Todd Nienkerk and Aaron Stanush presented on creating Drupal themes that are optimized for Drupal. They recommend brainstorming the purpose and content of the site before starting design work. Key aspects to define include goals, content types, site maps, and wireframes. Themes should be built using template files and CSS to style common Drupal components like nodes, blocks, menus and regions. Using techniques like template suggestions, subthemes, and grid frameworks can accelerate the design and development process.