1. Pericarditis is inflammation of the pericardial sac surrounding the heart. Common causes include viral, bacterial, and fungal infections.
2. Symptoms include chest pain that increases with inspiration and improves when leaning forward. A pericardial rub may also be heard on examination.
3. Pericardial effusion is a complication where fluid accumulates in the pericardial sac, which can progress to cardiac tamponade if severe. Tamponade occurs when fluid pressure prevents the heart from filling properly.
Pericarditis is an inflammation of the pericardium surrounding the heart that can be caused by infections, autoimmune diseases, or other etiologies. It is classified as acute, subacute, or chronic based on duration. The document defines pericarditis and its types, describes the pathophysiology involving fluid accumulation in the pericardial space, lists clinical manifestations such as chest pain and potential complications like cardiac tamponade, and outlines the diagnostic and management approaches including medications, imaging, and procedures.
The document summarizes different types of pericardial diseases. It describes the normal anatomy and functions of the pericardium. It then discusses various pericardial conditions such as acute pericarditis, pericardial effusion, constrictive pericarditis and their causes, symptoms, diagnostic criteria and treatments. Acute pericarditis is usually caused by viral or bacterial infections and presents with chest pain and pericardial friction rub. Constrictive pericarditis occurs after acute pericarditis and causes decreased diastolic filling through pericardial thickening and fibrosis.
The document discusses pericarditis, pericardial effusion, cardiac tamponade, and chronic constrictive pericarditis. It describes the functions of the pericardium, signs and symptoms, diagnostic tests including EKG changes and imaging, and treatments for the different conditions including medications, pericardiocentesis, and pericardial stripping. Chronic constrictive pericarditis results from scarring and thickening of the pericardium limiting ventricular filling, with symptoms of exertional dyspnea and elevated jugular venous pressure.
Truncus arteriosus occurs when the aorta and pulmonary artery arise as one common trunk from both ventricles, often accompanied by a VSD and cyanosis. Treatment involves surgically restructuring the vessels. Ebstein anomaly is a rare congenital heart defect characterized by downward displacement of the tricuspid valve, causing right heart enlargement and cyanosis. Hypoplastic left heart syndrome involves severe underdevelopment of the left heart structures. Pulmonary stenosis can be valvular, subvalvular, or supravalvular and causes obstruction of blood flow from the right ventricle to the lungs. Congestive cardiac failure results from various heart defects or diseases impairing the heart's ability to pump
1) The document discusses various infective diseases of the heart, focusing on pericarditis. It defines pericarditis as inflammation of the pericardium, and describes different types including acute and chronic forms.
2) Causes of pericarditis include viral, bacterial, parasitic and fungal infections, drug reactions, collagen diseases, myocardial injury, radiation, and neoplasms. Common symptoms are chest pain, palpitations, fever and dyspnea. Diagnosis involves EKG, echocardiogram, cardiac enzymes and sometimes pericardiocentesis.
3) Treatment involves NSAIDs, colchicines, or corticosteroids depending on severity. Some
Approach to patient with cardiovascular disease.pptxtesa10
This document provides guidance on evaluating patients with cardiovascular disease. It outlines how to take a thorough history, examine the patient, and identify relevant investigations. Key aspects of history taking include presenting complaint, review of symptoms, past medical history, and family history. The examination involves inspection for signs like cyanosis, palpation of pulses and precordium, and auscultation of heart sounds. Common symptoms like chest pain, dyspnea, palpitations, and edema are described. Relevant investigations include ECG, echocardiogram, chest X-ray, and cardiac enzymes.
Pericarditis is an inflammation of the pericardium surrounding the heart that can be caused by infections, autoimmune diseases, or other etiologies. It is classified as acute, subacute, or chronic based on duration. The document defines pericarditis and its types, describes the pathophysiology involving fluid accumulation in the pericardial space, lists clinical manifestations such as chest pain and potential complications like cardiac tamponade, and outlines the diagnostic and management approaches including medications, imaging, and procedures.
The document summarizes different types of pericardial diseases. It describes the normal anatomy and functions of the pericardium. It then discusses various pericardial conditions such as acute pericarditis, pericardial effusion, constrictive pericarditis and their causes, symptoms, diagnostic criteria and treatments. Acute pericarditis is usually caused by viral or bacterial infections and presents with chest pain and pericardial friction rub. Constrictive pericarditis occurs after acute pericarditis and causes decreased diastolic filling through pericardial thickening and fibrosis.
The document discusses pericarditis, pericardial effusion, cardiac tamponade, and chronic constrictive pericarditis. It describes the functions of the pericardium, signs and symptoms, diagnostic tests including EKG changes and imaging, and treatments for the different conditions including medications, pericardiocentesis, and pericardial stripping. Chronic constrictive pericarditis results from scarring and thickening of the pericardium limiting ventricular filling, with symptoms of exertional dyspnea and elevated jugular venous pressure.
Truncus arteriosus occurs when the aorta and pulmonary artery arise as one common trunk from both ventricles, often accompanied by a VSD and cyanosis. Treatment involves surgically restructuring the vessels. Ebstein anomaly is a rare congenital heart defect characterized by downward displacement of the tricuspid valve, causing right heart enlargement and cyanosis. Hypoplastic left heart syndrome involves severe underdevelopment of the left heart structures. Pulmonary stenosis can be valvular, subvalvular, or supravalvular and causes obstruction of blood flow from the right ventricle to the lungs. Congestive cardiac failure results from various heart defects or diseases impairing the heart's ability to pump
1) The document discusses various infective diseases of the heart, focusing on pericarditis. It defines pericarditis as inflammation of the pericardium, and describes different types including acute and chronic forms.
2) Causes of pericarditis include viral, bacterial, parasitic and fungal infections, drug reactions, collagen diseases, myocardial injury, radiation, and neoplasms. Common symptoms are chest pain, palpitations, fever and dyspnea. Diagnosis involves EKG, echocardiogram, cardiac enzymes and sometimes pericardiocentesis.
3) Treatment involves NSAIDs, colchicines, or corticosteroids depending on severity. Some
Approach to patient with cardiovascular disease.pptxtesa10
This document provides guidance on evaluating patients with cardiovascular disease. It outlines how to take a thorough history, examine the patient, and identify relevant investigations. Key aspects of history taking include presenting complaint, review of symptoms, past medical history, and family history. The examination involves inspection for signs like cyanosis, palpation of pulses and precordium, and auscultation of heart sounds. Common symptoms like chest pain, dyspnea, palpitations, and edema are described. Relevant investigations include ECG, echocardiogram, chest X-ray, and cardiac enzymes.
Aortic stenosis is a narrowing of the aortic valve that obstructs blood flow from the left ventricle to the aorta. It can be congenital due to conditions like bicuspid aortic valve, or acquired through rheumatic heart disease, atherosclerosis or idiopathic hypertrophic subaortic stenosis. Over time, the obstruction causes the left ventricle to hypertrophy to maintain cardiac output, which can lead to heart failure. Symptoms include chest pain, syncope and dyspnea that worsen with exertion. Examination may reveal murmurs, decreased pulses and elevated blood pressure. Echocardiography can diagnose the severity of stenosis. Treatment involves managing symptoms, avoiding
Pericarditis is an inflammation of the pericardium that commonly affects men aged 20-50. It has several causes including viral or bacterial infections, certain cancers, autoimmune diseases, or physical trauma. Symptoms include chest pain that increases with deep breathing or lying flat. Diagnosis involves electrocardiograms, echocardiograms, and blood tests. Treatment focuses on reducing inflammation with medications like aspirin, ibuprofen, or colchicine. Surgery may be required in severe cases to drain fluid or remove the pericardium.
The document summarizes pericardial diseases. It discusses the anatomy and physiology of the pericardium, acute pericarditis including symptoms, diagnosis and treatment, and pericardial effusion and tamponade. Acute pericarditis is usually self-limited and treated with NSAIDs. Larger effusions may require hospitalization. Pericardial effusion can progress to tamponade, where fluid accumulation compresses the heart and impairs filling.
The document discusses various pericardial diseases including normal anatomy, pericarditis, pericardial effusions, cardiac tamponade, and constrictive pericarditis. Key points include:
- Pericardial effusions can lead to cardiac tamponade by exerting pressure on the heart and restricting filling.
- Cardiac tamponade is diagnosed using echocardiogram, chest x-ray and equalized diastolic pressures on catheterization.
- Constrictive pericarditis involves thickened pericardium constraining all chambers and is diagnosed using characteristic hemodynamic tracings on catheterization.
The document discusses pericarditis, which is inflammation of the pericardium. Acute pericarditis is the most common disorder and presents with sudden onset chest pain that worsens with breathing or coughing. A pericardial friction rub may be heard on examination. ECG findings include ST segment elevations. Treatment involves NSAIDs which typically resolves symptoms in 2 weeks. Complications include cardiac tamponade and constrictive pericarditis from scarring.
This document provides information on cardiovascular history taking and physical examination. It discusses important symptoms of heart disease like dyspnea, palpitations, edema, and chest pain. It also outlines the steps for examining arterial pulses, blood pressure, jugular venous pressure, auscultation of heart sounds, and palpation of the precordium. The physical exam aims to evaluate symptoms, risk factors, and detect any abnormalities that could indicate cardiac issues.
Chest pain can have many potential causes. A thorough history and physical exam are important to help determine the likely diagnosis and guide appropriate testing. Key aspects of the history include characteristics of the pain such as location, radiation, onset and nature. The physical exam focuses on identifying potential causes of the pain or associated symptoms. Initial tests may include an ECG, blood tests, chest x-ray and echocardiogram to help differentiate causes such as heart disease, pulmonary embolism, pneumonia or musculoskeletal issues. Further tests are guided by the initial findings.
The document discusses pericarditis, which is inflammation of the pericardium surrounding the heart. It describes what causes pericarditis, the symptoms, diagnostic tests used to identify it, and treatments that may be given including medications like NSAIDs, colchicine, and corticosteroids or procedures like pericardiocentesis if fluid needs to be drained from around the heart. Pericarditis can range from mild and self-limiting to life-threatening in some cases if not properly diagnosed and treated.
Pericarditis is inflammation of the pericardium, the sac surrounding the heart. It commonly causes sharp chest pain that may spread to the shoulder or neck. Symptoms include cough, fatigue, fever and palpitations. Pericarditis is usually mild and resolves without treatment, but more severe cases may require medications or rarely surgery. Diagnosis involves listening to heart sounds and tests like EKG, echocardiogram and blood tests. Causes can include infection, autoimmune diseases, injury or other health conditions. Complications include fluid buildup around the heart or thickening of the pericardium.
This document provides an overview of chest pain differentials (DDx). It begins by defining chest pain and discussing acute coronary syndrome. It then covers risk factors, symptoms, and physical exam findings for conditions like aortic dissection, acute pericarditis, cardiac tamponade, pulmonary embolism, tension pneumothorax, and esophageal rupture. Investigations, treatments, and management are described for each potential cause. The goal is to educate on evaluating and distinguishing between cardiac and non-cardiac causes of chest pain.
The document discusses various acyanotic heart diseases including atrial septal defect (ASD), ventricular septal defect (VSD), patent ductus arteriosus (PDA), coarctation of aorta, pulmonary stenosis, and aortic stenosis. It provides details on the pathophysiology, clinical features, investigations, and management of each condition. Key points include that ASD is the most common congenital heart disease, VSD has a pansystolic murmur at the lower left sternal edge, PDA causes a continuous murmur and loud P2 with pulmonary hypertension, coarctation causes hypertension and rib notching on CXR, and large defects can lead to pulmonary hypertension and
This document provides an overview of how to perform a cardiovascular examination, including assessing the pulse, blood pressure, jugular venous pressure, auscultation of heart sounds, characterization of murmurs, and examination of peripheral vessels and limbs. It describes the approach to inspection, palpation, percussion, and auscultation of the heart and vessels, as well as common symptoms of heart disease. Classification of murmurs, heart sounds, and jugular venous pressure are also outlined.
Myocarditis is an inflammation of the heart muscle that can reduce the heart's ability to pump and cause arrhythmias. Common symptoms include chest pain and shortness of breath. Pericarditis is inflammation of the sac surrounding the heart and causes sharp chest pain that gets worse when coughing or breathing deeply. Both conditions are often caused by viruses and can be diagnosed through ECG, imaging tests, and cardiac enzyme levels. Treatment involves managing symptoms, treating any infections, and using medications like NSAIDs or colchicine.
This document provides an overview of pericardial disease, including the anatomy and functions of the pericardium. It discusses acute pericarditis and its typical features, treatment with NSAIDs and colchicine, and recurrent pericarditis. Pericardial effusion and cardiac tamponade are explained, including their causes, signs, and echo findings. Constrictive pericarditis is characterized by chronic scarring and fibrosis of the pericardium leading to diastolic dysfunction. Surgical pericardiectomy is the definitive treatment for constrictive pericarditis.
Cardiac tamponade is caused by fluid accumulation in the pericardial space that compresses the heart and impairs its filling. It is characterized hemodynamically by decreased intracardiac volumes and increased diastolic filling pressures. Echocardiography is useful for diagnosing tamponade by showing fluid around the heart and collapse of the ventricles. Initial treatment involves fluid resuscitation while definitive treatment is pericardiocentesis to drain fluid or surgery in refractory cases.
Cardiac tamponade is caused by fluid accumulation in the pericardial space that compresses the heart and impairs its filling. It is characterized hemodynamically by decreased intracardiac volumes and increased diastolic filling pressures. Echocardiography is useful for diagnosing tamponade by showing fluid around the heart and collapse of the ventricles. Initial treatment involves resuscitating the patient with fluids and inotropes, while needle pericardiocentesis is often needed for definitive treatment by draining the pericardial fluid. Constrictive pericarditis involves thickening and scarring of the pericardium that restricts heart filling over time.
This document discusses various pericardial diseases including acute pericarditis, pericardial effusion, cardiac tamponade, chronic constrictive pericarditis, and tuberculous pericardial diseases. Acute pericarditis is often caused by viral infections and presents with chest pain. A pericardial friction rub may be heard. Pericardial effusion can occur with any disease causing pericarditis and may lead to cardiac tamponade, presenting with Beck's triad of hypotension, muffled heart sounds, and jugular venous distention. Chronic constrictive pericarditis results from fibrosis and scarring of the pericardium, limiting
This document presents the case of a 22-year-old male who presented with symptoms of easy fatigability, abdominal discomfort, lower extremity edema, and breathlessness on exertion. Physical examination revealed cachexia, elevated jugular venous pressure, pitting edema, hepatomegaly, and elevated heart rate and respiratory rate. Initial testing suggested right heart failure and differentials included constrictive pericarditis, restrictive cardiomyopathy, and dilated cardiomyopathy. Further testing including echocardiogram, cardiac catheterization, and CT scan established a diagnosis of constrictive pericarditis based on findings of pericardial thickening and equalization of diastolic pressures between the right and left ventricles
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Aortic stenosis is a narrowing of the aortic valve that obstructs blood flow from the left ventricle to the aorta. It can be congenital due to conditions like bicuspid aortic valve, or acquired through rheumatic heart disease, atherosclerosis or idiopathic hypertrophic subaortic stenosis. Over time, the obstruction causes the left ventricle to hypertrophy to maintain cardiac output, which can lead to heart failure. Symptoms include chest pain, syncope and dyspnea that worsen with exertion. Examination may reveal murmurs, decreased pulses and elevated blood pressure. Echocardiography can diagnose the severity of stenosis. Treatment involves managing symptoms, avoiding
Pericarditis is an inflammation of the pericardium that commonly affects men aged 20-50. It has several causes including viral or bacterial infections, certain cancers, autoimmune diseases, or physical trauma. Symptoms include chest pain that increases with deep breathing or lying flat. Diagnosis involves electrocardiograms, echocardiograms, and blood tests. Treatment focuses on reducing inflammation with medications like aspirin, ibuprofen, or colchicine. Surgery may be required in severe cases to drain fluid or remove the pericardium.
The document summarizes pericardial diseases. It discusses the anatomy and physiology of the pericardium, acute pericarditis including symptoms, diagnosis and treatment, and pericardial effusion and tamponade. Acute pericarditis is usually self-limited and treated with NSAIDs. Larger effusions may require hospitalization. Pericardial effusion can progress to tamponade, where fluid accumulation compresses the heart and impairs filling.
The document discusses various pericardial diseases including normal anatomy, pericarditis, pericardial effusions, cardiac tamponade, and constrictive pericarditis. Key points include:
- Pericardial effusions can lead to cardiac tamponade by exerting pressure on the heart and restricting filling.
- Cardiac tamponade is diagnosed using echocardiogram, chest x-ray and equalized diastolic pressures on catheterization.
- Constrictive pericarditis involves thickened pericardium constraining all chambers and is diagnosed using characteristic hemodynamic tracings on catheterization.
The document discusses pericarditis, which is inflammation of the pericardium. Acute pericarditis is the most common disorder and presents with sudden onset chest pain that worsens with breathing or coughing. A pericardial friction rub may be heard on examination. ECG findings include ST segment elevations. Treatment involves NSAIDs which typically resolves symptoms in 2 weeks. Complications include cardiac tamponade and constrictive pericarditis from scarring.
This document provides information on cardiovascular history taking and physical examination. It discusses important symptoms of heart disease like dyspnea, palpitations, edema, and chest pain. It also outlines the steps for examining arterial pulses, blood pressure, jugular venous pressure, auscultation of heart sounds, and palpation of the precordium. The physical exam aims to evaluate symptoms, risk factors, and detect any abnormalities that could indicate cardiac issues.
Chest pain can have many potential causes. A thorough history and physical exam are important to help determine the likely diagnosis and guide appropriate testing. Key aspects of the history include characteristics of the pain such as location, radiation, onset and nature. The physical exam focuses on identifying potential causes of the pain or associated symptoms. Initial tests may include an ECG, blood tests, chest x-ray and echocardiogram to help differentiate causes such as heart disease, pulmonary embolism, pneumonia or musculoskeletal issues. Further tests are guided by the initial findings.
The document discusses pericarditis, which is inflammation of the pericardium surrounding the heart. It describes what causes pericarditis, the symptoms, diagnostic tests used to identify it, and treatments that may be given including medications like NSAIDs, colchicine, and corticosteroids or procedures like pericardiocentesis if fluid needs to be drained from around the heart. Pericarditis can range from mild and self-limiting to life-threatening in some cases if not properly diagnosed and treated.
Pericarditis is inflammation of the pericardium, the sac surrounding the heart. It commonly causes sharp chest pain that may spread to the shoulder or neck. Symptoms include cough, fatigue, fever and palpitations. Pericarditis is usually mild and resolves without treatment, but more severe cases may require medications or rarely surgery. Diagnosis involves listening to heart sounds and tests like EKG, echocardiogram and blood tests. Causes can include infection, autoimmune diseases, injury or other health conditions. Complications include fluid buildup around the heart or thickening of the pericardium.
This document provides an overview of chest pain differentials (DDx). It begins by defining chest pain and discussing acute coronary syndrome. It then covers risk factors, symptoms, and physical exam findings for conditions like aortic dissection, acute pericarditis, cardiac tamponade, pulmonary embolism, tension pneumothorax, and esophageal rupture. Investigations, treatments, and management are described for each potential cause. The goal is to educate on evaluating and distinguishing between cardiac and non-cardiac causes of chest pain.
The document discusses various acyanotic heart diseases including atrial septal defect (ASD), ventricular septal defect (VSD), patent ductus arteriosus (PDA), coarctation of aorta, pulmonary stenosis, and aortic stenosis. It provides details on the pathophysiology, clinical features, investigations, and management of each condition. Key points include that ASD is the most common congenital heart disease, VSD has a pansystolic murmur at the lower left sternal edge, PDA causes a continuous murmur and loud P2 with pulmonary hypertension, coarctation causes hypertension and rib notching on CXR, and large defects can lead to pulmonary hypertension and
This document provides an overview of how to perform a cardiovascular examination, including assessing the pulse, blood pressure, jugular venous pressure, auscultation of heart sounds, characterization of murmurs, and examination of peripheral vessels and limbs. It describes the approach to inspection, palpation, percussion, and auscultation of the heart and vessels, as well as common symptoms of heart disease. Classification of murmurs, heart sounds, and jugular venous pressure are also outlined.
Myocarditis is an inflammation of the heart muscle that can reduce the heart's ability to pump and cause arrhythmias. Common symptoms include chest pain and shortness of breath. Pericarditis is inflammation of the sac surrounding the heart and causes sharp chest pain that gets worse when coughing or breathing deeply. Both conditions are often caused by viruses and can be diagnosed through ECG, imaging tests, and cardiac enzyme levels. Treatment involves managing symptoms, treating any infections, and using medications like NSAIDs or colchicine.
This document provides an overview of pericardial disease, including the anatomy and functions of the pericardium. It discusses acute pericarditis and its typical features, treatment with NSAIDs and colchicine, and recurrent pericarditis. Pericardial effusion and cardiac tamponade are explained, including their causes, signs, and echo findings. Constrictive pericarditis is characterized by chronic scarring and fibrosis of the pericardium leading to diastolic dysfunction. Surgical pericardiectomy is the definitive treatment for constrictive pericarditis.
Cardiac tamponade is caused by fluid accumulation in the pericardial space that compresses the heart and impairs its filling. It is characterized hemodynamically by decreased intracardiac volumes and increased diastolic filling pressures. Echocardiography is useful for diagnosing tamponade by showing fluid around the heart and collapse of the ventricles. Initial treatment involves fluid resuscitation while definitive treatment is pericardiocentesis to drain fluid or surgery in refractory cases.
Cardiac tamponade is caused by fluid accumulation in the pericardial space that compresses the heart and impairs its filling. It is characterized hemodynamically by decreased intracardiac volumes and increased diastolic filling pressures. Echocardiography is useful for diagnosing tamponade by showing fluid around the heart and collapse of the ventricles. Initial treatment involves resuscitating the patient with fluids and inotropes, while needle pericardiocentesis is often needed for definitive treatment by draining the pericardial fluid. Constrictive pericarditis involves thickening and scarring of the pericardium that restricts heart filling over time.
This document discusses various pericardial diseases including acute pericarditis, pericardial effusion, cardiac tamponade, chronic constrictive pericarditis, and tuberculous pericardial diseases. Acute pericarditis is often caused by viral infections and presents with chest pain. A pericardial friction rub may be heard. Pericardial effusion can occur with any disease causing pericarditis and may lead to cardiac tamponade, presenting with Beck's triad of hypotension, muffled heart sounds, and jugular venous distention. Chronic constrictive pericarditis results from fibrosis and scarring of the pericardium, limiting
This document presents the case of a 22-year-old male who presented with symptoms of easy fatigability, abdominal discomfort, lower extremity edema, and breathlessness on exertion. Physical examination revealed cachexia, elevated jugular venous pressure, pitting edema, hepatomegaly, and elevated heart rate and respiratory rate. Initial testing suggested right heart failure and differentials included constrictive pericarditis, restrictive cardiomyopathy, and dilated cardiomyopathy. Further testing including echocardiogram, cardiac catheterization, and CT scan established a diagnosis of constrictive pericarditis based on findings of pericardial thickening and equalization of diastolic pressures between the right and left ventricles
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxwalterHu5
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
2. Definition:
Is inflammation of pericardial layer of
the heart. pericardial layer covers the
heart and protect it from any
infection.
3. A. Viral infection: this is the most important
cause in infection coxachi A virus.
And B commonest one. B3 , B5.
ECHO virus, influenza V. hepatitis V.
B. Bacterial infection – Tubercle bacilli
Staphylo coccus
Strepto coccus
Pneumo coccus
Causes:
I. Infection: is the most important cause:
4. C.Fugal Infection
D.Parasitic Infection
Those causes same as the causes of
myocordotis and so the patient with
acute myocarditis can present with
pericarditis and vice versa that the
disease could start in the myocardium
and spread to the pericardium.
5. II. Hyper sensitively reaction.
• Follow myocardial infarction
dressler syndrome ).post
pericardits 2nd ry to M.I in 3rd
or 4th day of infection.(late
presentation ).
6. Post pericardiotomy syndrome .auto
immune self limiting disease affect pleura
and pericardium .common after cardiac
surgery specially mitral valve “mitral
comissuratomy”
Serum sickness and drug reaction as
(hydralazine)
III. Direct and indirect wound as
stab wound .
7. Iv.Metabolic disorders as uraemia. (most
important). Present with pericaditis
effusion and espically after
introduction of renal dialysis .The
pericardial effusion enhanced after
renal dialysis .
v.Myxedema.
vi.Malignancy like lymphoma.
vii.Aortic dissection + myocardial
infection.
8. viii. Cobalt pear cardiomyopathy. Pear can.
Lead to
ix. Radiation therpay .
Myocarditis
cardiomyopathy
9. Clinical Finding
Depond on the:
- Type of inflammation.
- Sevirety of inflammation.
- Formation of pericardial fluid.
1. Dry pericarditis.
2. Percardial effusion without cardiac temponade.
3. Cardiac temponade.
4. Pericardial constriction.
11. 1/ Dry Pericarditis or Fibronous:
• Chest pain:
It is precardial, sever, radiate to shoulder, so mimic the
acute myocardial infraction pain. But the pain of
pericarditis increase intensity with inspiration or lying
flat and improve when standing or sit down or leaning
forward ( (
الساجد وضع .
• Fever:
Arthralgia rigors, anxiaty and general weakness.
Symptoms:
12. Signs:
Pericardial rub: Is the harsh sound continuous
atrail systole, Ventricular systole and ventricular
diastole. It is superficial sound has no relation to
heart sound. Nearly periodical area. and easy to
heard when the patient hold it’s breathing so
you should differentiate between pleural rub and
pericardial rub. Pleural rub might be heard
during inspiration. Pericardial rub start to
disappear when effusion develops. And
pericardial pain improve.
16. Symptoms:
• disapperance of cheast pain.
1. ECG changes - Flat T wave.
- Low voltage ECG
2/ Precardial effusion without temponade:
17. Signs:
- Blood pressure normal.
- Pulse normal.
- Only heart sound become distant.
- Invisible cardiac pulse.
- Pericardial rub might disappear or
it may remain and this indication
to previous pericarditis so no pain
and no rub.
18. ECG:
Change in T wave not specific for P. effusion.
T wave flat or T wave inverted.
Low voltage.
Low QRS complex.
19. ECHO:
• It is 99% diagnostic to pericardial effusion.
• ECHO: Showed free area between
pericardium and posterior wall of L.
ventricle.
20. • The ECHO not useful in early stage of dry
pericarditis but in late when there is
fibrosis.
21. Differential Diagnosis
3rd heart sound. Normal heart
sound. In the pericardial
effusion there is distant heart
sounds and apical impulse not
visible.
Heart failure:
22. Complication of pericardial effusion:
1. Cardiac temponade
2. Fibrosis:
minimal effusion and this called sero
constrictive or sub acute inflammation.
23. Treatment of pericarditis without effusion:
1. Salicylate NSID in high dose.
2. Bed Rest.
most patient respond to those points. If
patient after 10 day of starting salicylate or
NSIDrugs if still have signs or symptoms of
pericarditis corticosteroids can be added
but role of corticosteroids is doubt if start
from beginning of the disease.
24. Treatment of pericardial effusion:
1. Pericardio- synthesis:
This is diagnostic and therapeutic.
2. Thoracotomy:
( an open drainage).
25. 3/ Cardiac Temponade:
• In Temponade the amount of fluid inside pericardial sac
is increased. When intra pericardial pressure equal to the
diastolic pressure in the heart. ( the right vertical or right
atrial pressure) then temponade develops.
• The right side of the heart has less diastolic pressure
than left side of the heart and for that reason the cardiac
temponade compress right side of the heart because the
pressure reach to diastolic pressure of right ventricle or
right atrium before reach to left ventricle and so all
patients present with right side heart failure heart
problem.
27. - Increase venous pressure :
- Cardiac impulse:
Are not palpable.
- Heart sound:
Are distant and this is same as P. effusion.
Signs:
(Kussmaul’s sign). called inspiratory filling of
superior vena cava.
29. ECHO:
Is most helpful diagnotic method for
cardiac tamponade.
Fluid inside between pericardium and
posterior wall of ventride.
30. Invasive Method:
Abscent.Y Descend:
C.Tamponede the diastolic pressure in the
pericardial sac equal to diastolic pressure in Rt
ventricle and so there is interference with the
filling of Rt ventricle and so absent of Y descent.
For that reason it is an acute emergency we
would remove fluid to give chance to Rt ventricle
to dilate.
31. Differentia Dignosis
• From severly P. Emblism or acute
myocardial infraction or any acute
emergency state.
• Type of pain is similar
But pain of pericardial when lying flat.
34. 4. Constrictive Pericardits
There is sero constrictive and
constrictive pericarditis. The difference
between them, that the sero contrictive
affect Rt pericardium + minimal fluid in
pericardiuml so we called it sero
constrictive or sub acute type.
In constrictive pericarditits, whole
pericardium is thickened and fibrosis so
make thick fibrous layer around heart.
35. Symptoms:
Is swelling of abdomen and lower
limb as it mimic presentation as
acute Rt heart failure.
36. • Dyspnea is minmal in constrictive
pericarditis is not presenting symptom but
it can occur.
• Anaroxia.
• General weakness + wasting.
• In constrictive pericarditis, the history of
previous attack of pericarditis is important.
37. Signs:
- Low blood pressure.
- Pulsus paradoxus:
Is present in constrictive pericarditis and
cardiac tamponade and abscent in
pericardial effusion without tamponade
and in dry pericarditis.
- (it is change in sytolic blood pressure
more than 10 mm of Hg during insiration).
38. - Arrythmia:
(Atrail Fibrillation) in 30% in constrictive
pericarditis ( one of causes of artail
fibrillation is constrictive pericarditis) high
jaqular venous pressure.
- No deep Y wave descent :
This opposite to constrictive pericarditis
when there is Y wave (deep descent).
40. • But in constrictive dilated Rt ventricle at
early diastolic rapidy and there is Y rapid
descent until the pressure inside Rt
ventricle equal to whole distolic pressure
in the pericardium so there is squair root
phenomena.
• Percardial knock:
• Ascitis: