This document provides a summary of William J. Frazee's professional background and qualifications, including:
- Patents on ion channel modulators and blockers that Frazee co-authored.
- Publications in peer-reviewed journals on topics like drug screening assays and kinase inhibitors.
- Conference posters and presentations given by Frazee and collaborators on developing fluorescence-based screening assays.
- Contact information for William J. Frazee including address, phone numbers, and email.
This document provides a biography and curriculum vitae for Gabriel Fenteany. It summarizes his educational background, including a Ph.D. from Harvard University. It also outlines his professional experience, including his current role as a research scientist at NYC Health + Hospitals. Finally, it lists his publications, research funding, awards and other professional accomplishments.
This document lists publications and poster abstracts by Renna Stevens related to the effects of various drugs on neurotransmitter receptors in the brain. It includes 10 journal publications from 2001 to 2007 investigating how corticosterone, inhaled anesthetics, and alcohols modulate GABA and serotonin receptors. It also lists 5 poster abstracts presented between 2003 and 2005 examining how isoflurane and volatile anesthetics influence GABA and serotonin receptor currents and open probability.
Avanti Gokhale is an Assistant Professor at Emory University specializing in defining disease pathways and biomarkers. She has extensive experience researching schizophrenia and other complex diseases using systems biology and human samples. Her work has been published in peer-reviewed journals and presented nationally and internationally.
This document is a curriculum vitae for Gabriel Fenteany, Ph.D. It outlines his education, professional experience, awards, research funding, publications, and contact information. He received his Ph.D. from Harvard University and is currently a Research Scientist at NYC Health + Hospitals. His research focuses on developing small molecule inhibitors of cell migration and actin dynamics. He has over 30 peer-reviewed publications and has received grants from the National Institutes of Health and American Cancer Society to support his work.
This document provides a biography and resume for Gabriel Fenteany. It details his education, professional experience, awards, research funding, publications, and contact information. He currently works as a research scientist and advisor at NYC Health + Hospitals. His background includes positions as an associate professor and roles in research centers focused on structural biology, high throughput screening, and cancer research.
This patent document describes the isolation and characterization of a novel human coronavirus (SARS-CoV) that is the causative agent of severe acute respiratory syndrome (SARS). It provides the nucleic acid sequence of the SARS-CoV genome and the amino acid sequences of its open reading frames. Methods are described for using these molecules to detect SARS-CoV and detect infections. Immune stimulatory compositions are also provided, along with methods for their use.
The need for a phylogeny driven genomic encyclopedia of eukaryotes #SMBEEuksJonathan Eisen
This document discusses the need for a phylogeny-driven genomic encyclopedia of eukaryotes. It notes that current sources of information on sequenced eukaryotic genomes, such as Wikipedia and GOLD, are disorganized and lack phylogenetic context. The document then analyzes genomic data from the poorly studied protist Collodictyon using 18S and 28S ribosomal DNA sequencing and phylogenomic trees inferred from 124 genes. The analysis finds that Collodictyon is closely related to Diphylleia and occupies a very early divergence in the eukaryote tree of life, either alone or as the sister group to Malawimonas. This suggests Collodictyon represents an important new lineage for
This document provides a biography and curriculum vitae for Gabriel Fenteany. It summarizes his educational background, including a Ph.D. from Harvard University. It also outlines his professional experience, including his current role as a research scientist at NYC Health + Hospitals. Finally, it lists his publications, research funding, awards and other professional accomplishments.
This document lists publications and poster abstracts by Renna Stevens related to the effects of various drugs on neurotransmitter receptors in the brain. It includes 10 journal publications from 2001 to 2007 investigating how corticosterone, inhaled anesthetics, and alcohols modulate GABA and serotonin receptors. It also lists 5 poster abstracts presented between 2003 and 2005 examining how isoflurane and volatile anesthetics influence GABA and serotonin receptor currents and open probability.
Avanti Gokhale is an Assistant Professor at Emory University specializing in defining disease pathways and biomarkers. She has extensive experience researching schizophrenia and other complex diseases using systems biology and human samples. Her work has been published in peer-reviewed journals and presented nationally and internationally.
This document is a curriculum vitae for Gabriel Fenteany, Ph.D. It outlines his education, professional experience, awards, research funding, publications, and contact information. He received his Ph.D. from Harvard University and is currently a Research Scientist at NYC Health + Hospitals. His research focuses on developing small molecule inhibitors of cell migration and actin dynamics. He has over 30 peer-reviewed publications and has received grants from the National Institutes of Health and American Cancer Society to support his work.
This document provides a biography and resume for Gabriel Fenteany. It details his education, professional experience, awards, research funding, publications, and contact information. He currently works as a research scientist and advisor at NYC Health + Hospitals. His background includes positions as an associate professor and roles in research centers focused on structural biology, high throughput screening, and cancer research.
This patent document describes the isolation and characterization of a novel human coronavirus (SARS-CoV) that is the causative agent of severe acute respiratory syndrome (SARS). It provides the nucleic acid sequence of the SARS-CoV genome and the amino acid sequences of its open reading frames. Methods are described for using these molecules to detect SARS-CoV and detect infections. Immune stimulatory compositions are also provided, along with methods for their use.
The need for a phylogeny driven genomic encyclopedia of eukaryotes #SMBEEuksJonathan Eisen
This document discusses the need for a phylogeny-driven genomic encyclopedia of eukaryotes. It notes that current sources of information on sequenced eukaryotic genomes, such as Wikipedia and GOLD, are disorganized and lack phylogenetic context. The document then analyzes genomic data from the poorly studied protist Collodictyon using 18S and 28S ribosomal DNA sequencing and phylogenomic trees inferred from 124 genes. The analysis finds that Collodictyon is closely related to Diphylleia and occupies a very early divergence in the eukaryote tree of life, either alone or as the sister group to Malawimonas. This suggests Collodictyon represents an important new lineage for
James J. Campbell has had an extensive career in immunology research. He is currently a Senior Director at ChemoCentryx, where he leads pre-clinical research teams investigating drug mechanisms of action. Previously, he was a Principal Investigator and Professor at Harvard Medical School, where he managed an immunology lab and published over 60 peer-reviewed papers. He has received many awards and honors for his research and expertise in T cell biology, chemokines, and skin and intestinal immunity.
Evolution of microbiomes and the evolution of the study and politics of micro...Jonathan Eisen
The document discusses the evolution of microbiomes and the study of microbiomes. It notes that microbiomes can be both overhyped yet underappreciated. It provides background on the rise of interest in microbiomes since the 2000s due to technological advances enabling their study as well as appreciation of their important functions. The author then discusses their own research focusing on using phylogenomic methods to study microbial communities and symbioses, especially how microbes and microbiomes help hosts adapt to stress. Examples discussed include chemosymbioses, pathogen resistance, environmental changes, and more.
Jonathan Eisen talk for 2019 ADVANCE Scholar Award SymposiumJonathan Eisen
Slides for my talk at the 2019 ADVANCE Scholar Award Symposium. Talk covered a little bit about mt research and more about STEM Diversity. See https://diversity.ucdavis.edu/2019-advance-scholar-award-symposium
Rory Eutsey has over 10 years of experience as a laboratory manager and senior microbiologist researching pathogens like Streptococcus pneumoniae and Haemophilus influenzae, with expertise in genomics, molecular biology techniques, and biofilm analysis; he has supervised many students and published numerous papers characterizing bacterial strains, virulence factors, and developing anti-biofilm strategies. Eutsey received his Master's and Bachelor's degrees in microbiology from the University of Georgia and Shippensburg University of Pennsylvania, respectively.
National FORUM of Educational Administration and Supervision Journal - Nation...William Kritsonis
National FORUM of Educational Administration and Supervision Journal - National Alumni Honor Roll of Published Writers - Editor, William Allan Kritsonis, PhD, NATIONAL FORUM JOURNALS, Houston, Texas - www.nationalforum.com
Despite greatly improved understanding of endothelial heterogeneity, the number of molecules discriminating human arterial and venous endothelium remains limited. Indeed, there have been few reports validating markers proposed in animal model studies in freshly isolated human tissues. We report here the global characterization of freshly isolated human umbilical arterial and venous endothelial cell (HUAECs and HUVECs) plasma membrane proteins using an experimentally validated label-free quantitative LC-MS/MS platform.
Jennifer M. Sealy has authored or co-authored several publications including papers in peer-reviewed journals and patents. Some of her notable publications include papers in Bioorganic & Medicinal Chemistry Letters on the design and synthesis of brain penetrant JNK inhibitors for neurodegeneration prevention, and on the design of hydroxyethylamine BACE-1 inhibitors for Alzheimer's disease. She is also listed as an inventor on several patents related to the preparation of inhibitors for conditions like Alzheimer's.
This curriculum vitae summarizes the qualifications and experience of Ximiao He. He received his Ph.D. in Genomics from the Beijing Institute of Genomics in China, where he conducted research on genome databases and the analysis of human CpG islands and DNA methylation in cancer. He is currently a postdoctoral research fellow at the National Cancer Institute studying the effects of nucleosome occupancy and methylation on gene regulation. His research interests include DNA methylation, alternative splicing, and computational genomics tools. He has over 20 publications in peer-reviewed journals and has presented his research at several conferences.
Sandra B. Boles is an expert in the systematics, phylogenetics, and evolution of Sphagnum mosses. She has authored or co-authored over 20 publications on this topic, using molecular techniques like microsatellites to resolve relationships between species and investigate polyploid origins. Her work has helped delineate species boundaries and relationships within sections of Sphagnum.
This curriculum vitae summarizes the career of Ethan Royal Signer, PhD. He has had a long career as a consultant for non-profit foundations focused on neurodegenerative diseases from 2016-2018. Prior to that, he was a senior scientific advisor for similar foundations from 2006-2016 and founding managing director from 2001-2006. Academically, he was a professor of biology emeritus at MIT from 1997 until retiring. He has authored over 50 publications in peer-reviewed journals focused on genetics and genetic engineering in plants, bacteria, and viruses.
GWAS analysis of QTL for resistance against Edwardsiella ictaluri in F2 inter...Golden Helix
This document summarizes a genome-wide association study (GWAS) conducted by Suxu Tan at Auburn University to identify genetic variants associated with resistance to enteric septicemia of catfish (ESC) using an interspecific backcross catfish population. The study utilized catfish genomic resources including a 690K SNP array to genotype phenotypic extremes for ESC resistance. Statistical analyses using EMMAX and QFAM identified significant quantitative trait loci (QTL) associated with resistance on linkage groups 1 and 23. Examination of associated SNPs found superior alleles from blue catfish conferring strong resistance. Candidate genes in the identified QTL were found to be involved in phagocytosis and T-cell activation pathways.
Pamela L. Gordon is a scientist with an active Top Secret clearance from the Department of Defense. She has published numerous refereed journal articles and book chapters on topics related to actinide chemistry, including studies of neptunium, plutonium, and uranium speciation under various conditions. Gordon also has other publications, presentations, and reports on emerging chemical threats and nanotechnology.
This document lists publications, abstracts, and a patent by Arthur D.B. and others from 1998-2007 related to neuronal differentiation and P2 receptor expression and function. It includes 10 journal articles, 7 abstracts from conferences, and 1 pending patent application from 2007. The publications investigate the roles of nucleotides, P2Y receptors, and nerve growth factor in neuronal differentiation, survival, and catecholamine release using cell models like PC12 cells.
Genetic variation and evolution and their importance to medicineDavid Enoma
Genetic variation is the driving force of evolution and is important in medicine. Single nucleotide polymorphisms are the most common genetic variation and can influence disease risk and drug responses between individuals and populations. Understanding genetic variation through studies of populations and single genes can provide insights into human evolutionary history, disease susceptibility, and treatment effectiveness.
STUDY OF THE PHYSIOLOGICAL AND GENETIC DIFFERENCES BETWEEN THE WHITE COLLARE...Maria Drahulian
Study of the physiological and genetic differences between the White collared flycatcher and Pied flycatcher of the genus Ficedula / M.V Drahulian, A.B Chaplygina, S.O. Kostenko, N.O.Savynska, P.P. Ostrovskyi, K.Yu.Gusar, Yu.V Grishenko // Conference: FEBS3+ Meeting - XI Parnas Conference - young scientistits forum "Biochemistry and Molecular Biology for Innovative Medicine" 3-5 September, 2018, Kyiv Ukraine. Ukr. Biochem. J., 2018. Vol. 90, Special Issue. P. 130. DOI: 10.13140/RG.2.2.29972.14723/1
Mohamed Ahmed Abdul-Azeem is a Mechanical Power Engineer from Egypt seeking new opportunities. He has over 8 years of experience in mechanical projects, manufacturing, and maintenance. Currently he works as a Project Engineer at ESH EL MALAHA PETROLUM COMPANY, where he is responsible for planning, estimating, coordinating, and supervising various projects related to power generation, pipelines, pumps, and more. He has strong skills in project management, engineering, maintenance, and operations.
This document provides an overview and configuration guide for the CCMS Alert Monitor. It describes the key components of the monitoring architecture including data collection methods, monitoring objects/attributes, and data consumers. The alert monitor collects data from various sources, analyzes it according to configured rules, and triggers alerts/notifications when thresholds are exceeded. The document provides instructions for setting up monitor sets, transporting configurations, configuring rule nodes, notification methods, and step-by-step configuration of the alert monitoring system.
Gunderao Patil is a software test engineer with over 2 years of experience in automated testing using TestNG, Selenium WebDriver, and Maven. He has expertise in functional, integration, regression, and compatibility testing. Some of his projects include testing the Video Rocket video conferencing product and the E-Karmika online shop registration application. He is proficient in core Java, bug tracking with Jira, and communicating with development teams.
This short document promotes the creation of presentations using Haiku Deck on SlideShare. It includes photos from Riebart and Nic's events to inspire the reader. The reader is encouraged to get started making their own Haiku Deck presentation by uploading it to SlideShare.
James J. Campbell has had an extensive career in immunology research. He is currently a Senior Director at ChemoCentryx, where he leads pre-clinical research teams investigating drug mechanisms of action. Previously, he was a Principal Investigator and Professor at Harvard Medical School, where he managed an immunology lab and published over 60 peer-reviewed papers. He has received many awards and honors for his research and expertise in T cell biology, chemokines, and skin and intestinal immunity.
Evolution of microbiomes and the evolution of the study and politics of micro...Jonathan Eisen
The document discusses the evolution of microbiomes and the study of microbiomes. It notes that microbiomes can be both overhyped yet underappreciated. It provides background on the rise of interest in microbiomes since the 2000s due to technological advances enabling their study as well as appreciation of their important functions. The author then discusses their own research focusing on using phylogenomic methods to study microbial communities and symbioses, especially how microbes and microbiomes help hosts adapt to stress. Examples discussed include chemosymbioses, pathogen resistance, environmental changes, and more.
Jonathan Eisen talk for 2019 ADVANCE Scholar Award SymposiumJonathan Eisen
Slides for my talk at the 2019 ADVANCE Scholar Award Symposium. Talk covered a little bit about mt research and more about STEM Diversity. See https://diversity.ucdavis.edu/2019-advance-scholar-award-symposium
Rory Eutsey has over 10 years of experience as a laboratory manager and senior microbiologist researching pathogens like Streptococcus pneumoniae and Haemophilus influenzae, with expertise in genomics, molecular biology techniques, and biofilm analysis; he has supervised many students and published numerous papers characterizing bacterial strains, virulence factors, and developing anti-biofilm strategies. Eutsey received his Master's and Bachelor's degrees in microbiology from the University of Georgia and Shippensburg University of Pennsylvania, respectively.
National FORUM of Educational Administration and Supervision Journal - Nation...William Kritsonis
National FORUM of Educational Administration and Supervision Journal - National Alumni Honor Roll of Published Writers - Editor, William Allan Kritsonis, PhD, NATIONAL FORUM JOURNALS, Houston, Texas - www.nationalforum.com
Despite greatly improved understanding of endothelial heterogeneity, the number of molecules discriminating human arterial and venous endothelium remains limited. Indeed, there have been few reports validating markers proposed in animal model studies in freshly isolated human tissues. We report here the global characterization of freshly isolated human umbilical arterial and venous endothelial cell (HUAECs and HUVECs) plasma membrane proteins using an experimentally validated label-free quantitative LC-MS/MS platform.
Jennifer M. Sealy has authored or co-authored several publications including papers in peer-reviewed journals and patents. Some of her notable publications include papers in Bioorganic & Medicinal Chemistry Letters on the design and synthesis of brain penetrant JNK inhibitors for neurodegeneration prevention, and on the design of hydroxyethylamine BACE-1 inhibitors for Alzheimer's disease. She is also listed as an inventor on several patents related to the preparation of inhibitors for conditions like Alzheimer's.
This curriculum vitae summarizes the qualifications and experience of Ximiao He. He received his Ph.D. in Genomics from the Beijing Institute of Genomics in China, where he conducted research on genome databases and the analysis of human CpG islands and DNA methylation in cancer. He is currently a postdoctoral research fellow at the National Cancer Institute studying the effects of nucleosome occupancy and methylation on gene regulation. His research interests include DNA methylation, alternative splicing, and computational genomics tools. He has over 20 publications in peer-reviewed journals and has presented his research at several conferences.
Sandra B. Boles is an expert in the systematics, phylogenetics, and evolution of Sphagnum mosses. She has authored or co-authored over 20 publications on this topic, using molecular techniques like microsatellites to resolve relationships between species and investigate polyploid origins. Her work has helped delineate species boundaries and relationships within sections of Sphagnum.
This curriculum vitae summarizes the career of Ethan Royal Signer, PhD. He has had a long career as a consultant for non-profit foundations focused on neurodegenerative diseases from 2016-2018. Prior to that, he was a senior scientific advisor for similar foundations from 2006-2016 and founding managing director from 2001-2006. Academically, he was a professor of biology emeritus at MIT from 1997 until retiring. He has authored over 50 publications in peer-reviewed journals focused on genetics and genetic engineering in plants, bacteria, and viruses.
GWAS analysis of QTL for resistance against Edwardsiella ictaluri in F2 inter...Golden Helix
This document summarizes a genome-wide association study (GWAS) conducted by Suxu Tan at Auburn University to identify genetic variants associated with resistance to enteric septicemia of catfish (ESC) using an interspecific backcross catfish population. The study utilized catfish genomic resources including a 690K SNP array to genotype phenotypic extremes for ESC resistance. Statistical analyses using EMMAX and QFAM identified significant quantitative trait loci (QTL) associated with resistance on linkage groups 1 and 23. Examination of associated SNPs found superior alleles from blue catfish conferring strong resistance. Candidate genes in the identified QTL were found to be involved in phagocytosis and T-cell activation pathways.
Pamela L. Gordon is a scientist with an active Top Secret clearance from the Department of Defense. She has published numerous refereed journal articles and book chapters on topics related to actinide chemistry, including studies of neptunium, plutonium, and uranium speciation under various conditions. Gordon also has other publications, presentations, and reports on emerging chemical threats and nanotechnology.
This document lists publications, abstracts, and a patent by Arthur D.B. and others from 1998-2007 related to neuronal differentiation and P2 receptor expression and function. It includes 10 journal articles, 7 abstracts from conferences, and 1 pending patent application from 2007. The publications investigate the roles of nucleotides, P2Y receptors, and nerve growth factor in neuronal differentiation, survival, and catecholamine release using cell models like PC12 cells.
Genetic variation and evolution and their importance to medicineDavid Enoma
Genetic variation is the driving force of evolution and is important in medicine. Single nucleotide polymorphisms are the most common genetic variation and can influence disease risk and drug responses between individuals and populations. Understanding genetic variation through studies of populations and single genes can provide insights into human evolutionary history, disease susceptibility, and treatment effectiveness.
STUDY OF THE PHYSIOLOGICAL AND GENETIC DIFFERENCES BETWEEN THE WHITE COLLARE...Maria Drahulian
Study of the physiological and genetic differences between the White collared flycatcher and Pied flycatcher of the genus Ficedula / M.V Drahulian, A.B Chaplygina, S.O. Kostenko, N.O.Savynska, P.P. Ostrovskyi, K.Yu.Gusar, Yu.V Grishenko // Conference: FEBS3+ Meeting - XI Parnas Conference - young scientistits forum "Biochemistry and Molecular Biology for Innovative Medicine" 3-5 September, 2018, Kyiv Ukraine. Ukr. Biochem. J., 2018. Vol. 90, Special Issue. P. 130. DOI: 10.13140/RG.2.2.29972.14723/1
Mohamed Ahmed Abdul-Azeem is a Mechanical Power Engineer from Egypt seeking new opportunities. He has over 8 years of experience in mechanical projects, manufacturing, and maintenance. Currently he works as a Project Engineer at ESH EL MALAHA PETROLUM COMPANY, where he is responsible for planning, estimating, coordinating, and supervising various projects related to power generation, pipelines, pumps, and more. He has strong skills in project management, engineering, maintenance, and operations.
This document provides an overview and configuration guide for the CCMS Alert Monitor. It describes the key components of the monitoring architecture including data collection methods, monitoring objects/attributes, and data consumers. The alert monitor collects data from various sources, analyzes it according to configured rules, and triggers alerts/notifications when thresholds are exceeded. The document provides instructions for setting up monitor sets, transporting configurations, configuring rule nodes, notification methods, and step-by-step configuration of the alert monitoring system.
Gunderao Patil is a software test engineer with over 2 years of experience in automated testing using TestNG, Selenium WebDriver, and Maven. He has expertise in functional, integration, regression, and compatibility testing. Some of his projects include testing the Video Rocket video conferencing product and the E-Karmika online shop registration application. He is proficient in core Java, bug tracking with Jira, and communicating with development teams.
This short document promotes the creation of presentations using Haiku Deck on SlideShare. It includes photos from Riebart and Nic's events to inspire the reader. The reader is encouraged to get started making their own Haiku Deck presentation by uploading it to SlideShare.
This short document promotes the creation of presentations using Haiku Deck on SlideShare. It features a stock photo and text prompting the reader to get started making their own Haiku Deck presentation. In just a few words, it pitches the idea of using Haiku Deck on SlideShare to easily create engaging presentations.
This document contains the resume of Somam Metha, including contact information, 9 years of experience in office administration and secretarial work in Dubai and India, education including a bachelor's degree in tourism and hotel management diploma, and positions held including secretary to managing director, admin/secretary executive, sales executive, and step trainee. Key skills listed are communication, time management, executive support, document management, presentation skills, and client engagement.
Blend with care - Activerende blends met videos Wiebe Dijkstra
Dit is de presentatie voor de workshop "Activerende Blends met Videos". Deze workshop is gegeven tijdens het E-merge event Blend with care (27 september 2016).
This document contains Grace Walker's resume. It includes her contact information, objective, qualifications, employment history from 2014 to 2010 in roles such as sales associate and tutor, education history graduating high school in 2013 and currently studying at York University, and references. Her experience includes customer service, cash handling, stock organization, and volunteer work in childcare and feeding the homeless. She aims to maintain a positive attitude and meet expectations in an organized professional manner.
Blend with Care - Learning from games: serious??Wiebe Dijkstra
Dit is de presentatie van de keynote "Learning from games: serious??". Deze keynote is gegeven door Dr. Mary Dankbaar tijdens het E-merge event Blend with care (27 september 2016).
Dit is de presentatie van de workshop "Virtual Patients". Deze workshop is gegeven door Evelien de Schepper tijdens het E-merge event Blend with care (27 september 2016).
This document discusses the role of emotional intelligence. It begins by outlining the objectives to discuss the importance of emotional intelligence and its role in business. The theoretical part defines emotional intelligence and the practical part discusses interviews conducted and a questionnaire used to study the process. It concludes that emotional intelligence is essential for business and that problems were encountered in completing the project.
Este documento presenta un juego dirigido a estudiantes adultos para que puedan elaborar una dieta saludable para una persona, seleccionando las tarjetas adecuadas de alimentos y raciones para cada comida del día. El objetivo es que aprendan a diseñar dietas equilibradas basadas en las recomendaciones de consumo de los diferentes grupos de alimentos. Los estudiantes trabajarán en grupos y revisarán las dietas diseñadas por los demás.
This document describes research on developing a solution phase combinatorial chemistry approach to generate novel polyazapyridinophane libraries with antimicrobial activity. Key points:
- Researchers developed a method to chemically modify pre-formed asymmetric scaffolds by simultaneously adding functional groups in solution, avoiding solid phase bead-splitting methods.
- They synthesized novel polyazapyridinophane scaffolds and generated 16 libraries totaling 1600 compounds by simultaneously adding 10 benzylic bromide groups to the scaffolds in solution.
- Screening of sublibraries found several with potent antimicrobial activity. Twenty single compounds were also synthesized and some had more or less activity than the parent mixtures.
This document provides a bibliography of journal publications and abstracts authored by Gregory S. Hamilton, Ph.D. It lists 34 journal publications from 1986 to 2006 on topics including organic synthesis, glutamate receptor antagonists, neurotrophic agents, and immunophilin ligands. It also lists 7 conference abstracts from 1988 to 1995 on related topics.
Jeffrey J. Whyte is a researcher who has published extensively on topics related to swine genetics, cloning, and using pig models for human diseases. Some of his publications include studies looking at using zinc finger nucleases and CRISPR to genetically modify pigs, producing cloned knockout pig models, and investigating cytokines and placental development in pigs. He has also researched using pig models to study cardiovascular conditions in humans.
The Type 6 Secretion System (T6SS) is a syringe-like structure found in over 25% of Gram-negative bacteria that is used to deliver harmful effector proteins into both competing bacteria and eukaryotic cells during infections. It shows structural and functional similarities to the bacteriophage T4 tail and is believed to have evolved from bacteriophages. The T6SS uses a contractile mechanism to eject effectors from the tip of a tube composed of Hcp proteins in a manner analogous to phage injection. Effectors are used for defense against other bacteria or for pathogenesis, while immunity proteins protect the host bacteria from its own effectors. A better understanding of T6SS could provide new treatments for
The document summarizes the formal synthesis of (−)-clavosolide A, a natural product with a highly functionalized 16-membered macrocyclic structure containing 14 stereocenters. The synthesis involved initial retrosynthetic analyses, exploration of various reaction strategies reported in literature for constructing key structural motifs, and development of a revised retrosynthetic route involving D-malic acid as the starting material. Key steps included preparation of an auxiliary, aldehyde synthesis, lactone formation, and generation of the C9 diastereomeric monomer.
Edward B. Siwak's curriculum vitae provides information about his education and professional experience. He received a Bachelor of Science in Biology from Indiana University of Pennsylvania in 1972, a Master of Science in Epidemiology from the University of Hawaii at Manoa in 1982, and a Doctor of Philosophy in Microbiology from the University of Hawaii at Manoa in 1990. Since 2002, he has worked as an Assistant Professor in the Division of Molecular Virology and Microbiology at Baylor College of Medicine in Houston, Texas.
This document summarizes a PhD thesis on sequencing the hexaploid genome of wheat. The thesis involved developing a new method for sequencing wheat's group 7 chromosomes using second-generation sequencing technology. Key contributions included sequencing and assembling low-copy and genic regions of isolated chromosome arm 7DS, sequencing chromosome arm 7BS to delimit a translocation and reveal gene conservation, developing an integrated wheat genome database and portal, and outlining applications of next-generation sequencing for wheat crop improvement. The thesis represents a significant step toward fully sequencing the large and complex wheat genome.
This document is a curriculum vitae for Dr. Avi L. Friedlich summarizing his personal and educational background, academic positions held, research support and medical certification, professional memberships, honors and awards, publications, and editorial experience. It details that he received a B.S. from UCLA and an M.D. from Case Western Reserve University, held various academic and research positions at institutions including Harvard Medical School and MIT, has over 50 publications in peer-reviewed journals, and has received several honors and awards for his research work.
This document lists the presentations, publications, and other work of E. Meierhenry. It includes over 30 publications, many in peer-reviewed journals, on topics related to toxicology pathology in animals. The publications span from the 1970s to planned 2018 publication and cover a wide range of topics including neurotoxicity, carcinogenicity, hepatic pathology, and more.
This document is a CV for Gabriel Fenteany, a research scientist and grants advisor at NYC Health + Hospitals. It outlines his educational background, including a Ph.D. from Harvard University. It details his professional experience holding faculty and research positions at several universities. It also lists his publications, research funding and awards, including grants from the National Institutes of Health and the American Cancer Society.
Sarah Fox-Greer is seeking an industrial scientist position where she can apply her strong expertise in pharmacology, inflammation biology, and immunology gained over a decade of lab experience. She has a Ph.D. in cation exchanged zeolites as storage materials for nitric oxide and their therapeutic potential, and has extensive experience isolating and culturing various cells, performing assays and techniques such as flow cytometry and confocal imaging. Her research has focused on investigating pathways involved in apoptotic cell clearance and the progression of inflammation, and the potential of CDK inhibitor drugs as anti-inflammatory therapeutics. She has mentored students and published multiple papers in peer-reviewed journals.
This document outlines the objectives of a SciFinder exercise which are to:
- Explore the chemical literature database SciFinder and learn how to use it
- Learn how to create citations using ACS style
- Explore chemical naming conventions and reaction sequences
- Learn about the research interests and productivity of Brock organic chemists
It includes 19 references as examples of papers that could be explored using SciFinder.
This document discusses fluorescent microscopy studies of meadow plants and aquatic grass. It includes:
1) A study examining the expression of green fluorescent protein (GFP) in nitrogen-fixing bacteria in the cells of various plants at different growth phases. GFP fluorescence allowed observation of bacterial activity.
2) Mention of researchers involved in developing new varieties of fluorescent lawn seeds using biotechnology methods.
3) Details on the integration of a nifh-GFP fusion plasmid into the chromosome of a nitrogen-fixing bacteria strain to monitor nitrogen fixation activity.
This document summarizes a study that used anionic photoelectron spectroscopy to investigate the electronic structures of six [MoOS4]- complexes. The study revealed new information about how the energy separations between the highest occupied molecular orbitals depend on ligand types and dihedral angles. It also showed that the threshold photoelectron feature observed in all six complexes is due to detaching an unpaired electron that is mainly of Mo 4d character, consistent with previous theoretical calculations. The results provide insights into the electronic structures and chemical bonding of these molybdenum-containing complexes.
This document lists Jacob M. Kowalewski's publications, including 12 peer-reviewed articles, 5 selected peer-reviewed conference contributions, and 3 theses. The peer-reviewed articles cover a range of topics including cell migration, cellular responses to heterogeneity, inertial focusing in curved channels, astrocyte and neuronal receptor dynamics, natural killer cell migration, integrin-mediated cell attachment, mechanical properties of primary cilia, quantum dot recombination, erythropoietin modulation of astrocytes, microfluidic devices for flow studies, intracellular calcium oscillations, and allosteric changes of the NMDA receptor.
This document lists publications and abstracts by David C. Fritzinger Ph.D. relating to research on cobra venom factor (CVF) and its role in activating the complement system. It includes 23 peer-reviewed publications from 1994-2015 describing molecular cloning and structure-function analysis of CVF and development of humanized CVF proteins for therapeutic complement depletion. It also lists 25 conference abstracts from 2009-2016 presenting research on using humanized CVF to deplete complement in preclinical disease models and potential therapies.
This document provides a list of publications and patents by Christopher J. Aquino related to drug discovery across several therapeutic areas, including diabetes/obesity, cancer, HIV, and obesity. The list includes over 50 publications describing Aquino's work discovering and developing inhibitors of the ileal bile acid transporter, fatty acid synthase, CCR5 chemokine receptor, and reverse transcriptase for various indications. Additional publications cover Aquino's research on neuropeptide YY5 antagonists for obesity and cholecystokinin receptor agonists/antagonists for obesity and cancer.
This document discusses the development of a tandem reaction involving carbanion-induced ring-opening of a three-membered ring followed by a [3+2] annulation. Specifically, it involves the [3+2] annulation of tosylmethylcyclopropane mediated by carbanions, where intermediates of the reaction were isolated. The document references several other papers on related topics like donor-acceptor cyclopropanes, Lewis acid-catalyzed cyclopropane/aldehyde cycloadditions, and oxyanion-induced ring opening of cyclopropanes.
This document provides a biography and curriculum vitae for Gabriel Fenteany, Ph.D. It outlines his education, professional experience, research grants, publications, and contact information. Specifically, it details that he received his Ph.D. from Harvard University in 1997 and currently works as a Research Scientist at NYC Health + Hospitals. He has over 20 years of experience in biochemistry research and has received grants from the National Institutes of Health and the American Cancer Society to support his work studying cell migration and identifying new anti-cancer agents.
Self-replicating Molecules: An introductionBrian Frezza
The document discusses various methods of chemical self-replication, including ligation-based systems using hexadeoxynucleotides, RNA ligase, and peptides that have demonstrated exponential or near-exponential amplification. It also describes cleavage-based self-replication by ribozymes, compartmentalization-based systems using reverse micelles and encapsulated reagents, and conformation-based systems like hybridization chain reactions and prion-like protein aggregation. The document concludes that while examples of classic template-directed ligation self-replication have been achieved, more work is still needed to improve catalytic efficiencies and explore new forms and applications of chemical self-replication.
1. WILLIAM J. FRAZEE, Ph.D.
1114 Minton Road
Madison, Wisconsin 53711-3141
608-442-7101 (home)
608-669-8055 (cell)
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PATENTS
Zelle, R.; Galullo, V. P.; Baker, C. T.; Will, P.; Frazee, W. J. Ion Channel Modulators. WO 2005/087750 A1
(published 22 September 2005).
Zelle, R.; Galullo, V. P.; Baker, C. T.; Will, P.; Frazee, W. J.; Masdiyasni, H.; Guo, J. Ion Channel Modulators.
WO 2005/086836 A2 (published 22 September 2005).
Zelle, R.; Galullo, V. P.; Baker, C. T.; Will, P.; Frazee, W. J.; Mazdiyasni, H.; Guo, J. Ion Channel Blockers for
Treating Disease. PCT Application No. PCT/US05/07667 (filed 7 March 2005).
Jacobs, R. T.; Folmer, J. J.; Simpson, T. R.; Chaudhari, B.; Frazee, W. J.; Davenport, T. W.; Sundarababu, G.
Therapeutic Heterocycles. US Patent 6,399,603 (4 June 2002).
Lewis, J. J.; Brush, K. A.; Garcia-Davenport, L. E.; Frazee, W. J.; Chapdelaine, M. J. Azolobenzazepine Derivatives
and Compositions and Method of Use Thereof. US Patent 6,313,290 (6 November 2001).
Jacobs, R. T.; Folmer, J.; Simpson, T. R.; Chaudhari, B.; Frazee, W. J.; Davenport, T. W. Therapeutic Quinazoline
Compounds. WO 01/21598 (published 29 March 2001).
Brush, K. A.; Chapdelaine, M. J.; Frazee, W. J.; Garcia-Davenport, L. E.; Lewis, J. J. Azolobenzazepine Derivatives
as Neurologically Active Agents. WO 97/32883 (published 12 September 1997), US Patent 6,124,281 (26 September
2000).
PUBLICATIONS
Marks, B. D.; Fakhoury, S. A.; Frazee, W. J.; Eliason, H. C.; Riddle, S. M. A Substrate-Independent TR-FRET
Histone Deacetylase Inhibitor Assay. J. Biomol. Screen. 2011, 16, 1247-1253.
Lebakken, C. S.; Riddle, S. M.; Singh, U.; Frazee, W. J.; Eliason, H. C.; Gao, Y.; Reichling, L. J.; Marks, B. D.;
Vogel, K. W. Development and Applications of a Broad-Coverage, TR-FRET Based Kinase Binding Assay Platform.
J. Biomol. Screen. 2009, 14, 924-935.
Shukla, S. J.; Nguyen, D.-T.; MacArthur, R.; Simeonov, A.; Frazee, W. J.; Hallis, T. M.; Marks, B. D.; Singh, U.;
Eliason, H. C.; Printen, J.; Austin, C. P.; Inglese, J.; Auld, D. S. Identification of Pregnane X Receptor Ligands Using
Time-Resolved Fluorescence Resonance Energy Transfer and Quantitative High-Throughput Screening. Assay Drug
Dev. Technol. 2009, 7, 143-169.
Piper, D. R.; Duff, S. R.; Eliason, H. C.; Frazee, W. J.; Frey, E. A.; Fuerstenau-Sharp, M.; Jachec, C.; Marks, B. D.;
Pollok, B. A.; Shekhani, M. S.; Thompson, D. V.; Whitney, P.; Vogel, K. W.; Hess, S. D. Development of the
Predictor hERG Fluorescence Polarization Assay Using a Membrane Protein Enrichment Approach. Assay Drug Dev.
Technol. 2008, 6, 213-223.
2. WILLIAM J. FRAZEE, Ph.D.
Page Two
Scott, C. W.; Sobotka-Briner, C.; Wilkins, D. E.; Jacobs, R. T.; Folmer, J. J.; Frazee, W. J.; Bhat, R. V.; Ghanekar,
S. V.; Aharony, D. Novel Small Molecule Inhibitors of Caspase-3 Block Cellular and Biochemical Features of
Apoptosis. J. Pharmacol. Exp. Therap. 2003, 304, 433.
Frazee, W. J. Dimethyl Bromomalonate. In Encyclopedia of Reagents for Organic Synthesis; Paquette, L. A., Ed.;
Wiley: New York, 1995; Vol.3, pp 2036-2038.
Frazee, W. J.; Ohnmacht, C. J.; Malick; J. B. Antidepressants. Annual Reports in Medicinal Chemistry 1985, 20, 31.
Ko, K.-Y.; Frazee, W. J.; Eliel, E. L. Asymmetric Reactions Based on 1,3-Oxathianes—3. Secondary α-Hydroxyacids
RCHOHCO2
H and Glycols RCHOHCH2OH. Tetrahedron 1984, 40, 1333.
Ohnmacht, C. J.; Malick, J. B.; Frazee, W. J. Antidepressants. Annual Reports in Medicinal Chemistry 1983, 18, 41.
Eliel, E. L.; Koskimies, J. K.; Lohri, B.; Frazee, W. J.; Morris-Natschke, S.; Lynch, J. E.; Soai, K. Asymmetric
Synthesis of Chiral Tertiary Alcohols in High Enantiomeric Excess; in Asymmetric Reactions and Processes in
Chemistry, Eliel, E. L.; Otsuka, S., Eds.; American Chemical Society, Washington, DC, 1982, p. 37.
Posner, G. H.; Babiak, K. A.; Loomis, G. L.; Frazee, W. J.; Mittal, R. D.; Karle, I. L. Stereocontrolled Total Synthesis
of an α-Methylene Guaianolide in the 4,5-Epoxyosmitopsin Family. J. Am. Chem. Soc. 1980, 102, 7498.
Eliel, E. L.; Frazee, W. J. Asymmetric Synthesis of Nearly Optically Pure Atrolactic Acid Methyl Ether. J. Org.
Chem. 1979, 44, 3598.
Posner, G. H.; Loomis, G. L.; Mittal, R. D.; Frazee, W. J.; Schmidt, D. M.; Babiak, K. A. Synthesis and
Characterization of Two Stereoisomeric Hydroazulenones. Versatile Precursors to Guaianolides. Tetrahedron Lett.
1978, 4213.
Trost, B. M.; Bogdanowicz, M. J.; Frazee, W. J.; Salzmann, T. N. Oxasecoalkylation via Cyclobutanone Intermediates.
J. Am. Chem. Soc. 1978, 100, 5512.
Trost, B. M.; Frazee, W. J. New Synthetic Reactions. Double Chain Extension. J. Am. Chem. Soc. 1977, 99, 6124.
Allen, J. R.; Chesney, C. F.; Frazee, W. J. Modifications of Pyrrolizidine Alkaloid Intoxication Resulting from Altered
Hepatic Microsomal Enzymes. Toxicol. Appl. Pharmacol. 1972, 23, 470.
Kretchmer, R. A.; Frazee, W. J. Hydroazulenes. I. A Thermal Epoxide Rearrangement. J. Org. Chem. 1971, 36, 2855.
POSTERS & PRESENTATIONS
Frazee, W. J.; Riddle, S. M.; Wolken, J. K.; Marks, B. D.; Lebakken, C. S.; Eliason, H. E.; Singh, U.; Rukavishnikov,
A.; Fakhoury, S. A. Competitive TR-FRET Binding Assays for PI3K Family Inhibitors. Society for Biomolecular
Sciences 16th
Annual Conference, Phoenix, AZ, 2010.
Singh, U.; Lebakken, C.; Riddle, S.; Marks, B.; Frazee, J.; Eliason, H.; Wolken, J.; Gao, Y.; Reichling, L.; Vogel, K.
New fluorescence-based binding assay for identification and characterization of kinase inhibitors. Abstracts of Papers,
237th
National Meeting of the American Chemical Society, Salt Lake City, Utah; American Chemical Society;
Washington, DC, 2008; MEDI 225.
3. WILLIAM J. FRAZEE, Ph.D.
Page Three
Piper, D. R.; Frazee, W. J.; Marks, B. D.; Hess, S. D. The Predictor™ Fluorescence Polarization Assay for High-
Throughput Screening of hERG Channel Affinity. Abstracts of Papers, 31st
National Medicinal Chemistry
Symposium, Pittsburgh, Pennsylvania; Division of Medicinal Chemistry, American Chemical Society, Washington,
DC, 2008; Abstract 242.
Riddle, S.; Singh, U.; Lebakken, C.; Frazee, J.; Marks, B.; Eliason, H.; Wolken, J.; Vogel, K. A One-step, Mix-and-
Read, TR-FRET Binding Assay to Characterize Kinase Inhibitors. 3rd
Protein Kinases in Drug Discovery Conference,
San Diego, CA, 2008.
Hereley, S.; Singh, U.; Lebakken, C.; Frazee, J.; Marks, B.; Eliason, H.; Wolken, J.; Riddle, S.; Vogel, K. A One-step,
Mix-and-Read, TR-FRET Binding Assay to Characterize Kinase Inhibitors. Society for Biomolecular Sciences 14th
Annual Conference, St. Louis, MO, 2008.
Piper, D. R.; Duff, S. R.; Eliason, H. C.; Frazee, W. J.; Frey, E. A.; Fuerstenau-Sharp, M.; Jachec, C.; Marks, B. D.;
Pollok, B. A.; Shekhani, M. S.; Thompson, D. V.; Whitney, P.; Vogel, K. W.; Zhong, Z.; Hess, S. D. Building the
Predictor™ Fluorescence Polarization Assay for High-Throughput Screening of hERG Channel Affinity. Society for
Biomolecular Sciences 14th
Annual Conference, St. Louis, MO, 2008.
VanDenHeuvel-Kramer, K.; Marks, B. D.; Stafslien, D. K.; Singh, U.; Eliason, H. C.; Wolken, J. K.; Frazee, W. J.
Fluorescence-based Biochemical Assays for the Study of Pregnane X Receptor and Constitutive Androstane Receptor.
5th
Annual Screening Europe Conference, Stockholm, Sweden, 2008.
Leathers, R.; Kupcho, K.; Stafslien, D. K.; Singh, U.; Eliason, H. C.; Reichling, L.; Frazee, W. J.; Horton, R. A.;
Riddle, S.; Gao, Y. Enabling compound profiling across the entire PI3K family using the Adapta™ universal kinase
assay. 5th
Annual Screening Europe Conference, Stockholm, Sweden, 2008.
Frazee, W. J.; Singh, U.; Marks, B. D.; Eliason, H. E.; Stafslien, D. K.; Wolken, J. K.; Vogel, K. W. Early Screening
for PXR- and CAR-mediated ADME-Tox liabilities: New fluorescence-based ligand binding and coregulator
recruitment assays. Abstracts of Papers, 235th
National Meeting of the American Chemical Society, New Orleans,
Louisiana; American Chemical Society; Washington, DC, 2008; MEDI 059.
Singh, U.; Marks, B. D.; Eliason, H. E.; Stafslien, D. K.; Wilkinson, J. M.; De Rosier, T.; Hallis, T. M.; Vogel, K. W.;
Miao, G.; Frazee, W. J. New fluorescence-based assays for identification and characterization of selective PPARα,
δ(β), and γ ligands. Abstracts of Papers, 235th
National Meeting of the American Chemical Society, New Orleans,
Louisiana; American Chemical Society; Washington, DC, 2008; MEDI 061.
Hereley, S.; Marks, Bryan D.; Stafslien, D. K.; Singh, U.; Eliason, H. C.; Wolken, J. K.; Frazee, W. J. Fluorescence-
Based Biochemical Assays for the Study of Pregnane X Receptor and Constitutive Androstane Receptor. 8th
International ISSX (International Society for the Study of Xenobiotics) Meeting, Sendai, Japan, October 9-12, 2007.
Duff, S. R.; Farnham, J. G.; Marks, B. D.; Qadir, N.; Eliason, H. C.; Shekhani, M. S.; Fernandez-Perez, C.; Vogel, K.
W.; Frazee, W. J. Fluorescence polarization (FP) assay for identification of vitamin D receptor (VDR) ligands.
Abstracts of Papers, 232nd
National Meeting of the American Chemical Society, San Francisco, California; American
Chemical Society; Washington, DC, 2006; MEDI 543.
Brush, K. A.; Frazee, W. J.; Garcia-Davenport, L. E.; Lewis, J. J.; Goldstein, J. M.; Pullan, L. M. Synthesis and
Structure Activity Studies of a Novel Series of Glycine Antagonists: Tricyclic Benzazepine Analogs. Abstracts of
Papers, 213th
National Meeting of the American Chemical Society, San Francisco, California; American Chemical
Society; Washington, DC, 1997; MEDI 34.
4. WILLIAM J. FRAZEE, Ph.D.
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Payne-Gallimore, P. A.; Frazee, W. J.; Brush, K. A.; Pullan, L. M.; Goldstein, J. M.; Patel, J. B. Synthesis and
Structure Activity Studies of a Novel Series of Tricyclic Benzazepine Analogs. Abstracts of Papers, 213th
National
Meeting of the American Chemical Society, San Francisco, California; American Chemical Society; Washington, DC,
1997; MEDI 35.
Silverman, S. M.; Frazee, W. J.; Hall, J. E.; Ceccarelli, C.; Chow, M. M. A Method for Determination of the Oxime
Stereochemistry of Isatin-3-oximes Utilizing 13
C NMR Spectroscopy. Abstracts of Papers, 203rd
National Meeting of
the American Chemical Society, San Francisco, California; American Chemical Society; Washington, DC, 1992;
ORGN 329.
Frazee, W. J.; Chesney, C. F.; Allen, J. R. Effects of Altered Hepatic Drug-Metabolizing Enzyme Activities on the
Antimitotic Action of Monocrotaline in the Liver of Rats. Federation Proc. 1972, 31, 611.