with dictionaries, the key towns and the keep on as we've seen here earlier, keep on with right across and going into deep. What should you do to us, I mean today? Customer. Very important use cases which are developing around which took my mind are
tell. Why September the 26th, I don't have a good picture, but I know for the first half the intelligence was saying it's gonna be a long war. He decided then to do it, and he had set it up so he could just say yes and a day later would blow away. You said it and say work by sonars. Frequency, you can blow them up, you can do it. So tough thing to do. And so why at that point, whether he was deciding is this is going to be a long war, it's going to cost a lot of money. I'm going to go all the way. He's now moving a lot of American troops and equipment into Poland. I don't know if he's going to commit native to it. I don't know if NATO wants to go, but he basically gave Chancellor Schultz, took away the option of Schultz to say I'm going to stop giving them arms. Winter's coming. I want that pipeline. I want to keep my people warm and wealthy. So he blew it up. So there's been a lot of news reporting, a lot of interest on this very simple question. Who blew up the North Stream pipelines? Remember in September of last year, the North Stream One and N Stream Two, which are two parallelly running pipelines carrying natural gas from Russia to Germany, were blown up. There were massive explosions which happened 250 feet are below the sea. Now the first report that came out, which was last month by a famous American journalist, which seemed to suggest that this was an inside job, it was carried out by the United States using state actors. now just this past week there's been some follow up reporting
September the 26th last year and. I there was no way. Common sense. You have to deal with common sense. Well, let's see. I knew that no Russia would have done it because of Putin already had responded. There's two major pipelines, N Stream one, which has been alive for since 2011, and Nord Stream two, which is. These are huge. They moved millions of whatever the measurement is of natural gas. There is a different measurement and it's not cubic feet, it's they they they move in, they mouth stream one turn Germany because they supplied cheap natural gas. That was very clear. Then they needed it anyway. I'm just giving you all this because I'm not here. I can answer your question, but I be coming from the blue one. I don't want to come from the blue. I want people to understand I've done this a long time. So the White House, Mr. Hush, they have rejected your story outright. They've called it a figment of your imagination. More fiction than fact is the wording that they used. Germany has also taken a very cautious mind on your story. You referred before in your first answer to Western media like the New York Times, The Washington Post. Had you taken your story to the editors there, would they have published such a consequential story basis, Just one single, unnamed anonymous source? How would you react to that? This source? Would I the way described the story and the intent of how I sourced it? Was to be as as vague as possible. It would have been very
tell. Why September the 26th, I don't have a good picture, but I know for the first half the intelligence was saying it's gonna be a long war. He decided then to do it, and he had set it up so he could just say yes and a day later would blow away. You said it and say work by sonars. Frequency, you can blow them up, you can do it. So tough thing to do. And so why at that point, whether he was deciding is this is going to be a long war, it's going to cost a lot of money. I'm going to go all the way. He's now moving a lot of American troops and equipment into Poland. I don't know if he's going to commit native to it. I don't know if NATO wants to go, but he basically gave Chancellor Schultz, took away the option of Schultz to say I'm going to stop giving them arms. Winter's coming. I want that pipeline. I want to keep my people warm and wealthy. So he blew it up. So there's been a lot of news reporting, a lot of interest on this very simple question. Who blew up the North Stream pipelines? Remember in September of last year, the North Stream One and N Stream Two, which are two parallelly running pipelines carrying natural gas from Russia to Germany, were blown up. There were massive explosions which happened 250 feet are below the sea. Now the first report that came out, which was last month by a famous American journalist, which seemed to suggest that this was an inside job, it was carried out by the United States using state actors. now just this past week there's been some follow up reporting
September the 26th last year and. I there was no way. Common sense. You have to deal with common sense. Well, let's see. I knew that no Russia would have done it because of Putin already had responded. There's two major pipelines, N Stream one, which has been alive for since 2011, and Nord Stream two, which is. These are huge. They moved millions of whatever the measurement is of natural gas. There is a different measurement and it's not cubic feet, it's they they they move in, they mouth stream one turn Germany because they supplied cheap natural gas. That was very clear. Then they needed it anyway. I'm just giving you all this because I'm not here. I can answer your question, but I be coming from the blue one. I don't want to come from the blue. I want people to understand I've done this a long time. So the White House, Mr. Hush, they have rejected your story outright. They've called it a figment of your imagination. More fiction than fact is the wording that they used. Germany has also taken a very cautious mind on your story. You referred before in your first answer to Western media like the New York Times, The Washington Post. Had you taken your story to the editors there, would they have published such a consequential story basis, Just one single, unnamed anonymous source? How would you react to that? This source? Would I the way described the story and the intent of how I sourced it? Was to be as as vague as possible. It would have been
tell. Why September the 26th, I don't have a good picture, but I know for the first half the intelligence was saying it's gonna be a long war. He decided then to do it, and he had set it up so he could just say yes and a day later would blow away. You said it and say work by sonars. Frequency, you can blow them up, you can do it. So tough thing to do. And so why at that point, whether he was deciding is this is going to be a long war, it's going to cost a lot of money. I'm going to go all the way. He's now moving a lot of American troops and equipment into Poland. I don't know if he's going to commit native to it. I don't know if NATO wants to go, but he basically gave Chancellor Schultz, took away the option of Schultz to say I'm going to stop giving them arms. Winter's coming. I want that pipeline. I want to keep my people warm and wealthy. So he blew it up. So there's been a lot of news reporting, a lot of interest on this very simple question. Who blew up the North Stream pipelines? Remember in September of last year, the North Stream One and N Stream Two, which are two parallelly running pipelines carrying natural gas from Russia to Germany, were blown up. There were massive explosions which happened 250 feet are below the sea. Now the first report that came out, which was last month by a famous American journalist, which seemed to suggest that this was an inside job, it was carried out by the United States using state actors. now just this past week there's been some follow up reporting
September the 26th last year and. I there was no way. Common sense. You have to deal with common sense. Well, let's see. I knew that no Russia would have done it because of Putin already had responded. There's two major pipelines, N Stream one, which has been alive for since 2011, and Nord Stream two, which is. These are huge. They moved millions of whatever the measurement is of natural gas. There is a different measurement and it's not cubic feet, it's they they they move in, they mouth stream one turn Germany because they supplied cheap natural gas. That was very clear. Then they needed it anyway. I'm just giving you all this because I'm not here. I can answer your question, but I be coming from the blue one. I don't want to come from the blue. I want people to understand I've done this a long time. So the White House, Mr. Hush, they have rejected your story outright. They've called it a figment of your imagination. More fiction than fact is the wording that they used. Germany has also taken a very cautious mind on your story. You referred before in your first answer to Western media like the New York Times, The Washington Post. Had you taken your story to the editors there, would they have published such a consequential story basis, Just one single, unnamed anonymous source? How would you react to that? This source? Would I the way described the story and the intent of how I sourced it? Was to be as as vague as possible. It would have been very
AboutAbout
As a Machine Learning Engineer, I am enthusiastic about exploring the fascinating field of machine learning and its potential applications in solving real-world problems. I have a good amount of knowledge in mathematics, statistics, and computer science, which enables me to understand and implement the fundamental concepts and techniques of machine learning.
My experience includes working with various data analytics tools and technologies, such as SQL, Python, Tableau, and Power BI. I have developed expertise in data cleaning and exploratory data analysis, statistical inference, and machine learning techniques such as regression, and clustering, my experience also includes working with a variety of machine learning tools and frameworks, including, Scikit-learn, TensorFlow and Keras. I have also developed expertise in data pre-processing, feature engineering, and model selection, which has enabled me to create robust and accurate machine-learning models.
I am eager to expand my knowledge and expertise in machine learning research and AI-related fields. I am a quick learner, and I am always willing to take on new challenges and stretch myself to develop new skills. Furthermore, I am a good communicator and collaborator, able to work effectively in a team and learn from more experienced colleagues.
I am excited about the potential of machine learning to create positive change and improve people's lives specifically in Health Care industries. I am committed to staying up-to-date with the latest developments in machine learning and related fields, attending conferences and workshops, and engaging in continuous learning. I am eager to apply my skills and experience to solve complex problems and create value for organizations.
https://www.linkedin.com/in/sudharmendra-gv-7214361b2/
Machine Learning EngineerMachine Learning Engineer
Longevity InTime BioTech · Part-timeLongevity InTime BioTech · Part-time
Nov 2022 - Present · 6 mosNov 2022 - Present · 6 mos
Wilmington, Delaware, United StatesWilmington, Delaware, United States
Longevity Intime is a company developing online technology, which enables early diagnosis of diseases using real-time biometrics from the human body.
The Longevity InTime team includes experienced biotechnologists, award-winning scientists, developers, and experienced executives with years of experience. Together we are solving the global problem of life expectancy for each person and for all mankind.
Our goal is to extend a person's life by more than 20 active and happy years without any restrictions to him. We respond to both the personal and public interests of every country on Earth.Longevity Intime is a company developing online technology, which enables early diagnosis of diseases using real-time biometrics from the human body. The Longevity InTime team includes experienced biotechnologists, award-winning scientists, developers, and experienced executives with years of experience.
Patent Number : 411898 Date of Patent : 24/05/2014
Application Number : 10903/DELNP/2015 Date of Grant : 21/11/2022
Type of Application : PCT NATIONAL PHASE APPLICATION Date of Recordal : 21/11/2022
Parent Application Number : --- Appropriate Office : DELHI
PCT International Application Number : PCT/JP2014/063758 PCT International Filing Date : 24/05/2014
Grant Title : VERTICAL AXIS WATER/WIND TURBINE MOTOR USING FLIGHT FEATHER OPENING/CLOSING WING SYSTEM
Sl No Name of Grantee Grantee Type Grantee Address
1 TAMATSU Yoshiji NATURAL PERSON Room16Toyota Apartment1656 5Aza OrokuNaha shi Okinawa 9010152
Sl No Name of Patentee Patentee Type Address of Patentee
1 TAMATSU Yoshiji NATURAL PERSON Room16Toyota Apartment1656 5Aza OrokuNaha shi Okinawa 9010152
Address of Service : Tech Corp. International Strategist TCIS, lndia 5th Floor, Caddie Commercial Tower, Aerocity, New Delhi- 110037 India
Additional Address of Service : --
Priority Date : 25/05/2013
Year Due dates for Renewal CBR No CBR Date Renewal Amount Renewal Certificate No Date of Renewal Renewal Period:
Normal Due Date Due Date with Extension From To
3rd year 21/02/2023 21/08/2023 12919 21/03/2023 800 27207 21/03/2023 24/05/2016 24/05/2017
4th year 21/02/2023 21/08/2023 12919 21/03/2023 800 27208 21/03/2023 24/05/2017 24/05/2018
5th year 21/02/2023 21/08/2023 12919 21/03/2023 800 27209 21/03/2023 24/05/2018 24/05/2019
6th year 21/02/2023 21/08/2023 12919 21/03/2023 800 27210 21/03/2023 24/05/2019 24/05/2020
7th year 21/02/2023 21/08/2023 12919 21/03/2023 2400 27211 21/03/2023 24/05/2020 24/05/2021
8th year 21/02/2023 21/08/2023 12919 21/03/2023 2400 27212 21/03/2023 24/05/2021 24/05/2022
9th year 21/02/2023 21/08/2023 12919 21/03/2023 2400 27213 21/03/2023 24/05/2022 24/05/2023
10th year 24/05/2023 24/11/2023 12919 21/03/2023 2400 27214 21/03/2023 24/05/2023 24/05/2024
11th year 24/05/2024 24/11/2024 12919 21/03/2023 4800 27215 21/03/2023 24/05/2024 24/05/2025
12th year 24/05/2025 24/11/2025 12919 21/03/2023 4800 27216 21/03/2023 24/05/2025 24/05/2026
13th year 24/05/2026 24/11/2026 12919 21/03/2023 4800 27217 21/03/2023 24/05/2026 24/05/2027
14th year 24/05/2027 24/11/2027 12919 21/03/2023 4800 27218 21/03/2023 24/05/2027 24/05/2028
15th year 24/05/2028 24/11/2028 12919 21/03/2023 4800 27219 21/03/2023 24/05/2028 24/05/2029
16th year 24/05/2029 24/11/2029 12919 21/03/2023 8000 27220 21/03/2023 24/05/2029 24/05/2030
17th year -- -- -- -- -- -- -- -- --
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Sl No Date of Entry Particulars/Remarks
Information u/s 146 (Working of Patents)
Sl No Patent Number Year
1 411898
TITLE OF INVENTION VERTICAL AXIS WATER/WIND TURBINE MOTOR USING FLIGHT FEATHER OPENING/CLOSING WING SYSTEM
FIELD OF INVENTION MECHANICAL ENGINEERING
E-MAIL (As Per Record) prity.khastgir@gmail.com
ADDITIONAL-EMAIL (As Per Record)
E-MAIL (UPDATED Online) khasip@khastgir.com
PCT INTERNATIONAL APPLICATION NUMBER PCT
Dear Sir/ Madam,
Congratulations, you have been shortlisted for our next phase of audition of Shark Tank India, which is the In-Person Audition! At this stage of the audition our team will be meeting you in-person to further discuss your business/idea. Please note, we will be conducting these “In-Person Auditions” in Mumbai, Bengaluru, Delhi & Kolkata.
As per your form, your audition city is Delhi
Audition Venue: WelcomHotel ITC Dwarka, Plot No 3, District Center, Sector 10 Dwarka, New Delhi, Delhi 110075.
Landline - 01142229222
Location – Welcomhotel Dwarka offers easy access to the Delhi Metro Blue Line near by metro station Dwarka Sector 10. Located 20 minutes away from Indira Gandhi International Airport and the domestic airport in New Delhi.
Audition Date & Time: 15th July'22 Friday at 1pm
Time commitment required: 4 hours on the audition day
Kindly note the following guidelines for the in-person audition -
COVID Mandatory Safety Guidelines:
Applicants and any accompanying persons will need to wear a mask at all times and adhere to all the social distancing guidelines communicated by us, while at the venue
In case, you and any accompanying persons are vaccinated please carry your updated vaccination certificate (first and second dosage) or the Arogya Setu Pass.
In case you and any accompanying persons are not vaccinated, RT PCR Test with a 48 hour validity is mandatory and the status will be checked prior to at the venue.
A mandatory Rapid Antigen Test will be administered at the venue and only if the same turns out to be negative, will the applicant be allowed to proceed further.
Please note, that all applicants and any accompanying person will at all times have to comply with the rules and regulations mandated by the Central or State Government with respect to COVID 19 prevention issued at that time.
Documents for verification required at the time of audition: -
(Please note the documents are required for verification at the time of audition, kindly carry original copies too & also please do email us these documents scanned copies before the audition date and also get it on your pen drive at the venue also. Email us on - sharktankindia1@setindia.com)
Mandatory
Applicant’s Photo Identity proof & Address Proofs (Aadhar Card & Pan-Card)
Document proofs to validate accreditation & Audited Financials - Balance Sheets, Net worth Certificate (if any) and Income Statement for last 3 years. Please note, the certificate should be taken from the CA/CA Firm (on their letterhead)
Certificates evidencing any change of name, Memorandum of Association, Articles of Association, registered partnership deed, etc. or equivalent documents
No Objection Certificate (NOC), signed & dated, from all shareholders/co-founders/partners/investors
Company PAN CARD/GST Certificates
Income Tax Returns for the last 3 years (according to the business tenure)
If Applicable
Certificate of Incorporation or registration for your firm/partnership/LLP/company
#Node CC: Philippe RochePhilippe Roche : 2nd Connect
Founding & Managing Partner
The distinction between private equity (PE) and venture capital (VC)
They differ in:
- Their amounts of investment
- Types of firms they choose to invest in
- Timing of their involvement in a company's lifespan
- Equity they receive as a result of their investments.
VCs often invest $10M or less.
PEs often spend $50 million or more.
Early-stage startups are the focus of VCs.
PEs focus on seasoned businesses.
A small portion of the corporation is owned by VCs.
PEs purchase a controlling stake from the stockholders.
VCs research exit strategies and fast growth.
PEs consider scaling businesses to increase productivity and profits.
Examples
VC firms: Bessemer Venture Partners, Andreessen Horowitz, and Sequoia Capital
VC-backed businesses: Juul, Stripe, SpaceX, Waymon, and Ripple Labs
Private equity firms: The Blackstone Group Inc., CVC Capital Partners, and TPG Capital are
Companies with PE backing: EQ Office, Panera Bread, and Refinitiv
PEs and VCs are, of course, much more complicated than this.
Please feel free to remark with your observations.
#startups #entrepreneurship #venturecapital #investing #finance #crossborder #inovexus #startup #VC #earlystage
#galeshapley
#smartcontracts
Ms. Prity Khastgir (b. 26 Dec. 1984). Obtained B.A.Sc (Hons) in Applied Sciences specialising in Food technology from University of Delhi and M.Sc in Biotechnology and LLB from University of Rajasthan. Did Entrepreneurship course from Indian School of Business (ISB) sponsored by Goldman Sachs 10,000 Women Entrepreneurs Initiative. She is Certified Mediator for Commercial Disputes and Negotiator in India. Currently, she is working towards launching innovation hub in
domestic and international level.
She is passionate about technology, law and business on a global scale. Recently, she was invited by China Government for China International Big Data Expo 2018, Guiyang. She is active in international technology arena and recently participated in the 4th Annual Asia Pacific Spectrum Management Conference and in World Summit on the Information Society (WSIS) Forum 2018, Geneva.
Senior executive profile with featured publications: BBC World, Nature Group (Nature Reviews Drug Discovery), BusinessWorld, BioSpectrum Asia etc. Previous work experience with US Law Firm headquartered in Greater New York City Area. Problem solver and Business Strategist with 12+ yrs exp. Seasoned Patent Strategist with expertise in IP portfolio research, cross-border tech transactions, licensing agreements, product clearance, FTO opinion, patent infringement and invalidity, IPR R&D Consultancy.
Aligning and facilitating youth to be driven in the industry 4.0 era is her motto to take India’s GDP to next level. She is a guest faculty at IMT, Ghaziabad taking lectures on legal aspects of doing business in India and understanding the innovation ethos globally.
#ITU Guide to drive Citizens' engagement for #Innovation #OpenGeneva
https://www.itu.int/net4/wsis/forum/2020/en/Agenda
Julia Dallest
Chief Operation Officer
Open Geneva
Julia Dallest is the Chief Operation Officer at Open Geneva. After 4 years as a change management consultant in Paris, Julia worked 2 years for a humanitarian mission in Madagascar as a partnership manager. Wishing to continue her involvement in the associative world, Julia joined Open Geneva as a volunteer in 2018 and as Chief Operation Officer since 2019.
Cristina Bueti
Counsellor of ITU-T Study Group 20 “Internet of things (IoT) and smart cities and communities (SC&C)”
International Telecommunication Union
Cristina Bueti is the Counsellor of ITU-T Study Group 20 “Internet of things (IoT) and smart cities and communities (SC&C)” at the International Telecommunication Union (ITU). She is responsible for ITU-T's activities on IoT and smart sustainable cities. She is the ITU focal point for environment and climate change including e-waste management. She also serves as TSB focal point for Latin America.
Cristina Bueti graduated from the Faculty of Political Science, Law and International Cooperation and Development of the University of Florence, where she completed postgraduate studies in International Cooperation and Telecommunications Law in Europe. She also holds a specialization in Environmental Law with a special focus on Telecommunications.
In 2003, Ms. Bueti built on her academic credentials by completing a specialized course in peace keeping and international cooperation with special focus on telecommunications at the Faculty of Laws, University of Malta, before joining the International Telecommunication Union in Geneva in January 2004.
As part of the International Women's Day 2016, she was named as one of the twenty Geneva-based inspirational women working to protect the environment.
She has authored over 40 reports on telecommunication issues. A native Italian speaker, Cristina is also fluent in English, French and Spanish.
Thomas Diez
FabCity
Venezuelan Urbanist specialized in digital fabrication and its implications on the future cities and society. He is the co-founder and director of Fab Lab Barcelona at the Institute for Advanced Architecture of Catalonia (IAAC), and is a founding partner of the Fab City Global Initiative. He is also the director of the recently launched Master in Design for Emergent Futures at IAAC. Tomas has been appointed by The Guardian and Nesta as one of the top 10 digital social innovators to watch in 2013, and has been awarded by the Catalan ICT association as the entrepreneur of the year in 2014.
More from Prity Khastgir IPR Strategic India Patent Attorney Amplify Innovation (20)
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Breast Cancer and Gene therapy Patent Landscape: Discussion on Myriad Genetics and Indian Ministry Wants To Cancel Patent on Trastuzumab under section 66 of the Indian Patent Act